Prognostic Role of MMPs in Colorectal Cancer

Moo-Jun Baek

doi:10.3393/jksc.2011.27.3.105

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Editorial Prognostic Role of MMPs in Colorectal Cancer: Moo-Jun Baek; Journal of the Korean Society of Coloproctology 2011;27(3):105-106.
DOI: https://doi.org/10.3393/jksc.2011.27.3.105
Published online: June 30, 2011

Department of Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.

Correspondence to: Moo Jun Baek, M.D. Department of Surgery, Soonchunhyang University Cheonan Hospital, 23-20 Bongmyeong-dong, Dongnam-gu, Cheonan 330-721, Korea. Tel: +82-41-570-3633, Fax: +82-41-571-0129, ssurge@sch.ac.kr

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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While most matrix metalloproteinases (MMPs) are produced in stromal cells, MMP-7 is produced in cancer cells and is known to affect the invasion and the metastasis of cancer cells by destroying the basement membrane [1]. MMP-7 is expressed mainly in the epithelial cells of the large intestine [2], and the over-expression of MMP-7 is known to influence early carcinogenesis of colorectal cancer from a normal colorectal mucosa to an adenoma [3]. Due to this mechanism, MMP-7 was reported to be an independent prognostic factor upon which to base a prognosis for colorectal cancer patients [4]. In this study, no correlation between the expression of MMP-7 and the prognosis for colorectal cancer patients was found. However, by using immunohistochemistry, this study confirmed a finding of a previous study by showing that MMP-7 was expressed mainly in cancer cells rather than in interstitial cells.

MMP-2 is one of the zinc-dependant matrix metalloproteinases working as main extracellular matrix remodelling enzymes, and it is called gelatinase. MMP-2 is regulated positively or negatively at the gene transcription level by various oncogenes, cytokines or growth factors [5]. The up-regulation of MMP-2 provokes the loss of basement membrane type IV collagen to destroy the extracellular matrix and promote the progression and the local invasion by a tumor [6]. As mentioned in many reports, over-expression of MMP-2 is expected for a higher-stage tumor [7]. However, unlike MMP-7, the down-regulation of MMP-2 was also reported at a higher stage [8], so the role of MMP-2 in colorectal cancer has not been clearly determined. Considering that tissue inhibitor of metalloproteinase (TIMP)-1, (or an inhibitor of MMP-2) is significantly up-regulated at higher stages, such as stage III or IV, than stage I or II [9], the action of MMP-2 is thought to be determined by the interaction with TIMP1.

According to the results of this study, no correlations of the expression of MMP-2 with factors related with the tumor's stage, differentiation, lymphovascular invasion, distant metastasis and recurrence were found, so drawing a conclusion in this study about the prognostic role of MMPs was difficult. This study aimed to investigate the expressions of MMP-2 and -7 in patients with colorectal cancer and to determine their meaning as prognostic factors by examining the characteristics of the expressions, the correlations with other pathologic findings and the correlation with prognosis, but it did not fulfill that aim. However, the study did include an in-depth morphologic study on the ways in which MMP-2 and MMP-7 are expressed in colorectal cancer tissues, so it should help in understanding the mechanisms for the expressions of the two MMPs.

Future studies to investigate whether the expression of MMP-7 actually has a negative influence on the prognosis for colorectal cancer and how it is related with other substances such as β catenin, survivin or PRL-3 will be meaningful. For MMP-2, continuous studies to examine its correlation with its inhibitor TIMP-1, as mentioned above, at a molecular biological level are recommended.

REFERENCES

1. Miyata Y, Iwata T, Ohba K, Kanda S, Nishikido M, Kanetake H. Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis. Clin Cancer Res 2006;12:6998–7003. Article PubMed
2. Saarialho-Kere UK, Crouch EC, Parks WC. Matrix metalloproteinase matrilysin is constitutively expressed in adult human exocrine epithelium. J Invest Dermatol 1995;105:190–196. Article PubMed
3. Heslin MJ, Yan J, Johnson MR, Weiss H, Diasio RB, Urist MM. Role of matrix metalloproteinases in colorectal carcinogenesis. Ann Surg 2001;233:786–792. Article PubMed PMC
4. Fang YJ, Lu ZH, Wang GQ, Pan ZZ, Zhou ZW, Yun JP, et al. Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis 2009;24:875–884. Article PubMed
5. Wagenaar-Miller RA, Gorden L, Matrisian LM. Matrix metallo-proteinases in colorectal cancer: is it worth talking about? Cancer Metastasis Rev 2004;23:119–135. Article PubMed
6. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 1997;277:225–228. Article PubMed
7. Li BH, Zhao P, Liu SZ, Yu YM, Han M, Wen JK. Matrix metalloproteinase-2 and tissue inhibitor of metallo-proteinase-2 in colorectal carcinoma invasion and metastasis. World J Gastroenterol 2005;11:3046–3050. Article PubMed PMC
8. Waas ET, Hendriks T, Lomme RM, Wobbes T. Plasma levels of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 correlate with disease stage and survival in colorectal cancer patients. Dis Colon Rectum 2005;48:700–710. Article PubMed
9. Zeng ZS, Cohen AM, Zhang ZF, Stetler-Stevenson W, Guillem JG. Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases. Clin Cancer Res 1995;1:899–906. PubMed

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Prognostic Role of MMPs in Colorectal Cancer

J Korean Soc Coloproctol. 2011;27(3):105-106. Published online June 30, 2011

DOI: https://doi.org/10.3393/jksc.2011.27.3.105

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