Annals of Coloproctology

Display

Sort by :

Original Articles

Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer: Han Jo Kim, Moo-Jun Baek, Dong Hyun Kang, Sang-Cheol Lee, Sang Byung Bae, Kyu Taek Lee, Namsu Lee, Hyungjoo Kim, Dongjun Jeong, Tae Sung Ahn, Moon Soo Lee, Dae Sik Hong, Jong-Ho Won; Ann Coloproctol. 2018;34(2):88-93. Published online April 30, 2018; DOI: https://doi.org/10.3393/ac.2017.10.10

7,322 View
118 Download
5 Web of Science
4 Citations

Purpose
Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods
A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results
Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion
Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.

Citations

Citations to this article as recorded by

Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression
Ricella Souza da Silva, Eduardo M. Queiroga, Cynthia de Toledo Osório, Karin S. Cunha, Fabiana P. Neves, Julieth P. Andrade, Eliane P. Dias
Pathobiology.2024; 91(2): 99. CrossRef
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
Giuseppe Floresta, Vincenzo Abbate
Medicinal Research Reviews.2022; 42(4): 1588. CrossRef
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
World Journal of Gastroenterology.2022; 28(26): 3177. CrossRef
The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
Seyed Mostafa Parizadeh, Reza Jafarzadeh‐Esfehani, Danial Fazilat‐Panah, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Majid Khazaei, Seyed Mohammad Reza Parizadeh, Majid Ghayour‐Mobarhan, Gordon A. Ferns, Amir Avan
IUBMB Life.2019; 71(7): 802. CrossRef

Expressions and Clinical Significances of Angiopoietin-1, Angiopoietin-2, and Tie-2 Receptor in Patients With Colorectal Cancer: Sunghoon Hong, Hae Il Jung, Tae Sung Ahn, Han-Jo Kim, Kyu-Taek Lee, Moo-Jun Baek, Sang-Byung Bae; Ann Coloproctol. 2017;33(1):9-15. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.9

5,790 View
55 Download
17 Web of Science
16 Citations

Abstract PDF

Purpose

Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis in several malignancies. Hence, we estimated the increased expression of Ang-2 relative to Ang-1 in patients with colorectal cancer and correlated our finding with prognosis in order to investigate the relationships between the expressions of Ang-1/Ang-2/Tie-2 receptor and the clinical parameters or overall survival of such patients.

Methods

We retrospectively analyzed 114 tissue samples from patients with colorectal cancer by using immunohistochemistry (IHC) to examine Ang-1, Ang-2, and Tie-2 expressions and to investigate the relationship between those expressions and clinical parameters or overall survival of such patients. A Western blot analysis was used for Ang-2 expression.

Results

IHC staining showed a link between Ang-1 and Tie-2 (P = 0.018), as well as meaningful correlations between Ang-2 and Tie-2 receptor (P = 0.022) and between lymph-node metastasis and Ang-2 (P = 0.025). The stronger the IHC staining for Ang-2 expression was, the shorter the cumulative survival was (P = 0.016).

Conclusion

A relationship was found to exist between Ang-2 and Tie-2 expressions. The Ang-2 was correlated with lymph-node metastasis, and high expression of Ang-2 was indicative of poor overall survival. These findings suggest that Ang-2 is a useful prognostic marker in the management of patients with colorectal cancer. In addition, we suggest that Ang/Tie-2 signaling plays an important role in the progression of colorectal cancer.

Citations

Citations to this article as recorded by

The Impact of the Renin-Angiotensin System on the Development of Chronic Obstructive Pulmonary Disease
森曹
Advances in Clinical Medicine.2025; 15(01): 1396. CrossRef
The BMI1-Angiopoietin-2 axis as an independent prognostic factor in colorectal cancer
Yin-Chou Hsu, Chi-Wen Luo, Shu-Jyuan Chang, Chiao-Ying Lai, Yu-Tzu Yang, Yi-Zi Chen, Mei-Hsiang Hsu, Cheuk-Kwan Sun, Mei-Ren Pan
Experimental Cell Research.2025; 450(1): 114622. CrossRef
Putative Role of Tie2-Expressing Monocytes/Macrophages in Colorectal Cancer Progression Through Enhancement of Angiogenesis and Metastasis
Eman Amin M. Ali, Alaa Muayad Altaie, Iman M. Talaat, Rifat Hamoudi
Cancers.2025; 17(17): 2856. CrossRef
Differential expression of angiogenesis-related genes ‘VEGF’ and ‘angiopoietin-1’ in metastatic and EMAST-positive colorectal cancer patients
Amir Torshizi Esfahani, Somayeh Mohammadpour, Pooya Jalali, Alireza Yaghoobi, Raana Karimpour, Soha Torkamani, Ali Pardakhtchi, Zahra Salehi, Ehsan Nazemalhosseini-Mojarad
Scientific Reports.2024;[Epub] CrossRef
Platelet Angiopoietin-1 Protects Against Murine Models of Tumor Metastasis
Harvey G. Roweth, Isabelle C. Becker, Michael W. Malloy, Emily M. Clarke, Sophie A. Munn, Priya L. Kumar, Ivan Aivasovsky, Kobe Tray, Alec A. Schmaier, Elisabeth M. Battinelli
Arteriosclerosis, Thrombosis, and Vascular Biology.2024; 44(9): 2024. CrossRef
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Kayoko Hosaka, Patrik Andersson, Jieyu Wu, Xingkang He, Qiqiao Du, Xu Jing, Takahiro Seki, Juan Gao, Yin Zhang, Xiaoting Sun, Ping Huang, Yunlong Yang, Minghua Ge, Yihai Cao
Proceedings of the National Academy of Sciences.2023;[Epub] CrossRef
Angiopoietin-2 as a Prognostic Factor in Patients with Incurable Stage IV Colorectal Cancer
Shinya Munakata, Takae Ueyama, Haruna Ishihara, Hiromitsu Komiyama, Ryoichi Tsukamoto, Masaya Kawai, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Kazuhiro Sakamoto
Journal of Gastrointestinal Cancer.2021; 52(1): 237. CrossRef
Dual Antiangiogenesis Agents Bevacizumab Plus Trebananib, without Chemotherapy, in First-line Treatment of Metastatic Colorectal Cancer: Results of a Phase II Study
Jennifer Mooi, Fiona Chionh, Peter Savas, Jessica Da Gama Duarte, Geoffrey Chong, Stephen Brown, Rachel Wong, Timothy J. Price, Alysson Wann, Effie Skrinos, John M. Mariadason, Niall C. Tebbutt
Clinical Cancer Research.2021; 27(8): 2159. CrossRef
6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice
Ebenezer O. Farombi, Babajide O. Ajayi, Isaac A. Adedara
Food and Chemical Toxicology.2020; 142: 111483. CrossRef
High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
Minna Sopo, Hanna Sallinen, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Maarit Anttila, Elizabeth Christie
PLOS ONE.2020; 15(11): e0241484. CrossRef
Evaluation of plasma angiopoietin‐2 and vascular endothelial growth factor in healthy dogs and dogs with systemic inflammatory response syndrome or sepsis
Maya König, Alice Nentwig, Eliane Marti, Jelena Mirkovitch, Katja‐Nicole Adamik, Simone Schuller
Journal of Veterinary Internal Medicine.2019; 33(2): 569. CrossRef
Targeting Receptor Kinases in Colorectal Cancer
Marilina García-Aranda, Maximino Redondo
Cancers.2019; 11(4): 433. CrossRef
Gene expression and promoter methylation of angiogenic and lymphangiogenic factors as prognostic markers in melanoma
Ana Carolina Monteiro, Julienne K. Muenzner, Fernando Andrade, Flávia Eichemberger Rius, Christian Ostalecki, Carol I. Geppert, Abbas Agaimy, Arndt Hartmann, André Fujita, Regine Schneider‐Stock, Miriam Galvonas Jasiulionis
Molecular Oncology.2019; 13(6): 1433. CrossRef
“Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer
Adriano Angelucci, Simona Delle Monache, Alessio Cortellini, Monica Di Padova, Corrado Ficorella
International Journal of Molecular Sciences.2018; 19(1): 299. CrossRef
Angiopoietin-2 (Ang-2) is a useful serum tumor marker for liver cancer in the Chinese population
Yuxin Chen, Yanping Wu, Xiao Zhang, Hong Zeng, Ya Liu, Qi Wu, Yan Chen, GuoQing Zhu, Qiuhui Pan, Lei Jin, Lin Guo, Fenyong Sun
Clinica Chimica Acta.2018; 478: 18. CrossRef
Efforts to Find Targets Involving Angiogenesis: Step to Improve the Efficacy of Target Therapy in the Era of Colorectal Cancer Treatment
In Ja Park
Annals of Coloproctology.2017; 33(1): 1. CrossRef

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis: Jeong Yeon Kim, Dongjun Jeong, Tae Sung Ahn, Hyung Ju Kim, Doo San Park, So Yong Park, Sang Byung Bae, Sookyoung Lee, Sung Soo Lee, Moon Soo Lee, Hyun Deuk Cho, Moo Jun Baek; Ann Coloproctol. 2013;29(3):93-99. Published online June 30, 2013; DOI: https://doi.org/10.3393/ac.2013.29.3.93

7,662 View
30 Download
15 Web of Science
11 Citations

Abstract PDF

Purpose

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods

The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results

The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion

These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

Citations to this article as recorded by

SPARC Induces COL1A1/COL3A1 Expressions Representing Aggressive Molecular Cancer-Associated Fibroblasts Signatures and CSF1-Mediated Cancer Invasion in Colorectal Cancer
Yusuke Nie, Yoshiki Fujiyama, Shumpei Shibaki, Riku Okamoto, Kota Okuno, Keiko Oki, Akiko Watanabe, Yu Kuroda, Takuya Goto, Kazuko Yokota, Keita Kojima, Hiroki Harada, Mikiko Kidachi, Takafumi Soeno, Mitsuo Yokota, Takeshi Kaida, Shuji Nakamoto, Nobuyuki
Annals of Surgical Oncology.2025; 32(12): 9354. CrossRef
CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy
Keishi Yamashita, Yusuke Kumamoto
International Journal of Molecular Sciences.2024; 25(11): 6003. CrossRef
Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun, Raj Kumar Koiri
PLOS ONE.2022; 17(8): e0273317. CrossRef
SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression
Qing Nian, Jingwei Li, ZhongYu Han, Qi Liang, Maoyu Liu, Chan Yang, Fernando Rodrigues-Lima, Tao Jiang, Liyun Zhao, Jinhao Zeng, Chi Liu, Jianyou Shi
Biomedicine & Pharmacotherapy.2022; 153: 113519. CrossRef
Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda Lopez-Moncada, Alexander Herrera, María José Torres, Exequiel Alonso, Norberto Ariel Gandini, Graciela Gigola, Hector R. Contreras, Claudia Gentili
Molecular and Cellular Endocrinology.2021; 530: 111253. CrossRef
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen,
eLife.2021;[Epub] CrossRef
Secreted protein acidic and rich in cysteine gene variants: Impact on susceptibility and survival of hepatocellular carcinoma patients
Samar Kamal Darweesh, Rasha Ahmed Abd Alziz, Heba Omar, Dina Sabry, Wael Fathy
Journal of Gastroenterology and Hepatology.2019; 34(8): 1424. CrossRef
Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy
Fwu‐Long Mi, Thierry Burnouf, Shih‐Yuan Lu, Yu‐Jen Lu, Kun‐Ying Lu, Yi‐Cheng Ho, Chang‐Yi Kuo, Er‐Yuan Chuang
Advanced Healthcare Materials.2017;[Epub] CrossRef
SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy
Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
Cancer Biomarkers.2017; 18(4): 459. CrossRef
Tumor–stroma ratio is an independent predictor for survival in early cervical carcinoma
Jing Liu, Juan Liu, Jinsong Li, Yingling Chen, Xiaoling Guan, Xiaojuan Wu, Chunyan Hao, Yanlin Sun, Yan Wang, Xiao Wang
Gynecologic Oncology.2014; 132(1): 81. CrossRef
Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma
Young Jin Kim
Annals of Coloproctology.2013; 29(3): 87. CrossRef

First
Prev
Page of 1
Next
Last

Search