Efficacy and Safety of Ramosetron Injection for Nausea and Vomiting in Colorectal-Cancer Patients Undergoing a Laparoscopic Colectomy: A Randomized, Double-Blind, Comparative Study

Han Eol Park; Min Ki Kim; Won-Kyung Kang

doi:10.3393/ac.2018.34.1.36

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Original Article Efficacy and Safety of Ramosetron Injection for Nausea and Vomiting in Colorectal-Cancer Patients Undergoing a Laparoscopic Colectomy: A Randomized, Double-Blind, Comparative Study: Han Eol Park, Min Ki Kim, Won-Kyung Kang; Annals of Coloproctology 2018;34(1):36-41.
DOI: https://doi.org/10.3393/ac.2018.34.1.36
Published online: February 28, 2018

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Correspondence to: Won-Kyung Kang, M.D. Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10 63 (yuksam)-ro, Yeongdeungpo-gu, Seoul 07345, Korea. Tel: +82-2-3779-1033, Fax: +82-2-780-9114, wonkkang@catholic.ac.kr

• Received: June 28, 2017 • Accepted: October 30, 2017

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ARTICLE INFORMATION
REFERENCES

Abstract

Purpose
A laparoscopic colectomy in colorectal-cancer patients is usually associated with a high risk of postoperative nausea and vomiting (PONV). The purpose of this study is to evaluate the efficacy of injection of long-acting 5-hydroxytryptamine type 3 (5-HT₃) receptor antagonist for the reduction of PONV in patients with colorectal cancer.
Methods
A total of 48 patients scheduled to undergo a laparoscopic colectomy for colorectal cancer were randomized in a double-blinded fashion. Patients were randomly allocated to 1 of 2 groups and assigned to receive either 0.3 mg of ramosetron intravenously (group A, n = 25) or 2 mL of normal saline (placebo) (group B, n = 22) immediately after the operation. The incidence of PONV, the nausea severity scale score, the visual analogue scale (VAS) score for pain, the total amount of patient-controlled analgesia used, the recovery of bowel function, and morbidities were assessed at 1 hour and at 24, 48, and 72 hours after surgery.
Results
The baseline and the operative characteristics were similar between the groups (P > 0.05). The number of cases without PONV (complete response) was higher for group A (ramosetron) than group B (normal saline): 24 hours after surgery, 92.0% (23 of 25) for group A versus 54.5% (12 of 22) for group B; 48 hours after surgery, 92% (23 of 25) for group A versus 81.8% (18 of 22) for group B (both P < 0.05). No serious adverse events occurred.
Conclusion
Postoperative ramosetron injection is effective for the prevention of PONV after a laparoscopic colectomy in colorectal-cancer patients.
Keywords: Ramosetron; Postoperative nausea and vomiting; Laparoscopic colectomy

INTRODUCTION

Postoperative nausea and vomiting (PONV) is a common complication after surgery and is related to the patient's quality of life and compliance with treatment [1 2]. The preoperative nasogastric tube, patient-controlled anesthesia (PCA), and postoperative analgesics in the postanesthetic recovery room might be associated with PONV. Approximately 80% of postoperative patients have been reported to suffer distress from PONV [3 4].

Major abdominal surgery is known to be associated with more severe postoperative bowel dysfunction, such as nausea, vomiting, and reinsertion of a nasogastric tube, compared with other surgeries. Even though some reports have stated that laparoscopic abdominal surgeries have better outcomes than open surgeries in terms of PONV [5], the patients still complain of postoperative bowel symptoms similar to those of open surgeries [6]. Based on the multiple factors mentioned above, patients who have undergone laparoscopic colorectal surgery can be classified as a high-risk group for PONV.

Several drugs and anesthetic methods have been studied over the last few years in order to reduce the symptoms of postoperative bowel dysfunction and PONV. Several reports have been published on the efficacy of metoclopramide, droperidol, and ondansetron regarding reductions in the incidence of PONV [7 8 9]. Although combination therapies involving more than two antiemetic drugs have been reported to be effective for prophylaxis of PONV [10 11], single use of 5-hydroxytryptamine type 3 (5-HT₃) receptor antagonists has emerged as a better alternative therapy. Of several 5-HT₃ antagonists, ramosetron (Nasea, ODl Astellas Pharma Inc., Tokyo, Japan), which was developed to reduce gastrointestinal symptoms caused by chemotherapy [12] and irritable bowel syndrome, is a long-acting drug with high potency for 48 hours. The strong effects of ramosetron on abnormal bowel function and symptoms were proven in several studies [13 14].

Previous studies have discussed the effects of ramosetron during breast surgery [15], a thyroidectomy [16], gynecologic surgery [17], cardiac surgery [18], a cholecystectomy [19], and other surgeries [20 21]. However, not many of those studies were prospective and randomized, and few discussed the efficacy of ramosetron for the prophylaxis of PONV after laparoscopic colorectal surgeries, even though these patients are in a high-risk group for PONV. We, therefore, conducted a prospective, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of ramosetron injection after the completion of surgery.

METHODS

This study was approved by the Institutional Review Board of Seoul St. Mary's Hospital (approval number: KC12MISV0327). All patients who had been diagnosed with colon and rectal cancer by using colonoscopic biopsies, abdominal computed tomography scans, and other diagnostic tools were enrolled. All enrolled patients were planned for laparoscopic colorectal surgery, including a colectomy, under general anesthesia. Each patient signed informed consent to be enrolled in this study. Exclusion criteria were as follows: patients under 18 or over 80 years of age; patients requiring excision of other organs or another part of the colon due to synchronous/double primary cancers or other diseases; patients with American Society of Anesthesiologists (ASA) physical status classification greater than IV; patients unable to undergo radical surgery due to general medical condition; patients with a history of emergent surgery due to mechanical obstruction or intestinal bleeding; patients refusing to participate in the study or those unable to agree to participate by themselves; patients unable to participate in clinical trials due to legal reasons; patients that were definitely going to drop out from the trial and those unable to visit the hospital regularly; patients who were pregnant and lactating; patients with severe intra-abdominal adhesion due to previous abdominal surgery; patients with a previous history of intestinal inertia or severe constipation that might affect bowel motility after surgery; patients with a previous history of neoadjuvant chemotherapy or radiation therapy.

Patients were allocated into 2 groups by using a computer-generated randomizing method. The 2 groups were based on a placebo-controlled trial in a double-blind condition. At the completion of surgery and before the patient was fully awake from anesthesia, the patients in the ramosetron group (group A) received intravenously 0.3 mg of ramosetron and the patients in the placebo group (group B) received 2 mL intravenously of normal saline. The injected samples were kept in a sealed envelope.

All of the target patients were under standard general anesthesia. Anesthesia was maintained by sevoflurane 1.5%–2.5% (per volume), FiO₂ 0.440% (without N₂O), and remifentanil 0.05–0.3 µg/kg/min. Remifentanil was the only opioid used during the whole operation. At the completion of surgery, the total volume (µg) of remifentanil administered was assessed. None of the target patients received any antiemetics at the completion of surgery.

All patients were under the same PCA device regimen. Using a PCA device (Ace Medical PCA, mechanic version), fentanyl, 25 µg/kg (total volume including normal saline 100 mL), was injected at a 2 mL/hr basal rate, 0.5 mL/hr of a bolus, and 15 minutes of lockout time. PCA devices were working under continuous infusion of fentanyl from the completion of surgery. The target patients did not receive any other analgesics. Postoperative patients that were distressed due to severe pain and that had a visual analogue scale (VAS) score greater than 5 were injected with 25-µg units of fentanyl in the postanesthetic recovery room. 5-HT₃ receptor antagonists, such as ramosetron were never used as antiemetics.

After 1 to 2 hours from the completion of surgery, patients were transferred from the postanesthesia recovery room to the general ward under appropriate conditions and were observed closely for 72 hours. All events of PONV were checked by medical staff. The nausea severity scale (NSS) score, vomiting, and VAS score for pain were recorded at a regular time of day (0–24 hours, 24–48 hours, and 48–72 hours after transfer) [22 23]. The NSS was evaluated based on a 4-point scale (0 = none; 1 = mild; 2 = moderate; 3 = severe). The highest NSS scores that the patient reported were selected as meaningful scores. Vomiting was recorded as the number of occurrences and the time of each occurrence. Postoperative pain was assessed with an 11-point VAS from 0 (no pain) to 10 (worst pain imaginable). In addition to scores recorded within postoperative 72 hours, the total volume of PCA used and the total consumptions of additional metoclopramide for antiemetic effect and analgesics were precisely recorded. The times of return to diet and discharge from hospital were also recorded. The diet was decided by a medical attendant and depended on bowel sounds and gastrointestinal symptoms. Supplementary oxygen was given for 24 hours after surgery via a nasal prong at a rate of 2 L/min. Postoperative complications and remarkable findings were also recorded in detail. Second-generation cephalosporin was used as a prophylactic antibiotic until 24 hours after surgery.

We used the Fisher exact test with a type I error of 0.05 to calculate that the inclusion of 24 patients per group would afford an 80% chance of detection of a 40% reduction in the incidence of PONV. Considering a dropout rate of 5%, we increased the sample size to 26 patients per group. Data were expressed as mean ± standard deviation or number (%). Statistical analyses were performed using IBM SPSS Statistics ver. 24.0 (IBM Co., Armonk, NY, USA). Continuous data were analyzed using the t-test. Discrete data were analyzed using the chi-square test or the Fisher exact test, and post hoc comparisons were made with Bonferroni correction. P < 0.05 was considered statistically significant.

RESULTS

Between February 2013 and August 2014, 52 patients were found to be eligible for the study. Among them, 5 patients declined to participate in the study for personal reasons, so a total of 47 patients were enrolled in the study. Target patients were randomly allocated into 2 groups (group A, 3 mg of ramosetron, n = 27; group B, 2 mL of normal saline, n = 22) (Fig. 1). There were no significant differences in patients' demographic data and intraoperative variables between the 2 groups (Table 1). With regard to postoperative recovery course, 2 patients in group A (ramosetron group) needed metoclopramide as a rescue antiemetic (P < 0.05). Other than that, no significant differences were found between the 2 groups (Table 2).

We defined an improvement in patient's subjective feeling of nausea with a corresponding decrease in the NSS score as a complete response. The complete response rates at 24 hours and 48 hours after surgery were 92.0% (23 of 25) for group A versus 54.5% (12 of 22) for group B and 96.0% (24 of 25) for group A versus 81.8% (18 of 22) for group B, respectively. No statistically significant differences in the NSS score between the 2 groups were observed immediately after the surgery and at 24 hours and 48 hours after surgery (P = 0.635, P = 0.411, and P = 0.632, respectively) (Table 3). In addition, no serious adverse events, such as headaches and dizziness, occurred during the study.

DISCUSSION

PONV is a significant concern for patients and physicians. Many trials have aimed to reduce postoperative bowel dysfunction and PONV, and several drugs and anesthetic methods have been studied over the last few years; however, which method or drug is most effective in reducing PONV is controversial. The etiology of PONV remains unclear, but is probably multifactorial. Independent PONV risk factors include female sex, nonsmoking status, history of PONV and/or motion sickness, and perioperative opioid use; the frequency of PONV is 10% for patients with no risk factor, but increases to 60% to 80% for patients with more than three risk factors [24 25]. In this study, these factors were well controlled. The characteristics of the patients (including a history of PONV, motion sickness, or both), the anesthetic used, and operative data were similar for both groups.

In addition to the general risk factors of PONV, the central action of carbon dioxide, stretching of the peritoneum, and increased blood pressure in the peritoneal cavity after gas insufflation during laparoscopic surgery all have been proposed to provoke nausea and vomiting [26] by reducing intestinal blood flow [27] and inducing the release of emetogenic substances, including serotonin [28]. A variety of pharmacologic approaches (antihistamines, butyrophenones, and dopamine receptor antagonists) have been investigated for the prevention and treatment of PONV. However, use of traditional antiemetics, such as droperidol and metoclopramide, has been limited due to undesirable adverse effects, including excessive sedation, hypotension, dry mouth, dysphoria, hallucinations, and extrapyramidal symptoms [7 8 9 29]. Considering the etiopathogenetic mechanism of PONV after laparoscopic colorectal surgery, 5-HT₃ antagonists may be more effective than other antiemetics in preventing and treating PONV without these adverse effects. In this background, injection of the long-acting 5-HT₃ receptor antagonist ramosetron has emerged as an effective method for reducing PONV in patients who have undergone many different kinds of surgeries [10 13 15 16 17 18 19 20 21]. The most common adverse events caused by 5-HT₃ antagonists are headache and dizziness. The current study found no difference in the incidence of these side effects between the groups, and no clinically important adverse events occurred. In the present study, treatment with ramosetron was more effective for preventing PONV than the placebo at 0–24 and 24–48 hours after surgery. This result was consistent with those of previous studies.

A limitation of this study was the differences in the types of operations that the patients underwent. In group A (ramosetron), 8 patients (32%) underwent a right hemicolectomy or an extended right hemicolectomy, compared with 1 patient (4.5%) in group B (placebo). Operations managing the right-side colon have more contact with the small intestines, which might result in dysfunction of bowel motility. The randomization protocol did not consider the types of operations that the patients were scheduled for. Future studies regarding the effect of ramosetron in reducing PONV after laparoscopic colorectal surgeries should consider the specific operation type.

ARTICLE INFORMATION

This content was poster presented at the 2015 annual Scientific Meeting of the American Society of Colon and Rectal Surgeons (ASCRS).

CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

REFERENCES

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Fig. 1

Flow diagram showing the study design.

Table 1

Baseline characteristics and information on surgery and anesthesia of the patients

Values are presented as mean ± standard deviation or number (%).

Group A, ramosetron group; group B, placebo group; APA PS, American Society of Anesthesiologists physical status; RHC, right hemicolectomy; ERHC, extended right hemicolectomy; T-colectomy, transverse colon colectomy; LHC, left hemicolectomy; ELHC, extended left hemicolectomy; AR, anterior resection; LAR, low anterior resection.

Table 2

Recovery course of the patients

Values are presented as mean ± standard deviation or number.

Group A, ramosetron group; group B, placebo group; VAS, visual analogue scale; PCA, patient-controlled analgesia.

Table 3

Comparison of nausea and vomiting scales

Values are presented as number (%).

Group A, ramosetron group; group B, placebo group; NSS, nausea severity scale.

Figure & Data

References

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Efficacy and Safety of Ramosetron Injection for Nausea and Vomiting in Colorectal-Cancer Patients Undergoing a Laparoscopic Colectomy: A Randomized, Double-Blind, Comparative Study

Ann Coloproctol. 2018;34(1):36-41. Published online February 28, 2018

DOI: https://doi.org/10.3393/ac.2018.34.1.36

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Figure

Efficacy and Safety of Ramosetron Injection for Nausea and Vomiting in Colorectal-Cancer Patients Undergoing a Laparoscopic Colectomy: A Randomized, Double-Blind, Comparative Study

Fig. 1 Flow diagram showing the study design.

Fig. 1

Efficacy and Safety of Ramosetron Injection for Nausea and Vomiting in Colorectal-Cancer Patients Undergoing a Laparoscopic Colectomy: A Randomized, Double-Blind, Comparative Study

Table 1