Annals of Coloproctology

Review

Malignant disease,Prognosis and adjuvant therapy

Survival and Operative Outcomes After Salvage Surgery for Recurrent or Persistent Anal Cancer: In Ja Park, George Chang; Ann Coloproctol. 2020;36(6):361-373. Published online December 31, 2020; DOI: https://doi.org/10.3393/ac.2020.12.29

6,428 View
152 Download
16 Web of Science
17 Citations

Anal squamous cell carcinoma (SCC) is a relatively rare cancer comprising less than 2.5% of all gastrointestinal malignancies. The standard treatment for anal SCC is primary chemoradiation therapy which can result in complete regression. After successful treatment, the 5-year survival is approximately 80%. However, up to 30% of patients experience recurrent persistent or recurrent disease. The role of surgery in the treatment of anal cancer, therefore, is limited to the management of recurrent or persistent disease with abdominoperineal resection and/or en bloc adjacent organ excision. Salvage surgery after irradiated anal cancer can be technically demanding in terms of acquisition of oncologically safe surgical margins and minimization of postoperative morbidity. In addition, 5-year survival outcomes after salvage resection have been reported to vary from 23% to 69%. Positive resection margins are generally regarded as the important risk factor associated with poor survival outcome. Perineal wound complications are the most common major postoperative morbidity. Because of the challenges of primary wound closure after salvage abdominoperineal resection, myocutaneous flap reconstruction has been performed to reduce the severity of perianal would complications. We, therefore, descriptively reviewed contemporary published evidence describing the treatment and outcomes after salvage surgery for persistent or recurrent anal SCC.

Citations

Citations to this article as recorded by

Management of Recurrent Anal Cancer
James Blake Littlejohn, Kelly Ann Brister
Surgical Oncology Clinics of North America.2025; 34(1): 91. CrossRef
Prognostic factors associated with worse outcomes following chemoradiation therapy in patients with anal carcinoma
Muhammad Khurrum, Alejandro Cruz, David Schaub, Joseph Gunderson, Andrea Moreno, Daniom Tecle, Amanda Gong, Manijeh Assar, McKenzie Hargis, Danielle Alexandra Dooley, Jose Cruz, Valentine Nfonsam
Colorectal Disease.2025;[Epub] CrossRef
Brazilian Society of Surgical Oncology: Guidelines for the management of anal canal cancer
Marcus Valadão, Rachel P. Riechelmann, José Antonio Cunha e Silva, Jorge Mali, Bruno Azevedo, Samuel Aguiar, Rodrigo Araújo, Mario Feitoza, Eid Coelho, Arthur Accioly Rosa, Naomi Jay, Alexcia Camila Braun, Rodrigo Pinheiro, Héber Salvador
Journal of Surgical Oncology.2024; 130(4): 810. CrossRef
Improving R0 Resection Rates With a Posterior-First, 2-Stage Approach for En Bloc Resection of Locally Advanced Primary and Recurrent Anorectal Cancers Involving the Deep Pelvic Sidewall
Shinichiro Sakata, S. Mohammed Karim, Jorys Martinez-Jorge, David W. Larson, Kellie L. Mathis, Scott R. Kelley, Peter S. Rose, Eric J. Dozois
Diseases of the Colon & Rectum.2024; 67(1): 90. CrossRef
Oncologic Outcomes of Salvage Abdominoperineal Resection for Anal Squamous Cell Carcinoma Initially Managed with Chemoradiation
Roni Rosen, Felipe F. Quezada-Diaz, Mithat Gönen, Georgios Karagkounis, Maria Widmar, Iris H. Wei, J. Joshua Smith, Garrett M. Nash, Martin R. Weiser, Philip B. Paty, Andrea Cercek, Paul B. Romesser, Francisco Sanchez-Vega, Mohammad Adileh, Diana Roth O’B
Journal of Clinical Medicine.2024; 13(8): 2156. CrossRef
Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment
Kevan J English
World Journal of Experimental Medicine.2024;[Epub] CrossRef
A systematic review on the role of interventional radiotherapy for treatment of anal squamous cell cancer: multimodal and multidisciplinary therapeutic approach
Maria Concetta Campisi, Valentina Lancellotta, Bruno Fionda, Martina De Angeli, Stefania Manfrida, Patrizia Cornacchione, Gabriella Macchia, Alessio Giuseppe Morganti, Gian Carlo Mattiucci, Maria Antonietta Gambacorta, Roberto Iezzi, Luca Tagliaferri
La radiologia medica.2024; 129(12): 1739. CrossRef
SURVIVAL AND PROGNOSTIC FACTORS OF ANAL CANCER: A STUDY BASED ON DATA FROM THE HOSPITAL-BASED CANCER REGISTRY OF A HIGH-COMPLEXITY ONCOLOGY CARE CENTER
Wallace Henrique Pinho da PAIXÃO, Gelcio Luiz Quintella MENDES, Débora Santos da SILVA, Rosyane Garcês Moreira Lima de SOUZA, Rodrigo Otavio de Castro ARAUJO, Karina Cardoso MEIRA, Rafael Tavares JOMAR
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo).2024;[Epub] CrossRef
Comparison of Perineal Closure Techniques after Abdominoperineal Resections for Carcinoma of the Anus
Jose L. Cataneo, Sydney A. Mathis, Sabreen Faqihi, Diana D. del Valle, Alejandra M. Perez-Tamayo, Anders F. Mellgren, Lee W. T. Alkureishi, Gerald GanttJr
The American Surgeon™.2023; 89(2): 238. CrossRef
Follow-up imaging of anal cancer after treatment
Maria El Homsi, Shannon P. Sheedy, Gaiane M. Rauch, Dhakshina M. Ganeshan, Randy D. Ernst, Jennifer S. Golia Pernicka
Abdominal Radiology.2023; 48(9): 2888. CrossRef
Survival outcomes following salvage abdominoperineal resection for recurrent and persistent anal squamous cell carcinoma
Daichi Kitaguchi, Yuichiro Tsukada, Masaaki Ito, Satoshi Horasawa, Hideaki Bando, Takayuki Yoshino, Kazutaka Yamada, Yoichi Ajioka, Kenichi Sugihara
European Journal of Surgical Oncology.2023; 49(9): 106929. CrossRef
Risk factors and outcome following salvage surgery for squamous cell carcinoma of the anus
Julie Borg, Karen-Lise Garm Spindler, Birgitte Mayland Havelund, Mette Møller Sørensen, Jonas Amstrup Funder
European Journal of Surgical Oncology.2023; 49(10): 107050. CrossRef
Pelvic Exenteration for Squamous Cell Carcinoma of the Anus: Oncological, Morbidity, and Quality-of-Life Outcomes
Kilian G.M. Brown, Michael J. Solomon, Daniel Steffens, Kheng-Seong Ng, Christopher M. Byrne, Kirk K.S. Austin, Peter J. Lee
Diseases of the Colon & Rectum.2023; 66(11): 1427. CrossRef
Prognostic Value of Fusobacterium nucleatum after Abdominoperineal Resection for Anal Squamous Cell Carcinoma
Marc Hilmi, Cindy Neuzillet, Jérémie H. Lefèvre, Magali Svrcek, Sophie Vacher, Leonor Benhaim, Peggy Dartigues, Emmanuelle Samalin, Julien Lazartigues, Jean-François Emile, Eugénie Rigault, Nathalie Rioux-Leclercq, Christelle de La Fouchardière, David Tou
Cancers.2022; 14(7): 1606. CrossRef
Failure of Initial Curative Treatment for Non-Metastatic Anal Squamous Cell Carcinoma: From Prognostic Factors Analysis to Stratified Treatment
Claire Jaraudias, Lucile Montagneb Angélique Saint, Renaud Schiappa, David Baron, Léa Marie, Karen Benezery, Cyrielle Scouarnec, Éric François, Ludovic Evesque
Clinical Colorectal Cancer.2022; 21(4): 362. CrossRef
Rekonstruktion onkologischer Defekte der Perianalregion
Raymund E. Horch, Ingo Ludolph, Andreas Arkudas
Der Chirurg.2021; 92(12): 1159. CrossRef
Rekonstruktion onkologischer Defekte der Perianalregion
Raymund E. Horch, Ingo Ludolph, Andreas Arkudas
coloproctology.2021; 43(6): 431. CrossRef

First
Prev
Page of 1
Next
Last

Search