Annals of Coloproctology

Case Reports

Metastasis

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report: Sungchul Lee, Euitae Kim, Dong-Guk Park; Ann Coloproctol. 2024;40(Suppl 1):S18-S22. Published online November 21, 2022; DOI: https://doi.org/10.3393/ac.2022.00339.0048

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A 61-year-old man presented with abdominal distension without any symptoms. On colonoscopy and computed tomography findings, it was clinically diagnosed as peritoneal metastasis of sigmoid colon cancer, and diagnostic laparoscopy was performed. Only the peritoneum was partially resected, and the pathology was signet ring cell carcinoma with predominantly local mucinous carcinoma component. However, the patient complained of persistent symptoms and, despite the progress of chemotherapy, the peritoneal dissemination worsened, and additional cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) was performed. Mixed adenoneuroendocrine carcinomas (MANECs) were reported in the appendix with perforated visceral peritoneum. After additional chemotherapy, the patient was discharged. Patients with advanced MANEC with peritoneal spreading may benefit from aggressive treatment by cytoreduction surgery with HIPEC, followed by intravenous chemotherapy.

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Mixed neuroendocrine non-neuroendocrine neoplasms in gastroenteropancreatic tract
Sebastián Díaz-López, Jerónimo Jiménez-Castro, Carlos Enrique Robles-Barraza, Carlos Ayala-de Miguel, Manuel Chaves-Conde
World Journal of Gastrointestinal Oncology.2024; 16(4): 1166. CrossRef

High-Grade Mixed Adenoneuroendocrine Carcinoma in the Cecum: A Case Report: Sang Ho Shin, Sae Hee Kim, Sung Hee Jung, Ji Woong Jang, Min Seok Kang, Sang Il Kim, Ji Hye Kim, Jun Ho Lee; Ann Coloproctol. 2017;33(1):39-42. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.39

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Gastrointestinal neoplasms with an exocrine and a neuroendocrine component are rare. Such neoplasms are called “mixed adenoneuroendocrine carcinomas” (MANECs) according to the most recent World Health Organization classification of gastrointestinal tract neoplasms. MANECs have no specific findings that distinguish them from pure adenocarcinomas. In addition, the optimal management strategy of MANECs is largely unknown. We describe the case of a 32-year-old man with dizziness and abdominal bloating. A cecal mass was suspected based on an image study done at a local clinic. We evaluated the cecal mass by using colonoscopy, contrast enhanced computed tomography of the abdomen, positron emission tomography-computed tomography, and laboratory studies. The patient underwent a right hemicolectomy and adjuvant chemotherapy. The final histopathological diagnosis was a high-grade MANEC of the ascending colon, tumor stage T3N2M0.

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Mixed neuroendocrine-non-neuroendocrine neoplasm of the colon treated with laparoscopic resection and adjuvant chemotherapy: a case report
Yuya Tanaka, Masayuki Takagi, Toshihiro Nakayama, Shuhei Kawada, Reika Matsushita, Tsunehisa Matsushita, Takahiro Ozaki, Shimpei Takagi, Sota Komai, Yasuhiro Sumi
Clinical Journal of Gastroenterology.2025; 18(2): 314. CrossRef
Colonic Mixed Neuroendocrine Nonneuroendocrine Neoplasm: Two Case Reports with Brief Review of Literature
Sanjay Sharma, Manoj Sharma, Neha Sethi, Abha Mathur, Maneesh K Vijay, Shweta Bansal, Shikha Goyal, Ankur Puniya
Journal of Mahatma Gandhi University of Medical Sciences and Technology.2024; 9(1): 53. CrossRef
Mixed adenoneuroendocrine carcinoma of the caecum presenting as extensive ileocolonic intussusception
Alessandro Iacomino, Ugo Grossi, Stefano Doratiotto, Alberto Brun Peressut, Patrizia Pelizzo, Giacomo Zanus
ANZ Journal of Surgery.2021;[Epub] CrossRef
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis
Ugo Grossi, Alessandro Bonis, Emma V. Carrington, Enrico Mazzobel, Giulio Aniello Santoro, Laura Cattaneo, Giovanni Centonze, Gaetano Gallo, Andrea Kazemi Nava, Maurizio Romano, Gian Luca Di Tanna, Giacomo Zanus
European Journal of Surgical Oncology.2021; 47(11): 2893. CrossRef
Neoadjuvant and Adjuvant Chemotherapeutic Strategy of Colorectal Mixed Adeno-Neuroendocrine Carcinomas
Anita Michael, Debashis K Nath
Cureus.2021;[Epub] CrossRef
Oncologic outcome of mixed adenoneuroendocrine carcinoma (MANEC): A single center case series
Audrius Dulskas, Algirdas Pilvelis
European Journal of Surgical Oncology.2020; 46(1): 105. CrossRef
Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review
Rani Kanthan, Suresh Tharmaradinam, Tehmina Asif, Shahid Ahmed, Selliah C Kanthan
World Journal of Gastroenterology.2020; 26(32): 5181. CrossRef
Colorectal neuroendocrine carcinoma: A case report and review of the literature
Tomoaki Yoshida, Kenya Kamimura, Kazunori Hosaka, Koji Doumori, Hiromitsu Oka, Akito Sato, Yasuo Fukuhara, Shoji Watanabe, Tomomi Sato, Akira Yoshikawa, Takashi Tomidokoro, Shuji Terai
World Journal of Clinical Cases.2019; 7(14): 1865. CrossRef
Management of MANEC of the colon and rectum: A comprehensive review of the literature
Anna Paspala, Nikolaos Machairas, Anastasia Prodromidou, Eleftherios Spartalis, Argyrios Ioannidis, Ioannis Kostakis, Dimetrios Papaconstantinou, Nikolaos Nikiteas
Molecular and Clinical Oncology.2018;[Epub] CrossRef

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