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Original Articles
Colorectal cancer
- How appropriately can generative artificial intelligence platforms, including GPT-4, Gemini, Bing, and Wrtn, answer questions about colon cancer in the Korean language?
- Sun Huh
- Ann Coloproctol. 2025;41(3):190-197. Published online June 25, 2025
- DOI: https://doi.org/10.3393/ac.2024.00122.0017
- 5,510 View
- 56 Download
- 3 Web of Science
- 4 Citations
-
Abstract
PDF
Supplementary Material - Purpose
This study aims to assess the performance of 4 generative artificial intelligence (AI) platforms—Gemini (formerly Bard), Bing, GPT-4, and Wrtn—in answering questions about colon cancer in the Korean language. Two main research questions guided this study. First, which AI platform provides the most accurate answers? Second, can these AI-generated answers be reliably used to educate patients and their families about colon cancer?
Methods
Ten questions selected by the author were posed to the 4 generative AI platforms on February 22, 2024. Two colorectal surgeons in Korea, each with over 20 years of clinical experience, independently evaluated the answers provided by these generative AI platforms.
Results
The generative AI platforms scored an average of 5.5 out of 10 points. Wrtn achieved the highest score at 6 points, followed by GPT-4 and Gemini, each with 5.5, and Bing, scoring 5 points. The weighted κ for inter-rater reliability was 0.597 (P<0.001). The generative AI platforms performed well in explaining the occult blood test for cancer screening, keyhole surgery, and dietary recommendations for cancer prevention. However, they demonstrated significant limitations in answering more complex topics, such as estimating survival rates following surgery, choosing targeted therapy after surgery, and accurately reporting the mortality rate due to colon cancer in Korea.
Conclusion
The findings suggest that using these generative AI platforms as educational resources for patients and their families regarding colon cancer is premature. Further training on colorectal diseases is required before these AI platforms can be considered reliable information sources for the general public in Korea. -
Citations
Citations to this article as recorded by
- Expert Review on the Quality of Responses to the Questions of Multiple Myeloma Patients: A Validation Study of the Medical Artificial Intelligence System “Myelobot”
Aleksander Sergeevich Luchinin, O. E. Ochirova, V. G. Potapenko, V. V. Ryabchikova
Clinical Oncohematology.2026; 19(1): 81. CrossRef - Agentic artificial intelligence is the future of cancer detection and diagnosis
Sayedur Rahman, Md. Tanzib Hosain, Nafiz Fahad, Md. Kishor Morol, Md. Jakir Hossen
Array.2026; 29: 100676. CrossRef - Role of Medical Editors in the Age of Generative Artificial Intelligence
Sun Huh
Healthcare Informatics Research.2025; 31(4): 317. CrossRef - Temporal evolution of large language models (LLMs) in oncology
Zilin Qiu, Aimin Jiang, Chang Qi, Wenyi Gan, Lingxuan Zhu, Weiming Mou, Dongqiang Zeng, Mingjia Xiao, Guangdi Chu, Shengkun Peng, Hank Z. H. Wong, Lin Zhang, Hengguo Zhang, Xinpei Deng, Quan Cheng, Bufu Tang, Yaxuan Wang, Jian Zhang, Anqi Lin, Peng Luo
Journal of Translational Medicine.2025;[Epub] CrossRef
- Expert Review on the Quality of Responses to the Questions of Multiple Myeloma Patients: A Validation Study of the Medical Artificial Intelligence System “Myelobot”
Complications
- Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study
- Daniela Rega, Ernesto De Giulio, Raffaele De Luca, Andrea Muratore, Marco Milone, Giuseppe Sica, Paolo Millo, Carmela Cervone, Nicola Cillara, Patrizia Marsanic, Brunella Maria Pirozzi, Valeria Grazia Malagnino, Pietro Anoldo, Marcello Calabrò, Giovanni De Palma, Michele Simone, Paolo Delrio
- Ann Coloproctol. 2025;41(4):293-302. Published online June 4, 2025
- DOI: https://doi.org/10.3393/ac.2024.00899.0128
- 5,899 View
- 153 Download
- 2 Web of Science
- 2 Citations
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Graphical Abstract
Abstract
PDF - Purpose
Anastomotic leaks (AL) remain a major complication following right colectomy for colon cancer. This multicenter, prospective, observational study evaluated the efficacy of Glubran 2, a cyanoacrylate-based sealant, in reducing the incidence of AL by reinforcing ileocolic anastomoses.
Methods
The study enrolled 380 patients undergoing right colectomy for colon cancer across 7 Italian hospitals. Glubran 2 was applied to reinforce ileocolic anastomoses. The primary endpoint was a 50% reduction in AL incidence from a baseline of 6.18% within 10 days after surgery. Secondary endpoints included examining the correlation between AL and preexisting risk factors and determining the rate of anastomotic bleeding. Statistical analyses employed binomial tests and logistic regression.
Results
The AL rate was reduced to 1.85% compared to the reference rate of 6.18% (P<0.01). Glubran 2 exhibited a protective effect even in patients with preexisting risk factors such as smoking, diabetes, or prior surgeries; none of these factors was significantly associated with AL (P>0.05). Surgical technique (P=0.687), anastomosis technique (P=0.998), and anastomosis type (P=0.998) did not influence AL rates. Operation time was similar across groups (P=0.613), and anastomotic bleeding occurred in 1.3% of cases, with no association with AL (P=0.989).
Conclusion
Glubran 2 was safely applied to ileocolic anastomoses, significantly reducing AL rates and potentially providing a protective effect even in patients with known risk factors. Its hemostatic and bacteriostatic properties support improved postoperative outcomes, highlighting its potential as an effective adjunct in colorectal surgery. Further studies are warranted to confirm these findings and explore broader applications. -
Citations
Citations to this article as recorded by- Comments on “Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study”
Nabil Mohammad Azmi, Mohd Firdaus Mohd Hayati, Zairul Azwan Mohd Azwan
Annals of Coloproctology.2025; 41(6): 596. CrossRef - In reply to: Comments on "Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study”
Daniela Rega, Carmela Cevone, Paolo Delrio
Annals of Coloproctology.2025; 41(6): 598. CrossRef
- Comments on “Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study”
Minimally invasive surgery
- Impact of single-port laparoscopic approach on scar assessment by patients and observers: a multicenter retrospective study
- Sung Uk Bae, Kyeong Eui Kim, Chang-Woo Kim, Ji-Hoon Kim, Woon Kyung Jeong, Yoon-Suk Lee, Seong Kyu Baek, Suk-Hwan Lee, Jun-Gi Kim
- Ann Coloproctol. 2025;41(2):154-161. Published online April 29, 2025
- DOI: https://doi.org/10.3393/ac.2024.00563.0080
- 4,494 View
- 80 Download
- 1 Citations
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Abstract
PDF
- Purpose
This study aimed to compare the wound cosmesis of a single-incision approach on scar assessment after laparoscopic surgery for colon cancer.
Methods
This study included 32 patients undergoing single-port laparoscopic surgery (SPLS) and 61 patients undergoing multiport laparoscopic surgery (MPLS) for colon cancer at 3 tertiary referral hospitals between September 2011 and December 2019. We modified and applied the Korean version of the Patient and Observer Scar Assessment Scale (POSAS) to assess cosmetic outcomes. To assess the interobserver reliability using intraclass correlation coefficient values for the Observer Scar Assessment Scale (OSAS), the surgeons evaluated 5 images of postoperative scars.
Results
No significant differences were observed in the time before the return of normal bowel function, time to sips of water and soft diet initiation, length of in-hospital stay, and postoperative complication rate. The SPLS group had a shorter total incision length than the MPLS group. The POSAS favored the SPLS approach, revealing significant differences in the Patient Scar Assessment Scale (PSAS), OSAS, and overall scores. The SPLS approach was an independent factor influencing the POSAS, PSAS, and OSAS scores. Eleven colorectal surgeons had a significantly substantial intraclass coefficient.
Conclusion
The cosmetic outcomes of SPLS as assessed by the patients and surgeons were superior to those of MPLS in colon cancer. Reducing the number of ports is an independent factor affecting scar assessment by patients and observers. -
Citations
Citations to this article as recorded by- Investigating the Efficacy of Layered Moderate Tension Reduction Suturing in Facial Aesthetic Surgery
Gui H Wang, Jin Y Gang, Yan Li
Cureus.2025;[Epub] CrossRef
- Investigating the Efficacy of Layered Moderate Tension Reduction Suturing in Facial Aesthetic Surgery
Minimally invasive surgery
- Robotic surgery may lead to reduced postoperative inflammatory stress in colon cancer: a propensity score–matched analysis
- Eun Ji Park, Gyong Tae Noh, Yong Joon Lee, Min Young Park, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Byung Soh Min
- Ann Coloproctol. 2024;40(6):594-601. Published online December 6, 2024
- DOI: https://doi.org/10.3393/ac.2024.00171.0024
- 3,464 View
- 93 Download
- 5 Web of Science
- 6 Citations
-
Abstract
PDFSupplementary Material
- Purpose
Robot-assisted surgery is readily applied to every type of colorectal surgeries. However, studies showing the safety and feasibility of robotic surgery (RS) have dealt with rectal cancer more than colon cancer. This study aimed to investigate how technical advantages of RS can translate into actual clinical outcomes that represent postoperative systemic response.
Methods
This study retrospectively reviewed consecutive cases in a single tertiary medical center in Korea. Patients with primary colon cancer who underwent curative resection between 2006 and 2012 were included. Propensity score matching was done to adjust baseline patient characteristics (age, sex, body mass index, American Society of Anesthesiologists physical status, tumor profile, pathologic stage, operating surgeon, surgery extent) between open surgery (OS), laparoscopic surgery (LS), and RS groups.
Results
After propensity score matching, there were 66 patients in each group for analysis, and there was no significant differences in baseline patient characteristics. Maximal postoperative leukocyte count was lowest in the RS group and highest in the OS group (P=0.021). Similar results were observed for postoperative neutrophil count (P=0.024). Postoperative prognostic nutritional index was highest in the RS group and lowest in the OS group (P<0.001). The time taken to first flatus and soft diet resumption was longest in the OS group and shortest in the RS group (P=0.001 and P<0.001, respectively). Among all groups, other short-term postoperative outcomes such as hospital stay and complications did not show significant difference, and oncological survival results were similar.
Conclusion
Better postoperative inflammatory indices in the RS group may correlate with their faster recovery of bowel motility and diet resumption compared to LS and OS groups. -
Citations
Citations to this article as recorded by- Open, Laparoscopic, and robotic approaches in colorectal surgery: a comprehensive review with focus on colorectal cancer
Farhad Shafiei, Fatemeh Kani, Nargess Porkar, Maede Mirzaee, Fatemeh Heidarzadeh, Mahdi Kolivand, Soheila Behdad, Amir Shokri
Journal of Robotic Surgery.2026;[Epub] CrossRef - Übergangsphase zur roboterassistierten Chirurgie beim kolorektalen Karzinom: eine vergleichende konsekutive Kohortenstudie
U. A. Dietz, M. Kalisvaart, S. Maksimovic, R. Frey, M. Ramser, B. M. Erhart, U. Pfefferkorn
Die Chirurgie.2025; 96(11): 942. CrossRef - Comparative clinical efficacy of three surgical modalities for the treatment of malignant tumours of the left hemicolon
Hao Chen, Dong-Ping Han, Jian-Yang Xiong, Zhen-Sheng Li, Teng-Cheng Hu, Zheng-Rong Li, Yi Cao
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef - Comparison of the perioperative outcomes of robotic vs. open distal pancreatectomy: a meta-analysis of propensity-score-matched studies
Junjie Wang, Yuanjun Liu, Yakun Wu
Frontiers in Surgery.2025;[Epub] CrossRef - Effectiveness of Guardix-SG in Preventing Postoperative Bowel Complications After Radical Cystectomy: A Single-Arm Prospective Observational Study
Jiwoong Yu, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Seong Il Seo, Seong Soo Jeon, Byong Chang Jeong
Journal of Urologic Oncology.2025; 23(3): 253. CrossRef - Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis
Xiaomei Jiang, Hang Zhou, Zhaoyang Zheng, Xiaodong Wang, Zongguang Zhou, Lie Yang
Updates in Surgery.2025;[Epub] CrossRef
- Open, Laparoscopic, and robotic approaches in colorectal surgery: a comprehensive review with focus on colorectal cancer
ERAS
- Impact of an Enhanced Recovery After Surgery (ERAS) program on the management of complications after laparoscopic or robotic colectomy for cancer
- Victoria Weets, Hélène Meillat, Jacques Emmanuel Saadoun, Marie Dazza, Cécile de Chaisemartin, Bernard Lelong
- Ann Coloproctol. 2024;40(5):440-450. Published online September 20, 2024
- DOI: https://doi.org/10.3393/ac.2023.00850.0121
- 10,691 View
- 238 Download
- 4 Web of Science
- 5 Citations
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Graphical Abstract
Abstract
PDFSupplementary Material
- Purpose
Enhanced Recovery After Surgery (ERAS) reduces postoperative complications (POCs) after colorectal surgery; however, its impact on the management of POCs remains unclear. This study compared the diagnosis and management of POCs before and after implementing our ERAS protocol after laparoscopic or robotic colectomy for cancer and examined the short- and mid-term oncologic impacts.
Methods
This single-center, retrospective study evaluated all consecutive patients who underwent laparoscopic or robotic colectomy for cancer between 2012 and 2021, focusing on the incidence of POCs within 90 days. We compared outcomes before (standard group) and after (ERAS group) the implementation of our ERAS protocol in January 2016.
Results
Significantly fewer patients in the ERAS group developed POCs (standard vs. ERAS, 136 of 380 patients [35.8%] vs.136 of 660 patients [20.6%]; P<0.01). The ERAS group had a significantly shorter mean total length of stay after POCs (13.1 days vs. 11.4 days, P=0.04), and the rates of life-threatening complications (6.7% vs. 0.7%) and 1-year mortality (7.4% vs. 1.5%) were significantly lower in the ERAS group than in the standard group. Among patients with anastomotic complications, laparoscopic reoperation was significantly more common in the ERAS group than in the standard group (8.3% vs. 75.0%, P<0.01). Among patients with postoperative ileus, the diagnosis and recovery times were significantly shorter in the ERAS group than in the standard group, resulting in a shorter total length of stay (13.5 days vs. 10 days, P<0.01).
Conclusion
The implementation of an ERAS protocol did not eliminate all POCs, but it did accelerate their diagnosis and management and improved patient outcomes. -
Citations
Citations to this article as recorded by- The ultrasonographic measure of postoperative day 2 gastric volume may be a useful tool to improve the management of colorectal surgery patients: results of an ancillary study
Aurélien Venara, Anita Paisant, Julien Gillet, Lise Morgado, Emeline Rebmann, Jean-Francois Hamel
International Journal of Colorectal Disease.2026;[Epub] CrossRef - Less is more: simplifying patient-centered cancer care
In Ja Park
Annals of Coloproctology.2025; 41(3): 173. CrossRef - Research Progress on the Application of ERAS Concept in the Perioperative Period of Colorectal Cancer Patients
梦云 孙
Advances in Clinical Medicine.2025; 15(08): 1208. CrossRef - Can Surgical Approach and Postoperative Factors Impact Survival in Rectal Cancer? Robotic Versus Laparoscopic Insights
Ahmed Abdelsamad, Seyidali Mirzazada, Karsten Ridwelski, Mohamad Nour Nasif, Florian Gebauer
Cancer Medicine.2025;[Epub] CrossRef - Optimizing postoperative pain management in minimally invasive colorectal surgery
Soo Young Lee
Annals of Coloproctology.2024; 40(6): 525. CrossRef
- The ultrasonographic measure of postoperative day 2 gastric volume may be a useful tool to improve the management of colorectal surgery patients: results of an ancillary study
Colorectal cancer
- Colonic stenting: is the bridge to surgery worth its cost? A cost-effectiveness analysis at a single Asian institution
- Michelle Shi Qing Khoo, Frederick H. Koh, Sharmini Su Sivarajah, Leonard Ming-Li Ho, Darius Kang-Lie Aw, Cheryl Xi-Zi Chong, Fung Joon Foo, Winson Jianhong Tan
- Ann Coloproctol. 2024;40(6):555-563. Published online August 5, 2024
- DOI: https://doi.org/10.3393/ac.2023.00738.0105
- 8,662 View
- 151 Download
- 2 Web of Science
- 2 Citations
-
Abstract
PDF
- Purpose
In patients with acute left-sided colonic obstruction, stenting can convert an emergency operation into a semi-elective procedure. However, its use continues to be debated. We performed a cost-effective analysis using our institution’s experiences.
Methods
Endoscopic, surgical, and financial details were prospectively collected for patients who presented with acute colonic obstruction and underwent stenting between 2019 and 2022. Outcomes were defined as technical/clinical success and successful surgical resection. The financial cost of stenting was compared with the expected cost without stenting.
Results
Forty patients were included, with 29 undergoing definitive resection. The most common pathology was primary colon cancer (27 patients, 93%). Endoscopic stenting had high technical (90%) and clinical (83%) success rates, with low rates of complications such as perforation (2 patients, 7%) and migration (0 patients, 0%). As a bridge to surgery, the median procedure time was 226 minutes and the surgical outcomes also showed a low rate of complications (3 patients, 11%), such as anastomotic leakage (0 patients, 0%), intraabdominal abscesses (2 patients, 7%), and 30-day postoperative mortality (0 patients, 0%). The cumulative costs with colonic stenting were $32,900, while the expected costs with emergency surgery, including stoma reversal, were $40,700 (healthcare cost-savings of $7,800 per person). The difference was mainly due to the avoidance of upfront emergency surgery. The incremental cost-effectiveness ratio was 0.81, favoring colonic stenting over upfront emergency surgery.
Conclusion
Colonic stenting as a bridge to surgery is safe and cost-effective for treating left-sided colonic obstruction with high success rates and low complication rates. -
Citations
Citations to this article as recorded by- Nationwide Analysis of Right-Sided Colonic Stenting: Rarely Used but Reduces Stoma Creation Significantly
Khalid Ahmed, Ahmed Dirweesh, Zachary D. Leslie, Yasmin Ali, Nabeel Azeem, Eric Wise, Cyrus Jahansouz, Martin Freeman, Stuart K. Amateau
Techniques and Innovations in Gastrointestinal Endoscopy.2026; 28(1): 250952. CrossRef - Global Use and Outcomes of Endoscopic Stenting in Acute Malignant Left-Sided Colonic Obstruction: A Secondary Analysis of APOLLO, An International, Prospective Cohort Study
Diseases of the Colon & Rectum.2025; 68(12): 1458. CrossRef
- Nationwide Analysis of Right-Sided Colonic Stenting: Rarely Used but Reduces Stoma Creation Significantly
Colorectal cancer
- Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older
- Byeo Lee Lim, In Ja Park, Jun-Soo Ro, Young Il Kim, Seok-Byung Lim, Chang Sik Yu
- Ann Coloproctol. 2025;41(3):198-206. Published online August 5, 2024
- DOI: https://doi.org/10.3393/ac.2023.00367.0052
- 7,848 View
- 94 Download
- 4 Web of Science
- 6 Citations
-
Abstract
PDFSupplementary Material
- Purpose
The aim of this study was to examine the prognosis and associated risk factors, including adjuvant chemotherapy (CTx), in elderly patients with colon cancer.
Methods
This retrospective study included patients who underwent radical resection for colon cancer between January 2010 and December 2014 at Asan Medical Center. The effects of stage, risk factors, and chemotherapy on overall survival (OS) and recurrence-free survival (RFS) were compared in patients aged ≥70 and <70 years.
Results
Of 3,313 patients, 933 (28.1%) was aged ≥70 years. Of the 1,921 patients indicated for adjuvant CTx, 1,294 of 1,395 patients (92.8%) aged <70 years and 369 of 526 patients (70.2%) aged ≥70 years received adjuvant CTx. Old age (≥70 years) was independently associated with RFS in overall cohort. Among patients aged ≥70 years indicated for adjuvant CTx, the 5-year OS (81.6% vs. 50.4%, P<0.001) and RFS (82.9% vs. 67.4%, P=0.025) rates were significantly higher in those who did than did not receive adjuvant CTx. Additionally, adjuvant CTx was confirmed as independent risk factor of both OS and RFS in patients aged ≥70 years indicated for adjuvant CTx.
Conclusion
Old age was associated with poor RFS and adjuvant CTx had benefits in OS as well as RFS in elderly patients eligible for adjuvant CTx. -
Citations
Citations to this article as recorded by- Immunological changes and recovery-related factors in older patients with colon cancer: A pilot trial
Byeo Lee Lim, Young Il Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Yousun Ko, Kyung Won Kim, In Ja Park
Journal of Geriatric Oncology.2025; 16(3): 102200. CrossRef - Stage II-III colorectal cancer in geriatric patients: Clinicopathological features and chemotherapy utilization
Yakup Duzkopru, Özlem Doğan
Turkish Journal of Clinics and Laboratory.2025; 16(1): 118. CrossRef - Does Oxaliplatin-based Adjuvant Therapy Benefit Older Colorectal Cancer Patients?
Peter Hofland
Onco Zine - The International Oncology Network.2025;[Epub] CrossRef - Disease-Free Survival of Patients with Stage II Stroma-Rich Colorectal Adenocarcinomas with Microsatellite Stability
Ángel Romo-Navarro, Juan Ruiz Martín, Irene García-Camacha Gutiérrez, Mariano Amo-Salas, María Recuero Pradillo, César Sánchez-Muñoz, Cristina María Murillo Lázaro, Esperanza Carabias López, Raquel Sánchez Simón, Carlos Quimbayo-Arcila, Yasmina Hernández
International Journal of Molecular Sciences.2025; 26(24): 11795. CrossRef - Early detection of anastomotic leakage in colon cancer surgery: the role of early warning score and C-reactive protein
Gyung Mo Son
Annals of Coloproctology.2024; 40(5): 415. CrossRef - Efficacy of Neoadjuvant Hypofractionated Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer: A Single-Center Retrospective Analysis
Jae Seung Kim, Jaram Lee, Hyeung-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
Cancers.2024; 16(24): 4280. CrossRef
- Immunological changes and recovery-related factors in older patients with colon cancer: A pilot trial
Video
Video clip
- Cranial-first approach for laparoscopic extended right hemicolectomy
- Kyong-Min Kang, Heung-Kwon Oh, Hong-Min Ahn, Tae-Gyun Lee, Hye-Rim Shin, Mi-Jeong Choi, Duck-Woo Kim, Sung-Bum Kang
- Ann Coloproctol. 2024;40(3):282-284. Published online June 19, 2024
- DOI: https://doi.org/10.3393/ac.2023.00661.0094
- 7,306 View
- 229 Download
-
Abstract
PDFSupplementary Material
- Complete mesocolic excision and central vascular ligation with D3 lymphadenectomy are important surgical principles for improving oncological outcomes in colon cancer. The cranial-first approach is a colonic mobilization–first approach to radical right hemicolectomy, which has several advantages, including early feasibility assessment, safe dissection from surrounding organs, preestablished inferior margin of lymph node dissection, and revelation of the tangible anatomy of the tributaries of the gastrocolic trunk. This video demonstrates the cranial-first approach to radical right hemicolectomy in a 66-year-old man with locally advanced cecal cancer.
Original Article
Minimally invasive surgery
- Preoperative localization of potentially invisible colonic lesions on the laparoscopic operation field: using autologous blood tattooing
- Ji Yeon Mun, Hyunjoon An, Ri Na Yoo, Hyeon-Min Cho, Bong-Hyeon Kye
- Ann Coloproctol. 2024;40(3):225-233. Published online June 19, 2024
- DOI: https://doi.org/10.3393/ac.2023.00059.0008
- 5,396 View
- 203 Download
- 2 Web of Science
- 2 Citations
-
Graphical Abstract
Abstract
PDF
- Purpose
Preoperative colonoscopic (POC) localization is recommended for patients scheduled for elective laparoscopic colectomy for early colon cancer. Among the various localization method, POC tattooing localization has been widely used. Several dyes have been used for tattooing, but dye has disadvantages, including foreign body reactions. For this reason, we have used autologous blood tattooing for POC localization. This study aimed to evaluate the safety and efficacy of the autologous blood tattooing method.
Methods
This study included patients who required POC localization of the colonic neoplasm among the patients who were scheduled for elective colon resection. The indication for localization was early colon cancer (clinically T1 or T2) or colonic neoplasms that could not be resected endoscopically. POC autologous blood tattooing was performed after saline injection, and 2 hemoclips were applied.
Results
A total of 45 patients who underwent autologous blood tattooing and laparoscopic colectomy were included in this study. All POC localization sites were visible in the laparoscopic view. POC localization sites showed almost perfect agreement with intraoperative surgical findings. There were no complications like bowel perforation, peritonitis, hemoperitoneum, and mesenteric hematoma.
Conclusion
Autologous blood is a safe and effective agent for localizing materials that can replace previous dyes. However, a large prospective case-control study is required for the routine application of this procedure in early colon cancer or colonic neoplasms. -
Citations
Citations to this article as recorded by- Meeting report on the 8th Asian Science Editors’ Conference and Workshop 2024
Eun Jung Park
Science Editing.2025; 12(1): 66. CrossRef - Preoperative Localization, Margins, and Intraoperative Endoscopy in Minimally Invasive Sigmoid Colectomy: A Matched Cohort
Chang-Lin Lin, Feng-Fan Chiang, Ming-Cheng Chen, Chun-Yu Lin, Shang-Chih Huang, Ching-Shiang Lin
Journal of Surgical Research.2025; 315: 847. CrossRef
- Meeting report on the 8th Asian Science Editors’ Conference and Workshop 2024
Guideline
Colorectal cancer
- Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
- Hyo Seon Ryu, Hyun Jung Kim, Woong Bae Ji, Byung Chang Kim, Ji Hun Kim, Sung Kyung Moon, Sung Il Kang, Han Deok Kwak, Eun Sun Kim, Chang Hyun Kim, Tae Hyung Kim, Gyoung Tae Noh, Byung-Soo Park, Hyeung-Min Park, Jeong Mo Bae, Jung Hoon Bae, Ni Eun Seo, Chang Hoon Song, Mi Sun Ahn, Jae Seon Eo, Young Chul Yoon, Joon-Kee Yoon, Kyung Ha Lee, Kyung Hee Lee, Kil-Yong Lee, Myung Su Lee, Sung Hak Lee, Jong Min Lee, Ji Eun Lee, Han Hee Lee, Myong Hoon Ihn, Je-Ho Jang, Sun Kyung Jeon, Kum Ju Chae, Jin-Ho Choi, Dae Hee Pyo, Gi Won Ha, Kyung Su Han, Young Ki Hong, Chang Won Hong, Jung-Myun Kwak, Korean Colon Cancer Multidisciplinary Committee
- Ann Coloproctol. 2024;40(2):89-113. Published online April 30, 2024
- DOI: https://doi.org/10.3393/ac.2024.00059.0008
- 17,740 View
- 474 Download
- 11 Web of Science
- 12 Citations
-
Abstract
PDFSupplementary Material
- Colorectal cancer is the third most common cancer in Korea and the third leading cause of death from cancer. Treatment outcomes for colon cancer are steadily improving due to national health screening programs with advances in diagnostic methods, surgical techniques, and therapeutic agents.. The Korea Colon Cancer Multidisciplinary (KCCM) Committee intends to provide professionals who treat colon cancer with the most up-to-date, evidence-based practice guidelines to improve outcomes and help them make decisions that reflect their patients’ values and preferences. These guidelines have been established by consensus reached by the KCCM Guideline Committee based on a systematic literature review and evidence synthesis and by considering the national health insurance system in real clinical practice settings. Each recommendation is presented with a recommendation strength and level of evidence based on the consensus of the committee.
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Citations
Citations to this article as recorded by- Optimal extent of lymph node dissection in clinical early-stage right colon cancer: a retrospective analysis
Hyeung-min Park, Jaram Lee, Soo Young Lee, Suk Hee Heo, Yong Yeon Jeong, Hyeong Rok Kim, Chang Hyun Kim
Annals of Surgical Treatment and Research.2025; 108(1): 49. CrossRef - Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans
Rıdvan Yavuz, Orhan Aras, Hüseyin Çiyiltepe, Onur İlkay Dinçer, Ahmet Şükrü Alparslan, Tebessüm Çakır
Diagnostics.2025; 15(2): 190. CrossRef - Epigenetic Regulation of Nuclear Factor Erythroid-2-Related Factor 2 in Colorectal Cancer Cells Resistant to Ionizing Radiation
Kyoung Ah Kang, Jinny Park, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Herath Mudiyanselage Maheshika Madhuwanthi Senavirathna, Jung-Hwan Kim, Suk Ju Cho, Jin Won Hyun
Biomolecules & Therapeutics.2025; 33(1): 182. CrossRef - Meeting report on the 8th Asian Science Editors’ Conference and Workshop 2024
Eun Jung Park
Science Editing.2025; 12(1): 66. CrossRef - The Diagnostic Value of Virtual Colonoscopy in Colonic Diseases
İhsaniye Süer Doğan, Esin Çakmakçı Midia, Yıldıran Songür, Baki Hekimoğlu
Turkish Journal of Clinics and Laboratory.2025; 16(1): 27. CrossRef - National Guidelines for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Peritoneal Malignancies: A Worldwide Systematic Review and Recommendations of Strength Analysis
Marco Tonello, Carola Cenzi, Elisa Pizzolato, Manuela Martini, Pierluigi Pilati, Antonio Sommariva
Annals of Surgical Oncology.2025; 32(8): 5795. CrossRef - Advancements in Image‐Based Analyses for Morphology and Staging of Colon Cancer: A Comprehensive Review
Samuel Arthur Ameyaw, Derrick Adu Afari, John Boateng, Marcello Maida
BioMed Research International.2025;[Epub] CrossRef - Curcumin in colorectal cancer: preventive strategies and therapeutic mechanisms
Amit Sharma, Bhavin Parekh, Vinay Patil, Usamah Sayed, Renuka Jyothi, Priya Priyadarshini Nayak, Ashish Singh Chauhan, Siya Singla
Cancer Chemotherapy and Pharmacology.2025;[Epub] CrossRef - 2023 Korean Multidisciplinary Guidelines for Colon Cancer Management: Summary of Radiological Points
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Korean Journal of Radiology.2024; 25(9): 769. CrossRef - Effect of Fluorescence Lymph Node Mapping on Improving Diagnostic Values of CT D3 Lymph Node Staging for Right-Sided Colon Cancer
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Jing Zhao, Fei Wang, Rong-Fu Wang
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Soo Young Lee, Eon Chul Han
Digestive Surgery.2024; : 1. CrossRef
- Optimal extent of lymph node dissection in clinical early-stage right colon cancer: a retrospective analysis
Original Article
Minimally invasive surgery
- Learning curve for single-port robot-assisted colectomy
- Moon Suk Choi, Seong Hyeon Yun, Sung Chul Lee, Jung Kyong Shin, Yoon Ah Park, Jungwook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee
- Ann Coloproctol. 2024;40(1):44-51. Published online December 20, 2022
- DOI: https://doi.org/10.3393/ac.2022.00745.0106
- 6,809 View
- 260 Download
- 9 Web of Science
- 8 Citations
-
Abstract
PDF
- Purpose
Since the introduction of robotic surgery, robots for colorectal cancer have replaced laparoscopic surgery, and a single-port robot (SPR) platform has been launched and is being used to treat patients. We analyzed the learning curve and initial complications of using an SPR platform in colorectal cancer surgery.
Methods
We reviewed 39 patients who underwent SPR colectomy from April to October 2019. All surgeries were performed by the same surgeon using an SPR device. A learning curve was generated using the cumulative sum methodology to assess changes in total operation time, docking time, and surgeon console time. We grouped the patients into 3 groups according to the time period: the first 11 were phase 1, the next 11 were phase 2, and the last 17 were phase 3.
Results
The mean age of the patients was 61.28±13.03 years, and they had a mean body mass index of 23.79±2.86 kg/m2. Among the patients, 23 (59.0%) were male, and 16 (41.0%) were female. The average operation time was 186.59±51.30 minutes, the average surgeon console time was 95.49±35.33 minutes, and the average docking time (time from skin incision to robot docking) was 14.87±10.38 minutes. The surgeon console time differed significantly among the different phases (P<0.001). Complications occurred in 8 patients: 2 ileus, 2 postoperation hemoglobin changes, 3 urinary retentions, and 1 complicated fluid collection.
Conclusion
In our experience, the learning curve for SPR colectomy was achieved after the 18th case. -
Citations
Citations to this article as recorded by- Clinical applications of the da Vinci Single-Port robotic system for treatment of colorectal cancer: a narrative review
Gyu-Seog Choi, Hye Jin Kim
Annals of Surgical Treatment and Research.2026; 110(1): 35. CrossRef - A systematic review of the Da Vinci® Single-Port system (DVSP) in the context of colorectal surgery
Francesco Brucchi, Isacco Montroni, Roberto Cirocchi, Giovanni Taffurelli, Marco Vitellaro, Gianluca Mascianà, Giovanni Battista Levi Sandri, Gianlorenzo Dionigi, Sara Lauricella
International Journal of Colorectal Disease.2025;[Epub] CrossRef - Assessing the learning curve in robot-assisted intracorporeal colorectal anastomosis and transrectal extraction (NICE) procedure: from Initial Learning to Mastery
Jacques Bistre-Varon, Muhammed Elhadi, Robert Wei, Jimena Alcocer-Barrios, Ryan Gunter, Joshua Coursey, Priya Prakash, Erin McAtee, Haley Lanser, Rachel Ellsworth, Matthew Weaver, Jean-Paul LeFave, Eric M. Haas
Journal of Robotic Surgery.2025;[Epub] CrossRef - Short-term outcomes of single-port robotic surgery versus single-port laparoscopic surgery for colon cancer: a multicenter matched-cohort analysis
Gyoung Tae Noh, Young Il Kim, Seung Ho Song, Hye Jin Kim, Song-Soo Yang, Yong Sik Yoon, Ji Hoon Kim, Hyung Jin Kim, Byung Mo Kang, Chang Woo Kim, Suk-Hwan Lee, Jun Gi Kim, Yoon Suk Lee
Surgical Endoscopy.2025; 39(12): 8444. CrossRef - Application of the Da Vinci Single‐Port (SP) Robot in General Surgery: A First Systematic Review
Antonio Cubisino, Maurice Chazal, Fabrizio Panaro
The International Journal of Medical Robotics and Computer Assisted Surgery.2025;[Epub] CrossRef - Da Vinci single-port robotic system current application and future perspective in general surgery: A scoping review
Francesco Celotto, Niccolò Ramacciotti, Alberto Mangano, Giacomo Danieli, Federico Pinto, Paula Lopez, Alvaro Ducas, Jessica Cassiani, Luca Morelli, Gaya Spolverato, Francesco Maria Bianco
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Sung Uk Bae
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Reviews
Malignant disease, Rectal cancer,Colorectal cancer,Prognosis,Biomarker & risk factor
- Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
- Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
- Ann Coloproctol. 2022;38(2):97-108. Published online March 29, 2022
- DOI: https://doi.org/10.3393/ac.2021.01004.0143
- 11,769 View
- 223 Download
- 38 Web of Science
- 40 Citations
-
Abstract
PDF
- We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior survival. In patients with rectal cancer, elevated neutrophil-lymphocyte ratio (NLR) and thrombocytosis were associated with postoperative complications, poor overall survival (OS), and disease-free survival (DFS). A high C-reactive protein/albumin ratio (CAR) was associated with poor OS and DFS. In patients with metastatic CRC, increased NLR and platelet-lymphocyte ratio (PLR) were associated with poor OS, DFS, and progression-free survival (PFS). In addition, high CAR and a low albumin/globulin ratio on blood chemistry tests were associated with poor OS and PFS. Although universal cut-off values were not available, various types of pretreatment laboratory markers could be utilized as adjuncts to predict prognosis in patients with CRC.
-
Citations
Citations to this article as recorded by- Correlation between inflammatory markers and enhanced recovery after surgery (ERAS) failure in laparoscopic colectomy
Ji Hyeong Song, Yoonsoo Shin, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim
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Journal of Palliative Medicine.2025; 28(5): 592. CrossRef - Immunological changes and recovery-related factors in older patients with colon cancer: A pilot trial
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Journal of Geriatric Oncology.2025; 16(3): 102200. CrossRef - Advancing Colorectal Cancer Diagnostics from Barium Enema to AI-Assisted Colonoscopy
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Malignant disease,Prognosis and adjuvant therapy,Colorectal cancer,Minimally invasive surgery,Surgical technique
- Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?
- Gyung Mo Son, In Young Lee, Yoon Suk Lee, Bong-Hyeon Kye, Hyeon-Min Cho, Je-Ho Jang, Chang-Nam Kim, Kil Yeon Lee, Suk-Hwan Lee, Jun-Gi Kim, On behalf of The Korean Laparoscopic Colorectal Surgery Study Group
- Ann Coloproctol. 2021;37(6):434-444. Published online December 8, 2021
- DOI: https://doi.org/10.3393/ac.2021.00955.0136
- 10,000 View
- 301 Download
- 21 Web of Science
- 24 Citations
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Abstract
PDF
- Colon cancer treatment is on the way to evolution over several decades. The minimally invasive surgery has improved postoperative short-term outcomes. Adjuvant chemotherapy has prolonged the survival of advanced colon cancer patients. Hohenberger proposed the noble concept of complete mesocolic excision (CME) which consists of 3 components: plane surgery, sufficient longitudinal bowel resection, and central vascular ligation (CVL). Mesocolic plane surgery shares the same surgical principle of total mesorectal excision, which is maintaining the intact mesothelial envelope. However, there remain debates about the extent of bowel resection and the level of CVL for maximizing lymph node dissection. There is no solid clinical evidence for the oncological necessity and benefit of extended radical dissection in right hemicolectomy. CME with CVL based on open surgery has been adopted in laparoscopic surgery. So, it is also necessary to look at how the CME could be transformed and successfully implanted in the laparoscopic era. Recent rapid advances in surgical technology and cancer biology are preparing for fundamental changes in cancer surgery. In this study, we reviewed the history, oncological necessity, and compatibility of CME for the right hemicolectomy in the laparoscopic era and outline the new perspectives on the evolution of cancer surgery.
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Citations
Citations to this article as recorded by- Optimal extent of lymph node dissection in clinical early-stage right colon cancer: a retrospective analysis
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Original Articles
- Influence of colonic mesenteric area on the number of lymph node retrieval for colon cancer: a prospective cohort study
- Nadir Adnan Hacım, Ahmet Akbaş, Yigit Ulgen, Talar Vartanoglu Aktokmakyan, Serhat Meric, Merve Tokocin, Onder Karabay, Yuksel Altinel
- Ann Coloproctol. 2023;39(1):77-84. Published online September 16, 2021
- DOI: https://doi.org/10.3393/ac.2021.00444.0063
- 9,724 View
- 167 Download
- 6 Web of Science
- 6 Citations
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Abstract
PDF
- Purpose
The minimum harvested 12 lymph nodes (LNs) is regarded as the limit for accurate staging of nodal status in colorectal cancer patients. Besides the association of the lengths of resected intestinal segments and vascular pedicles, the mesocolic mesenteric area’s impact on LN count has not been studied. We aimed to evaluate the associations between metric variables, including the mesocolic mesentery area on the nodal harvest.
Methods
All consecutive patients who underwent elective colectomy with a curative intention for colon adenocarcinoma were prospectively included. The metric variables included the lengths of resected intestinal segments, vascular pedicle, and colonic mesenteric area. The variables influencing the LN count and the correlation between the total LN count and the specimens’ relevant metric measurements were analyzed.
Results
There were 46 patients with a median age of 64 years. The median count for total LNs was 22, and the LN positivity was 59.2%. There was an inadequate LN yield (<12) in 3 patients (6.1%). No significant associations were found between the adequacy of nodal harvest and the demographic, clinical, and tumoral features (P>0.05). There were significant positive correlations between total LN number and length of vascular pedicle and mesenteric area (r=0.576, P<0.001 and r=0.566, P<0.001).
Conclusion
The length of the vascular pedicle and mesenteric area were significantly correlated with total LN counts. Although there was no significant impact on the length of resected segments, the colonic mesenteric area can be used alone as a measure for the assessment of the nodal yield in colon cancer. -
Citations
Citations to this article as recorded by- Deep learning model for predicting lymph node metastasis around rectal cancer based on rectal tumor core area and mesangial imaging features
Lili Guo, Kuang Fu, Wenjia Wang, Li Zhou, Lu Chen, Miaomiao Jiang
BMC Medical Imaging.2025;[Epub] CrossRef - Effect of Fluorescence Lymph Node Mapping on Improving Diagnostic Values of CT D3 Lymph Node Staging for Right-Sided Colon Cancer
Gyung Mo Son, Tae Un Kim, Mi Sook Yun, ChangYeop Kim, In Young Lee, Su Bum Park, Dong-Hoon Shin, Gi Won Ha
Cancers.2024; 16(20): 3496. CrossRef - Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study
Gyung Mo Son, Mi Sook Yun, In Young Lee, Sun Bin Im, Kyung Hee Kim, Su Bum Park, Tae Un Kim, Dong-Hoon Shin, Armaan M. Nazir, Gi Won Ha
Cancers.2023; 15(20): 4927. CrossRef - The Relationship Between the Resected Colon Length and the Number of Lymph Nodes in Colorectal Cancer: A Retrospective Cohort Study
Ulaş Karabay, Latif Yılmaz, Alper Aytekin, Aziz Bulut
European Journal of Therapeutics.2023; 29(4): 731. CrossRef - Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 203. CrossRef - Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?
Gyung Mo Son, In Young Lee, Yoon Suk Lee, Bong-Hyeon Kye, Hyeon-Min Cho, Je-Ho Jang, Chang-Nam Kim, Kil Yeon Lee, Suk-Hwan Lee, Jun-Gi Kim
Annals of Coloproctology.2021; 37(6): 434. CrossRef
- Deep learning model for predicting lymph node metastasis around rectal cancer based on rectal tumor core area and mesangial imaging features
Malignant disease,Colorectal cancer
- Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer
- Young Hun Kim, Kyung Jong Kim
- Ann Coloproctol. 2022;38(2):153-159. Published online August 31, 2021
- DOI: https://doi.org/10.3393/ac.2021.00374.0053
- 5,306 View
- 158 Download
- 9 Web of Science
- 9 Citations
-
Abstract
PDF
- Purpose
Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH). The current study aims to determine how PGE2 is expressed by examining patients with colorectal cancer and evaluating colon cancer cells to gain insight into changes in relevant enzymes upon induction of PGE2.
Methods
The concentration of PGE2 was measured in tumor tissues and adjacent normal mucosal tissues of 26 patients with colon cancer. The expression of COX-1, COX-2, mPGES-1, and 15-PGDH proteins was measured. The concentration of PGE2 in FET colon cancer cells was measured both in the initial status and after stimulation by tumor necrosis factor (TNF)-α. The expression levels of PGE2-related enzymes were measured as well.
Results
There was no significant difference in the average concentration of PGE2, which was measured at 453.1 pg/mL in cancer tissues and 401.2 pg/mL in normal mucosa. Among PGE2-related enzymes, 15-PGDH was expressed at a lower level in tumor cells than in normal mucosa. In colon cancer cells, PGE2 was found to be upregulated upon stimulation by TNF-α, which led to strong induction of mPGES-1 without any change in the expression of COX-2 among the PGE2-related enzymes.
Conclusion
These results demonstrated that PGE2 can be induced by stimuli such as TNF-α, and suggest that activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE2 on colon cancer. -
Citations
Citations to this article as recorded by- 5‐methyl‐2‐carboxamidepyrrole‐based novel dual mPGES‐1/sEH inhibitors as promising anticancer candidates
Ester Colarusso, Gianluigi Lauro, Marianna Potenza, Paola Galatello, Maria Luisa d'Aulisio Garigliota, Maria Grazia Ferraro, Marialuisa Piccolo, Maria Giovanna Chini, Carlo Irace, Pietro Campiglia, Robert Klaus Hoffstetter, Oliver Werz, Anna Ramunno, Gius
Archiv der Pharmazie.2025;[Epub] CrossRef - Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition
Gianluigi Lauro, Michela Aliberti, Mauro De Nisco, Silvana Pedatella, Giacomo Pepe, Manuela Giovanna Basilicata, Maria Giovanna Chini, Katrin Fischer, Robert K. Hofstetter, Oliver Werz, Maria Grazia Ferraro, Marialuisa Piccolo, Carlo Irace, Anella Saviano
European Journal of Medicinal Chemistry.2025; 289: 117402. CrossRef - Antioxidant, Antidiabetic, Anti-Obesity, and Anti-Inflammatory Activity of Tomato-Based Functional Snack Bars Enriched with Pea and RuBisCO Proteins
Elena Tomassi, Morena Gabriele, Agnese Sgalippa, Muhammed Rasim Gul, Ozan Tas, Mecit Halil Oztop, Laura Pucci
Foods.2025; 14(19): 3340. CrossRef - The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer
Mario Macia Guardado, Valentina Lutz, Markus Hengstschläger, Helmut Dolznig
International Journal of Molecular Sciences.2025; 26(24): 12191. CrossRef - Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Ana Santiso, Akos Heinemann, Julia Kargl
Pharmacological Reviews.2024; 76(3): 388. CrossRef - The calcium-sensing receptor modulates the prostaglandin E2 pathway in intestinal inflammation
Valeriya Gushchina, Nadja Kupper, Michael Schwarzkopf, Gitta Frisch, Karina Piatek, Cornelia Aigner, Alexandra Michel, Hemma Schueffl, Luca Iamartino, Taha Elajnaf, Teresa Manhardt, Andrea Vlasaty, Petra Heffeter, Marcella Bassetto, Enikö Kállay, Martin S
Frontiers in Pharmacology.2023;[Epub] CrossRef - Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef - Prostaglandin E2 Exposure Disrupts E-Cadherin/Caveolin-1-Mediated Tumor Suppression to Favor Caveolin-1-Enhanced Migration, Invasion, and Metastasis in Melanoma Models
Lorena Lobos-González, Lorena Oróstica, Natalia Díaz-Valdivia, Victoria Rojas-Celis, America Campos, Eduardo Duran-Jara, Nicole Farfán, Lisette Leyton, Andrew F. G. Quest
International Journal of Molecular Sciences.2023; 24(23): 16947. CrossRef - Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
Minsung Kim, Il Tae Son, Bo Young Oh
The Ewha Medical Journal.2023;[Epub] CrossRef
- 5‐methyl‐2‐carboxamidepyrrole‐based novel dual mPGES‐1/sEH inhibitors as promising anticancer candidates
Malignant disease,Rectal cancer, Prognosis and adjuvant therapy,Colorectal cancer
- Effect of Adjuvant Chemotherapy on Elderly Stage II High-Risk Colorectal Cancer Patients
- Yujin Lee, Inseok Park, Hyunjin Cho, Geumhee Gwak, Keunho Yang, Byung-Noe Bae
- Ann Coloproctol. 2021;37(5):298-305. Published online July 6, 2021
- DOI: https://doi.org/10.3393/ac.2020.00829.0118
- 6,530 View
- 100 Download
- 17 Web of Science
- 20 Citations
-
Abstract
PDF
- Purpose
Adjuvant chemotherapy (AC) is recommended for patients with stage II colorectal cancer with adverse features. However, the effect of adjuvant treatment in elderly patients with high-risk stage II colorectal cancer remains controversial. This study aimed to investigate the oncologic outcomes in elderly high-risk stage II colorectal cancer patients who underwent curative resection with or without AC.
Methods
Patients aged over 70 years having stage II colorectal adenocarcinoma with at least 1 adverse feature who underwent radical surgery between 2008 and 2017 at a single center were included. We compared recurrence-free survival (RFS) and overall survival (OS) between patients who received more than 80% of the planned AC cycle (the AC+ group) and those who did not receive it (the AC− group).
Results
The AC+ and AC– group contained 46 patients and 50 patients, respectively. The log-rank test revealed no significant intergroup differences in RFS (P = 0.083) and OS (P = 0.122). In the subgroup of 27 patients with more than 2 adverse features, the AC+ group (n = 16) showed better RFS (P = 0.006) and OS (P = 0.025) than the AC− group. In this subgroup, AC was the only significant factor affecting RFS in the multivariate analysis (P = 0.023). AC was significantly associated with OS (P = 0.033) in the univariate analysis, but not in the multivariate analysis (P = 0.332).
Conclusion
Among elderly patients with stage II high-risk colorectal cancer, the AC+ group did not show better RFS or OS than the AC− group. However, selected patients with more than 2 adverse features might benefit from AC. -
Citations
Citations to this article as recorded by- Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer
Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang
Journal of Translational Medicine.2025;[Epub] CrossRef - Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older
Byeo Lee Lim, In Ja Park, Jun-Soo Ro, Young Il Kim, Seok-Byung Lim, Chang Sik Yu
Annals of Coloproctology.2025; 41(3): 198. CrossRef - Predicting venous thromboembolism and determining appropriate prophylaxis in elderly patients undergoing colorectal cancer surgery with Enhanced Recovery After Surgery (ERAS) using the adjusted Caprini score
Young Sun Choi, Hyung Jin Cho, Chul Seung Lee, Dong Geun Lee, Choon Sik Chung, Gwan Cheol Lee, Dong Woo Kang, Jeong Sub Kim, Tae Gyu Kim
Annals of Coloproctology.2025; 41(4): 279. CrossRef - Oncologic outcomes of multivisceral resection for locally advanced colorectal cancer: a single-center retrospective cohort study
Jaram Lee, Hyeung-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
BMC Surgery.2025;[Epub] CrossRef - A Prognostic Model Based on the Log Odds Ratio of Positive Lymph Nodes Predicts Prognosis of Patients with Rectal Cancer
Jian Li, Yu zhou Yang, Peng Xu, Cheng Zhang
Journal of Gastrointestinal Cancer.2024; 55(3): 1111. CrossRef - Complete Obstruction, a Real Risk Factor: A Comprehensive Study on Obstruction in Stage IIA Colon Cancer With Propensity Score Matching Analysis
Soo Young Oh, Chan Wook Kim, Seonok Kim, Min Hyun Kim, Young Il Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Clinical Colorectal Cancer.2024; 23(2): 135. CrossRef - Clinical implication of tissue carcinoembryonic antigen expression in association with serum carcinoembryonic antigen in colorectal cancer
Abdulmohsin Fawzi Aldilaijan, Young Il Kim, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jihun Kim, Jun-Soo Ro, Jin Cheon Kim
Scientific Reports.2023;[Epub] CrossRef - Advances in the Treatment of Colorectal Cancer with Peritoneal Metastases: A Focus on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Youngbae Jeon, Eun Jung Park
The Ewha Medical Journal.2023;[Epub] CrossRef - Oncologic outcomes in elderly patients who underwent hysterectomy for endometrial cancer: a multi-institutional survey in Kinki District, Japan
Tomohito Tanaka, Suguru Yamashita, Haruo Kuroboshi, Junya Kamibayashi, Atsushi Sugiura, Kaori Yoriki, Taisuke Mori, Kazuharu Tanaka, Aiko Nagashima, Michihide Maeda, Shoji Kamiura, Yukako Mizuno, Noriko Ohtake, Tomoyuki Ichimura, Taiki Kikuchi, Yuri Nobut
International Journal of Clinical Oncology.2022; 27(6): 1084. CrossRef - Does adjuvant chemotherapy improve outcomes in elderly patients with colorectal cancer? A systematic review and meta-analysis of real-world studies
Jianbing Chen, Chengda Zhang, Yajuan Wu
Expert Review of Gastroenterology & Hepatology.2022; 16(4): 383. CrossRef - Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study
Takuki Yagyu, Manabu Yamamoto, Akimitsu Tanio, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Kyoichi Kihara, Shigeru Tatebe, Yasuro Kurisu, Shunsuke Shibata, Toshio Yamamoto, Hiroshi Nishie, Setsujo Shiota, Hiroaki Saito, Takuji Naka, Kenji Sugamura, Kuniyu
BMC Cancer.2022;[Epub] CrossRef - Effects of the Enhanced Recovery After Surgery (ERAS) Program for Colorectal Cancer Patients Undergoing Laparoscopic Surgery
Jeongwon Yeom, Hee-Sook Lim
Clinical Nutrition Research.2022; 11(2): 75. CrossRef - The Prognostic Reliability of Lymphovascular Invasion for Patients with T3N0 Colorectal Cancer in Adjuvant Chemotherapy Decision Making
Hayoung Lee, Seung-Yeon Yoo, In Ja Park, Seung-Mo Hong, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Cancers.2022; 14(12): 2833. CrossRef - Is the oncological impact of vascular invasion more important in right colon cancer?
Gyung Mo Son
Journal of Minimally Invasive Surgery.2022; 25(2): 49. CrossRef - Molecular analyses of peritoneal metastasis from colorectal cancer
Chang Hyun Kim
Journal of the Korean Medical Association.2022; 65(9): 586. CrossRef - Epidemiology, risk factors, and prevention of colorectal cancer
Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
Journal of the Korean Medical Association.2022; 65(9): 549. CrossRef - Molecular Analyses in Peritoneal Metastasis from Colorectal Cancer: A Review-An English Version
Chang Hyun Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 197. CrossRef - Epidemiology, Risk Factors, and Prevention of Colorectal Cancer-An English Version
Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 231. CrossRef - Adjuvant chemotherapy benefits on patients with elevated carcinoembryonic antigen in stage IIA colon cancer: a SEER-based analysis
Huabin Zhou, Songsheng Wang, Zhai Cai, Enming Qiu, Qianyun Chen, Xi Rao, Shuai Han, Zhou Li
International Journal of Colorectal Disease.2022; 37(12): 2481. CrossRef - Elderly High-Risk Stage II Colorectal Cancer Patients: Candidates for Improving Outcome?
Min Ki Kim
Annals of Coloproctology.2021; 37(5): 267. CrossRef
- Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer
Malignant disease,Prognosis and adjuvant therapy,Functional outcomes,Postoperative outcome & ERAS
- The impact of variations in care and complications within a colorectal Enhanced Recovery After Surgery program on length of stay
- James Wei Tatt Toh, Jack Cecire, Kerry Hitos, Karen Shedden, Fiona Gavegan, Nimalan Pathmanathan, Toufic El Khoury, Angelina Di Re, Annelise Cocco, Alex Limmer, Tom Liang, Kar Yin Fok, James Rogers, Edgardo Solis, Grahame Ctercteko
- Ann Coloproctol. 2022;38(1):36-46. Published online May 6, 2021
- DOI: https://doi.org/10.3393/ac.2020.11.23
- 8,359 View
- 221 Download
- 17 Web of Science
- 18 Citations
-
Abstract
PDFSupplementary Material
- Purpose
Enhanced Recovery After Surgery (ERAS) has become standard of care in colorectal surgery. However, there is not a universally accepted colorectal ERAS protocol and significant variations in care exist between institutions. The aim of this study was to examine the impact of variations in ERAS interventions and complications on length of stay (LOS).
Methods
This study was a single-center review of the first 200 consecutive patients recruited into our prospectively collected ERAS database. The primary outcome of this study was to examine the rate of compliance to ERAS interventions and the impact of these interventions on LOS. The secondary outcome was to assess the impact of complications (anastomotic leak, ileus, and surgical site infections) on LOS. ERAS interventions, rate of adherence, LOS, readmissions, morbidity, and mortality were recorded, and statistical analysis was performed.
Results
ERAS variations and complications significantly influenced patient LOS on both univariate and multivariate analysis. ERAS interventions identified as the most important strategies in reducing LOS included laparoscopic surgery, mobilization twice daily postoperative day (POD) 0 to 1, discontinuation of intravenous fluids on POD 0 to 1, upgrading to solid diet by POD 0 to 2, removal of indwelling catheter by POD 0 to 2, avoiding nasogastric tube reinsertion and removing drains early. Both major and minor complications increased LOS. Anastomotic leak and ileus were associated with the greatest increase in LOS.
Conclusion
Seven high-yield ERAS interventions reduced LOS. Major and minor complications increased LOS. Reducing variations in care and complications can improve outcomes following colorectal surgery. -
Citations
Citations to this article as recorded by- Effects of the Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls score on postoperative clinical outcomes following colorectal cancer surgery: a retrospective study
Young Jae Kim, Sung Uk Bae, Kyeong Eui Kim, Woon Kyung Jeong, Seong Kyu Baek
European Journal of Clinical Nutrition.2025; 79(4): 358. CrossRef - Comparative Risk of Complications Following Intestinal Surgery After Infliximab, Vedolizumab, or Ustekinumab Treatment: Systematic Review & Meta-Analysis
Alexandra-Eleftheria Menni, Georgios Tzikos, George Petrakis, Patroklos Goulas, Panagiotis V. Karathanasis, Stylianos Apostolidis
Pharmaceuticals.2025; 18(10): 1466. CrossRef - Post-surgical diets in the ERAS protocol: D-ERAS scoping review
Camilla Fiorindi, Pauline Raoul, Valentina Moretto, Ilaria Trestini, Laura Rossini, Giovanna Colasanto, Rita Schiano di Cola, Silvia Lazzaris, Benedetta Beltrame, Sara Carnevale, Francesco Giudici, Luca Gianotti
European Journal of Clinical Nutrition.2025;[Epub] CrossRef - Sex Disparities in Rectal Cancer Surgery: An In-Depth Analysis of Surgical Approaches and Outcomes
Chungyeop Lee, In Ja Park
The World Journal of Men's Health.2024; 42(2): 304. CrossRef - So many measures in ERAS protocol: Which matters most?
Nan Xie, Hua Xie, Wei Li, Zhongxian Zhu, Xu Wang, Weibing Tang
Nutrition.2024; 122: 112384. CrossRef - Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia: A cohort study
James Wei Tatt Toh, Devansh Shah, Henry Wang, Charlotte Kwik, Joseph Do Woong Choi, Chelsie Leonie Beinke, Paul Morris, Eleni Baird-Gunning, Geoffrey Peter Collins, Fiona Gavegan, Karen Shedden, Toufic El-Khoury, Nimalan Pathma-Nathan, Kerry Hitos
Laparoscopic, Endoscopic and Robotic Surgery.2024; 7(2): 72. CrossRef - Influence of additional prophylactic oral antibiotics during mechanical bowel preparation on surgical site infection in patients receiving colorectal surgery
Hayoung Lee, Jong Lyul Lee, Ji Sung Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok‐Byung Lim
World Journal of Surgery.2024; 48(6): 1534. CrossRef - Outcomes before and after Implementation of the ERAS (Enhanced Recovery after Surgery) Protocol in Open and Laparoscopic Colorectal Surgery: A Comparative Real-World Study from Northern Italy
Lucia Mangone, Federica Mereu, Maurizio Zizzo, Andrea Morini, Magda Zanelli, Francesco Marinelli, Isabella Bisceglia, Maria Barbara Braghiroli, Fortunato Morabito, Antonino Neri, Massimiliano Fabozzi
Current Oncology.2024; 31(6): 2907. CrossRef - Current perioperative care in patients undergoing a beyond total mesorectal excision procedure for rectal cancer: What are the differences with the colorectal enhanced recovery after surgery protocol?
Stefi Nordkamp, Stijn H. J. Ketelaers, Floor Piqeur, Harm J. Scholten, Silvie van de Calseijde, Jip L. Tolenaar, Grard A. P. Nieuwenhuijzen, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen
Colorectal Disease.2024; 26(11): 1903. CrossRef - Early detection of anastomotic leakage in colon cancer surgery: the role of early warning score and C-reactive protein
Gyung Mo Son
Annals of Coloproctology.2024; 40(5): 415. CrossRef - Clinical outcomes and future directions of enhanced recovery after surgery in colorectal surgery: a narrative review
Ji Hyeong Song, Minsung Kim
The Ewha Medical Journal.2024;[Epub] CrossRef - Impact of Early Oral Feeding on Postoperative Outcomes after Elective Colorectal Surgery: A Systematic Review and Meta-Analysis
Soo Young Lee, Eon Chul Han
Digestive Surgery.2024; : 1. CrossRef - Beyond the Operating Room: A Narrative Review of Enhanced Recovery Strategies in Colorectal Surgery
Hamed Ibrahim Hamed Albalawi, Rawshan Khalid A Alyoubi, Nawaf Mohsen Mubarak Alsuhaymi, Farha Abdullah K Aldossary, Alkathiry Abdulrahman Mohammed G, Fayez Mubarak Albishi, Jumana Aljeddawi, Fedaa Ahmed Omar Najm, Neda Ahmed Najem, Mohamed Mirza Ali Alma
Cureus.2024;[Epub] CrossRef - Implementation of an Enhanced Recovery after Surgery Protocol in Advanced and Recurrent Rectal Cancer Patients after beyond Total Mesorectal Excision Surgery: A Feasibility Study
Stefi Nordkamp, Davy M. J. Creemers, Sofie Glazemakers, Stijn H. J. Ketelaers, Harm J. Scholten, Silvie van de Calseijde, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Hendi W. Crezee, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen
Cancers.2023; 15(18): 4523. CrossRef - Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef - Influence of the COVID-19 Pandemic on the Treatment Patterns and Outcomes of Colorectal Cancer
In Ja Park
The Ewha Medical Journal.2023;[Epub] CrossRef - The Latest Results and Future Directions of Research for Enhanced Recovery after Surgery in the Field of Colorectal Surgery
Min Ki Kim
The Ewha Medical Journal.2023;[Epub] CrossRef - Future direction of Enhanced Recovery After Surgery (ERAS) program in colorectal surgery
In Ja Park
Annals of Coloproctology.2022; 38(1): 1. CrossRef
- Effects of the Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls score on postoperative clinical outcomes following colorectal cancer surgery: a retrospective study
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer
- The Impact of Primary Tumor Resection on Survival in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases
- Ki Yoon Doah, Ui Sup Shin, Byong Ho Jeon, Sang Sik Cho, Sun Mi Moon
- Ann Coloproctol. 2021;37(2):94-100. Published online April 30, 2021
- DOI: https://doi.org/10.3393/ac.2020.09.15.1
- 7,041 View
- 95 Download
- 18 Citations
-
Abstract
PDF
- Purpose
This study was conducted to evaluate the effectiveness of primary tumor resection (PTR) in asymptomatic colorectal cancer (CRC) patients with unresectable metastases using the inverse probability of treatment weighting (IPTW) method to minimize selection bias.
Methods
We selected 146 patients diagnosed with stage IV CRC with unresectable metastasis between 2001 and 2018 from our institutional database. In a multivariate logistic regression model using the patients’ baseline covariates associated with PTR, we applied the IPTW method based on a propensity score and performed a weighted Cox proportional regression analysis to estimate survival according to PTR.
Results
Upfront PTR was performed in 98 patients, and no significant differences in baseline factors were detected. The upweighted median survival of the PTR group was 18 months and that of the non-PTR group was 15 months (P = 0.15). After applying the IPTW, the PTR was still insignificant in the univariate Cox regression (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.5–1.21). However, in the multivariate weighted Cox regression with adjustment for other covariates, the PTR showed a significantly decreased risk of cancer-related death (HR, 0.61; 95% CI, 0.40–0.94).
Conclusion
In this study, we showed that asymptomatic CRC patients with unresectable metastases could gain a survival benefit from upfront PTR by analysis with the IPTW method. However, randomized controlled trials are mandatory. -
Citations
Citations to this article as recorded by- Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis
Junpei Takashima, Hirotoshi Kobayashi, Daisuke Fujimoto, Fumihiko Miura
Annals of Gastroenterological Surgery.2026;[Epub] CrossRef - A predictive model to identify optimal candidates for surgery among patients with metastatic colorectal cancer
Xiqiang Zhang, Zhaoyi Jing, Longchao Wu, Ze Tao, Dandan Lu
Frontiers in Oncology.2025;[Epub] CrossRef - Recurrence Rates and Postoperative Complications Following Colorectal Cancer Surgery: A 5-Year Study at a Tertiary Care Hospital in Peshawar
Tilal Ahmed Raza, Hussain Jan Abbasi, Farrukh Ozair, Hajra Imtiaz
Pakistan Journal of Health Sciences.2025; : 120. CrossRef - Primary tumor resection for asymptomatic colorectal cancer patients with synchronous unresectable metastases: a meta-analysis of randomized controlled trials and case-matched studies
Jun Huang, Jiahao Zhou, Ping Zhang, Qingbin Wu, Ziqiang Wang
Langenbeck's Archives of Surgery.2024;[Epub] CrossRef - Effect of primary tumor resection on survival in patients with asymptomatic unresectable metastatic colorectal cancer: a systematic review and meta-analysis
Chengren Zhang, Cong Cao, Lili Liu, Yaochun Lv, Jingjing Li, Jiyong Lu, Shuai Wang, Binbin Du, Xiongfei Yang
Expert Review of Anticancer Therapy.2023; 23(1): 107. CrossRef - The role of upfront primary tumor resection in asymptomatic patients with unresectable stage IV colorectal cancer: A systematic review and meta-analysis
Zongyu Liang, Zhiyuan Liu, Chengzhi Huang, Xin Chen, Zhaojun Zhang, Meijuan Xiang, Weixian Hu, Junjiang Wang, Xingyu Feng, Xueqing Yao
Frontiers in Surgery.2023;[Epub] CrossRef - Primary tumor resection in colorectal cancer patients with unresectable distant metastases: a minireview
Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
Frontiers in Oncology.2023;[Epub] CrossRef - Palliative primary tumor resection in minimally symptomatic (asymptomatic) patients with colorectal cancer and synchronous unresectable metastases versus chemotherapy alone: a metaanalysis
Iu. V. Alimova, Yu. A. Shelygin, E. G. Rybakov, M. V. Alekseev
Koloproktologia.2023; 22(2): 126. CrossRef - The impact of primary tumor resection for asymptomatic colorectal cancer patients with unresectable metastases: a systematic review and meta-analysis
Shuyuan Li, Liqiang Ji, Jie Huang, Ye Wang, Peng Liu, Wei Zhang, Zheng Lou
International Journal of Colorectal Disease.2023;[Epub] CrossRef - The impact of palliative primary tumor resection on overall survival in minimally symptomatic (asymptomatic) colorectal cancer and synchronous unresectable metastases vs chemotherapy only: a comparative study of outcomes
Iu. V. Alimova, S. I. Achkasov, Yu. A. Shelygin, M. V. Alekseev, V. N. Kashnikov, M. Yu. Fedyanin, M. A. Danilov, E. G. Rybakov
Koloproktologia.2023; 22(4): 10. CrossRef - Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies
Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak
Cancers.2023; 15(24): 5791. CrossRef - Palliative primary tumor resection in minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases: when is it necessary? (systematic review)
Iu. V. Alimova, Yu. A. Shelygin, E. G. Rybakov
Koloproktologia.2022; 21(3): 99. CrossRef - Surgical treatment for metastatic colorectal cancer
Eun Jung Park, Seung Hyuk Baik
Journal of the Korean Medical Association.2022; 65(9): 568. CrossRef - Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version
Eun Jung Park, Seung Hyuk Baik
Journal of the Anus, Rectum and Colon.2022; 6(4): 213. CrossRef - Molecular analyses of peritoneal metastasis from colorectal cancer
Chang Hyun Kim
Journal of the Korean Medical Association.2022; 65(9): 586. CrossRef - Molecular Analyses in Peritoneal Metastasis from Colorectal Cancer: A Review-An English Version
Chang Hyun Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 197. CrossRef - Primary Tumor Resection in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases: Can It Improve Survival?
Myong Hoon Ihn
Annals of Coloproctology.2021; 37(2): 71. CrossRef - Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Annals of Coloproctology.2021; 37(6): 425. CrossRef
- Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis
Malignant disease,Colorectal cancer,Surgical technique
- Comparison of Short-term Results after Laparoscopic Complete Mesocolic Excision and Standard Colectomy for Right-Sided Colon Cancer: Analysis of a Western Center Cohort
- Cristian Conti, Corrado Pedrazzani, Giulia Turri, Eduardo Fernandes, Enrico Lazzarini, Raffaele De Luca, Alessandro Valdegamberi, Andrea Ruzzenente, Alfredo Guglielmi
- Ann Coloproctol. 2021;37(3):166-173. Published online April 22, 2021
- DOI: https://doi.org/10.3393/ac.2020.05.18
- 7,254 View
- 168 Download
- 12 Web of Science
- 13 Citations
-
Abstract
PDF
- Purpose
Laparoscopic complete mesocolic excision (CME) right colectomy is a technically demanding procedure infrequently employed in Western centers. This retrospective cohort study aims to analyze the safety of laparoscopic CME colectomy compared to standard colectomy for right-sided colon cancer in a Western series.
Methods
Prospectively collected data from 60 patients who underwent laparoscopic CME right colectomy were compared to the ones of 55 patients who underwent laparoscopic standard right colectomy.
Results
No differences in clinical characteristics were observed between the CME and standard right colectomy groups. No differences were demonstrated in terms of blood loss (P = 0.060), intraoperative complications (P = 1), conversion rate (P = 0.102), and operative time (P = 0.473). No deaths were observed in either group, while complication rate was 40.0% in the CME and 49.1% in the standard group (P = 0.353). Severe complications occurred in 10.0% vs. 9.1% (P = 0.842), redo surgery in 5.0% vs. 7.3% (P = 0.708), and unplanned readmission in 5.0% vs. 5.5% (P = 1) after CME and standard colectomy, respectively. A significant difference in favor of CME was observed in the total length of specimen (P < 0.001), proximal (P = 0.018), and distal margins (P = 0.037). The number of lymph nodes harvested was significantly higher in the CME group (27 vs. 22, P = 0.037).
Conclusion
In Western series, where patients have less favorable clinical characteristics, laparoscopic CME allows to obtain better quality surgical specimens and comparable short-term outcomes compared to standard right colectomy. -
Citations
Citations to this article as recorded by- Complete Mesocolic Excision Compared With Conventional Right Hemicolectomy for Colorectal Cancer Outcomes: A Systematic Review and Meta-Analysis of Observational Cohorts
Imran Gul Shiekh, Hafiz Muhammad Ijaz Ul Haq, Syed Hasan Raza
Cureus.2026;[Epub] CrossRef - Minimally invasive complete mesocolic excision versus conventional right hemicolectomy for right-sided colon cancer: a systematic review and meta-analysis
Xin Yu Zhuang, Jia Li Zhang, Xue Fei Yang, Zhong Hui Liu
BMC Surgery.2025;[Epub] CrossRef - Retrocaecal, supracolic and medial dissection (the RESUME approach) as an optimal surgical procedure for right‐sided colon cancer—A Video Vignette
Hong‐min Ahn, Min Hyeong Jo, Mi Jeong Choi, Heung‐Kwon Oh, Duck‐Woo Kim, Sung‐Bum Kang
Colorectal Disease.2024; 26(7): 1480. CrossRef - Complete mesocolic excision (CME) impacts survival only for Stage III right-sided colon cancer: a systematic review and meta-analysis
Kengo Hayashi, Roberto Passera, Chiara Meroni, Rebecca Dallorto, Chiara Marafante, Carlo Alberto Ammirati, Alberto Arezzo
Minimally Invasive Therapy & Allied Technologies.2024; 33(6): 323. CrossRef - Effect of Fluorescence Lymph Node Mapping on Improving Diagnostic Values of CT D3 Lymph Node Staging for Right-Sided Colon Cancer
Gyung Mo Son, Tae Un Kim, Mi Sook Yun, ChangYeop Kim, In Young Lee, Su Bum Park, Dong-Hoon Shin, Gi Won Ha
Cancers.2024; 16(20): 3496. CrossRef - Robot-assisted versus laparoscopic short- and long-term outcomes in complete mesocolic excision for right-sided colonic cancer: a systematic review and meta-analysis
Pedja Cuk, Mohamad Jawhara, Issam Al-Najami, Per Helligsø, Andreas Kristian Pedersen, Mark Bremholm Ellebæk
Techniques in Coloproctology.2023; 27(3): 171. CrossRef - Influence of colonic mesenteric area on the number of lymph node retrieval for colon cancer: a prospective cohort study
Nadir Adnan Hacım, Ahmet Akbaş, Yigit Ulgen, Talar Vartanoglu Aktokmakyan, Serhat Meric, Merve Tokocin, Onder Karabay, Yuksel Altinel
Annals of Coloproctology.2023; 39(1): 77. CrossRef - Uptake of robot-assisted colon cancer surgery in the Netherlands
Marlou F. M. Sterk, Rogier M. P. H. Crolla, Mareille Verseveld, Jan Willem T. Dekker, George P. van der Schelling, Cornelis Verhoef, Pim B. Olthof
Surgical Endoscopy.2023; 37(11): 8196. CrossRef - Do Laparoscopic Approaches Ensure Oncological Safety and Prognosis for Serosa-Exposed Colon Cancer? A Comparative Study against the Open Approach
Ji-Hyun Seo, In-Ja Park
Cancers.2023; 15(21): 5211. CrossRef - Direction of diagnosis and treatment improvement in colorectal cancer
In Ja Park
Journal of the Korean Medical Association.2022; 65(9): 540. CrossRef - Multidisciplinary treatment strategy for early colon cancer
Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
Journal of the Korean Medical Association.2022; 65(9): 558. CrossRef - Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 203. CrossRef - Robot-Assisted Colorectal Surgery
Young Il Kim
The Ewha Medical Journal.2022;[Epub] CrossRef
- Complete Mesocolic Excision Compared With Conventional Right Hemicolectomy for Colorectal Cancer Outcomes: A Systematic Review and Meta-Analysis of Observational Cohorts
Malignant disease,Prognosis and adjuvant therapy,Colorectal cancer,Biomarker & risk factor
- Prognostic Factor and Survival Benefit of Adjuvant Chemotherapy in Stage IIA Colon Cancer
- Mok-Won Lee, Jin-Su Kim, Ji-Yeon Kim, Kyung-ha Lee
- Ann Coloproctol. 2021;37(1):35-43. Published online September 18, 2020
- DOI: https://doi.org/10.3393/ac.2020.09.03
- 6,337 View
- 137 Download
- 11 Web of Science
- 9 Citations
-
Abstract
PDF
- Purpose
There is no clear evidence of the benefit of adjuvant chemotherapy (AC) in stage IIA colon cancer. Therefore, we aimed to evaluate the prognostic factors and survival benefit of AC in this disease.
Methods
A retrospective data collection for patients who underwent radical surgery for colon cancer between January 2008 and December 2015 was undertaken. The cohort was divided into the no-AC and AC groups.
Results
We included 227 patients with stage IIA colon cancer in our study cohort, including 67 and 160 patients in the no-AC and AC groups, respectively. The number of retrieved lymph nodes and the presence of tumor complications as obstruction or perforation were independent risk factors for survival. In the no-AC group, there was a significant difference in survival according to the number of retrieved lymph nodes. In the AC group, there were significant differences in survival according to sidedness and preoperative carcinoembryonic antigen (CEA). There was no significant difference in survival between the no-AC and the AC groups.
Conclusion
The number of retrieved lymph nodes and the presence of tumor complications were prognostic factors for stage IIA colon cancer but lymphovascular and perineural invasion were not. Sidedness and preoperative CEA could be used as factors to predict the benefit of adjuvant chemotherapy. Currently, it is believed that there is no benefit of AC for stage IIA colon cancer. Further studies are needed to determine the survival benefit of adjuvant chemotherapy in stage IIA colon cancer. -
Citations
Citations to this article as recorded by- Oncologic outcomes of multivisceral resection for locally advanced colorectal cancer: a single-center retrospective cohort study
Jaram Lee, Hyeung-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
BMC Surgery.2025;[Epub] CrossRef - Can clinicopathologic high-risk features in T3N0 colon cancer be reliable prognostic factors?
Hyun Gu Lee, Young IL Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Annals of Surgical Treatment and Research.2023; 104(2): 109. CrossRef - Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study
Gyung Mo Son, Mi Sook Yun, In Young Lee, Sun Bin Im, Kyung Hee Kim, Su Bum Park, Tae Un Kim, Dong-Hoon Shin, Armaan M. Nazir, Gi Won Ha
Cancers.2023; 15(20): 4927. CrossRef - Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef - The Prognostic Reliability of Lymphovascular Invasion for Patients with T3N0 Colorectal Cancer in Adjuvant Chemotherapy Decision Making
Hayoung Lee, Seung-Yeon Yoo, In Ja Park, Seung-Mo Hong, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Cancers.2022; 14(12): 2833. CrossRef - Molecular Analyses in Peritoneal Metastasis from Colorectal Cancer: A Review-An English Version
Chang Hyun Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 197. CrossRef - Adjuvant chemotherapy benefits on patients with elevated carcinoembryonic antigen in stage IIA colon cancer: a SEER-based analysis
Huabin Zhou, Songsheng Wang, Zhai Cai, Enming Qiu, Qianyun Chen, Xi Rao, Shuai Han, Zhou Li
International Journal of Colorectal Disease.2022; 37(12): 2481. CrossRef - Molecular analyses of peritoneal metastasis from colorectal cancer
Chang Hyun Kim
Journal of the Korean Medical Association.2022; 65(9): 586. CrossRef - Direction of diagnosis and treatment improvement in colorectal cancer
In Ja Park
Journal of the Korean Medical Association.2022; 65(9): 540. CrossRef
- Oncologic outcomes of multivisceral resection for locally advanced colorectal cancer: a single-center retrospective cohort study
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer,Biomarker & risk factor
- Surgical Risk and Pathological Results of Emergency Resection in the Treatment of Acutely Obstructing Colorectal Cancers: A Retrospective Cohort Study
- Giovanni Domenico Tebala, Andrea Mingoli, Andrea Natili, Abdul Qayyum Khan, Gioia Brachini
- Ann Coloproctol. 2021;37(1):21-28. Published online March 16, 2020
- DOI: https://doi.org/10.3393/ac.2019.03.10.1
- 5,921 View
- 160 Download
- 5 Web of Science
- 6 Citations
-
Abstract
PDF
- Purpose
The treatment of acutely obstructing colorectal cancers is still a matter of debate. The prevailing opinion is that an immediate resection should be performed whenever possible. This study sought to determine whether immediate resection is safe and oncologically valid.
Methods
We completed a retrospective 2-center cohort study using the medical records of patients admitted for acutely obstructing colorectal cancer under the care of the Colorectal Team, Noble’s Hospital, Isle of Man, and the Emergency Surgery Unit, Umberto I University Hospital, Rome, from March 2013 to May 2017. The primary endpoints were 90-day mortality and morbidity, reoperation rate, and length of stay. The secondary endpoints were status of margins, number of lymph nodes retrieved, and the rate of adequate nodal harvest.
Results
Sixty-three patients were retrospectively enrolled in the study. Mortality was associated with age > 80 years and Dukes B tumors. The length of hospital stay was shorter in patients who had their resection less than 24 hours from their admission, in those who had laparoscopic resection and in those with distal tumors. The number of lymph nodes retrieved and rate of R0 resections were similar to those reported in elective colorectal surgery and were greater in laparoscopic resections and in patients operated on within 24 hours, respectively.
Conclusion
Immediate resection is a safe and reliable option in patients with acutely obstructing colorectal cancer. -
Citations
Citations to this article as recorded by- Complete Obstruction, a Real Risk Factor: A Comprehensive Study on Obstruction in Stage IIA Colon Cancer With Propensity Score Matching Analysis
Soo Young Oh, Chan Wook Kim, Seonok Kim, Min Hyun Kim, Young Il Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Clinical Colorectal Cancer.2024; 23(2): 135. CrossRef - Can clinicopathologic high-risk features in T3N0 colon cancer be reliable prognostic factors?
Hyun Gu Lee, Young IL Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Annals of Surgical Treatment and Research.2023; 104(2): 109. CrossRef - Fluorescence-guided colorectal surgery: applications, clinical results, and protocols
Jin-Min Jung, In Ja Park, Eun Jung Park, Gyung Mo Son
Annals of Surgical Treatment and Research.2023; 105(5): 252. CrossRef - Surgical safety in the COVID-19 era: present and future considerations
Young Il Kim, In Ja Park
Annals of Surgical Treatment and Research.2022; 102(6): 295. CrossRef - Failure to rescue after reoperation for major complications of elective and emergency colorectal surgery: A population-based multicenter cohort study
Marie T. Grönroos-Korhonen, Laura E. Koskenvuo, Panu J. Mentula, Selja K. Koskensalo, Ari K. Leppäniemi, Ville J. Sallinen
Surgery.2022; 172(4): 1076. CrossRef - Quality issues in emergency colorectal surgery
Tara Russell, Formosa Chen
Seminars in Colon and Rectal Surgery.2020; 31(4): 100784. CrossRef
- Complete Obstruction, a Real Risk Factor: A Comprehensive Study on Obstruction in Stage IIA Colon Cancer With Propensity Score Matching Analysis
Malignant disease,Prognosis and adjuvant therapy
- Identification of Risk Factors Associated With Stage III Disease in Nonmetastatic Colon Cancer: Results From a Prospective National Cohort Study
- Jakob Lykke, Ole Roikjaer, Per Jess, Jacob Rosenberg, On behalf of the Danish Colorectal Cancer Group
- Ann Coloproctol. 2020;36(5):316-322. Published online February 18, 2020
- DOI: https://doi.org/10.3393/ac.2019.03.03
- 4,953 View
- 120 Download
- 6 Web of Science
- 6 Citations
-
Abstract
PDF
- Purpose
This study aimed to identify possible patient- and tumor-related factors associated with risk of TNM stage III disease in nonmetastatic colon cancer.
Methods
The associations between stage III disease and age, sex, lymph node yield, pathological tumor (pT) stage, tumor subsite, type of surgery, and priority of surgery were assessed in a nationwide cohort of 13,766 patients treated with curative resection of colon cancer. Each level of age, lymph node yield, and pT stage was compared to the preceding level.
Results
Age, lymph node yield, pT stage, tumor subsite, and priority of surgery were associated with stage III disease. Odds ratios (95% confidence interval [CI]) were as follows: age < 65/65–75 years: 1.28 (95% CI, 1.15–1.43) and 65–75/ > 75 years: 1.22 (95% CI, 1.13–1.32); lymph node yield 0–5/6–11: 0.60 (95% CI, 0.50–0.72), lymph node yield 6–11/12–17: 0.84 (95% CI, 0.76–0.93), and lymph node yield 12–17/ ≥ 18: 0.97 (95% CI, 0.89–1.05); pT1/pT2: 0.74 (95% CI, 0.57–0.95), pT2/pT3: 0.35 (95% CI, 0.30–0.40), and pT3/pT4: 0.49 (95% CI, 0.47–0.54). Only tumors of the transverse colon were independently associated with lower risk of stage III disease than tumors in the sigmoid colon (sigmoid colon: 1, transverse colon: 0.84 [95% CI, 0.73–0.96]; elective surgery: 1, acute surgery: 1.43 [95% CI, 1.29–1.60]).
Conclusion
In this study, stage III disease in colon cancer was significantly associated with age, lymph node yield, pT stage, tumor subsite, and priority of surgery but was not associated with right-sided location compared with stage I and II cancers. -
Citations
Citations to this article as recorded by- Optimized workup of lymph nodes in regard to UICC classification of colorectal carcinoma
Moritz Rust, Nabih Farkouh, Piet Beusker, Ali Eissing‐Al‐Mukahal, Clara Böker, Julian Mall, Ludwig Wilkens
Histopathology.2026;[Epub] CrossRef - Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study
Wei Jiang, Huaiming Wang, Xiaoyu Dong, Yandong Zhao, Chenyan Long, Dexin Chen, Botao Yan, Jiaxin Cheng, Zexi Lin, Shuangmu Zhuo, Hui Wang, Jun Yan
Journal of Translational Medicine.2024;[Epub] CrossRef - Can clinicopathologic high-risk features in T3N0 colon cancer be reliable prognostic factors?
Hyun Gu Lee, Young IL Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Annals of Surgical Treatment and Research.2023; 104(2): 109. CrossRef - Deep learning-based pathology signature could reveal lymph node status and act as a novel prognostic marker across multiple cancer types
Siteng Chen, Jinxi Xiang, Xiyue Wang, Jun Zhang, Sen Yang, Wei Yang, Junhua Zheng, Xiao Han
British Journal of Cancer.2023; 129(1): 46. CrossRef - Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case–Control Study
Gyung Mo Son, Mi Sook Yun, In Young Lee, Sun Bin Im, Kyung Hee Kim, Su Bum Park, Tae Un Kim, Dong-Hoon Shin, Armaan M. Nazir, Gi Won Ha
Cancers.2023; 15(20): 4927. CrossRef - Deep learning can predict lymph node status directly from histology in colorectal cancer
Lennard Kiehl, Sara Kuntz, Julia Höhn, Tanja Jutzi, Eva Krieghoff-Henning, Jakob N. Kather, Tim Holland-Letz, Annette Kopp-Schneider, Jenny Chang-Claude, Alexander Brobeil, Christof von Kalle, Stefan Fröhling, Elizabeth Alwers, Hermann Brenner, Michael Ho
European Journal of Cancer.2021; 157: 464. CrossRef
- Optimized workup of lymph nodes in regard to UICC classification of colorectal carcinoma
Review
Malignant disease, Rectal cancer
- Current Colorectal Cancer in Thailand
- Varut Lohsiriwat, Nopdanai Chaisomboon, Jirawat Pattana-Arun, for the Society of Colorectal Surgeons of Thailand
- Ann Coloproctol. 2020;36(2):78-82. Published online January 31, 2020
- DOI: https://doi.org/10.3393/ac.2020.01.07
- 14,370 View
- 343 Download
- 22 Web of Science
- 21 Citations
-
Abstract
PDF
- This article aimed to summarize the current status of colorectal cancer (CRC) in Thailand. In brief, CRC is the third most common cancer and accounts for 11% of the cancer burden in Thailand. It is the only malignancy with an increased incidence in both sexes in Thailand. Over 10,000 new CRC cases occur annually, and about 40% are rectal cancer. Due to the lack of CRC screening and public awareness, nonmetastatic cancer accounts only for 60%–70% of overall cases. The demand for general or colorectal surgeons outmatches the supply at a ratio of 1 general surgeon to 35,000 individuals. There are about 70 board-certified colorectal surgeons serving Thailand’s population of nearly 70 million. As a result, >25% of cancer patients wait more than 1 month before surgery. Regarding training for colorectal surgery, there are 3 major institutes in Bangkok providing a 2-year fellowship program. Cadaveric workshops are an important part of training – especially in laparoscopy for CRC. Recently, a population-based CRC screening program was launched using a fecal immunochemical test. The Ministry of Public Health of Thailand has established additional platforms for laparoscopy to support the potential detection of early CRC following implementation of this nationwide screening program.
-
Citations
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Pharmaceutics.2026; 18(1): 79. CrossRef - Verification of intensity-modulated proton therapy (IMPT) plans for rectal cancer using MCsquare and TOPAS Monte Carlo simulations
Nipon Saiwong, Sasikarn Chamchod, Thiansin Liamsuwan
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BMC Gastroenterology.2025;[Epub] CrossRef - New oxepin and dihydrobenzofuran derivatives from Bauhinia saccocalyx roots and their anti-inflammatory, cytotoxic, and antioxidant activities
Lueacha Tabtimmai, Thanyathon Phonchan, Natrinee Thongprik, Sutin Kaennakam, Nuttapon Yodsin, Kiattawee Choowongkomon, Chanikan Sonklin, Supachai Jadsadajerm, Awat Wisetsai
Journal of Natural Medicines.2025; 79(3): 543. CrossRef - Relationship between the protein expression of ARID1A, ARID1B and ARID2 with the clinicopathological characteristics of colorectal cancer
Wariya Mongkolwat, Phattarapon Sonthi, Keerakarn Somsuan, Siripat Aluksanasuwan, Ratirath Samol, Natthiya Sakulsak, Sasithorn Wanna‑Udom
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Awat Wisetsai, Lueacha Tabtimmai, Chanikan Sonklin, Anupong Joompang, Nuttakarn Srisukpachin, Supachai Jadsadajerm, Sutarin Preepram
Natural Resources for Human Health.2025; 5(3): 449. CrossRef - Estimation of secondary cancer risks following rectal cancer photon and proton therapy: A computational phantom study
Nipon Saiwong, Sasikarn Chamchod, Pattarakan Suwanbut, Sawanee Suntiwong, Thiansin Liamsuwan
Physica Medica.2025; 137: 105083. CrossRef - Evaluation of the advantage of surgeons certified by the endoscopic surgical skill qualification system participating in laparoscopic low anterior rectal resection
Naruhiko Sawada, Tomonori Akagi, Manabu Shimomura, Yukitoshi Todate, Kunihiko Nagakari, Hiroaki Takeshita, Satoshi Maruyama, Manabu Takata, Nobuki Ichikawa, Koya Hida, Hiroaki Iijima, Shigeki Yamaguchi, Akinobu Taketomi, Takeshi Naitoh
Annals of Gastroenterological Surgery.2024; 8(3): 464. CrossRef - Cost-Effectiveness of Increasing Access to Colorectal Cancer Diagnosis: Analysis From Thailand
Peeradon Wongseree, Zeynep Hasgul, Mohammad S. Jalali
Value in Health Regional Issues.2024; 43: 101010. CrossRef - Phytochemical Profile of Cymbopogon citratus (DC.) Stapf Lemongrass Essential Oil from Northeastern Thailand and Its Antioxidant and Antimicrobial Attributes and Cytotoxic Effects on HT-29 Human Colorectal Adenocarcinoma Cells
Vijitra Luang-In, Worachot Saengha, Thipphiya Karirat, Chadaporn Senakun, Sirithon Siriamornpun
Foods.2024; 13(18): 2928. CrossRef - Impact of a Health Promotion Program on Knowledge, Physical Health, Mental Health, and Social Health Behaviors in Individuals at Risk for Colorectal Cancer
Surachet Fakkiew, Supat Teravecharoenchai, Panit Khemtong, Wanich Suksatan
Societies.2024; 14(9): 182. CrossRef - Cytotoxic effect of metformin on butyrate-resistant PMF-K014 colorectal cancer spheroid cells
Kesara Nittayaboon, Kittinun Leetanaporn, Surasak Sangkhathat, Sittirak Roytrakul, Raphatphorn Navakanitworakul
Biomedicine & Pharmacotherapy.2022; 151: 113214. CrossRef - Effects of polymorphisms in the MTHFR gene on 5-FU hematological toxicity and efficacy in Thai colorectal cancer patients
Chalirmporn Atasilp, Rinradee Lenavat, Natchaya Vanwong, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Pimonpan Jinda, Somthawin Aiempradit, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch, Nipaporn Sankuntaw, Patom
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Kesara Nittayaboon, Kittinun Leetanaporn, Surasak Sangkhathat, Sittiruk Roytrakul, Raphatphorn Navakanitworakul, Krzysztof Siemianowicz
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Varut LOHSIRIWAT
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Original Articles
- Short-term Outcomes After Upfront Chemotherapy Followed by Curative Surgery in Metastatic Colon Cancer: A Comparison With Upfront Surgery Patients
- Myung Hyun Han, Youn Young Park, Shiva Pratap, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
- Ann Coloproctol. 2019;35(6):327-334. Published online December 31, 2019
- DOI: https://doi.org/10.3393/ac.2019.03.04.1
- 5,009 View
- 71 Download
- 2 Web of Science
- 2 Citations
-
Abstract
PDF
- Purpose
Upfront systemic chemotherapy with target agents has been recommended for patients with stage IV colon cancer. Some with partial response are considered for curative resection. There is high risk of developing postoperative complications following upfront systemic chemotherapy. We aimed to evaluate short-term perioperative outcomes of curative surgery after upfront chemotherapy in comparison with upfront surgery in patients with metastatic colon cancer.
Methods
Between January 2010 and October 2015, 146 patients (80 in the surgery first group, 66 in the upfront chemotherapy group) who underwent surgical resection before or after systemic chemotherapy for metastatic colon cancer were included in the present study. All decisions for treatment were made through a multidisciplinary team. Postoperative clinical outcomes and complications were analyzed to compare the groups.
Results
There was no difference between the 2 groups in terms of postoperative clinical outcomes. Overall complication rates were not different between the groups (surgery first group: 46.3% vs. upfront chemotherapy group: 60.6%; P = 0.084). When classified according to the Clavien-Dindo method, there was no difference between the 2 groups in terms of major complications (grade 3 or more) (surgery first group: 18.9% vs. upfront chemotherapy group: 27.5%; P = 0.374).
Conclusion
There was no significant increase in major postoperative complications in metastatic colon cancer patients who received upfront chemotherapy followed by curative surgery. Careful patient selection and treatment planning are important. -
Citations
Citations to this article as recorded by- Impact of preoperative chemotherapy on perioperative morbidity in combined resection of colon cancer and liver metastases
Joy Z. Done, Angelos Papanikolaou, Miloslawa Stem, Shannon N. Radomski, Sophia Y. Chen, Chady Atallah, Jonathan E. Efron, Bashar Safar
Journal of Gastrointestinal Surgery.2023; 27(11): 2380. CrossRef - Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Young Jin Kim, Chang Hyun Kim
Annals of Coloproctology.2021; 37(6): 425. CrossRef
- Impact of preoperative chemotherapy on perioperative morbidity in combined resection of colon cancer and liver metastases
- Indication for and Effect of Adjuvant Chemotherapy for Stage IIa (T3N0M0) Colon Cancer
- Chul-Hyo Jeon, Min Ki Kim, In Kyu Lee
- Ann Coloproctol. 2019;35(5):254-261. Published online October 31, 2019
- DOI: https://doi.org/10.3393/ac.2018.12.04
- 10,390 View
- 95 Download
- 2 Web of Science
- 2 Citations
-
Abstract
PDF
- Purpose
The efficacy of adjuvant chemotherapy (AC) in stage IIa colon cancer is controversial. This study aimed to investigate the factors influencing survival in patients with stage IIa colon cancer, the role of AC, and the indications for AC utilization by surgical oncologists.
Methods
Between January 2004 and December 2010, 736 patients with stage IIa colon cancer underwent curative resection in 1 of 6 participating hospitals. Factors related to survival were identified and analyzed according to whether AC was administered or not. After high- and low-risk groups were identified, their respective results were analyzed.
Results
The 5-year overall survival (OS) of stage IIa colon cancer was 90.3%. With the exception of poorly differentiated histology, indications for AC did not include typical high-risk factors. The indications for AC were significantly younger patients, higher body mass index (BMI), lower American Society of Anesthesiologists (ASA) physical status classification, and higher histologic grade. BMI, preoperative carcinoembryonic antigen, and harvested lymph node (LN) count were significant factors for disease-free survival, while BMI and ASA physical status classification were significant factors for OS in the chemotherapy group. In the high-risk group, AC was associated with increased OS in univariate analysis. BMI and harvested LN count were statistically significant in multivariate analysis.
Conclusion
Surgical oncologists consider the patient’s condition and postoperative course rather than high-risk factors to determine use of AC. Regardless of AC use, both the extent of surgery and the patient’s subsequent status affected the survival rate in the high-risk group. None of the factors identified influenced survival rate in the low-risk group. -
Citations
Citations to this article as recorded by- Use of ascitic CEA levels as a predictive value for distant metastasis in high-risk stage II and III colorectal cancer
Abdullah Al-Sawat, Jung Hoon Bea, Seung-Rim Han, Hyo Jin Lee, Mi Ran Yoon, Yoon Suk Lee, Do Sang Lee, Chul Seung Lee, In Kyu Lee
International Journal of Colorectal Disease.2022; 37(2): 365. CrossRef - Prognostic Factor and Survival Benefit of Adjuvant Chemotherapy in Stage IIA Colon Cancer
Mok-Won Lee, Jin-Su Kim, Ji-Yeon Kim, Kyung-ha Lee
Annals of Coloproctology.2021; 37(1): 35. CrossRef
- Use of ascitic CEA levels as a predictive value for distant metastasis in high-risk stage II and III colorectal cancer
- Bowel Preparation for Surveillance Colonoscopy After Colorectal Resection: A New Perspective
- Donghyoun Lee, Ho-Kyung Chun
- Ann Coloproctol. 2019;35(3):129-136. Published online June 30, 2019
- DOI: https://doi.org/10.3393/ac.2018.11.08
- 5,635 View
- 71 Download
- 1 Web of Science
- 3 Citations
-
Abstract
PDF
- Purpose
Inadequate bowel preparation (IBP) is commonly observed during surveillance colonoscopy after colorectal resection. We investigated potential risk factors affecting bowel preparation.
Methods
We studied potential factors affecting bowel preparation quality. The Boston bowel preparation score was used to measure bowel preparation quality. Factors affecting IBP were analyzed, including age, body mass index, time elapsed between surgery and colonoscopy, and amount of bowel preparation drug consumed (conventional-volume vs. low-volume). Odds ratios were calculated for IBP.
Results
This retrospective cohort study included 1,317 patients who underwent colorectal resection due to malignancy. Of these patients, 79% had adequate bowel preparation and 21% had IBP. In multivariate regression analysis, a surveillance colonoscopy within 1 year after surgery and age >80 were used as independent predictors of IBP. IBP rate of the low-volume group was significantly higher than that of the conventional-volume group among patients who underwent a surveillance colonoscopy within 1 year after surgery.
Conclusion
For surveillance colonoscopy after colorectal resection, bowel preparation is affected by factors including colonoscopy timing after surgery and age. We recommend the use of conventional-volume 4-L polyethylene glycol solution when performing a surveillance colonoscopy, especially up to 1 year after surgery. -
Citations
Citations to this article as recorded by- Criteria of qualitative colonoscopy in patients after colorectal surgery (case reports)
I. Y. Korzheva, K. V. Krasnova, A. A. Likutov
Koloproktologia.2025; 24(1): 73. CrossRef - A Modified Boston Bowel Preparation Scale After Colorectal Surgery
Lorenzo Dioscoridi, Edoardo Forti, Francesco Pugliese, Marcello Cintolo, Angelo Italia, Marta Bini, Giulia Bonato, Aurora Giannetti, Massimiliano Mutignani
Annals of Coloproctology.2021; 37(4): 195. CrossRef - Bowel Preparation for Surveillance Colonoscopy After a Colorectal Resection: A New Perspective
Jin Soo Kim
Annals of Coloproctology.2019; 35(3): 107. CrossRef
- Criteria of qualitative colonoscopy in patients after colorectal surgery (case reports)
- Does the Different Locations of Colon Cancer Affect the Oncologic Outcome? A Propensity-Score Matched Analysis
- Kwan Mo Yang, In Ja Park, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Na Young Kim, Shinae Hong, Chang Sik Yu, Jin Cheon Kim
- Ann Coloproctol. 2019;35(1):15-23. Published online February 28, 2019
- DOI: https://doi.org/10.3393/ac.2018.07.25
- 5,669 View
- 125 Download
- 4 Web of Science
- 3 Citations
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Abstract
PDF
- Purpose
We evaluate the prognostic value of primary tumor location for oncologic outcomes in patients with colon cancer (CC).
Methods
CC patients treated with curative surgery between 2009 and 2012 were classified into 2 groups: right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Recurrence-free survival (RFS) and overall survival (OS) were examined based on tumor stage. Propensity scores were created using eight variables (age, sex, T stage, N stage, histologic grade, presence of lymphovascular invasion/perineural invasion, and microsatellite instability status).
Results
Overall, 2,329 patients were identified. The 5-year RFSs for RCC and LCC patients were 89.7% and 88.4% (P = 0.328), respectively, and their 5-year OSs were 90.9% and 93.4% (P = 0.062). Multivariate survival analyses were carried out by using the Cox regression proportional hazard model. In the unadjusted analysis, a marginal increase in overall mortality was seen in RCC patients (hazard ratio [HR], 1.297; 95% confidence interval [CI], 0.987–1.704, P = 0.062); however, after multivariable adjustment, similar OSs were observed in those patients (HR, 1.219; 95% CI, 0.91–1.633; P = 0.183). After propensity-score matching with a total of 1,560 patients, no significant difference was identified (P = 0.183). A slightly worse OS was seen for stage III RCC patients (HR, 1.561; 95% CI, 0.967–2.522; P = 0.068) than for stage III LCC patients. The 5-year OSs for patients with stage III RCC and stage III LCC were 85.5% and 90.5%, respectively (P = 0.133).
Conclusion
Although the results are inconclusive, tumor location tended to be associated with OS in CC patients with lymph node metastasis, but it was not related to oncologic outcome. -
Citations
Citations to this article as recorded by- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis
Hanieh Gholamalizadeh, Nima Zafari, Mahla Velayati, Hamid Fiuji, Mina Maftooh, Elnaz Ghorbani, Seyed Mahdi Hassanian, Majid Khazaei, Gordon A. Ferns, Elham Nazari, Amir Avan
Clinical and Experimental Medicine.2023; 23(8): 4369. CrossRef - Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation
Kristian-Christos Ngamsri, Christoph Jans, Rizki A. Putri, Katharina Schindler, Jutta Gamper-Tsigaras, Claudia Eggstein, David Köhler, Franziska M. Konrad
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World Journal of Surgical Oncology.2020;[Epub] CrossRef
- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis
Review
- Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
- Kwangmin Kim, Ernes John T. Castro, Hongjin Shim, John Vincent G. Advincula, Young-Wan Kim
- Ann Coloproctol. 2018;34(6):280-285. Published online December 31, 2018
- DOI: https://doi.org/10.3393/ac.2018.12.17
- 10,458 View
- 277 Download
- 47 Web of Science
- 46 Citations
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Abstract
PDF
- For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.
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Original Article
- Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection
- Jung Ho Park, Hyoung-Chul Park, Sung Chan Park, Jae Hwan Oh, Duck-Woo Kim, Sung-Bum Kang, Seung Chul Heo, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park, for the Seoul Colorectal Group (SECOG)
- Ann Coloproctol. 2018;34(6):286-291. Published online December 31, 2018
- DOI: https://doi.org/10.3393/ac.2018.10.29
- 6,317 View
- 120 Download
- 1 Web of Science
- 1 Citations
-
Abstract
PDF
- Purpose
Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer.
Methods
From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS.
Results
The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1–134 months). A multivariate Cox regression revealed that female sex (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.19–1.90; P < 0.01), right-sided tumor location (HR, 1.65; 95% CI, 1.29–2.11; P < 0.01), lymphatic invasion (HR, 1.52; 95% CI, 1.08–2.15; P < 0.01) and a high (≥0.4) metastatic lymph node ratio (HR, 3.72; 95% CI, 2.63–5.24; P < 0.01) were independent predictors of worse 5-year DFS. Female patients with RCC were 1.79 fold more likely to experience recurrence than male patients with LCC.
Conclusion
Female sex and right-sided tumor location are associated with higher tumor recurrence rates in patients with stage-IIIC colon cancers. Aggressive treatment and close surveillance should be planned for patients in these groups. -
Citations
Citations to this article as recorded by- Development and external validation of a nomogram predicting overall survival after curative resection of colon cancer
Shuanhu Wang, Yakui Liu, Yi Shi, Jiajia Guan, Mulin Liu, Wenbin Wang
Journal of International Medical Research.2021;[Epub] CrossRef
- Development and external validation of a nomogram predicting overall survival after curative resection of colon cancer
Video
- Reduced-Port Laparoscopic Surgery for Patients With Proximal Transverse Colon Cancer With Situs Inversus Totalis: A Case Report
- Seung-Seop Yeom, Kyung Hwan Kim, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim, Young Jin Kim
- Ann Coloproctol. 2018;34(6):322-325. Published online December 31, 2018
- DOI: https://doi.org/10.3393/ac.2018.05.29.1
- 8,959 View
- 100 Download
- 5 Web of Science
- 4 Citations
-
Abstract
PDFSupplementary Material
- Situs inversus is a rare hereditary disorder in which various anomalies have been reported with internal rotation abnormalities. This case involved an 85-year-old woman who had been diagnosed with transverse colon cancer and who underwent reduced-port laparoscopic surgery. All intra-abdominal organs were reversed left to right and right to left. The aberrant midcolic artery was identified during surgery. The total surgery time was 170 minutes, and the patient lost 20 mL of blood. The patient was discharged on the 8th postoperative day without complications.
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Citations
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Bo-Ya Chiu, Shu-Hung Chuang, Shih-Chang Chuang, Kung-Kai Kuo
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Case Reports
- Toxocara canis Mimicking a Metastatic Omental Mass from Sigmoid Colon Cancer: A Case Report
- Han-Gil Kim, Jung-Wook Yang, Soon-Chan Hong, Young-Joon Lee, Young-Tae Ju, Chi-Young Jeong, Jin-Kwon Lee, Seung-Jin Kwag
- Ann Coloproctol. 2018;34(3):160-163. Published online June 30, 2018
- DOI: https://doi.org/10.3393/ac.2017.12.20
- 6,825 View
- 84 Download
- 3 Web of Science
- 4 Citations
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- Toxocara canis is an important roundworm of canids and a fearsome animal parasite of humans. Human infections can lead to syndromes called visceral larva migrans (VLM), ocular larva migrans, neurotoxocariasis, and covert toxocariasis. VLM is most commonly diagnosed in children younger than 8 years of age, but adult cases are relatively frequent among those infected by ingesting the raw tissue of paratenic hosts in East Asia. This research reports the case of a 59-year-old man with sigmoid colon cancer, who visited our institution for surgery. An intraperitoneal mass was found on preoperative computed tomography, and it was thought to be a metastatic mass from sigmoid colon cancer. A postoperative histologic examination and serum test showed eosinophilic granuloma due to toxocariasis. Diagnosis of VLM is often difficult and highly suspicious in adults. Researchers suggest, although rarely, that VLM be included in the differential diagnosis as a cause of intraperitoneal tumors.
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Citations
Citations to this article as recorded by- Current status of intestinal parasite infections in fecal samples of dogs in Korea
You-Jeong Lee, Beoul Kim, Dongmi Kwak, Min-Goo Seo
Parasites, Hosts and Diseases.2024; 62(4): 438. CrossRef - Human Toxocariasis in individuals with blood disorders and cancer patients: the first seroepidemiological study in Iran
Vahid Raissi, Nasrin Sohrabi, Fatemeh Bayat, Soudabeh Etemadi, Omid Raiesi, Pantea Jalali, Maryam Karami, Ali Abdollahi, Ziba Hoseiny, Mahdi Shayanfard, Gita Alizadeh, Mahmoud E. Gadalla, Asmaa Ibrahim
Journal of Parasitic Diseases.2021; 45(3): 643. CrossRef - Pulmonary Exacerbation of Undiagnosed Toxocariasis in Intensively-Treated High-Risk Neuroblastoma Patients
Szymon Janczar, Monika Bulas, Justyna Walenciak, Dobromila Baranska, Marek Ussowicz, Wojciech Młynarski, Beata Zalewska-Szewczyk
Children.2020; 7(10): 169. CrossRef - Toxocariasis Suspected of Having Infiltrated Directly from the Liver to the Lung through the Diaphragm
Masaki Kakimoto, Masayuki Murata, Fujiko Mitsumoto-Kaseida, Eiichi Ogawa, Yuji Matsumoto, Akira Kusaga, Kazuhiro Toyoda, Takeo Hayashi, Kazuya Ura, Keishi Kanno, Norihiro Furusyo, Susumu Tazuma
Internal Medicine.2019; 58(18): 2737. CrossRef
- Current status of intestinal parasite infections in fecal samples of dogs in Korea
- Incidentally Solitary, Synchronous, Metastatic Left Adrenal Mass From Colon Cancer
- Mina Alvandipour, Mohammad Yasin Karami, Mehdi Khalvati, Hamed Khodabakhsh
- Ann Coloproctol. 2016;32(2):79-82. Published online April 30, 2016
- DOI: https://doi.org/10.3393/ac.2016.32.2.79
- 7,853 View
- 50 Download
- 2 Web of Science
- 4 Citations
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The authors report the case of a 63-year-old man who underwent an open adrenalectomy for a synchronous, malignant, metastatic left adrenal tumor and a total colectomy for T3N0M1 (stage 4) primary, malignant colon cancer. Two polypoid lesions, one measuring 40 mm × 30 mm × 30 mm and the other measuring 20 mm × 10 mm × 10 mm, were found in the ascending colon and rectosigmoid (RS) junction, respectively, and a synchronous, malignant, left adrenal gland lesion measuring 70 mm × 50 mm × 30 mm was incidentally found on abdominal computed tomography scan. Histological examination revealed a metastatic, necrotic adenocarcinoma of the left adrenal mass, an adenocarcinoma of the cecal mass, and an adenomatous polyp (tubulovillous type) of the smallest polypoid lesion in RS junction that had invaded deeply into the submucosal layer. The patient recovered uneventfully, and his condition is now stable, with no evidence of local recurrence or metastatic disease, 2 years after the surgery. To the best of our knowledge, only 25 cases of an adrenalectomy for treating metastatic adrenal gland tumors have been reported to date; physicians should be aware of the possibility of this event.
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Citations
Citations to this article as recorded by- Surgical resection of adrenal metastasis from colorectal cancers: a systematic review
Thi Ai Van Terresa Nguyen, Sze Ling Wong, Zi Qin Ng
ANZ Journal of Surgery.2024; 94(4): 545. CrossRef - An Adrenal Incidentaloma After Colon/Rectal Cancer Surgery: A Primer Lesion or Metastasis—A Case Report
Adalet Daş, İbrahim Ethem Cakcak, Derya Karabulut, Dicle Tamer Türk
SN Comprehensive Clinical Medicine.2024;[Epub] CrossRef - Solitary metastasis of colorectal cancer in the left adrenal gland 4 years after surgery on the primary tumor. Case report
Marina D. Budurova, Vladimir S. Trifanov, Vladimir V. Kopylov, Olga S. Kuznetsova, Maria A. Chernichenko, Sergey I. Poluektov
Journal of Modern Oncology.2023; 25(3): 401. CrossRef - Synchronous contralateral adrenal metastasis of colorectal cancer: case report
Micaela Raices, Luis Boccalatte, Gustavo Rossi, Fernando Wright
Journal of Surgical Case Reports.2017;[Epub] CrossRef
- Surgical resection of adrenal metastasis from colorectal cancers: a systematic review
Original Article
- Age Over 80 is a Possible Risk Factor for Postoperative Morbidity After a Laparoscopic Resection of Colorectal Cancer
- Taekhyun Kang, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Won Kon Han, Kyung Uk Jung
- Ann Coloproctol. 2015;31(6):228-234. Published online December 31, 2015
- DOI: https://doi.org/10.3393/ac.2015.31.6.228
- 6,504 View
- 43 Download
- 15 Web of Science
- 18 Citations
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Purpose With extended life expectancy, the mean age of patients at the time of diagnosis of colorectal cancer and its treatment, including radical resection, is increasing gradually. We aimed to evaluate the impact of age on postoperative clinical outcomes after a laparoscopic resection of colorectal cancers.
Methods This is a retrospective review of prospectively collected data. Patients with primary colorectal malignancies or premalignant lesions who underwent laparoscopic colectomies between January 2009 and April 2013 were identified. Patients were divided into 6 groups by age using 70, 75, and 80 years as cutoffs: younger than 70, 70 or older, younger than 75, 75 or older, younger than 80, and 80 or older. Demographics, pathological parameters, and postoperative clinical outcomes, including postoperative morbidity, were compared between the younger and the older age groups.
Results All 578 patients underwent a laparoscopic colorectal resection. The overall postoperative complication rate was 21.1% (n = 122). There were 4 cases of operative mortality (0.7%). Postoperative complication rates were consistently higher in the older groups at all three cutoffs; however, only the comparison with a cutoff at 80 years showed a statistically significant difference between the younger and the older groups.
Conclusion Age over 80 is a possible risk factor for postoperative morbidity after a laparoscopic resection of colorectal cancer.
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Citations
Citations to this article as recorded by- Association between flurbiprofen axetil use and operative complications occurring following colorectal surgery
Weisi Ding, Kai Shen, Wenhui Ren, Xue Tian, Yi Feng
Experimental and Therapeutic Medicine.2025; 30(4): 1. CrossRef - Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges
Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen, Birger Henning Endreseth
BMC Cancer.2022;[Epub] CrossRef - Differential short-term outcomes of laparoscopic resection in colon and rectal cancer patients aged 80 and older: an analysis of Nationwide Inpatient Sample
Kuan-Chih Chung, Ko-Chao Lee, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song
Surgical Endoscopy.2021; 35(2): 872. CrossRef - Age and comorbidities do not affect short-term outcomes after laparoscopic rectal cancer resection in elderly patients. A multi-institutional cohort study in 287 patients
Roberto Peltrini, Nicola Imperatore, Filippo Carannante, Diego Cuccurullo, Gabriella Teresa Capolupo, Umberto Bracale, Marco Caricato, Francesco Corcione
Updates in Surgery.2021; 73(2): 527. CrossRef - Short-term and long-term outcomes after laparoscopic surgery for elderly patients with colorectal cancer aged over 80 years: a propensity score matching analysis
Masako Utsumi, Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Kyosuke Agawa, Naoki Urakawa, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Yoshihiro Kakeji
International Journal of Colorectal Disease.2021; 36(11): 2519. CrossRef - Type and Consequences of Short-Term Complications in Colon Cancer Surgery, Focusing on the Oldest Old
Marisa Baré, Laura Mora, Miguel Pera, Pablo Collera, Maximino Redondo, Antonio Escobar, Rocío Anula, José María Quintana, M. Redondo, F. Rivas, E. Briones, E. Campano, A.I. Sotelo, F. Medina, A. Del Rey, M.M. Morales, S. Gómez, M. Baré, M. Pont, N. Torà,
Clinical Colorectal Cancer.2020; 19(1): e18. CrossRef - Short-term outcomes of laparoscopic surgery for colorectal cancer in the elderly versus non-elderly: a systematic review and meta-analysis
Nobuaki Hoshino, Yudai Fukui, Koya Hida, Yoshiharu Sakai
International Journal of Colorectal Disease.2019; 34(3): 377. CrossRef - Safety and Prognosis of Transarterial Chemoembolization for Octogenarians with Hepatocellular Carcinoma
Hua-Ming Cheng, Toshihiro Tanaka, Hideyuki Nishiofuku, Yuto Chanoki, Katsutoshi Horiuchi, Tetsuya Masada, Shota Tatsumoto, Takeshi Matsumoto, Nagaaki Marugami, Kimihiko Kichikawa
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Z. B. Khalilov, A. Yu. Kalinichenko, R. Kh. Azimov, M. A. Chinikov, I. S. Panteleeva, F. S. Kurbanov
Khirurgiya. Zhurnal im. N.I. Pirogova.2018; (3): 76. CrossRef - Efficacy of video-assisted procedures in advanced age patients with colorectal cancer
Z. B. Khalilov, A. Yu. Kalinichenko, R. Kh. Azimov, I. S. Panteleeva, M. A. Chinikov, F. S. Kurbanov
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Hossein M Abdolahi, Ali S Asiabar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Aziz Rezapour
Asia-Pacific Journal of Oncology Nursing.2018; 5(1): 57. CrossRef - Laparoscopic surgery for colon cancer in elderly patients
Z. B. Khalilov, A. Yu. Kalinichenko
Khirurgiya. Zhurnal im. N.I. Pirogova.2017; (3): 86. CrossRef - Evaluation of safety, feasibility and the long-term outcomes of colorectomy for colorectal adenocarcinoma in patients older than 80 years of age
Norio Yukawa, Toru Aoyama, Tsutomu Sato, Takashi Oshima, Takaki Yoshikawa, Yasushi Rino, Munetaka Masuda
Molecular and Clinical Oncology.2017; 7(4): 564. CrossRef - Evaluation of short-term outcomes of laparoscopic-assisted surgery for colorectal cancer in elderly patients aged over 75 years old: a multi-institutional study (YSURG1401)
Keisuke Kazama, Toru Aoyama, Tsutomu Hayashi, Takanobu Yamada, Masakatsu Numata, Shinya Amano, Mariko Kamiya, Tsutomu Sato, Takaki Yoshikawa, Manabu Shiozawa, Takashi Oshima, Norio Yukawa, Yasushi Rino, Munetaka Masuda
BMC Surgery.2017;[Epub] CrossRef - The possibility of endovideosurgical interventions for the treatment of the older-age patients presenting with rectal cancer
Z. B. Khalilov, R. H. Azimov, M. A. Chinikov, I. S. Panteleeva, F. S. Kurbanov
Dokazatel'naya gastroenterologiya.2017; 6(4): 53. CrossRef - Impact of frailty on approach to colonic resection: Laparoscopy vs open surgery
Catalina Mosquera, Konstantinos Spaniolas, Timothy L Fitzgerald
World Journal of Gastroenterology.2016; 22(43): 9544. CrossRef - Colorectal Surgery in Elderly Patients
Byung Chun Kim
Annals of Coloproctology.2016; 32(4): 126. CrossRef - Impact of octogenarians on surgical outcome in colorectal cancer
Basilio Pirrera, Samuele Vaccari, Dajana Cuicchi, Ferdinando Lecce, Emilio De Raffele, Barbara Dalla Via, Marco Di Laudo, Valeria Tonini, Maurizio Cervellera, Bruno Cola
International Journal of Surgery.2016; 35: 28. CrossRef
- Association between flurbiprofen axetil use and operative complications occurring following colorectal surgery
Case Report
- Colonic Metastasis Presenting as an Intraluminal Fungating Mass 8 Years After Surgery for Ovarian Cancer
- Jeong Rye Kim, Bong Man Kim, You Me Kim, Won Ae Lee, Hwan Namgung
- Ann Coloproctol. 2015;31(5):198-201. Published online October 31, 2015
- DOI: https://doi.org/10.3393/ac.2015.31.5.198
- 7,282 View
- 45 Download
- 5 Web of Science
- 7 Citations
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We report a case of colonic metastasis from ovarian cancer presented as an intraluminal fungating mass mimicking primary colon cancer 8 years after surgery for ovarian cancer. A 70-year-old woman presented with constipation. She had undergone an extended total abdominal hysterectomy with bilateral salpingo-oophorectomy for an ovarian papillary serous cystadenocarcinoma 8 years earlier. Colonoscopy showed a large fungating mass 10 cm from the anal verge that was suspected to be colorectal cancer. A computed tomography scan showed a bulky intraluminal fungating mass in the rectosigmoid junction. After a lower anterior resection and a pathologic diagnosis, a diagnosis of a papillary serous adenocarcinoma due to metastasis from an ovarian tumor was made for this patient.
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Citations
Citations to this article as recorded by- Serous Carcinomas Initially Diagnosed on Colon Biopsies: A Case Series Highlighting the Role of p53 to Guide Management
Brianna Waller, John A. Steinharter, John M. Kennedy, Charles Ashley, Amer K. Abu Alfa, Kristen E. Muller, Bronwyn Bryant
International Journal of Surgical Pathology.2025;[Epub] CrossRef - A Case Report of Bilateral Endometrioid-Type Ovarian Carcinoma with Synchronous Dual Metastasis to the Colon
W. T. N. Widanage, K. S. Nathawitharanalage, N. A. Kodithuwakku, A. A. S. Samarathunga, H. M. S. P. Rajaguru, K. P. Dissanayake, L. R. A. Wijesooriya, J. A. S. B. Jayasundara
SN Comprehensive Clinical Medicine.2024;[Epub] CrossRef - Synchronous Tumors in the Cecum and Ovary: Differentiating a Primary Colonic Tumor from Metastasis
Raksha Ramesh, Shalini Shree Krishnamurthy, Jayashree Natarajan, Ramakrishnan Ayloor Seshadri
Indian Journal of Colo-Rectal Surgery.2024; 7(3): 54. CrossRef - Metastasis of Ovarian Cancer to the Descending Colon
Kentaro Abe, Hiroyuki Anzai, Satoko Eguchi, Masako Ikemura, Aya Shinozaki-Ushiku, Takahide Shinagawa, Hirofumi Sonoda, Yuichiro Yoshioka, Yuzo Nagai, Shinya Abe, Hiroyuki Matsuzaki, Yuichiro Yokoyama, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Hiroaki
Case Reports in Gastroenterology.2023; 17(1): 136. CrossRef - Clinicopathologic Features of Gynecologic Malignancies Presenting Clinically as Colonic Malignancies
Lanisha D Fuller, Andrew Dunn, Aaron R Huber, Monika Vyas, Raul S Gonzalez
American Journal of Clinical Pathology.2022; 157(1): 82. CrossRef - Rectorrhagia revealing colonic metastasis from an ovarian primary, an exceptional case report
Rachid Jabi, Siham Elmir, Soumia El Arabi, Achraf Merry, Mohammed Bouziane
International Journal of Surgery Case Reports.2021; 88(C): 106490. CrossRef - Metastatic colon cancer of an ovarian cancer origin mimicking primary colon cancer: A case report
Ji-Hyeon Park, Dong Hae Jung, Jeong-Heum Baek
Korean Journal of Clinical Oncology.2018; 14(1): 53. CrossRef
- Serous Carcinomas Initially Diagnosed on Colon Biopsies: A Case Series Highlighting the Role of p53 to Guide Management
Original Articles
- The Role of Hand-Assisted Laparoscopic Surgery in a Right Hemicolectomy for Right-Sided Colon Cancer
- Sung Uk Bae, Jin Seok Park, Young Jin Choi, Min Ku Lee, Byung Sun Cho, Yoon Jung Kang, Joo Seung Park, Chang Nam Kim
- Ann Coloproctol. 2014;30(1):11-17. Published online February 28, 2014
- DOI: https://doi.org/10.3393/ac.2014.30.1.11
- 7,637 View
- 47 Download
- 14 Web of Science
- 11 Citations
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Abstract
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Purpose The purpose of this study is to evaluate the perioperative and long-term oncologic outcomes of hand-assisted laparoscopic surgery (HALS) and standard laparoscopic surgery (SLS) and assess the role of HALS in the management of right-sided colon cancer.
Methods The study group included 53 patients who underwent HALS and 45 patients who underwent SLS for right-sided colon cancer between April 2002 and December 2008.
Results The patients in each group were similar in age, American Society of Anesthesiologist (ASA) score, body mass index, and history of previous abdominal surgeries. Eight patients in the HALS group and no patient in the SLS group exhibited signs of tumor invasion into adjacent structures. No differences were noted in the time to return of normal bowel function, time to toleration of diet, lengths of hospital stay and narcotic usage, and rate of postoperative complications. The median incision length was longer in the HALS group (HALS: 7.0 cm vs. SLS: 4.8 cm, P < 0.001). The HALS group had a significantly higher pathologic TNM stage and significantly larger tumor size (HALS: 6.0 cm vs. SLS: 3.3 cm, P < 0.001). The 5-year overall, disease-free, and cancer-specific survival rates of the HALS and the SLS groups were 87.3%, 75.2%, and 93.9% and 86.4%, 78.0%, and 90.7%, respectively (P = 0.826, P = 0.574, and P = 0.826).
Conclusion Although patients in the HALS group had more advanced disease and underwent more complex procedures than those in the SLS group, the short-term benefits and the oncologic outcomes between the two groups were comparable. HALS can, therefore, be considered an alternative to SLS for bulky and fixed right-sided colon cancer.
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Citations
Citations to this article as recorded by- The terminal ileal vein approach: a novel and simple technique for locating the superior mesenteric vein and en bloc resection of the ileal mesentery in laparoscopic right hemicolectomy
Yi-Jun Liao, Si-Yuan Mi, Da Kang, Xin Tang, Gong Chen, Zhi-Zhong Pan, Rong-Xin Zhang
Updates in Surgery.2025; 77(8): 2311. CrossRef - Effect of postoperative complications on 5-year survival following laparoscopic surgery for resectable colorectal cancer: a retrospective study
Jae Eun Lee, Kyeong Eui Kim, Woon Kyung Jeong, Seong Kyu Baek, Sung Uk Bae
International Journal of Colorectal Disease.2024;[Epub] CrossRef - Right hemicolectomy: a network meta-analysis comparing open, laparoscopic-assisted, total laparoscopic, and robotic approach
Emanuele Rausa, Michael Eamon Kelly, Emanuele Asti, Alberto Aiolfi, Gianluca Bonitta, Luigi Bonavina
Surgical Endoscopy.2019; 33(4): 1020. CrossRef - Outcomes of open, laparoscopic, and hand-assisted laparoscopic surgeries in elderly patients with right colon cancers
Mingtian Wei, Xubing Zhang, Pingfan Ma, Wanbin He, Liang Bi, Ziqiang Wang
Medicine.2018; 97(35): e11907. CrossRef - Hand-assisted laparoscopic right hemicolectomy with complete mesocolic excision and central vascular ligation: a novel technique for right colon cancer
Qing-Bin Wu, Xiang-Bing Deng, Xu-Yang Yang, Bing-Chen Chen, Wan-Bin He, Tao Hu, Ming-Tian Wei, Zi-Qiang Wang
Surgical Endoscopy.2017; 31(8): 3383. CrossRef - Hand-assisted laparoscopic surgery versus laparoscopic right colectomy: a meta-analysis
Guosen Wang, Jianping Zhou, Weiwei Sheng, Ming Dong
World Journal of Surgical Oncology.2017;[Epub] CrossRef - Robotic Complete Mesocolic Excision and Intracorporeal Anastomosis Using a Robotic Stapler for Right-Sided Colon Cancer With Reduced-Port Access
Sung Uk Bae, Woon Kyung Jeong, Seong Kyu Baek
Diseases of the Colon & Rectum.2017; 60(4): 456. CrossRef - Advances in Laparoscopic Colorectal Surgery
James Michael Parker, Timothy F. Feldmann, Kyle G. Cologne
Surgical Clinics of North America.2017; 97(3): 547. CrossRef - Need for Reappraisal of Hand-Assisted Laparoscopic Surgery for Colorectal Diseases in the Era of Desiring Small Incisions
Chang-Nam Kim
Annals of Coloproctology.2017; 33(4): 119. CrossRef - Hand-Assisted Laparoscopic Surgery Versus Conventional Laparoscopic Surgery for Colorectal Cancer: A Systematic Review and Meta-Analysis
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
Journal of Laparoendoscopic & Advanced Surgical Techniques.2017; 27(12): 1251. CrossRef - Hand-Assisted Laparoscopic Right Colectomy: Is It Useful?
Hungdai Kim
Annals of Coloproctology.2014; 30(1): 1. CrossRef
- The terminal ileal vein approach: a novel and simple technique for locating the superior mesenteric vein and en bloc resection of the ileal mesentery in laparoscopic right hemicolectomy
- Short-term Outcomes of Hand-Assisted Laparoscopic Surgery vs. Open Surgery on Right Colon Cancer: A Case-Controlled Study
- Jae-Hoon Sim, Eun-Joo Jung, Chun-Geun Ryu, Jin Hee Paik, Gangmi Kim, Su Ran Kim, Dae-Yong Hwang
- Ann Coloproctol. 2013;29(2):72-76. Published online April 30, 2013
- DOI: https://doi.org/10.3393/ac.2013.29.2.72
- 10,585 View
- 46 Download
- 14 Citations
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Abstract
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Purpose This study was designed to evaluate short-term clinical outcomes by comparing hand-assisted laparoscopic surgery with open surgery for right colon cancer.
Methods Sixteen patients who underwent a hand-assisted laparoscopic right hemicolectomy (HAL-RHC group) and 33 patients who underwent a conventional open right hemicolectomy (open group) during the same period were enrolled in this study with a case-controlled design.
Results The operation time was 217 minutes in the HAL-RHC group and 213 minutes in the open group (P = 0.389). The numbers of retrieved lymph nodes were similar between the two groups (31 in the HAL-RHC group and 36 in the open group, P = 0.737). Also, there were no significant difference in the incidence of immediate postoperative leukocytosis, the administration of additional pain killers, and the postoperative recovery parameters. First flatus was shown on postoperative days 3.5 in the HAL-RHC group and 3.4 in the open group (P = 0.486). Drinking water and soft diet were started on postoperative days 4.8 and 5.9, respectively, in the HAL-RHC group and similarly 4.6 and 5.6 in the open group (P = 0.402 and P = 0.551). The duration of hospital stay was shorter in the HAL-RHC group than in the open group (10.3 days vs. 13.5 days, P = 0.048). No significant difference in the complication rates was shown between the two groups, and no postoperative mortality was encountered in either group.
Conclusion The patients with right colon cancer in the HAL-RHC group had similar pathologic and postoperative recovery parameters to those of the patients in the open group. The patients in the HAL-RHC group had shorter hospital stays than those in the open group. Therefore, hand-assisted laparoscopic right hemicolectomy for right-sided colon cancer is feasible.
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Citations
Citations to this article as recorded by- Evaluating the learning curves and surgical outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer: A retrospective analysis from a National Registry
Yunxiao Liu, Xu Guan, Qing Xu, Taiyuan Li, Yangchun Zheng, Chuangang Fu, Sergey Efetov, Xishan Wang, Guiyu Wang
Colorectal Disease.2025;[Epub] CrossRef - Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?
Gyung Mo Son, In Young Lee, Yoon Suk Lee, Bong-Hyeon Kye, Hyeon-Min Cho, Je-Ho Jang, Chang-Nam Kim, Kil Yeon Lee, Suk-Hwan Lee, Jun-Gi Kim
Annals of Coloproctology.2021; 37(6): 434. CrossRef - A meta-analysis comparing hand-assisted laparoscopic right hemicolectomy and open right hemicolectomy for right-sided colon cancer
Mohamed Ali Chaouch, Mohamed Wejih Dougaz, Meriem Mesbehi, Hichem Jerraya, Ramzi Nouira, Jim S. Khan, Chadli Dziri
World Journal of Surgical Oncology.2020;[Epub] CrossRef - Laparoscopic right-sided colon resection for colon cancer—has the control group so far been chosen correctly?
Jörg O. W. Pelz, Johanna Wagner, Sven Lichthardt, Johannes Baur, Caroline Kastner, Niels Matthes, Christoph-Thomas Germer, Armin Wiegering
World Journal of Surgical Oncology.2018;[Epub] CrossRef - Hand-assisted Laparoscopy: Expensive but Considerable Step Between Laparoscopic and Open Colectomy
Baris Gulcu, Ozgen Isik, Ersin Ozturk, Tuncay Yilmazlar
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Xubing Zhang, Qingbin Wu, Chaoyang Gu, Tao Hu, Liang Bi, Ziqiang Wang
Medicine.2017; 96(33): e7794. CrossRef - Comparison of hand-assisted laparoscopic surgery (HALS) and conventional laparotomy in patients with colorectal cancer: Final results from a single center
Takayuki Tajima, Masaya Mukai, Daiki Yokoyama, Shigeo Higami, Shuji Uda, Sayuri Hasegawa, Eiji Nomura, Sotaro Sadahiro, Seiei Yasuda, Hiroyasu Makuuchi
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Hernán Vaccarezza, Axel Sahovaler, Víctor Im, Gustavo Rossi, Carlos Vaccaro
Surgical Practice.2016; 20(3): 124. CrossRef - Laparoscopic resection of right colon cancer—a matched pairs analysis
M. Zimmermann, C. Benecke, C. Jung, M. Hoffmann, J. Nolde, E. Schlöricke, H. P. Bruch, T. Keck, T. Laubert
International Journal of Colorectal Disease.2016; 31(7): 1291. CrossRef - Comparative Study on Therapeutic Efficacy Between Hand-Assisted Laparoscopic Surgery and Conventional Laparotomy for Acute Obstructive Right-Sided Colon Cancer
Zhengrong Li, Daojiang Li, Zhigang Jie, Guoyang Zhang, Yi Liu
Journal of Laparoendoscopic & Advanced Surgical Techniques.2015; 25(7): 548. CrossRef - Comparison of hand-assisted laparoscopic surgery and conventional laparotomy for rectal cancer: Interim results from a single center
TAKAYUKI TAJIMA, MASAYA MUKAI, WATARU NOGUCHI, SHIGEO HIGAMI, SHUUJI UDA, SOUICHIROU YAMAMOTO, SAYURI HASEGAWA, EIJI NOMURA, SOTARO SADAHIRO, SEIEI YASUDA, HIROYASU MAKUUCHI
Molecular and Clinical Oncology.2015; 3(3): 533. CrossRef - Hand-assisted laparoscopic versus laparoscopy-assisted D2 radical gastrectomy: a prospective study
JiaQing Gong, YongKuan Cao, YunMing Li, GuoHu Zhang, PeiHong Wang, GuoDe Luo
Surgical Endoscopy.2014; 28(10): 2998. CrossRef - Comparison of hand-assisted laparoscopic surgery and conventional laparotomy for colorectal cancer: Interim results from a single institution
TAKAYUKI TAJIMA, MASAYA MUKAI, MASASHI YAMAZAKI, SHIGEO HIGAMI, SOUICHIROU YAMAMOTO, SAYURI HASEGAWA, EIJI NOMURA, SOTARO SADAHIRO, SEIEI YASUDA, HIROYASU MAKUUCHI
Oncology Letters.2014; 8(2): 627. CrossRef - Should Hand-Assisted Laparoscopic Surgery Be Placed in the Realm of Minimally Invasive Surgery?
Hungdai Kim
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- Evaluating the learning curves and surgical outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer: A retrospective analysis from a National Registry
Case Report
- A Case of Sigmoid Colon Tuberculosis Mimicking Colon Cancer
- Seong-Min Yu, Jong-Hwan Park, Min-Dae Kim, Hee-Ryong Lee, Peel Jung, Tae-Hyun Ryu, Seung-Ho Choi, Il-Seon Lee
- J Korean Soc Coloproctol. 2012;28(5):275-277. Published online October 31, 2012
- DOI: https://doi.org/10.3393/jksc.2012.28.5.275
- 6,403 View
- 48 Download
- 11 Citations
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Abstract
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Tuberculosis of the sigmoid colon is a rare disorder. An 80-year-old man visited Bongseng Memorial Hospital for medical examination. A colonoscopy was performed, and a lesion in the sigmoid colon that was suspected to be colon cancer was found. A biopsy was performed, and tuberculous enteritis with chronic granulomatous inflammation was diagnosed. Intestinal tuberculosis is most frequent in the ileocecal area, followed by the ascending colon, transverse colon, duodenum, stomach, and sigmoid colon, in descending order. Hence, we report a case of intestinal tuberculosis in the sigmoid colon, which is rare and almost indistinguishable from colon cancer.
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Citations
Citations to this article as recorded by- Case Report of Colonic Poorly Differentiated Adenocarcinoma Masquerading as Intestinal Tuberculosis
慧欣 植
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Original Articles
- Oncologic Outcomes of a Laparoscopic Right Hemicolectomy for Colon Cancer: Results of a 3-Year Follow-up
- Jung Hoon Cho, Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
- J Korean Soc Coloproctol. 2012;28(1):42-48. Published online February 29, 2012
- DOI: https://doi.org/10.3393/jksc.2012.28.1.42
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- 8 Citations
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Abstract
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Purpose The purpose of the study is to evaluate the oncologic outcomes of a laparoscopic-assisted right hemicolectomy for the treatment of colon cancer and compare the results with those of previous randomized trials.
Methods From June 2006, to December 2008, 156 consecutive patients who underwent a laparoscopic right hemicolectomy with a curative intent for colon cancer were evaluated. The clinicopatholgic outcomes and the oncologic outcomes were evaluated retrospectively by using electronic medical records.
Results There were 84 male patients and 72 female patients. The mean possible length of stay was 7.0 ± 1.5 days (range, 4 to 12 days). The conversion rate was 3.2%. The total number of complications was 30 (19.2%). Anastomotic leakage was not noted. There was no mortality within 30 days. The 3-year overall survival rate of all stages was 93.3%. The 3-year overall survival rates according to stages were 100% in stage I, 97.3% in stage II, and 84.8% in stage III. The 3-year disease-free survival rate of all stages was 86.1%. The 3-year disease-free survival rates according to stage were 96.2% in stage I, 90.3% in stage II, and 75.6% in stage III. The mean follow-up period was 36.3 (3 to 60) months.
Conclusion A laparoscopic right hemicolectomy for the treatment of colon cancer is technically feasible and safe to perform in terms of oncologic outcomes. The present data support previously reported randomized trials.
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Citations
Citations to this article as recorded by- Short-term outcomes and the learning curve for laparoscopic right hemicolectomy using the ArtiSential: a multicenter pooled analysis
Seijong Kim, Jaeim Lee, Heung-Kwon Oh, Dae Hee Pyo, Yoon Suk Lee, Yong Sik Yoon, Dong Hwan Bae, Byung Soh Min, Chang Hyun Kim, Jung Wook Huh
Surgical Endoscopy.2025; 39(5): 2931. CrossRef - Comparison of outcome and costs of robotic and laparoscopic right hemicolectomies
Nima Ahmadi, Isabella Mor, Ross Warner
Journal of Robotic Surgery.2022; 16(2): 429. CrossRef - Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?
Gyung Mo Son, In Young Lee, Yoon Suk Lee, Bong-Hyeon Kye, Hyeon-Min Cho, Je-Ho Jang, Chang-Nam Kim, Kil Yeon Lee, Suk-Hwan Lee, Jun-Gi Kim
Annals of Coloproctology.2021; 37(6): 434. CrossRef - Oncologic Outcomes of Self-Expandable Metallic Stent as a Bridge to Surgery and Safety and Feasibility of Minimally Invasive Surgery for Acute Malignant Colonic Obstruction
Seung Yoon Yang, Youn Young Park, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Annals of Surgical Oncology.2019; 26(9): 2787. CrossRef - Comparison of open, laparoscopic, and robotic approaches for total abdominal colectomy
Zhobin Moghadamyeghaneh, Mark H. Hanna, Joseph C. Carmichael, Alessio Pigazzi, Michael J. Stamos, Steven Mills
Surgical Endoscopy.2016; 30(7): 2792. CrossRef - Preoperative prediction of conversion from laparoscopic rectal resection to open surgery: a clinical study of conversion scoring of laparoscopic rectal resection to open surgery
Guang-Dong Zhang, Xu-Ting Zhi, Jian-Li Zhang, Guang-Bo Bu, Gang Ma, Kai-Lei Wang
International Journal of Colorectal Disease.2015; 30(9): 1209. CrossRef - Feasibility and safety of laparoscopic resection following stent insertion for obstructing left-sided colon cancer
Seoung Yoon Rho, Sung Uk Bae, Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
Journal of the Korean Surgical Society.2013; 85(6): 290. CrossRef - Totally Laparoscopic Right Hemicolectomy with Intracorporeal Anastomosis is a Technically and Oncologically Safe Procedure
V. N. N. Kornmann, J. Hagendoorn, S.van Koeverden, B.van Ramshorst, A. B. Smits
Acta Chirurgica Belgica.2013; 113(6): 439. CrossRef
- Short-term outcomes and the learning curve for laparoscopic right hemicolectomy using the ArtiSential: a multicenter pooled analysis
- Adjuvant Chemotherapy Using the FOLFOX Regimen in Colon Cancer
- Hyeong-Joon Jeon, Jin-Hee Woo, Hak-Yoon Lee, Ki-Jae Park, Hong-Jo Choi
- J Korean Soc Coloproctol. 2011;27(3):140-146. Published online June 30, 2011
- DOI: https://doi.org/10.3393/jksc.2011.27.3.140
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- 13 Citations
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Abstract
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Purpose Great progress has been made in the adjuvant treatment of colon cancer. The aim of this study was to evaluate the efficacy of postoperative adjuvant chemotherapy using the FOLFOX regimen in patients with stage III and high-risk stage II colon cancer.
Methods Eighty-two patients who underwent a potentially curative resection for stage III or high-risk stage II colon cancer were enrolled in this retrospective study. They received FOLFOX4 or modified FOLFOX6. The primary endpoint was disease-free survival.
Results During the median follow-up of 37 months (range, 21 to 61 months), 14 patients experienced disease relapse. The disease-free survival rate at 3 years was 82.9%: 84.6% for stage II and 82.6% for stage III. At the time of the analysis, 8 patients were dead from recurrence. The probability of overall survival at 5 years was 74.5%: 90% for stage II and 74.6% for stage III. Grade 3 or 4 hematologic adverse events included neutropenia (40.2%), anemia (2.4%), and thrombocytopenia (1.2%). Gastrointestinal toxicities included grade 3 or 4 nausea (4.9%) and stomatitis (2.4%). Peripheral sensory neuropathy was observed in 81.7% of the patients during treatment. Of the 11 patients (13.4%) who had grade 3 peripheral sensory neuropathy during treatment, grade 3 symptoms were persistent in 3 patients with gait disturbance at the time of analysis. No treatment-related deaths were recorded.
Conclusion Postoperative chemotherapy using the FOLFOX regimen, oxaliplatin in combination with 5-fluorouracil and leucovorin, is effective and tolerable in patients with stage III and high-risk stage II colon cancer.
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Citations
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Haiqiong Wu, Jun Li, Jidong Miao, Jiawei Li
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Bazarbashi Shouki, Alnajjar Abdelsalam, Al Sharm Abdullah, Alshammari Kanan, Al Sherhi Ahmed, Dawoud Emad, Heinemann Volker, Aseafan Mohamed, Chehal Aref, Alghamdi Mohammed, Hamza Dina, Khoury Maroun, Venniyoor Ajit, Mahrous Mervat, Rasul Kakil, Elsamany
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Apoptosis.2025; 30(11-12): 2830. CrossRef - Transcriptomic and Cytogenetic Analysis of Oxaliplatin-Resistant Colorectal Adenocarcinoma HCT116 Cells to Identify Markers Associated with Platinum Resistance
Alisa Morshneva, Olga Gnedina, Ksenia Fedotova, Natalija Yartseva, Nikolay Aksenov, Maria Igotti
International Journal of Molecular Sciences.2025; 26(18): 8869. CrossRef - Neoadjuvant chemotherapy outcome with taxane-based versus non-taxane protocols in gastric cancer
Shirin Kianersi, Sina Salari, Hamid Rezvani, Mohammad A. Araskhan, Alireza Shirangi, Mohammad R. Fathi, Mahmoud D. Ghorbi
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Lindsay A. Sceats, Seul Ku, Alanna Coughran, Britainy Barnes, Emily Grimm, Matthew Muffly, David A. Spain, Cindy Kin, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert
MDM Policy & Practice.2019;[Epub] CrossRef - Efficacy and clinical monitoring strategies for immune checkpoint inhibitors and targeted cytokine immunotherapy for locally advanced and metastatic colorectal cancer
Shelby N. Bess, Gage J. Greening, Timothy J. Muldoon
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Akie Watanabe, Chang Cheng Yang, Winson Y. Cheung
Medical Oncology.2018;[Epub] CrossRef - Risk Stratification in Patients with Stage II Colon Cancer
Ramzi Amri, Jonathan England, Liliana G. Bordeianou, David L. Berger
Annals of Surgical Oncology.2016; 23(12): 3907. CrossRef - Anti-Colorectal Cancer Chemotherapy-Induced Diarrhoea: Current Treatments and Side-Effects
Rachel M. McQuade, Joel C. Bornstein, Kulmira Nurgali
International Journal of Clinical Medicine.2014; 05(07): 393. CrossRef - Multiple Cancers in a Patient with Systemic Sclerosis and Aggravated Interstitial Lung Disease by Chemotherapy
Chan Kwon Park, Seok Jong Lee, Hyung Jun Cho, Kyeong Soo Lee, Sung Jun Kim, Gu Min Cho, Ha Ni Lee
Tuberculosis and Respiratory Diseases.2013; 75(3): 111. CrossRef
- Efficacy and safety of 3-month versus 6-month oxaliplatin-based adjuvant chemotherapy in colorectal cancer: a systematic review and meta-analysis
- Clinicopathological Correlation of hMLH1 and hMSH2 Protein Expressions in Stage III Colon Cancer.
- Cho, Young Kyu , Yu, Chang Sik , Namgung, Hwan , Kim, Hee Chul , Kim, Jung Seon , Lee, Je Hwan , Kim, Tae Won , Kim, Jin C
- J Korean Soc Coloproctol. 2004;20(4):218-224.
- 1,222 View
- 3 Download
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Abstract
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- PURPOSE
Functional loss of mismatch repair has been reported to be the reason for resistance to several chemotherapeutic drugs. The expressions of hMLH1 and hMSH2 were examined to assess whether they correlated with the biological behavior and the chemotherapeutic responsiveness in paflents with sporadic colon cancers.
METHODS
Ninety-one patients with stage III primary colon cancer were included from the tumor registry of the Asan Medical Center, Seoul, Korea. All patients underwent a curative operation and postoperative chemotherapy with 5- fluorouracil and leucovorin for 6 cycles between 1993 and 1997. Immunohistochemical staining for hMLH1 and hMSH2 was performed using archival paraffin blocks. A positive expression was determined when unequivocal nuclear staining was identified in more than 10% of the cancer cells. The survival and the clinicopathologic variables regarding hMLH1 and hMSH2 expressions were assessed using the log-rank test and the Cox proportional regression method.
RESULTS
Either hMLH1 or hMSH2 expression was lost in nine cases (9.9%). hMLH1 and hMSH2 expressions were significantly correlated with tumor invasion (P=0.012) and tumor differentiation (P=0.017). The disease-free survival did not differ with respect to hMLH1 and hMSH2 expressions. The number of metastatic lymph nodes and the preoperative serum CEA level were independent predictors of disease-free survival on a multivariate analysis.
CONCLUSIONS
The loss of hMLH1 or hMSH2 expresscon appears to be involved in the differentiation of and the invasion by colon cancer. However, nether hMLH1 nor hMSH2 expression was correlated withthe 5-fluorouracil responsiveness.
- Detection of Cytokeratin 19 and 20 in Portal Bloods in Right Colon Cancer Patients.
- Kim, Hong , Kim, Bong Wan , Kim, Hye Jin , Suh, Kwang Wook
- J Korean Soc Coloproctol. 2003;19(5):322-326.
- 1,299 View
- 5 Download
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Abstract
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- PURPOSE
We planned this prospective study to detect tumor cells in portal venous blood during a curative operation for colon cancer and to identify its clinical implications.
METHODS
From August to December 1998, we collected portal venous blood (10 ml) during curative operations on 20 patients with colon cancer. Cytokeratin (CK) 19 and 20 transcripts were amplified using a reverse transcriptase-PCR assay. As a negative control, 10 ml of portal blood from 10 patients who underwent benign surgery were assayed. The HCT-116 colon cancer cell line was used for the positive control. All patients were closely followed until May 2003 (mean follow-up: 55 months).
RESULTS
CK 19 was positive in 17 (85.0%) patients, and CK 20 was positive in 6 (30.0%) patients. However, CK 19 was also detected in 8 (66.7%) control patients, whereas CK 20 was negative in all control patients. CK 20 was found to be more relevant to the pathologic stage. During the follow-up period, liver metastases were found in 3 patients (50%) who had shown CK 20 in their portal bloods.
CONCLUSIONS
CK 20 is found to be more specific than CK 19 in the detection of epithelial cells from portal blood. Moreover, CK 20 is related to the stage and was predictive of hepatic metastases in 50% of the patients with colon cancer. With further accumulation of cases, the prognostic significance of CK 20 for hepatic metastases may be better evaluated.
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