Annals of Coloproctology

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Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?: Myung-Kyu Jung, Ui Sup Shin, Young-Jun Ki, Yong-Bae Kim, Sun-Mi Moon, Se-Jin Sung; Ann Coloproctol. 2017;33(6):210-218. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.210

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16 Citations

Purpose

In this study, we investigated both the characteristics of right colon cancer (RTCC) in comparison with those of left colon cancer (LTCC) and the impact of the location of the colon cancer on the prognosis.

Methods

We retrospectively analyzed the cases of 974 patients with nonmetastatic colon cancer who had undergone surgery with a curative intent from January 2001 to December 2011. RTCC was defined as a tumor located proximal to the splenic flexure. The characteristics of RTCC cancer were investigated by using descriptive analyses, and their impacts on the prognosis were assessed by using a Cox multivariate regression.

Results

Compared to LTCC, RTCC showed a female-dominant feature, and an undifferentiated pathology was more frequently observed. The number of lymph nodes retrieved from patients with RTCC was significantly higher than that retrieved from patients with LTCC. During 75 months of follow-up, peritoneal recurrence was more common in patients with RTCC than it was in patients with LTCC, and among the patients with stage III colon cancer, the disease-free and the overall survival rates were significantly worse in patients with RTCC. After adjustments with the other prognostic factors associated with colon cancer had been made, a tumor located at the right colon was found to be independently associated with poor prognosis.

Conclusion

RTCC showed unique clinicopathologic features and was associated with a poorer prognosis.

Citations

Citations to this article as recorded by

Differences in the expression of CMTM3 and SSTR2 genes in right and left colon tumors: A molecular insight into colorectal cancer
Tuğçe Binen, Etem Akbaş, Tahsin Çolak, Tuba Kara, Aslıhan Bakır, Badel İnce
Medical Oncology.2025;[Epub] CrossRef
The relationship between clinical and pathological findings and FDG - PET uptake in metastatic colorectal cancers
Bediz Kurt İnci, Fatih Gürler, Osman Sütcüoğlu, Gözde Tahtacı, Aytuğ Üner, Ahmet Özet, Nazan Günel, Ozan Yazıcı
Indian Journal of Cancer.2024; 61(3): 440. CrossRef
Splenic flexure cancer survival: a 25‐year experience and implications for complete mesocolic excision (CME) and central vascular ligation (CVL)
Krishanth Naidu, Pierre H. Chapuis, Kilian G. M. Brown, Charles Chan, Matthew J. F. X. Rickard, Kheng‐Seong Ng
ANZ Journal of Surgery.2023; 93(7-8): 1861. CrossRef
Prognostic Significance of MRE11 Overexpression in Colorectal Cancer Patients
Vincent Ho, Liping Chung, Kate Wilkinson, Vivienne Lea, Stephanie H. Lim, Askar Abubakar, Weng Ng, Mark Lee, Tara L. Roberts, Wei Chua, Cheok Soon Lee
Cancers.2023; 15(9): 2438. CrossRef
Colorectal Cancer: Disease Process, Current Treatment Options, and Future Perspectives
Amusa S. Adebayo, Kafilat Agbaje, Simeon K. Adesina, Oluwabukunmi Olajubutu
Pharmaceutics.2023; 15(11): 2620. CrossRef
Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival
Ramón Cantero-Cid, Karla Marina Montalbán-Hernández, Jenny Guevara, Alejandro Pascual-Iglesias, Elisa Pulido, José Carlos Casalvilla, Cristóbal Marcano, Cristina Barragán Serrano, Jaime Valentín, Gloria Cristina Bonel-Pérez, José Avendaño-Ortiz, Verónica
World Journal of Gastrointestinal Oncology.2022; 14(1): 295. CrossRef
Disparities in Healthcare: Evaluation of Equity in Access to Surveillance Colonoscopy After Hemicolectomy in Patients With Colon Cancer During the COVID-19 Pandemic
Ranbir Singh, Eshan Patel
Cureus.2022;[Epub] CrossRef
Comparison of prolonged postoperative ileus between laparoscopic right and left colectomy under enhanced recovery after surgery: a propensity score matching analysis
Zhenmeng Lin, Chunkang Yang, Yi Wang, Mingfang Yan, Huizhe Zheng
World Journal of Surgical Oncology.2022;[Epub] CrossRef
The Prognostic Impact of Primary Tumor Site Differs According to the KRAS Mutational Status
Georgios Antonios Margonis, Neda Amini, Stefan Buettner, Yuhree Kim, Jaeyun Wang, Nikolaos Andreatos, Doris Wagner, Kazunari Sasaki, Andrea Beer, Carsten Kamphues, Daisuke Morioka, Inger Marie Løes, Katsunori Imai, Jin He, Timothy M. Pawlik, Klaus Kaczire
Annals of Surgery.2021; 273(6): 1165. CrossRef
Are right-sided colectomies for neoplastic disease at increased risk of primary postoperative ileus compared to left-sided colectomies? A coarsened exact matched analysis
Richard Garfinkle, Faisal Al-Rashid, Nancy Morin, Gabriela Ghitulescu, Julio Faria, Carol-Ann Vasilevsky, Marylise Boutros
Surgical Endoscopy.2020; 34(12): 5304. CrossRef
Prognostic Heterogeneity of MRE11 Based on the Location of Primary Colorectal Cancer Is Caused by Activation of Different Immune Signals
Chuan-Wen Fan, Maria Kopsida, You-Bin Liu, Hong Zhang, Jing-Fang Gao, Gunnar Arbman, Si-Yu-Wei Cao, Yuan Li, Zong-Guang Zhou, Xiao-Feng Sun
Frontiers in Oncology.2020;[Epub] CrossRef
Early Outcome of Enhanced Recovery Programs Versus Conventional Perioperative Care in Elective Open Left Side Colonic Carcinoma Surgery: Analysis of 80 Cases
Emad M. Abd ElRahman, Mohamed S. Kharoub, Ahmed Shora, Nabil A. Emara, M. Ashraf Balbaa
Indian Journal of Surgical Oncology.2020; 11(3): 372. CrossRef
Evaluating the distribution of the locations of colorectal cancer after appendectomy and cholecystectomy
Szabolcs Ábrahám, Tibor Németh, Ria Benkő, Mária Matuz, Aurél Ottlakán, Dániel Váczi, Attila Paszt, Zsolt Simonka, György Lázár
World Journal of Surgical Oncology.2020;[Epub] CrossRef
Diagnostic and pathologic value of programmed death-ligand 1 expression in colonic carcinoma
DinaO Helmy, MahmoudT El-Sabah Hussein, MohamedS Negm, MinaE Onsy
Egyptian Journal of Pathology.2020; 40(2): 204. CrossRef
Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
Kwangmin Kim, Ernes John T. Castro, Hongjin Shim, John Vincent G. Advincula, Young-Wan Kim
Annals of Coloproctology.2018; 34(6): 280. CrossRef
Laterality: Right-Sided and Left-Sided Colon Cancer
Seong Kyu Baek
Annals of Coloproctology.2017; 33(6): 205. CrossRef

Surgical Treatment of a Parastomal Hernia: Seung Chul Heo, Heung-Kwon Oh, Yoon Suk Song, Mi Sun Seo, Eun Kyung Choe, Seungbum Ryoo, Kyu Joo Park; J Korean Soc Coloproctol. 2011;27(4):174-179. Published online August 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.4.174

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10 Citations

Abstract PDF

Purpose

Parastomal hernia is a major complication of an intestinal stoma. This study was performed to compare the results of various operative methods to treat parastomal hernias.

Methods

Results of surgical treatment for parastomal hernias (postoperative recurrence, complications and postoperative hospital stays) were surveyed in 39 patients over an 11-year period. The patients enrolled in this study underwent surgery by a single surgeon to exclude surgeon bias.

Results

Seventeen patients were male, and twenty-two patients were female. The mean age was 65.9 years (range, 36 to 86 years). The stomas were 35 sigmoid-end-colostomies (90%), 2 loop-colostomies (5%), and 2 double-barrel-colostomies. Over half of the hernias developed within two years after initial formation. Stoma relocation was performed in 8 patients, suture repair in 14 patients and mesh repair in 17 patients. Seven patients had recurrence of the hernia, and ten patients suffered from complications. Postoperative complications and recurrence were more frequent in stoma relocation than in suture repair and mesh repair. Emergency operations were performed in four patients (10.3%) with higher incidence of complications but not with increased risk of recurrence. Excluding emergency operations, complications of relocations were not higher than those of mesh repairs. Postoperative hospital stays were shortest in mesh repair patients.

Conclusion

In this study, mesh repair showed low recurrence and a low complication rate with shorter hospital stay than relocation methods, though these differences were not statistically significant. Further studies, including randomized trials, are necessary if more reliable data on the surgical treatment of parastomal hernias are to be obtained.

Citations

Citations to this article as recorded by

Long-term outcomes after open parastomal hernia repair at a high-volume center
Alexis M. Holland, William R. Lorenz, Brittany S. Mead, Gregory T. Scarola, Vedra A. Augenstein, B. Todd Heniford, Monica E. Polcz
Surgical Endoscopy.2025; 39(1): 639. CrossRef
Parastomal Hernia: direct repair versus relocation: is stoma relocation worth the risk? A comparative meta-analysis and systematic review
Ahmed Abdelsamad, Mohammed Khaled Mohammed, Mohamed Badr Almoshantaf, Aya Alrawi, Ziad A. Fadl, Ziad Tarek, Nada Osama Aboelmajd, Torsten Herzog, Florian Gebauer, Nada K. Abdelsattar, Taha Abd-ElSalam Ashraf Taha
Updates in Surgery.2025;[Epub] CrossRef
Outcomes of surgical techniques for parastomal hernia repair: a bayesian network meta-analysis
Jose Martín-Arévalo, Victoria Alejandra Lopez-Callejon, David Moro-Valdezate, Stephanie Anne Garcia-Botello, Leticia Perez-Santiago, Monica Millan, Fernando Lopez-Mozos, Guillermo Lillo-Albert, Julieta Puente-Monserrat, Vicente Pla-Marti
Hernia.2025;[Epub] CrossRef
Stoma-Related Complications: A Single-Center Experience and Literature Review
Zalán Benedek, Loránd Kocsis, Orsolya Bauer, Nicolae Suciu, Sorin Sorlea, Călin Crăciun, Rareș Georgescu, Marius Florin Coroș
Journal of Interdisciplinary Medicine.2022; 7(2): 31. CrossRef
The Association of Coloproctology of Great Britain and Ireland consensus guidelines in emergency colorectal surgery
Andrew S. Miller, Kathryn Boyce, Benjamin Box, Matthew D. Clarke, Sarah E. Duff, Niamh M. Foley, Richard J. Guy, Lisa H. Massey, George Ramsay, Dominic A. J. Slade, James A. Stephenson, Phil J. Tozer, Danette Wright
Colorectal Disease.2021; 23(2): 476. CrossRef
Prevention and treatment of parastomal hernia: a position statement on behalf of the Association of Coloproctology of Great Britain and Ireland

Colorectal Disease.2018; 20(S2): 5. CrossRef
Repair of complex parastomal hernias
G. S. Hwang, M. H. Hanna, J. C. Carmichael, S. D. Mills, A. Pigazzi, M. J. Stamos
Techniques in Coloproctology.2015; 19(3): 127. CrossRef
Systematic review of open techniques for parastomal hernia repair
J. Al Shakarchi, J. G. Williams
Techniques in Coloproctology.2014; 18(5): 427. CrossRef
Korrektur der parastomalen Hernie mit Netz
A. Lampel, N. Runkel
Der Urologe.2012; 51(7): 965. CrossRef
Analysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery
In Ho Song, Heon-Kyun Ha, Sang-Gi Choi, Byeong Geon Jeon, Min Jung Kim, Kyu Joo Park
Journal of the Korean Society of Coloproctology.2012; 28(6): 299. CrossRef

Prognosis and Recurrent Patterns of Sporadic Primary Colon Cancers According to Location.: Park, Jin Seok , Yu, Chang Sik , Kim, Chan Wook , Jeong, Kwang Yong , Shin, Ui Sup , Yoon, Sang Nam , Lim, Seok Byung , Kim, Jin Cheon; J Korean Soc Coloproctol. 2009;25(4):221-226.; DOI: https://doi.org/10.3393/jksc.2009.25.4.221

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28 Download
1 Citations

Abstract PDF

PURPOSE
We aimed to compare the prognosis and the recurrence patterns of sporadic primary colon cancers according to the location of the cancer. METHODS: One thousand four-hundred eighty-three (1,483) stage II, III colon cancer patients who had undergone a consecutive curative resection between January 1989 and December 2003 were analyzed. Hereditary, synchronous, metachronous, and recurrent colon cancers were excluded. The right colon was defined as being from the cecum to the transverse colon, and the left colon was defined as being from the splenic flexure colon to the rectosigmoid colon. The median follow-up time was 63 (3-228) mo. RESULTS: Poorly differentiated and mucinous cell type tumors were more frequent in the right colon. T3 tumors were more frequent in the right colon. Lymph-node-positive tumors were more frequent in the left colon. The recurrence rate was higher in the left colon, but the patterns of recurrence were not different according to the tumor's location. By univariate analysis, age, preoperative serum CEA level, T-stage, N-stage, lymphovascular invasion, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. By multivariate analysis, sex, preoperative serum CEA level, T-stage, N-stage, postoperative chemotherapy, and tumor location were significant prognostic factors associated with recurrence. The 5-yr disease-free survival rates were 84.0% for right colon cancer and 77.1% for left colon cancer (P=0.005). The recurrence rates for cancers in the sigmoid colon and the rectosigmoid colon were higher than those for cancers in the cecum and the ascending colon. CONCLUSION: The tumor's location was an independent prognostic factor for recurrence, but the pattern of recurrence did not vary with the tumor's location.

Citations

Citations to this article as recorded by

Survival analysis for colon subsite and rectal cancers: Experience from a single surgeon
Inhwa Lee, Seung-Hyun Baek, Hyunsung Kim, Hong-Jae Jo, Nahm-Gun Oh, Sanghwa Ko
Korean Journal of Clinical Oncology.2015; 11(2): 114. CrossRef

Distributions of MTHFR Gene Polymorphism according to the Location of Colon Cancer.: Kim, Jong Woo , Oh, Doyeun , Chong, So Young , Yim, Dong Jin , Kim, Jin Kyeoung , Kim, Nam Keun; J Korean Soc Coloproctol. 2006;22(2):69-74.

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Abstract PDF: PURPOSE
Colon carcinogenesis seems to vary according to the original location of tumor, especially theright and the left sides. Two common methylenetetrahydrofolate reductase (MTHFR) polymorphisms, 677C->T and 1298A->C, are now known. Especially, the TT type of the 677C->T mutation shows reduced catalytic activity at a rate 30% that of wild type. The aim of this study is to investigate the distributions of MTHFR polymorphisms of 677C->T and 1298A->C according to the location of the colon cancer.
METHODS
Blood samples were collected from 112 patients diagnosed in our hospital, as having colon cancer: 34 proximal and 78 distal cases to the splenic flexure and 448 healthy control subjects. In order to characterize MTHFR polymorphisms, we applied the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS
The distributions of MTHFR 677C->T polymorphisms as genotypes CC, CT, and TT were 32.4%, 53.1%, and 14.5% in the control group, and 34.8%, 58.0%, and 7.1% in the cancer group (P=0.056). In the 34 proximal cancers, the CC, CT, and TT distributions were 44.1%, 55.9%, and 0% (P<0.05), respectively. In the distal group, they were 30.8%, 59.0%, and 10.3%. The distributions of the MTHFR 1298 A->C polymorphism by genotypes, AA, AC, CC were 69.6%, 28.6%, and 1.8% in the control group, and 58.9%, 38.4%, and 2.7% in the cancer group. The proximal and the distal groups show genotype distributions of 44.1%, 53.0%, and 2.9% and 65.4%, 32.0%, and 2.6%, respectively, but the differences were not statistically significant.
CONCLUSIONS
There are no definite differences between control subjects and colon-cancer patients in the two polymorphisms 677C->T and 1298A->C. However, the TT genotype shows a lower frequency in the cancer group than in the control group with a marginal statistical value (P=0.056), which suggest a reduced risk of cancer incidence for this type, compared with a CC or a CT type.

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