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Original Articles
- Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor
- Sang-Oh Yun, Yong Beom Cho, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Jung Wook Huh
- Ann Coloproctol. 2017;33(6):232-238. Published online December 31, 2017
- DOI: https://doi.org/10.3393/ac.2017.33.6.232
- 5,118 View
- 47 Download
- 27 Web of Science
- 26 Citations
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Abstract
PDF Purpose The aim of this study is to evaluate the prognosis for patients with a signet-ring-cell carcinoma (SRCC) who undergo curative surgery by comparing them to patients with an adenocarcinoma (ADC), excluding a mucinous ADC.
Methods Between September 1994 and December 2013, 14,110 patients with colorectal cancer underwent surgery and among them, 12,631 patients were enrolled in this study. 71 patients with a SRCC and 12,570 patients with a ADC were identified. We analyzed the disease-free survival and the overall survival rates before and after a 1:2 propensity score matching and evaluated those rates after stage stratification.
Results The median follow-up durations were 48.5 months for the SRC group and 48.6 months for the ADC group. The disease-free survival rates and the overall survival rates were significantly lower in the SRC group before and after propensity score matching (P < 0.001). After stratification by stage, no differences were observed between the SRC and the ADC groups for the disease-free survival (DFS) and the overall survival (OS) rates for patients with cancer in its early stages (P = 0.913 and P = 0.380 for the DFS and the OS, respectively, in stages 0 and I, and P = 0.223 and P = 0.991 for the DFS and the OS, respectively, in stage II), but those rates were significantly lower in the SRC group for cancer in its later stages (P < 0.001, respectively in stages III and IV).
Conclusion For cancer in advanced stages, patients with a resectable colorectal SRCC had a poorer prognosis after propensity score matching than those with an ADC did. Therefore, more intensive surveillance and closer observation should be offered to such patients.
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Citations
Citations to this article as recorded by
- Prognostic implications of T stage in different pathological types of colorectal cancer: an observational study using SEER population-based data
Nan Yao, Wenqiang Li, Jiwei Wang, Hongyuan Chu, Ning Duan, Xinyu Niu, Guoyong Yu, Jun Qu
BMJ Open.2024; 14(2): e076579. CrossRef - Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma
Frederiek Nuytens, Vincent Drubay, Clarisse Eveno, Florence Renaud, Guillaume Piessen
World Journal of Gastrointestinal Oncology.2024; 16(5): 2141. CrossRef - Unraveling the complexities of colorectal cancer and its promising therapies – An updated review
Sayan Saha, Shreya Ghosh, Suman Ghosh, Sumit Nandi, Aditi Nayak
International Immunopharmacology.2024; 143: 113325. CrossRef - Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient
Erica Torchiaro, Consalvo Petti, Sabrina Arena, Francesco Sassi, Giorgia Migliardi, Alfredo Mellano, Roberta Porporato, Marco Basiricò, Loretta Gammaitoni, Enrico Berrino, Monica Montone, Giorgio Corti, Giovanni Crisafulli, Caterina Marchiò, Alberto Barde
Frontiers in Oncology.2023;[Epub] CrossRef - Prognosis of Different Histological Types in Patients with Stage II and III Colon Cancer
Yasmeen Z. Qwaider, Naomi M. Sell, Caitlin E. Stafford, Chloe Boudreau, Hiroko Kunitake, Robert N. Goldstone, Rocco Ricciardi, Liliana G. Bordeianou, Christy E. Cauley, David L. Berger
Journal of Gastrointestinal Surgery.2022; 26(2): 476. CrossRef - Tumor budding as a prognostic indicator in colorectal carcinoma: a retrospective study of primary colorectal carcinoma cases in a tertiary care center
Ashini H. Shah, Amisha J. Gami, Neetal H. Desai, Jahnavi S. Gandhi, Priti P. Trivedi
Indian Journal of Surgical Oncology.2022; 13(3): 459. CrossRef - The Association of Microbiome Dysbiosis With Colorectal Cancer
Artem Artemev, Sheetal Naik, Anastasia Pougno, Prasanna Honnavar, Nandan M Shanbhag
Cureus.2022;[Epub] CrossRef - Simple synthesis of WO3 based activated carbon co-doped CuS composites for photocatalytic applications
Tahir Iqbal, Maria Ashraf, Arslan Masood
Inorganic Chemistry Communications.2022; 139: 109322. CrossRef - Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study
Wuguang Zhang, Wenqian Gong, Changhai Wu, Mengting Li, Xiaolong Tu, Stephen Fink
Gastroenterology Research and Practice.2022; 2022: 1. CrossRef - Applications of propensity score matching: a case series of articles published in Annals of Coloproctology
Hwa Jung Kim
Annals of Coloproctology.2022; 38(6): 398. CrossRef - Does signet ring cell carcinoma component signify worse outcomes for patients with colorectal cancer?
Liming Wang, Yasumitsu Hirano, Gregory Heng, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Nao Obara, Masahiro Asari, Takuya Kato, Shigeki Yamaguchi
Asian Journal of Surgery.2021; 44(1): 105. CrossRef - The Impact of Histologic Subtype on Receipt of Adjuvant Chemotherapy and Overall Survival in Stage III Colon Cancer: a Retrospective Cohort Analysis
Benjamin D. Powers, Seth I. Felder, Iman Imanirad, Sophie Dessureault, Sean P. Dineen
Journal of Gastrointestinal Cancer.2021; 52(2): 719. CrossRef - Colorectal adenocarcinomas diagnosed following a negative faecal immunochemical test show high‐risk pathological features in a colon screening programme
Michael J. Steel, Hussam Bukhari, Laura Gentile, Jennifer Telford, David F. Schaeffer
Histopathology.2021; 78(5): 710. CrossRef - Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study
Matteo Mueller, Marcel André Schneider, Barla Deplazes, Daniela Cabalzar-Wondberg, Andreas Rickenbacher, Matthias Turina
World Journal of Gastrointestinal Surgery.2021; 13(2): 164. CrossRef - Clinicopathological factors and survival outcomes of signet-ring cell and mucinous carcinoma versus adenocarcinoma of the colon and rectum: a systematic review and meta-analysis
Michael G. Fadel, George Malietzis, Vasilis Constantinides, Gianluca Pellino, Paris Tekkis, Christos Kontovounisios
Discover Oncology.2021;[Epub] CrossRef - MRI features of signet ring rectal cancer
Meena Suthar, Akshay D. Baheti, Suman K. Ankathi, Amit Choudhari, Purvi D. Haria, Reena Engineer, Vikas Ostwal, Mukta S. Ramadwar, Ashwin Desouza, Avanish Saklani
Abdominal Radiology.2021; 46(12): 5536. CrossRef - Metastatic patterns and survival outcomes in patients with stage IV colon cancer: A population‐based analysis
Jiwei Wang, Song Li, Yanna Liu, Chunquan Zhang, Honglang Li, Bin Lai
Cancer Medicine.2020; 9(1): 361. CrossRef - Prognostic factors influencing survival in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for isolated colorectal peritoneal metastases: a systematic review and meta‐analysis
V. Narasimhan, S. Tan, J. Kong, T. Pham, M. Michael, R. Ramsay, S. Warrier, A. Heriot
Colorectal Disease.2020; 22(11): 1482. CrossRef - Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
Seon-Jin Yoon, Jungmin Park, Youngmin Shin, Yuna Choi, Sahng Wook Park, Seok-Gu Kang, Hye Young Son, Yong-Min Huh
BMC Cancer.2020;[Epub] CrossRef - Predictive factors of complete pathological response in patients with locally advanced rectal cancer
Rebekah M. Engel, Karen Oliva, Christine Koulis, Raymond Yap, Paul J. McMurrick
International Journal of Colorectal Disease.2020; 35(9): 1759. CrossRef - Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma
Jingci Chen, Liangrui Zhou, Jie Gao, Tao Lu, Jing Wang, Huanwen Wu, Zhiyong Liang
Frontiers in Oncology.2020;[Epub] CrossRef - Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer
Xue Chao, Zixian Wang, Shixun Lu, Yuhua Huang, Shengbing Zang, Peirong Ding, Huizhong Zhang, Jingping Yun
International Journal of Clinical Oncology.2020; 25(9): 1653. CrossRef - Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2013 to 2018
Sun Jin Park, Kil Yeon Lee, Suk-Hwan Lee
Cancer Research and Treatment.2020; 52(3): 938. CrossRef - Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
S. Raghavan, Deepak Kumar Singh, J. Rohila, A. DeSouza, R. Engineer, A. Ramaswamy, V. Ostwal, A. Saklani
Indian Journal of Surgical Oncology.2020; 11(4): 597. CrossRef - Aggressive Colorectal Cancer in the Young
Blake Read, Patricia Sylla
Clinics in Colon and Rectal Surgery.2020; 33(05): 298. CrossRef - Prognoses of different pathological subtypes of colorectal cancer at different stages: A population-based retrospective cohort study
Xiaoli Wu, Han Lin, Shaotang Li
BMC Gastroenterology.2019;[Epub] CrossRef
- Prognostic implications of T stage in different pathological types of colorectal cancer: an observational study using SEER population-based data
- Clinicopathologic Analysis of Gastrointestinal Stromal Tumors of the Colon and Rectum.
- Choi, Sung Hoon , Kim, Seo Jeon , Choi, Yun Jung , Min, Byung So , Kim, Jin Su , Baik, Seung Hyuk , Kim, Nam Kyu , Kang, Jung Gu
- J Korean Soc Coloproctol. 2009;25(5):323-333.
- DOI: https://doi.org/10.3393/jksc.2009.25.5.323
- 2,043 View
- 9 Download
- 4 Citations
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Abstract
PDF
- PURPOSE
This study's aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors.
METHODS
We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008.
RESULTS
Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health's (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group.
CONCLUSION
Poor prognosis of colorectal GISTs was closely related to the tumor's histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed. -
Citations
Citations to this article as recorded by- Transanal endoscopic microsurgery with alternative neoadjuvant imatinib for localized rectal gastrointestinal stromal tumor: a single center experience with long-term surveillance
Xueshan Bai, Weixun Zhou, Yunhao Li, Guole Lin
Surgical Endoscopy.2021; 35(7): 3607. CrossRef - Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group
Thanh-Khoa Huynh, Pierre Meeus, Philippe Cassier, Olivier Bouché, Sophie Lardière-Deguelte, Antoine Adenis, Thierry André, Julien Mancini, Olivier Collard, Michael Montemurro, Emmanuelle Bompas, Maria Rios, Nicolas Isambert, Didier Cupissol, Jean-Yves Bla
BMC Cancer.2014;[Epub] CrossRef - Efficacy of Imatinib Mesylate Neoadjuvant Treatment for a Locally Advanced Rectal Gastrointestinal Stromal Tumor
Kyu Jong Yoon, Nam Kyu Kim, Kang Young Lee, Byung Soh Min, Hyuk Hur, Jeonghyun Kang, Sarah Lee
Journal of the Korean Society of Coloproctology.2011; 27(3): 147. CrossRef - Multiple Colonic Metastases from Hepatocellular Carcinoma
Gwi Hong Jeong, Byong Duk Ye, Seung Jae Myung
The Korean Journal of Gastroenterology.2011; 58(5): 288. CrossRef
- Transanal endoscopic microsurgery with alternative neoadjuvant imatinib for localized rectal gastrointestinal stromal tumor: a single center experience with long-term surveillance
- Expression of MUC2 and MUC6 in Colorectal Adenomas and Adenocarcinomas.
- Park, Ho Sung , Kong, Tae Shik , Jang, Kyu Yun , Chung, Myoung Ja , Moon, Woo Sung , Lee, Dong Geun , Kang, Myoung Jae
- J Korean Soc Coloproctol. 2005;21(4):193-200.
- 943 View
- 5 Download
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Abstract
PDF
- PURPOSE
Although the expression of MUC2 is seen in colorectal tumors, there have been few reports about the expression of MUC6 in colorectal tumors. The aim of this study was to investigate the expressions of MUC2 and MUC6 in normal colorectal tissues and in tumors, as well as the association of MUC2 and MUC6 expressions with prognostic factors.
METHODS
Twenty (20) cases of colorectal adenomas treated by using a endoscopic polypectomy and 30 cases of colorectal carcinomas treated by using a resection were collected. Ten (10) normal tissue samples were obtained apart from the carcinomas. Sections were used for MUC2 and MUC6 immunostaining. The expressions of MUC2 and MUC6 were scored by using the sum of the percentages of the stained cells and the intensity of staining.
RESULTS
All of the ten normal colorectal tissues expressed MUC2 and MUC6. Of the 20 adenomas, 19 cases (95%) were MUC2 positive, and 17 cases (85%) were MUC6 positive. Adenomas with severe atypia tended to express lower levels of MUC2 and MUC6 than those with mild or moderate atypia. Of the 30 carcinomas, 28 cases (93%) were MUC2 positive and 19 cases (63.3%) were MUC6 positive. Colorectal mucinous carcinomas differed significantly from non-mucinous carcinomas in strong MUC6 expression. MUC2 expression showed a significant association with lymph-node metastasis.
CONCLUSIONS
The results suggest that MUC6 is expressed in normal colorectal tissues and tumors, that MUC6 expression is especially strong in mucinous carcinomas, and that MUC2 expression is associated with lymph-node metastasis, among the prognostic factors.
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