Annals of Coloproctology

Display

Sort by :

Original Articles

Colorectal cancer

Preoperative neutrophil to lymphocyte ratio as a survival predictor in nonmetastatic colon cancer in a Latin America–based population: Horacio N. López-Basave, Germán Calderillo-Ruíz, Flavia Morales-Vásquez, Gerardo Miranda-Dévora, David Tlelo-Amastal, Luis M. Alavez-Ortega, Wendy R. Muñoz-Montaño; Ann Coloproctol. 2026;42(4):396-406. Published online August 12, 2026; DOI: https://doi.org/10.3393/ac.2025.01347.0192

485 View
24 Download

Abstract PDF: Purpose
Colon cancer represents a major global health challenge, with a steadily increasing incidence. Therefore, the identification of novel and easily accessible biomarkers in colon cancer is essential. Although the neutrophil to lymphocyte ratio (NLR) has emerged as a potential prognostic indicator in various malignancies, its applicability in colon cancer within Latin America remains unexplored. This study evaluated the association between preoperative NLR and overall survival (OS) and disease-free survival (DFS).
Methods
We conducted a retrospective cohort study at the gastroenterology department of Mexico’s National Cancer Institute between 2008 and 2022. All patients with nonmetastatic colon cancer who underwent upfront surgery were screened for inclusion. The optimal NLR cutoff value was determined using X-tile software and receiver operating characteristic curve analysis. Prognostic factors were assessed using Cox proportional hazards regression models.
Results
A total of 522 patients were included in the analysis and categorized into high NLR (>3.0, n=230) and low NLR (≤3.0, n=292). High NLR was associated with worse 3- and 5-year OS compared with low NLR (89.9% vs. 97.5% and 84.8% vs. 94.8%, respectively) in both univariate (P<0.001) and multivariate analyses (hazard ratio [HR], 3.020; 95% confidence interval [CI], 1.638–5.570; P<0.001). High NLR was also associated with worse 3- and 5-year DFS compared with low NLR (74.2% vs. 86.5% and 72.4% vs. 82.9%, respectively) in univariate (P=0.002) and multivariate analyses (HR, 1.627; 95% CI, 1.106–2.392; P=0.013).
Conclusion
This exploratory study highlights the prognostic relevance of NLR in nonmetastatic colon cancer and supports its utility for predicting OS and DFS in a Latin American population. As a readily available biomarker, NLR may be particularly useful in low-income settings. Further prospective studies are required to validate its clinical applicability.

Right-sided acute diverticulitis in the West: experience at a university hospital in Argentina: René M. Palacios Huatuco, Diana A. Pantoja Pachajoa, Julian E. Liaño, Héctor A. Picón Molina, Rafael Palencia, Alejandro M. Doniquian, Matías Parodi; Ann Coloproctol. 2023;39(2):123-130. Published online November 24, 2021; DOI: https://doi.org/10.3393/ac.2021.00402.0057

10,141 View
168 Download
3 Web of Science
2 Citations

Abstract PDF

Purpose
In the West, diverticular disease is located mainly in the left colon. However, it can also present in the right colon, with an incidence of 1% to 2% in Caucasians. The purpose of this study was to describe our experience in right-sided acute diverticulitis (RD).
Methods
In this retrospective study, 410 patients with acute diverticulitis treated from 2013 to 2020 were included in a university hospital in Córdoba, Argentina. Colonic diverticulitis was stratified into 2 groups; RD and left-sided acute diverticulitis. Demographic and clinical variables, laboratory and imaging findings, type of treatment, follow-up, and recurrence were analyzed.
Results
Sixteen patients (3.9%) with RD were identified; 62.5% were male and the mean age was 40.7±11.7 years. A total of 81.3% were Caucasian and 18.7% Native American. Significant differences were found between both groups of diverticulitis; patients with RD were younger (P=0.001), with lower BMI (P=0.01), comorbidity rate (P=0.01), Charlson comorbidity index (P=0.02), hospital stay (P=0.01), severity according to the Hinchey classification (P=0.001) and had a lower recurrence rate (P=0.001). There were no significant differences in sex (P=0.95), duration of pain until admission (P=0.05), laboratory findings (P=0.23) and treatment (P=0.34).
Conclusion
Conservative treatment predominated in RD, with a lower rate of complications and recurrences, providing data that support conservative therapy as initial treatment in RD in our environment.

Citations

Citations to this article as recorded by

Diagnostic pitfalls and management patterns of pediatric right-sided colonic diverticulitis: a single-center retrospective study
Hao Shi, Jing Xiong, Qiongqiong Ji, Xiang Ren, Jiangbin Liu, Zhibao Lv, Haifa Hong, Ting Xu
Pediatric Surgery International.2026;[Epub] CrossRef
Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study
E. Karam, C. Sabbagh, L. Beyer-Bergeot, P. Zerbib, V. Bridoux, G. Manceau, Y. Panis, E. Buscail, A. Venara, I. Khaoudy, M. Gaillard, M. Viennet, A. Thobie, B. Menahem, C. Eveno, C. Bonnel, J.-Y. Mabrut, B. Badic, C. Godet, Y. Eid, E. Duchalais, Z. Lakkis,
Techniques in Coloproctology.2024;[Epub] CrossRef

Malignant disease, Rectal cancer,Colorectal cancer,Biomarker & risk factor

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery: Jiwei Guo, Aik Yong Chok, Hui Jun Lim, Wei Xuan Tay, Weng Kit Lye, Lasitha Bhagya Samarakoon, Emile John Tan, Ronnie Mathew; Ann Coloproctol. 2021;37(3):159-165. Published online May 28, 2021; DOI: https://doi.org/10.3393/ac.2020.05.25

7,139 View
80 Download
3 Web of Science
4 Citations

Abstract PDF Supplementary Material

Purpose
Neutrophil-to-lymphocyte ratio (NLR) has been reported to predict adverse survival outcomes among patients with colorectal cancer (CRC). This study evaluates the prognostic value of NLR among patients with obstructing CRC who successfully underwent stenting before curative surgery.
Methods
We retrospectively reviewed patients who underwent stenting before surgery. Patient demographics, tumor characteristics, perioperative outcomes, recurrence-free survival (RFS), and overall survival (OS) were analyzed. NLR was calculated from the differential white blood cell counts at least 4 days after successful stenting, before elective surgery. Optimal cutoff to dichotomize NLR was obtained by maximizing log-rank test statistic with recursive partitioning of KaplanMeier RFS and OS curves. The optimal cutoff for high NLR was ≥ 5 at presentation before stenting, and ≥ 4 after stenting.
Results
Fifty-seven patients with localized obstructing CRC underwent successful endoscopic stenting before curative surgery. High NLR was associated with lymphovascular invasion (P = 0.006) and apical lymph node involvement (P = 0.034). Major perioperative complication(s) (hazard ratio [HR], 11.34; 95% confidence interval [CI], 2.49 to 51.56; P < 0.01) and high NLR (HR, 3.69; 95% CI, 1.46 to 9.35; P < 0.01) negatively impacted OS on univariate and multivariate analyses. High NLR negatively impacted RFS on univariate analysis (HR, 2.91; 95% CI, 1.29 to 6.60; P = 0.01).
Conclusion
NLR of ≥ 4 after stenting is an independent prognostic factor among patients with obstructing localized CRC who are successfully decompressed by endoscopic stenting before curative surgery.

Citations

Citations to this article as recorded by

The Predictive Value of Clinical and Systemic Inflammatory Biomarkers in Emergency Colic Cancer Surgery: A Retrospective Study
Adrian Marius Silaghi, Crenguta Sorina Serboiu, Dragos Serban, Vlad Denis Constantin, Corneliu Tudor, Ion Motofei, Gebran Hussein, Paul Lorin Stoica, Marina Ionela Nedea, Ana Maria Dascalu, Tudor Mihai Badescu
Journal of Clinical Medicine.2026; 15(4): 1627. CrossRef
Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef
Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
Minsung Kim, Il Tae Son, Bo Young Oh
The Ewha Medical Journal.2023;[Epub] CrossRef
Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
Annals of Coloproctology.2022; 38(2): 97. CrossRef

First
Prev
Page of 1
Next
Last

Search