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HOME > J Korean Soc Coloproctol > Volume 14(3); 1998 > Article
Original Article
Small Flat Adenocarcinoma of the Colon Arising From Familial Adenomatous Polyposis Patient: Suggesting de novo Origin.
Park, Dong Kook , Lee, Min Chol , Jun, Ho Jin , Lee, Chan Young , Kim, Jung Tak , Jung, Min , Park, Jong Kwon , Ryu, Jin Woo
Journal of the Korean Society of Coloproctology 1998;14(3):655-660

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Abstract

Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.

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