A Case of Secondary Amyloid Colitis in Rheumatoid Arthritis.

, Cho, Jae Wan; , Chae, Hiun Suk; , Im, Kuk Hee; , Kim, Tae Ho; , Lee, Gang Mun; , Kim, Sung Soo; , Lee, Chang Don; , Choi, Gyu Yong; , Chung, In Sik; , Sun, Hee Sick; , Maeng, Yi So; , An, Chang Hyuk

Case Report

Journal of the Korean Society of Coloproctology 2000;16(2):125-130.

Cho, Jae Wan , Chae, Hiun Suk , Im, Kuk Hee , Kim, Tae Ho , Lee, Gang Mun , Kim, Sung Soo , Lee, Chang Don , Choi, Gyu Yong , Chung, In Sik , Sun, Hee Sick , Maeng, Yi So , An, Chang Hyuk

¹Department of Internal Medcine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
²Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
³Department of General Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Amyloidosis is known as a disease caused by the deposition of a insoluble and fibrous amyloid protein in the extracellular space of various organs and tissue. Intestinal amyloid deposition may develop motility disturbance, malabsorption, bleeding and perforation. A 70-year old woman with lower abdominal pain, watery diarrhea was admitted and had the past history of diabetes mellitus, hypertension for 8 years and rheumatoid arthritis for 10 year. On colonoscopic examination for evaluation of diarrhea, multiple edematous and shallow ulcers was found from distal sigmoid to terminal ileum. A green colored positive birifringent stained amorphous material was found in polarizing microscopy of colon biopsy specimen stained with Congo-red on microscopic examination,. We report a case of amyloidosis causing colon ulcers confirmed by colonoscopic biopsy with review literature.