Annals of Coloproctology

Original Articles

Minimally invasive surgery

Learning curve for single-port robot-assisted colectomy: Moon Suk Choi, Seong Hyeon Yun, Sung Chul Lee, Jung Kyong Shin, Yoon Ah Park, Jungwook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee; Ann Coloproctol. 2024;40(1):44-51. Published online December 20, 2022; DOI: https://doi.org/10.3393/ac.2022.00745.0106

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Purpose
Since the introduction of robotic surgery, robots for colorectal cancer have replaced laparoscopic surgery, and a single-port robot (SPR) platform has been launched and is being used to treat patients. We analyzed the learning curve and initial complications of using an SPR platform in colorectal cancer surgery.
Methods
We reviewed 39 patients who underwent SPR colectomy from April to October 2019. All surgeries were performed by the same surgeon using an SPR device. A learning curve was generated using the cumulative sum methodology to assess changes in total operation time, docking time, and surgeon console time. We grouped the patients into 3 groups according to the time period: the first 11 were phase 1, the next 11 were phase 2, and the last 17 were phase 3.
Results
The mean age of the patients was 61.28±13.03 years, and they had a mean body mass index of 23.79±2.86 kg/m2. Among the patients, 23 (59.0%) were male, and 16 (41.0%) were female. The average operation time was 186.59±51.30 minutes, the average surgeon console time was 95.49±35.33 minutes, and the average docking time (time from skin incision to robot docking) was 14.87±10.38 minutes. The surgeon console time differed significantly among the different phases (P<0.001). Complications occurred in 8 patients: 2 ileus, 2 postoperation hemoglobin changes, 3 urinary retentions, and 1 complicated fluid collection.
Conclusion
In our experience, the learning curve for SPR colectomy was achieved after the 18th case.

Citations

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Da Vinci single-port robotic system current application and future perspective in general surgery: A scoping review
Francesco Celotto, Niccolò Ramacciotti, Alberto Mangano, Giacomo Danieli, Federico Pinto, Paula Lopez, Alvaro Ducas, Jessica Cassiani, Luca Morelli, Gaya Spolverato, Francesco Maria Bianco
Surgical Endoscopy.2024; 38(9): 4814. CrossRef
Wristed articulated instrumentation for single‐incision plus one‐port laparoscopic surgery for obstructed sigmoid colon cancer—A video vignette
Sung Uk Bae
Colorectal Disease.2024; 26(9): 1782. CrossRef

Malignant disease,Colorectal cancer

Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues: Yongchul Lim, Da Young Gang, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Hee Cheol Kim; Ann Coloproctol. 2022;38(1):60-68. Published online January 27, 2022; DOI: https://doi.org/10.3393/ac.2020.00899.0128

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Abstract PDF Supplementary Material

Purpose
Identification of type I protein arginine methyltransferase (PRMT) substrates and their functional significance during tumorigenesis is becoming more important. The present study aimed to identify target substrates for type I PRMT using 2-dimensional (2D) gel electrophoresis (GE) and 2D Western blotting (WB).
Methods
Using immunoblot analysis, we compared the expression of type I PRMTs and endogenous levels of arginine methylation between the primary colorectal cancer (CRC) and adjacent noncancerous tissues paired from the same patient. To identify arginine-methylated proteins in HCT116 cells, we carried out 2D-GE and 2D-WB with a type I PRMT product-specific antibody (anti-dimethyl-arginine antibody, asymmetric [ASYM24]). Arginine-methylated protein spots were identified by mass spectrometry, and messenger RNA (mRNA) levels corresponding to the identified proteins were analyzed using National Center for Biotechnology Information (NCBI) microarray datasets between the primary CRC and noncancerous tissues.
Results
Type I PRMTs and methylarginine-containing proteins were highly maintained in CRC tissues compared to noncancerous tissues. We matched 142 spots using spot analysis software between a Coomassie blue (CBB)-stained 2D gel and 2D-WB, and we successfully identified 7 proteins that reacted with the ASYM24 antibody: CACYBP, GLOD4, MAPRE1, CCT7, TKT, CK8, and HSPA8. Among these proteins, the levels of 4 mRNAs including MAPRE1, CCT7, TKT, and HSPA8 in CRC tissues showed a statistically significant increase compared to noncancerous tissues from patients using the NCBI microarray datasets.
Conclusion
Our results indicate that the method shown here is useful in identifying arginine-methylated proteins, and significance of arginine modification in the proteins identified here should be further identified during CRC development.

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Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer
Xi Wang
American Journal of Cancer Research.2024; 14(3): 1402. CrossRef
Expression of GLOD4 in the Testis of the Qianbei Ma Goat and Its Effect on Leydig Cells
Jinqian Wang, Xiang Chen, Wei Sun, Wen Tang, Jiajing Chen, Yuan Zhang, Ruiyang Li, Yanfei Wang
Animals.2024; 14(17): 2611. CrossRef
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Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
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Technical Note

Malignant disease, Rectal cancer,Minimally invasive surgery

Single-port robot-assisted abdominoperineal resection: a case review of the first four experiences: Moon Suk Choi, Seong Hyeon Yun, Jung Kyong Shin, Yoon Ah Park, Jung Wook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee; Ann Coloproctol. 2022;38(1):88-92. Published online October 18, 2021; DOI: https://doi.org/10.3393/ac.2021.00395.0056

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Abstract PDF

Recently, abdominoperineal resection (APR) using a robot has been demonstrated in other studies. However, there has been no report on APR for rectal cancer using the single-port robot (SPR) platform. In response to this research gap, we described the clinical experience of APR using a SPR. From April 2019 to March 2020, APR using a SPR platform was performed in a total of 4 patients. Three patients had a transumbilical approach, and 1 patient had a transstoma site approach. The average operation time was 307 minutes, and the patient docking time to the SPR platform was 133.5 minutes. There were no complications during the operation, and no laparoscopy or open conversion. No reoperation occurred within 30 days. Mild postoperative complications occurred in 2 patients. We found that APR has safety and feasibility in surgery using an SPR platform. There was no intraoperative event and severe postoperative complications.

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Single-incision laparoscopic total extraperitoneal inguinal-hernia repair using the new articulating instruments: A video vignette
Chul Seung Lee, Gwan Chul Lee, Choon Sik Chung, Dong Keun Lee
Asian Journal of Surgery.2024; 47(8): 3586. CrossRef
Single-incision robotic colorectal surgery with the da Vinci SP® surgical system: initial results of 50 cases
H. S. Kim, B.-Y. Oh, C. Cheong, M. H. Park, S. S. Chung, R.-A. Lee, K. H. Kim, G. T. Noh
Techniques in Coloproctology.2023; 27(7): 589. CrossRef
Short-term outcomes of single-incision robotic colectomy versus conventional multiport laparoscopic colectomy for colon cancer
Ho Seung Kim, Bo-Young Oh, Soon Sup Chung, Ryung-Ah Lee, Gyoung Tae Noh
Journal of Robotic Surgery.2023; 17(5): 2351. CrossRef
Short-term outcomes of da Vinci SP versus Xi for colon cancer surgery: a propensity-score matching analysis of multicenter cohorts
Jin-Min Jung, Young Il Kim, Yong Sik Yoon, Songsoo Yang, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Journal of Robotic Surgery.2023; 17(6): 2911. CrossRef
Surgical Techniques for Transanal Local Excision for Early Rectal Cancer
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Original Articles

Special issue, Malignant disease, Rectal cancer,Colorectal cancer,Epidemiology & etiology

Has the COVID-19 Pandemic Caused Upshifting in Colorectal Cancer Stage?: Ji Ha Lim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin; Ann Coloproctol. 2021;37(4):253-258. Published online August 9, 2021; DOI: https://doi.org/10.3393/ac.2021.00269.0038

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Abstract PDF

Purpose
Coronavirus disease 2019 (COVID-19) has affected many parts of daily life and healthcare, including cancer screening and diagnosis. The purpose of this study was to determine whether there was an upshift in the colorectal cancer stage at diagnosis due to delays related to the COVID-19 outbreak.
Methods
From January to June of each year from 2017 to 2020, a total of 3,229 patients who were first diagnosed with colorectal cancer were retrospectively reviewed. Those enrolled from 2017 to 2019 were classified as the ‘pre-COVID’ group, and those enrolled in 2020 were classified as the ‘COVID’ group. The primary outcome was the rate of stage IV disease at the time of diagnosis.
Results
There was no statistically significant difference in the proportion of stage IV patients between the pre-COVID and COVID groups (P=0.19). The median preoperative carcinoembryonic antigen level in the COVID group was higher than in the pre-COVID group in all stages (all P<0.05). In stage I, II patients who underwent radical surgery, the lymphatic invasion was more presented in COVID patients (P=0.009).
Conclusion
We did not find significant stage upshifting in colorectal cancer during the COVID-19 outbreak. However, there were more initially unresectable stage IV colorectal cancer patients with a low conversion rate to resectable status, and more patients had factors related to poor prognosis. These results may become more apparent over time, so it is vital not to neglect cancer screening to not delay the diagnosis during the COVID-19 epidemic.

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Danielle Hanuschak, Mallori DePiero, Melissa DeMoraes, Shamoore Bailly, Muni Rubens, Paul Lindeman, Michael Zinner, Geoffrey Young
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Measuring the impact of the COVID‐19 pandemic on colorectal cancer presentation: a retrospective comparative study
Kirsten Fullard, Daniel Steffens, Michael Solomon, Joo‐Shik Shin, Cherry Koh
ANZ Journal of Surgery.2023; 93(12): 2951. CrossRef
Influence of the COVID-19 Pandemic on the Treatment Patterns and Outcomes of Colorectal Cancer
In Ja Park
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Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis
Nikolaos Pararas, Anastasia Pikouli, Dimitrios Papaconstantinou, Georgios Bagias, Constantinos Nastos, Andreas Pikoulis, Dionysios Dellaportas, Panagis Lykoudis, Emmanouil Pikoulis
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Short-Term Impact of Temporary Shutdown of a University-Affiliated Hospital on Patients With Colorectal Cancer During the Coronavirus Disease 2019 Pandemic
Youn Young Park, Jaeim Lee, Kil-yong Lee, Seong Taek Oh
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Surgical safety in the COVID-19 era: present and future considerations
Young Il Kim, In Ja Park
Annals of Surgical Treatment and Research.2022; 102(6): 295. CrossRef
The effect of the COVID-19 pandemic on the outcomes of surgically treated colorectal diseases: a retrospective cohort study
Gülten Çiçek Okuyan, Melih Yıldırım
Annals of Surgical Treatment and Research.2022; 103(2): 104. CrossRef
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Sami Akbulut, Abdirahman Sakulen Hargura, Ibrahim Umar Garzali, Ali Aloun, Cemil Colak
World Journal of Clinical Cases.2022; 10(26): 9228. CrossRef
Epidemiology, risk factors, and prevention of colorectal cancer
Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
Journal of the Korean Medical Association.2022; 65(9): 549. CrossRef
Epidemiology, Risk Factors, and Prevention of Colorectal Cancer-An English Version
Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 231. CrossRef
No evidence of delay in colorectal cancer diagnosis during the COVID-19 pandemic in Gwangju and Jeonnam, Korea
Hye-Yeon Kim, Min-Gyeong Kim, Mi-Ran Kang, Jeong-Ho Yang, Min-Ho Shin, Sun-Seog Kweon
Epidemiology and Health.2022; 44: e2022092. CrossRef

Malignant disease,Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer

Clinical Outcomes of Neoadjuvant Chemotherapy in Colorectal Cancer Patients With Synchronous Resectable Liver Metastasis: A Propensity Score Matching Analysis: Sung Hae Park, Jung Kyong Shin, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jin Seok Heo, Gyu Seong Choi, Seung Tae Kim, Young Suk Park, Hee Cheol Kim; Ann Coloproctol. 2021;37(4):244-252. Published online June 29, 2021; DOI: https://doi.org/10.3393/ac.2020.00710.0101

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Abstract PDF

Purpose
The survival benefit of neoadjuvant chemotherapy (NAC) prior to surgical resection in colorectal cancer with liver metastases (CRCLM) patients remains controversial. The aim of this study was to compare overall outcome of CRCLM patients who underwent NAC followed by surgical resection versus surgical treatment first.
Methods
We retrospectively analyzed 429 patients with stage IV colorectal cancer with synchronous liver metastases who underwent simultaneous liver resection between January 2008 and December 2016. Using propensity score matching, overall outcome between 60 patients who underwent NAC before surgical treatment and 60 patients who underwent surgical treatment first was compared.
Results
Before propensity score matching, metastatic cancer tended to involve a larger number of liver segments and the primary tumor size was bigger in the NAC group than in the primary resection group, so that a larger percentage of patients in the NAC group underwent major hepatectomy (P<0.001). After propensity score matching, demographic features and pathologic outcomes showed no significant differences between the 2 groups. In addition, there was no significant difference in short-term recovery outcomes such as postoperative morbidity (P=0.603) and oncologic outcome, including 3-year overall survival rate (P=0.285) and disease-free survival rate (P=0.730), between the 2 groups.
Conclusion
NAC prior to surgical treatment in CRCLM is considered a safe treatment that does not increase postoperative morbidity, and its impact on oncologic outcome was not inferior.

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Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
Hyo Seon Ryu, Hyun Jung Kim, Woong Bae Ji, Byung Chang Kim, Ji Hun Kim, Sung Kyung Moon, Sung Il Kang, Han Deok Kwak, Eun Sun Kim, Chang Hyun Kim, Tae Hyung Kim, Gyoung Tae Noh, Byung-Soo Park, Hyeung-Min Park, Jeong Mo Bae, Jung Hoon Bae, Ni Eun Seo, Cha
Annals of Coloproctology.2024; 40(2): 89. CrossRef
Survival of patients with colorectal liver metastases treated with and without preoperative chemotherapy: Nationwide propensity score-matched study
Michelle.R. de Graaff, Joost M. Klaase, Ronald M. van Dam, Koert F.D. Kuhlmann, Geert Kazemier, Rutger-Jan Swijnenburg, Arthur K.E. Elfrink, Cees Verhoef, J.Sven Mieog, Peter B. van den Boezem, Paul Gobardhan, Arjen M. Rijken, Daan J. Lips, Wouter G.K. Le
European Journal of Surgical Oncology.2023; 49(9): 106932. CrossRef
Laparoscopic right hemicolectomy with aortocaval lymphadenectomy, and pelvic peritoneum partial resection for ascending colon cancer
Hannah Kim, An Na Seo, Soo Yeun Park
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Jin-Min Jung, In Ja Park, Eun Jung Park, Gyung Mo Son
Annals of Surgical Treatment and Research.2023; 105(5): 252. CrossRef
Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies
Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak
Cancers.2023; 15(24): 5791. CrossRef
Surgical safety in the COVID-19 era: present and future considerations
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Yu-Juan Jiang, Si-Cheng Zhou, Jing-Hua Chen, Jian-Wei Liang
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Chang Hyun Kim
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Eun Jung Park, Seung Hyuk Baik
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Chan Wook Kim
The Ewha Medical Journal.2022;[Epub] CrossRef
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In Ja Park
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Current Practice in Asia-Pacific Region

Malignant disease, Rectal cancer

Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries: Jung Wook Huh, Kotaro Maeda, Zheng Liu, Xishan Wang, April Camilla Roslani, Woo Yong Lee; Ann Coloproctol. 2020;36(2):70-77. Published online January 31, 2020; DOI: https://doi.org/10.3393/ac.2020.01.19

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Abstract PDF

Purpose
Current acceptance of the watch-and-wait (W&W) approach by surgeons in Asia-Pacific countries is unknown. An international survey was performed to determine status of the W&W approach on behalf of the Asia-Pacific Federation of Coloproctology (APFCP).
Methods
Surgeons in the APFCP completed an Institutional Review Board-approved anonymous e-survey and/or printed letters (for China) containing 19 questions regarding nonsurgical close observation in patients who achieved clinical complete response (cCR) to neoadjuvant chemoradiotherapy (nCRT).
Results
Of the 417 responses, 80.8% (n = 337) supported the W&W approach and 65.5% (n = 273) treated patients who achieved cCR after nCRT. Importantly, 78% of participants (n = 326) preferred a selective W&W approach in patients with old age and medical comorbidities who achieved cCR. In regard to restaging methods after nCRT, the majority of respondents based their decision to use W&W on a combination of magnetic resonance imaging results (94.5%, n = 394) with other test results. For interval between nCRT completion and tumor response assessment, most participants used 8 weeks (n = 154, 36.9%), followed by 6 weeks (n = 127, 30.5%) and 4 weeks (n = 102, 24.5%). In response to the question of how often responders followed-up after W&W, the predominant period was every 3 months (209 participants, 50.1%) followed by every 2 months (75 participants, 18.0%). If local regrowth was found during follow-up, most participants (79.9%, n = 333) recommended radical surgery as an initial management.
Conclusion
The W&W approach is supported by 80% of Asia-Pacific surgeons and is practiced at 65%, although heterogeneous hospital or society protocols are also observed. These results inform oncologists of future clinical study participation.

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Helen Mohan, Mohammed Rabie, Ciaran Walsh, Deena Harji, Paul Sutton, Ian Geh, Ian Jackson, Emma Helbren, Martyn Evans, John T. Jenkins
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Gyung Mo Son
Annals of Coloproctology.2023; 39(3): 191. CrossRef
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In Ja Park
The Ewha Medical Journal.2022; 45(1): 3. CrossRef
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Correlation between T stage and lymph node metastasis in rectal cancer treated with preoperative chemoradiotherapy
Seijong Kim, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoonah Park, Jung Kyong Shin
Therapeutic Advances in Medical Oncology.2022;[Epub] CrossRef
Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version
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Journal of the Anus, Rectum and Colon.2022; 6(4): 213. CrossRef
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Chan Wook Kim
The Ewha Medical Journal.2022;[Epub] CrossRef
The watch-and-wait strategy versus radical resection for rectal cancer patients with a good response (≤ycT2) after neoadjuvant chemoradiotherapy
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Annals of Surgical Treatment and Research.2022; 103(6): 350. CrossRef
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Paola Germani, Francesca Di Candido, Daniel Léonard, Dajana Cuicchi, Ugo Elmore, Marco Ettore Allaix, Vittoria Pia Barbieri, Laura D’Allens, Seraina Faes, Marika Milani, Damiano Caputo, Carmen Martinez, Jan Grosek, Valerio Caracino, Niki Christou, Sapho X
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Non-operative Management (NOM) of Rectal Cancer: Literature Review and Translation of Evidence into Practice
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Current Colorectal Cancer Reports.2021; 17(2): 23. CrossRef
Comparison between Local Excision and Radical Resection for the Treatment of Rectal Cancer in ypT0-1 Patients: An Analysis of the Clinicopathological Factors and Survival Rates
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Original Article

Malignant disease, Prognosis and adjuvant therapy

Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery: Chang Kyu Oh, Jung Wook Huh, You Jin Lee, Moon Suk Choi, Dae Hee Pyo, Sung Chul Lee, Seong Mun Park, Jung Kyong Shin, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee; Ann Coloproctol. 2020;36(4):273-280. Published online November 13, 2019; DOI: https://doi.org/10.3393/ac.2019.10.15

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Abstract PDF

Purpose
The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.
Methods
From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I–III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared.
Results
Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).
Conclusion
Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.

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Case Report

Successful Conservative Management of Hepatic Portal Venous Gas due to Anastomosis Leakage After a Sigmoidectomy: Injae Hong, Seong Woo Hong, Yeo Gu Chang, Byungmo Lee, Woo Yong Lee, Haeng Jin Ohe, Young Ki Kim; Ann Coloproctol. 2019;35(5):282-284. Published online January 25, 2019; DOI: https://doi.org/10.3393/ac.2018.03.23.1

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Abstract PDF

In past decades, hepatic portal venous gas (HPVG) has rarely been reported, and the mortality rate has been very high. In most cases, surgical intervention was needed. Presently, abdominal computed tomography can be conveniently used to diagnose HPVG, which has various underlying causes and benign courses. We present the case of a patient with HPVG due to anastomosis leakage after a sigmoidectomy for diverticulitis; the patient was cured with conservative management.

Citations

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Clinical features and management of 20 patients with hepatic portal venous gas
Yuan Zhang, Hai-Long Liu, Min Tang, Hui Wang, Hui-Hong Jiang, Mou-Bin Lin
Experimental and Therapeutic Medicine.2022;[Epub] CrossRef
Conservative treatment of hepatic portal venous gas resulting from non-occlusive mesenteric ischemia: a case report
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Reply on “Successful Conservative Management of Hepatic Portal Venous Gas due to Anastomosis Leakage After a Sigmoidectomy”
Seongwoo Hong
Annals of Coloproctology.2020; 36(4): 212. CrossRef
Hepatic Portal Venous Gas and Anastomotic Leakage
Filippo Carannante, Gabriella Teresa Capolupo, Gianluca Mascianà, Marco Caricato
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Original Articles

Transanal Endoscopic and Transabdominal Robotic Total Mesorectal Excision for Mid-to-Low Rectal Cancer: Comparison of Short-term Postoperative and Oncologic Outcomes by Using a Case-Matched Analysis: Ki Young Lee, Jung Kyoung Shin, Yoon Ah Park, Seong Hyeon Yun, Jung Wook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee; Ann Coloproctol. 2018;34(1):29-35. Published online February 28, 2018; DOI: https://doi.org/10.3393/ac.2018.34.1.29

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Abstract PDF

Purpose

This study aimed to compare short-term postoperative and oncologic outcomes of a transanal endoscopic total mesorectal excision (TME) to those of a transabdominal robotic TME.

Methods

A total of 62 patients with rectal cancer underwent transanal (n = 26) or robotic (n = 36) TME between June 2013 and December 2014. After case-matching by tumor location and TNM stage, 45 patients were included for analysis. The median follow-up period was 21.3 months. Operative, histopathologic and postoperative outcomes and recurrences were analyzed.

Results

Patients younger than 60 years of age were more frequently observed in the robotic TME group (75.0% vs. 47.6%, P = 0.059), but tumor location, cT and cN category, and preoperative chemoradiotherapy were not different between the 2 groups. Estimated blood loss was greater in the transanal group (283 mL vs. 155 mL, P = 0.061); however, the operation time and the rate of a diverting ileostomy and subsequent ileostomy repair were not different between the groups. The proximal resection margin was longer in the transanal TME group (20.8 cm ± 16.0 cm, P = 0.030), but the distal resection margins, involvements of the circumferential resection margin, TME quality, numbers of retrieved lymph nodes, postoperative complications, including anastomotic leak and voiding difficulty, and recurrence rates for the 2 groups were not statistically different.

Conclusion

Transanal endoscopic and transabdominal robotic TME showed similar histopathologic and postoperative outcomes with the exception of the estimated blood loss and the proximal resection margin for a select group of patients.

Citations

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Peri-operative, oncological and functional outcomes of robotic versus transanal total mesorectal excision in patients with rectal cancer: A systematic review and meta-analysis
A. Y. Y. Mohamedahmed, S. Zaman, A. A. Wuheb, A. Ismail, M. Nnaji, A. A. Alyamani, H. A. Eltyeb, N. A. Yassin
Techniques in Coloproctology.2024;[Epub] CrossRef
Systematic review and meta-analysis comparing robotic total mesorectal excision versus transanal total mesorectal excision for rectal cancer
Mohamed Ali Chaouch, Mohammad Iqbal Hussain, Maissa Jellali, Amine Gouader, Alessandro Mazzotta, Adriano Carneiro da Costa, Bassem Krimi, Jim Khan, Hani Oweira
Scandinavian Journal of Surgery.2024;[Epub] CrossRef
A systematic review and meta-analysis of minimally invasive total mesorectal excision versus transanal total mesorectal excision for mid and low rectal cancer
Du Yong Gang, Lin Dong, Zhang DeChun, Zhang Yichi, Lu Ya
Frontiers in Oncology.2023;[Epub] CrossRef
Robotic-assisted laparoscopic low anterior resection versus trans-anal total mesorectal excision for malignant rectal lesion: a prospective cohort trial
Ahmed F.A. Farag, Ahmed M.A. Mahmoud, Haitham M. Azmy, Abdrabbou N. Mashhour, Ahmed S. Khalifa, Yasser Debakey, Mohamed Y. Elbarmelgi
The Egyptian Journal of Surgery.2023; 42(4): 859. CrossRef
Robotic or transanal total mesorectal excision (TaTME) approach for rectal cancer, how about both? Feasibility and outcomes from a single institution
Yusuke Inoue, Jing Yu Ng, Chun-Ho Chu, Yi-Ling Lai, I.-Ping Huang, Shung-Haur Yang, Chien-Chih Chen
Journal of Robotic Surgery.2022; 16(1): 149. CrossRef
Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis
Jae Young Moon, Min Ro Lee, Gi Won Ha
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Multidisciplinary treatment strategy for early rectal cancer
Gyung Mo Son, In Young Lee, Sung Hwan Cho, Byung-Soo Park, Hyun Sung Kim, Su Bum Park, Hyung Wook Kim, Sang Bo Oh, Tae Un Kim, Dong Hoon Shin
Precision and Future Medicine.2022; 6(1): 32. CrossRef
Comparison of transanal total mesorectal excision and robotic total mesorectal excision for low rectal cancer after neoadjuvant chemoradiotherapy
Jung Kyong Shin, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Yong Beom Cho, Jung Wook Huh, Woo Yong Lee
Surgical Endoscopy.2021; 35(12): 6998. CrossRef
Statistical, Clinical, Methodological Evaluation of Local Recurrence Following Transanal Total Mesorectal Excision for Rectal Cancer: A Systematic Review
Hans H. Wasmuth, Mahir Gachabayov, Les Bokey, Abe Fingerhut, Guy R. Orangio, Feza H. Remzi, Roberto Bergamaschi
Diseases of the Colon & Rectum.2021; 64(7): 899. CrossRef
A nationwide comparison of short‐term outcomes after transanal, open, laparoscopic, and robot‐assisted total mesorectal excision
Ilze Ose, Sharaf Karim Perdawood
Colorectal Disease.2021; 23(10): 2671. CrossRef
Robotic total mesorectal excision or transanal total mesorectal excision meta‐analysis
Michelle Zhiyun Chen, Yeng Kwang Tay, Satish K. Warrier, Alexander G. Heriot, Joseph C. Kong
ANZ Journal of Surgery.2021; 91(11): 2269. CrossRef
A systematic review and meta-analysis of robotic-assisted transabdominal total mesorectal excision and transanal total mesorectal excision: which approach offers optimal short-term outcomes for mid-to-low rectal adenocarcinoma?
J. W. Butterworth, W. A. Butterworth, J. Meyer, C. Giacobino, N. Buchs, F. Ris, R. Scarpinata
Techniques in Coloproctology.2021; 25(11): 1183. CrossRef
Outcomes of robotic low anterior resection versus transanal total mesorectal excision for rectal cancer
J L B Buan, W Z So, X C Lim, C S Chong
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Initial Experience of Robotic Total Mesorectal Excision for Rectal Cancer
Jung Kyong Shin, Jung Wook Huh
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Robotic Total Mesorectal Excision for Rectal Cancer: Current Evidences and Future Perspectives
Je-Ho Jang, Chang-Nam Kim
Annals of Coloproctology.2020; 36(5): 293. CrossRef
Systemic review and network meta‐analysis comparing minimal surgical techniques for rectal cancer: quality of total mesorectum excision, pathological, surgical, and oncological outcomes
Emanuele Rausa, Federica Bianco, Michael E. Kelly, Alberto Aiolfi, Fausto Petrelli, Gianluca Bonitta, Giovanni Sgroi
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Does transanal total mesorectal excision of rectal cancer improve histopathology metrics and/or complication rates? A meta-analysis
Mahir Gachabayov, Inna Tulina, Roberto Bergamaschi, Petr Tsarkov
Surgical Oncology.2019; 30: 47. CrossRef
Transanal Total Mesorectal Excision for Rectal Cancer: Perioperative and Oncological Outcomes
Hyuk Hur
Annals of Coloproctology.2018; 34(1): 1. CrossRef
Evolution of surgery for rectal cancer: Transanal total mesorectal excision~new standard or fad?~
Hirotoshi Hasegawa, Koji Okabayashi, Masashi Tsuruta, Takashi Ishida, Fumitaka Asahara, Mark G Coleman
Journal of the Anus, Rectum and Colon.2018; 2(4): 115. CrossRef

Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor: Sang-Oh Yun, Yong Beom Cho, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Jung Wook Huh; Ann Coloproctol. 2017;33(6):232-238. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.232

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Abstract PDF

Purpose

The aim of this study is to evaluate the prognosis for patients with a signet-ring-cell carcinoma (SRCC) who undergo curative surgery by comparing them to patients with an adenocarcinoma (ADC), excluding a mucinous ADC.

Methods

Between September 1994 and December 2013, 14,110 patients with colorectal cancer underwent surgery and among them, 12,631 patients were enrolled in this study. 71 patients with a SRCC and 12,570 patients with a ADC were identified. We analyzed the disease-free survival and the overall survival rates before and after a 1:2 propensity score matching and evaluated those rates after stage stratification.

Results

The median follow-up durations were 48.5 months for the SRC group and 48.6 months for the ADC group. The disease-free survival rates and the overall survival rates were significantly lower in the SRC group before and after propensity score matching (P < 0.001). After stratification by stage, no differences were observed between the SRC and the ADC groups for the disease-free survival (DFS) and the overall survival (OS) rates for patients with cancer in its early stages (P = 0.913 and P = 0.380 for the DFS and the OS, respectively, in stages 0 and I, and P = 0.223 and P = 0.991 for the DFS and the OS, respectively, in stage II), but those rates were significantly lower in the SRC group for cancer in its later stages (P < 0.001, respectively in stages III and IV).

Conclusion

For cancer in advanced stages, patients with a resectable colorectal SRCC had a poorer prognosis after propensity score matching than those with an ADC did. Therefore, more intensive surveillance and closer observation should be offered to such patients.

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Nan Yao, Wenqiang Li, Jiwei Wang, Hongyuan Chu, Ning Duan, Xinyu Niu, Guoyong Yu, Jun Qu
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Frederiek Nuytens, Vincent Drubay, Clarisse Eveno, Florence Renaud, Guillaume Piessen
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Yasmeen Z. Qwaider, Naomi M. Sell, Caitlin E. Stafford, Chloe Boudreau, Hiroko Kunitake, Robert N. Goldstone, Rocco Ricciardi, Liliana G. Bordeianou, Christy E. Cauley, David L. Berger
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Ashini H. Shah, Amisha J. Gami, Neetal H. Desai, Jahnavi S. Gandhi, Priti P. Trivedi
Indian Journal of Surgical Oncology.2022; 13(3): 459. CrossRef
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Artem Artemev, Sheetal Naik, Anastasia Pougno, Prasanna Honnavar, Nandan M Shanbhag
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Wuguang Zhang, Wenqian Gong, Changhai Wu, Mengting Li, Xiaolong Tu, Stephen Fink
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Does signet ring cell carcinoma component signify worse outcomes for patients with colorectal cancer?
Liming Wang, Yasumitsu Hirano, Gregory Heng, Toshimasa Ishii, Hiroka Kondo, Kiyoka Hara, Nao Obara, Masahiro Asari, Takuya Kato, Shigeki Yamaguchi
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Benjamin D. Powers, Seth I. Felder, Iman Imanirad, Sophie Dessureault, Sean P. Dineen
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Michael J. Steel, Hussam Bukhari, Laura Gentile, Jennifer Telford, David F. Schaeffer
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Matteo Mueller, Marcel André Schneider, Barla Deplazes, Daniela Cabalzar-Wondberg, Andreas Rickenbacher, Matthias Turina
World Journal of Gastrointestinal Surgery.2021; 13(2): 164. CrossRef
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Michael G. Fadel, George Malietzis, Vasilis Constantinides, Gianluca Pellino, Paris Tekkis, Christos Kontovounisios
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MRI features of signet ring rectal cancer
Meena Suthar, Akshay D. Baheti, Suman K. Ankathi, Amit Choudhari, Purvi D. Haria, Reena Engineer, Vikas Ostwal, Mukta S. Ramadwar, Ashwin Desouza, Avanish Saklani
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Jiwei Wang, Song Li, Yanna Liu, Chunquan Zhang, Honglang Li, Bin Lai
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Prognostic factors influencing survival in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for isolated colorectal peritoneal metastases: a systematic review and meta‐analysis
V. Narasimhan, S. Tan, J. Kong, T. Pham, M. Michael, R. Ramsay, S. Warrier, A. Heriot
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Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
Seon-Jin Yoon, Jungmin Park, Youngmin Shin, Yuna Choi, Sahng Wook Park, Seok-Gu Kang, Hye Young Son, Yong-Min Huh
BMC Cancer.2020;[Epub] CrossRef
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Rebekah M. Engel, Karen Oliva, Christine Koulis, Raymond Yap, Paul J. McMurrick
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Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma
Jingci Chen, Liangrui Zhou, Jie Gao, Tao Lu, Jing Wang, Huanwen Wu, Zhiyong Liang
Frontiers in Oncology.2020;[Epub] CrossRef
Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer
Xue Chao, Zixian Wang, Shixun Lu, Yuhua Huang, Shengbing Zang, Peirong Ding, Huizhong Zhang, Jingping Yun
International Journal of Clinical Oncology.2020; 25(9): 1653. CrossRef
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Sun Jin Park, Kil Yeon Lee, Suk-Hwan Lee
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Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
S. Raghavan, Deepak Kumar Singh, J. Rohila, A. DeSouza, R. Engineer, A. Ramaswamy, V. Ostwal, A. Saklani
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Aggressive Colorectal Cancer in the Young
Blake Read, Patricia Sylla
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Xiaoli Wu, Han Lin, Shaotang Li
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Expression of the Cancer Stem Cell Markers CD44 and CD133 in Colorectal Cancer: An Immunohistochemical Staining Analysis: Injae Hong, Seong Woo Hong, Yeo Goo Chang, Woo Yong Lee, Byungmo Lee, Yun Kyung Kang, You Sun Kim, In Wook Paik, Hyucksang Lee; Ann Coloproctol. 2015;31(3):84-91. Published online June 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.3.84

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Abstract PDF

Purpose

The aim of this study was to assess the expressions of CD44 and CD133 in colorectal cancer tissue by using immunohistochemical staining and to analyze the clinical significance of the expressions related to other clinicopathological data and survival results.

Methods

One hundred sixty-two patients with a biopsy-proven colorectal adenocarcinoma who were operated on between January 1998 and August 2004 were enrolled in this study. Immunohistochemical staining for CD44 and CD133 was performed on primary colorectal cancer tissue, metastatic lymph nodes, and synchronous and metachronous metastatic tumor tissues if available.

Results

CD44 expression was stronger in the primary tumor than in metastatic lymph nodes (P < 0.001), and CD133 expression tended to be stronger in primary tumor than in metastatic lymph nodes (P = 0.057). No significant correlation was found between the CD44 and the CD133 expressions. The cases with recurrence showed low expression of CD44 (P = 0.017). CD133 expression was lower in cases with elevated CA 19-9 serum levels (P = 0.028) and advanced T stage (P = 0.038). Multivariate analysis proved that low expression of CD44 was an independent prognosis factor for short disease-free survival (P = 0.028).

Conclusion

Low CD44 expression was correlated with increased tumor recurrence and short disease-free survival, and low CD133 expression was associated with advanced tumor stage. We suggest that further studies be performed to evaluate whether the immunohistochemical method for determining the CD44 and the CD133 expressions is appropriate for exploring cancer stem-cell biology in patients with colorectal cancer.

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Rania ES. Wasfy, Dina M. El-Guindy
Egyptian Journal of Pathology.2017; 37(1): 204. CrossRef
Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: Clinicopathological significance
Ji Eun Choi, Jun Sang Bae, Myoung Jae Kang, Myoung Ja Chung, Kyu Yun Jang, Ho Sung Park, Woo Sung Moon
Oncology Reports.2017; 38(3): 1695. CrossRef
Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells
Natasha Hodgkinson, Cherie A Kruger, Heidi Abrahamse
Tumor Biology.2017; 39(10): 101042831773469. CrossRef
Prognostic value of pretreatment serum carbohydrate antigen 19-9 level in patients with colorectal cancer: A meta-analysis
Zhan Yu, Zhen Chen, Jian Wu, Zhong Li, Yugang Wu, Surinder K. Batra
PLOS ONE.2017; 12(11): e0188139. CrossRef
Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence
Guanglin Cui, Gang Xu, Li Zhu, Zhigang Pang, Wei Zheng, Zhenfeng Li, Aping Yuan
Oncotarget.2017; 8(28): 45311. CrossRef
A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues
Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
Annals of Diagnostic Pathology.2016; 25: 60. CrossRef
Implications of OCT4 in breast carcinoma from initiation to lymph node metastasis
Hoda H. Abou Gabal, Riham M. Abu-Zeid, Maissa N. El-Maraghy
Egyptian Journal of Pathology.2016; 36(2): 194. CrossRef
CD133 expression may be useful as a prognostic indicator in colorectal cancer, a tool for optimizing therapy and supportive evidence for the cancer stem cell hypothesis: a meta-analysis
Yang Zhao, Jing Peng, Enlong Zhang, Ning Jiang, Jiang Li, Qi Zhang, Xuening Zhang, Yuanjie Niu
Oncotarget.2016; 7(9): 10023. CrossRef
Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses
Pu Xia, Xiao-Yan Xu
Oncotarget.2016; 7(29): 45538. CrossRef
Clinical Implication of Colorectal Cancer Stem Cells: Still Has a Long Way to Go
Hungdai Kim
Annals of Coloproctology.2015; 31(3): 79. CrossRef
Advances and perspectives of colorectal cancer stem cell vaccine
Mei Guo, Jun Dou
Biomedicine & Pharmacotherapy.2015; 76: 107. CrossRef

Investigation of Clinical Manifestations in Korean Colorectal Cancer Patients: Hye Young Koo, Kyu Joo Park, Jae Hwan Oh, Sung Bum Kang, Seong Taek Oh, Woo Yong Lee; Ann Coloproctol. 2013;29(4):139-143. Published online August 29, 2013; DOI: https://doi.org/10.3393/ac.2013.29.4.139

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5 Citations

Abstract PDF

Purpose

Early diagnostic work-up in patients with clinical symptoms of colorectal cancer (CRC) is important to achieve good treatment results. In this study, we investigated clinical symptoms when a diagnosis of CRC was made in patients who had a surgical resection, especially focusing on the relevance of constipation to CRC.

Methods

The clinical symptoms of 17,415 CRC patients who had curative surgery from January 2010 to December 2012 were collected from 24 training hospitals of surgery.

Results

The number of symptomatic patients before the diagnosis of CRC was 11,085 (63.7%). Hematochezia or melena, abdominal pain, anemia, and constipation were more often found in female than male patients while bowel habit change was more common in male patients. Considering age, bowel habit change and hematochezia or melena were more common in patients younger than 60. Anemia and constipation, however, were more common in patients older than 60. According to the group classification based on age, patients older than 60 had experienced more constipation (P = 0.049). Moreover, patients with constipation tended to have a more advanced disease status (P < 0.001).

Conclusion

In patients who had surgery due to CRC, bleeding, abdominal pain, bowel habit change and constipation were the most frequent symptoms before diagnosis. Although whether or not constipation is a cause of CRC is unclear, it is one of the important clinical symptoms that presents in patients with CRC, and patients with a symptom of constipation tend to present with a more advanced CRC stage.

Citations

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The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
Biljana Gigic, Johanna Nattenmüller, Martin Schneider, Yakup Kulu, Karen L. Syrjala, Jürgen Böhm, Petra Schrotz-King, Hermann Brenner, Graham A. Colditz, Jane C. Figueiredo, William M. Grady, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. T
Nutrients.2020; 12(5): 1247. CrossRef
Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study
Biljana Gigic, Heiner Boeing, Reka Toth, Jürgen Böhm, Nina Habermann, Dominique Scherer, Petra Schrotz-King, Clare Abbenhardt-Martin, Stephanie Skender, Hermann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Karen Syrjala, Paul B. Jacobsen, Martin Schn
Nutrition and Cancer.2018; 70(1): 51. CrossRef
Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease
Ahmed Bayoumi, Amer Sayed, Zuzana Broskova, Jian-Peng Teoh, James Wilson, Huabo Su, Yao-Liang Tang, Il-man Kim
International Journal of Molecular Sciences.2016; 17(3): 356. CrossRef
Constipation Risk in Patients Undergoing Abdominal Surgery
Sevim Celik, Nurdan Yalcin Atar, Nilgun Ozturk, Guler Mendes, Figen Kuytak, Esra Bakar, Duygu Dalgiran, Sumeyra Ergin
Iranian Red Crescent Medical Journal.2015;[Epub] CrossRef
Commentary on "Data on the Characteristics and the Survival of Korean Patients With Colorectal Cancer From the Korea Central Cancer Registry"
Mohammad Mohammadianpanah
Annals of Coloproctology.2014; 30(3): 151. CrossRef

Oncologic Outcomes of Stage IIIA Colon Cancer for Different Chemotherapeutic Regimens: Yoo Sung Lee, Hee Cheol Kim, Kyung Ook Jung, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun; J Korean Soc Coloproctol. 2012;28(5):259-264. Published online October 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.5.259

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2 Citations

Abstract PDF

Purpose

Adjuvant chemotherapy is currently recommended for Stage IIIA colon cancers. This study aimed to elucidate the oncologic outcomes of Stage IIIA colon cancer according to the chemotherapeutic regimen based on a retrospective review.

Methods

From 1995 to 2008, Stage IIIA colon cancer patients were identified from a prospectively maintained database at a single institution. Exclusion criteria were as follows: rectal cancer, another malignancy other than colon cancer, no adjuvant chemotherapy and unknown chemotherapeutic regimen. One hundred thirty-one patients were enrolled in the study, and the clinicopathologic and the oncologic characteristics were analyzed. The number of males was 72, and the number of females was 59; the mean age was 59.5 years (range, 25 to 76 years), and the median follow-up period was 33 months (range, 2 to 127 months).

Results

Of the 131 patients, fluorouracil/leucovorin (FL)/capecitabine chemotherapy was performed in 109 patients, and FOLFOX chemotherapy was performed in 22 patients. When the patients who received FL/capecitabine chemotherapy and the patients who received FOLFOX chemotherapy were compared, there was no significant difference in the clinicopathologic factors between the two groups. The 5-year overall survival and the 5-year disease-free survival were 97.2% and 94.5% in the FL/capecitabine patient group and 95.5% and 90.9% in the FOLFOX patient group, respectively, and no statistically significant differences were noted between the two groups.

Conclusion

Stage IIIA colon cancer showed good oncologic outcomes, and the chemotherapeutic regimen did not seem to affect the oncologic outcome.

Citations

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A New Method for Constructing Macrophage-Associated Predictors of Treatment Efficacy Based on Single-Cell Sequencing Analysis
Jianxiu Lin, Yang Ran, Tengfei Wu, Zishan Wang, Jinjin Zhao, Yun Tian
Journal of Immunotherapy.2024; 47(2): 33. CrossRef
Distinctive oncological features of stage IIIA colorectal cancer: Analysis of prognostic factors for selective adjuvant chemotherapy
Soo Yeun Park, Gyu‐Seog Choi, Jun Seok Park, Hye Jin Kim, Yoshiharu Sakai, Suguru Hasegawa, Toshiaki Watanabe, Seon Hahn Kim
Journal of Surgical Oncology.2015; 111(7): 882. CrossRef

Transanal Endoscopic Microsurgery for the Treatment of Well-Differentiated Rectal Neuroendocrine Tumors: Hyoung Ran Kim, Woo Yong Lee, Kyung Uk Jung, Hyuk Jun Chung, Chul Joong Kim, Hae-Ran Yun, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Ho-Kyung Chun; J Korean Soc Coloproctol. 2012;28(4):201-204. Published online August 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.4.201

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8 Citations

Abstract PDF

Purpose

Recently, an increase in well-differentiated rectal neuroendocrine tumors (WRNETs) has been noted. We aimed to evaluate transanal endoscopic microsurgery (TEM) for the treatment of WRNETs.

Methods

Between December 1995 and August 2009, 109 patients with WRNETs underwent TEM. TEM was performed for patients with tumors sizes of up to 20 mm and without a lymphadenopathy. These patients had been referred from other clinics after having been diagnosed with WRNETs by using a colonoscopic biopsy; they had undergone a failed endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) and exhibited an involved resection margin and remaining tumor after ESD or EMR, regardless of the distance from the anal verge. This study included 38 patients that had more than three years of follow-up.

Results

The mean age of the patients was 51.3 ± 11.9 years, the mean tumor size was 8.0 ± 3.9 mm, and no morbidity occurred. Thirty-five patients were asymptomatic. TEM was performed after a colonoscopic resection in 13 cases because of a positive resection margin, a residual tumor or a non-lifting lesion. Complete resections were performed in 37 patients; one patient with a positive margin was considered surgically complete. In one patient, liver metastasis and a recurrent mesorectal node occurred after five and 10 years, respectively.

Conclusion

TEM might provide an accessible and effective treatment either as an initial or as an adjunct after a colonoscopic resection for a WRNET.

Citations

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Oncological outcomes according to the treatment modality based on the size of rectal neuroendocrine tumors: a single-center retrospective study
Jimin Son, In Ja Park, Dong-Hoon Yang, Jisup Kim, Kyoung-Jo Kim, Jeong-Sik Byeon, Seung Mo Hong, Young Il Kim, Jong Beom Kim, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Surgical Endoscopy.2022; 36(4): 2445. CrossRef
Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors
Wei-Kun Shi, Rui Hou, Yun-Hao Li, Xiao-Yuan Qiu, Yu-Xin Liu, Bin Wu, Yi Xiao, Jiao-Lin Zhou, Guo-Le Lin
BMC Surgery.2022;[Epub] CrossRef
Non-conventional applications for transanal endoscopic microsurgery. A single center experience and a systematic review of literature
Rosita DE VINCENTI, Fabio CIANCHI, Francesco CORATTI
Minerva Surgery.2022;[Epub] CrossRef
Transanalis műtéti útmutató – második kiadás
Kálmán Almási, Szabolcs Ábrahám, József Baracs, Attila Bursics, Zoltán Jánó, Tamás Sztipits, Áron Szűts, Dezső Tóth, Attila Zaránd, Balázs Bánky
Orvosi Hetilap.2022; 163(Supplement): 3. CrossRef
Endoscopic submucosal dissection versus transanal local excision for rectal carcinoid: a comparative study
Fei-hu Yan, Zheng Lou, Shi-jie Hu, Xiao-dong Xu, Hao Wang, Han-tao Wang, Rong-gui Meng, Chuan-gang Fu, Wei Zhang, Jian He, En-da Yu
World Journal of Surgical Oncology.2016;[Epub] CrossRef
Efficacy and Safety of Endoscopic Resection Therapies for Rectal Carcinoid Tumors: A Meta-Analysis
Lei He, Tao Deng, Hesheng Luo
Yonsei Medical Journal.2015; 56(1): 72. CrossRef
Full-thickness excision using transanal endoscopic microsurgery for treatment of rectal neuroendocrine tumors
Wei-Jie Chen
World Journal of Gastroenterology.2015; 21(30): 9142. CrossRef
Current Issues Involving the Treatment of Small Rectal Carcinoid Tumors
Dae Kyung Sohn
Journal of the Korean Society of Coloproctology.2012; 28(4): 176. CrossRef

Matrix Metalloproteinase-2 and -7 Expression in Colorectal Cancer: Seong Woo Hong, Yun Kyung Kang, Byungmo Lee, Woo Yong Lee, Yeo Gu Jang, In Wook Paik, Hyucksang Lee; J Korean Soc Coloproctol. 2011;27(3):133-139. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.133

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19 Citations

Abstract PDF

Purpose

Matrix metalloproteinase-2 (MMP-2) and MMP-7 have been implicated in tumor growth and metastasis. This study aimed to investigate the expressions of MMP-2 and -7 in colorectal cancer and to evaluate their values as prognostic markers.

Methods

Immunohistochemical staining for MMP-2 and -7 was done in 144 resected colorectal cancer specimens. Clinicopathological data and survival results were compared with regard to the expression results.

Results

The expression rates of MMP-2 in tumor cells in the tumor center and the tumor border were 16.7% and 38.9%, respectively. That of MMP-2 in stromal cells was 27.8%. MMP-7 immunoreactivities of tumor cells in the tumor center and the tumor border were 6.9% and 23.6%. The expressions of MMP-2 and MMP-7 were correlated. MMP-2 expression in stromal cells was more increased in the distal part of the colorectum: 8.8% in right colon cancer, 29.5% in left colon cancer and 36.4% in rectal cancer. MMP-2 expression of tumor cells in the tumor border was correlated with T-stage. MMP-7 expression of tumor cells in the tumor border was increased in case of infiltrative cancer compared with fungating tumor. The expression patterns of MMP-2 and -7 were not correlated with other clinicopathological factors, including tumor markers, node metastasis, distant metastasis, lymphatic invasion, tumor differentiation, and recurrence. No significant associations between the overall and disease-free survival rates and the MMP-2 and -7 expression patterns were noted.

Conclusion

The high expression rates of MMP-2 and -7 in tumor borders suggest that MMP-2 and -7 have some role in tumor invasion, but in this study, MMP-2 and -7 did not appear to be significant predictors of prognosis in colorectal cancer.

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Lay Cheng Lim, Yang Mooi Lim
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