Colon Cancer Secondary to Hematologic Disease.

, Kim, Do Hyoung; , Jee, Sung Bae; , Si, Youn; , Lee, Yoon Suk; , Kang, Won Kyung; , Oh, Seong Taek; , Lee, In Kyu

doi:2009.25.4.248

Original Article

Journal of the Korean Society of Coloproctology 2009;25(4):248-251.
DOI: https://doi.org/10.3393/jksc.2009.25.4.248

Colon Cancer Secondary to Hematologic Disease.

Kim, Do Hyoung , Jee, Sung Bae , Si, Youn , Lee, Yoon Suk , Kang, Won Kyung , Oh, Seong Taek , Lee, In Kyu

¹Hang Colorectal Clinic, Seoul, Korea.
²Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. cmcgslee@catholic.ac.kr

Abstract

PURPOSE
The incidence of secondary malignancies in hematologic patients is known to be higher than it is in other patients. However, the characteristics of secondary malignancy and surveillance have not yet been established for colorectal cancer in leukemic patients.
METHODS
From 1995 to 2007, 6,030 patients who were diagnosed with acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphoid leukemia (CLL), and multiple myeloma (MM) were enrolled in this study. Among them, 9 patients were diagnosed with colorectal cancer at St. Mary's Hospital and were analyzed retrospectively.
RESULTS
Three of the 2,570 patients with AML, 1 of the 1,158 patients with CML, 2 of the 83 patients with CLL, 2 of the 422 patients with MM, and none of the 1,797 patients with ALL were found to have colorectal cancer. There were no operative mortalities, but 2 patients refused to have surgery. The ratio of observed to expected subsequent colorectal cancer in CLL was higher than it was in the other groups, indicating that the relative risk of colorectal cancer is higher in patients with CLL.
CONCLUSION
Compared to the Surveillance, Epidemiology and End-Result (SEER) program at the National Cancer Institute (NCI) in the United State, we have the same high relatively risk in CLL patients. Careful attention should be paid to the possibility of colorectal cancer in CLL patients.

Key Words: Colorectal cancer; Leukemia; Secondary malignancy