Expression of Tumor Metastasis Related Genes in Korean Colorectal Cancers and Cell lines.

, Bae, Ok Suk; , Suh, Seong Il; , Chun, So Young

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Original Article

Journal of the Korean Society of Coloproctology 1998;14(1):11-19.

Expression of Tumor Metastasis Related Genes in Korean Colorectal Cancers and Cell lines.

Bae, Ok Suk , Suh, Seong Il , Chun, So Young

Abstract

We studied the expressions of E-cadherin, MMP-7 and CD44V in colorectal cancer and their corresponding normal mucosa using RT-PCR. From the 26 patients whom a com parative study of clinical and histopathological data is available, MMP-7 and CD44V were significantly enhanced in cancer and their metastatic tissues, compared with their normal mucosa. E-cadherin did not reveal any difference between cancer and normal mucosa. The relashionship between these genes and colorectal cancer development can not be confirmed by this study, however CD44v and MMP-7 may be associated with metastasis of colorectal cancer.

Key Words: Colorectal cancer; CD44v; MMP-7; E-cadherin

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