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1 "Anorectal melanoma"
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Original Article
Treatment Outcomes of Anorectal Melanoma
Byung Min Choi, Hyoung Ran Kim, Hae-Ran Yun, Seung Ho Choi, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun
J Korean Soc Coloproctol. 2011;27(1):27-30.   Published online February 28, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.1.27
  • 3,252 View
  • 40 Download
  • 18 Citations
AbstractAbstract PDF
Purpose

An anorectal melanoma (AM) is a very rare tumor. However, sufficient data supporting effective surgical options for the disease do not exist. This retrospective review aimed to analyze treatment outcomes for an AM.

Methods

From June 1999 to December 2008, we retrospectively reviewed a prospectively collected consecutive series of 19 patients who had undergone a surgical resection for an AM at a single institute. Surgical method and clinicopathological factors were analyzed.

Results

The median age was 61.4 years (range, 46 to79 years). Main symptoms were an anal mass, hematochezia, perianal pain, tenesmus, fecal incontinence, and bowel habit change. The average duration of symptoms before diagnosis was 7.8 months (range, 1 to 36 months). S-100 and HMB-45 were positive in all patients, even in non-melanin pigmentation. There were 12 abdominoperineal resections (APRs) and 7 wide local excisions (WEs). The APR showed longer overall survival when compared with the WE (64.1 months vs. 10.9 months, P < 0.001). No patients who underwent a WE survived more than 13 months.

Conclusion

A high index of suspicion is necessary to establish the diagnosis for an AM in patients with anal symptoms, and S-100 and HMB-45 can be useful markers for an AM. Even with the small number of cases and the short follow-up, our data suggest that an APR for an AM may provide longer survival than a WE.

Citations

Citations to this article as recorded by  
  • Optimal surgical management strategy for treatment of primary anorectal malignant melanoma—a systematic review and meta-analysis
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    World Journal of Gastroenterology.2021; 27(3): 267.     CrossRef
  • Survival following surgical treatment for anorectal melanoma seems similar for local excision and extensive resection regardless of nodal involvement
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  • Response to Kahlke et al
    Audrius Dulskas
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  • Three Cases of Anorectal Malignant Melanoma Treated with Laparoscopic Abdominoperineal Resection
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    European Journal of Cancer.2020; 135: 113.     CrossRef
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    Ibrahim Atak
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  • Das anorektale maligne Melanom
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    Akihisa Matsuda, Masao Miyashita, Satoshi Matsumoto, Goro Takahashi, Takeshi Matsutani, Takeshi Yamada, Taro Kishi, Eiji Uchida
    Annals of Surgery.2015; 261(4): 670.     CrossRef
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    Medical Oncology.2015;[Epub]     CrossRef
  • Characteristics and Survival of Korean Anal Cancer From the Korea Central Cancer Registry Data
    Hyoung-Chul Park, Kyu-Won Jung, Byung-Woo Kim, Aesun Shin, Young-Joo Won, Jae Hwan Oh, Seung-Yong Jeong, Chang Sik Yu, Bong Hwa Lee
    Annals of Coloproctology.2013; 29(5): 182.     CrossRef
  • Incidence and Survival Patterns of Rare Anal Canal Neoplasms Using the Surveillance Epidemiology and End Results Registry
    Cristina Metildi, Elisabeth C. McLemore, Thuy Tran, David Chang, Bard Cosman, Sonia L. Ramamoorthy, Sidney L. Saltzstein, Georgia Robins Sadler
    The American Surgeon.2013; 79(10): 1068.     CrossRef
  • Rectal melanoma
    N. Patelis, P. Marselos, G. Sotiropoulou, S. Georgiou, A. Kominea
    Hellenic Journal of Surgery.2012; 84(3): 198.     CrossRef

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