Annals of Coloproctology

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Original Article

Malignant disease,Colorectal cancer

Upregulation of prostaglandin E₂ by inducible microsomal prostaglandin E synthase-1 in colon cancer: Young Hun Kim, Kyung Jong Kim; Ann Coloproctol. 2022;38(2):153-159. Published online August 31, 2021; DOI: https://doi.org/10.3393/ac.2021.00374.0053

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9 Citations

Purpose
Prostaglandin E₂ (PGE₂) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE₂ include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH). The current study aims to determine how PGE₂ is expressed by examining patients with colorectal cancer and evaluating colon cancer cells to gain insight into changes in relevant enzymes upon induction of PGE₂.
Methods
The concentration of PGE₂ was measured in tumor tissues and adjacent normal mucosal tissues of 26 patients with colon cancer. The expression of COX-1, COX-2, mPGES-1, and 15-PGDH proteins was measured. The concentration of PGE₂ in FET colon cancer cells was measured both in the initial status and after stimulation by tumor necrosis factor (TNF)-α. The expression levels of PGE₂-related enzymes were measured as well.
Results
There was no significant difference in the average concentration of PGE₂, which was measured at 453.1 pg/mL in cancer tissues and 401.2 pg/mL in normal mucosa. Among PGE₂-related enzymes, 15-PGDH was expressed at a lower level in tumor cells than in normal mucosa. In colon cancer cells, PGE₂ was found to be upregulated upon stimulation by TNF-α, which led to strong induction of mPGES-1 without any change in the expression of COX-2 among the PGE₂-related enzymes.
Conclusion
These results demonstrated that PGE₂ can be induced by stimuli such as TNF-α, and suggest that activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE₂ on colon cancer.

Citations

Citations to this article as recorded by

5‐methyl‐2‐carboxamidepyrrole‐based novel dual mPGES‐1/sEH inhibitors as promising anticancer candidates
Ester Colarusso, Gianluigi Lauro, Marianna Potenza, Paola Galatello, Maria Luisa d'Aulisio Garigliota, Maria Grazia Ferraro, Marialuisa Piccolo, Maria Giovanna Chini, Carlo Irace, Pietro Campiglia, Robert Klaus Hoffstetter, Oliver Werz, Anna Ramunno, Gius
Archiv der Pharmazie.2025;[Epub] CrossRef
Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition
Gianluigi Lauro, Michela Aliberti, Mauro De Nisco, Silvana Pedatella, Giacomo Pepe, Manuela Giovanna Basilicata, Maria Giovanna Chini, Katrin Fischer, Robert K. Hofstetter, Oliver Werz, Maria Grazia Ferraro, Marialuisa Piccolo, Carlo Irace, Anella Saviano
European Journal of Medicinal Chemistry.2025; 289: 117402. CrossRef
Antioxidant, Antidiabetic, Anti-Obesity, and Anti-Inflammatory Activity of Tomato-Based Functional Snack Bars Enriched with Pea and RuBisCO Proteins
Elena Tomassi, Morena Gabriele, Agnese Sgalippa, Muhammed Rasim Gul, Ozan Tas, Mecit Halil Oztop, Laura Pucci
Foods.2025; 14(19): 3340. CrossRef
The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer
Mario Macia Guardado, Valentina Lutz, Markus Hengstschläger, Helmut Dolznig
International Journal of Molecular Sciences.2025; 26(24): 12191. CrossRef
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Ana Santiso, Akos Heinemann, Julia Kargl
Pharmacological Reviews.2024; 76(3): 388. CrossRef
The calcium-sensing receptor modulates the prostaglandin E2 pathway in intestinal inflammation
Valeriya Gushchina, Nadja Kupper, Michael Schwarzkopf, Gitta Frisch, Karina Piatek, Cornelia Aigner, Alexandra Michel, Hemma Schueffl, Luca Iamartino, Taha Elajnaf, Teresa Manhardt, Andrea Vlasaty, Petra Heffeter, Marcella Bassetto, Enikö Kállay, Martin S
Frontiers in Pharmacology.2023;[Epub] CrossRef
Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Su Hyeong Park, Hye Seung Woo, In Kyung Hong, Eun Jung Park
Cancers.2023; 15(20): 5098. CrossRef
Prostaglandin E2 Exposure Disrupts E-Cadherin/Caveolin-1-Mediated Tumor Suppression to Favor Caveolin-1-Enhanced Migration, Invasion, and Metastasis in Melanoma Models
Lorena Lobos-González, Lorena Oróstica, Natalia Díaz-Valdivia, Victoria Rojas-Celis, America Campos, Eduardo Duran-Jara, Nicole Farfán, Lisette Leyton, Andrew F. G. Quest
International Journal of Molecular Sciences.2023; 24(23): 16947. CrossRef
Inflammatory Response Markers as Predictors of Colorectal Cancer Prognosis
Minsung Kim, Il Tae Son, Bo Young Oh
The Ewha Medical Journal.2023;[Epub] CrossRef

Editorial

Malignant disease, Rectal cancer

Simplification or Accuracy: In Assessing Functional Outcomes After Intersphincteric Resection for Low Rectal Cancer: Kyung Jong Kim; Ann Coloproctol. 2020;36(3):129-130. Published online June 30, 2020; DOI: https://doi.org/10.3393/ac.2020.06.15

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Original Articles

Management Outcomes of Colonoscopic Perforations Are Affected by the General Condition of the Patients: Jae Ho Park, Kyung Jong Kim; Ann Coloproctol. 2018;34(1):16-22. Published online February 28, 2018; DOI: https://doi.org/10.3393/ac.2018.34.1.16

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1 Web of Science
1 Citations

Abstract PDF

Purpose

The management of a colonoscopic perforation (CP) varies from conservative to surgical. The objective of this study was to evaluate the outcomes between surgical and conservative treatment of patients with a CP.

Methods

From 2003 to 2016, the medical records of patients with CP were retrospectively reviewed. Patients were divided into 2 groups depending on whether they initially received conservative or surgical treatment.

Results

During the study period, a total of 48 patients with a CP were treated. Among them, 5 patients had underlying colorectal cancer and underwent emergency radical cancer surgery; these patients were excluded. The mean age of the remaining 43 patients was 64.5 years old, and the most common perforation site was the sigmoid colon (15 patients). The initial conservative care group included 16 patients, and the surgery group included 27 patients. In the conservative group, 5 patients required conversion to surgery (failure rate: 5 of 16 [31.3%]). Of the surgery group, laparoscopic surgery was performed on 19 patients and open surgery on 8 patients, including 2 conversion cases. Major postoperative complications developed in 11 patients (34.4%), and postoperative mortality developed in 4 patients (12.5%). The only predictor for poor prognosis after surgery was a high American Society of Anesthesiologists physical status classification.

Conclusion

In this study, conservative treatment for patients with a CP had a relatively high failure rate. Furthermore, surgical treatment showed significant rates of complications and mortality, which depended on the general status of the patients.

Citations

Citations to this article as recorded by

Multicenter retrospective evaluation of ileocecocolic perforations associated with diagnostic lower gastrointestinal endoscopy in dogs and cats
Vanessa L. Woolhead, Jacqueline C. Whittemore, Sarah A. Stewart
Journal of Veterinary Internal Medicine.2020; 34(2): 684. CrossRef

Surgical Outcomes and Risk Factors in Patients Who Underwent Emergency Colorectal Surgery: Dai Sik Jeong, Young Hun Kim, Kyung Jong Kim; Ann Coloproctol. 2017;33(6):239-244. Published online December 31, 2017; DOI: https://doi.org/10.3393/ac.2017.33.6.239

6,984 View
114 Download
12 Web of Science
11 Citations

Abstract PDF

Purpose

Emergency colorectal surgery has high rates of complications and mortality because of incomplete bowel preparation and bacterial contamination. The authors aimed to evaluate the surgical outcomes and the risk factors for the mortality and the complication rates of patients who underwent emergency surgery to treat colorectal diseases.

Methods

This is a prospective study from January 2014 to April 2016, and the results are based on a retrospective analysis of the clinical results for patients who underwent emergency colorectal surgery at Chosun University Hospital.

Results

A total of 99 patients underwent emergency colorectal surgery during the study period. The most frequent indication of surgery was perforation (75.8%). The causes of disease were colorectal cancer (19.2%), complicated diverticulitis (21.2%), and ischemia (27.2%). There were 27 mortalities (27.3%). The major morbidity was 39.5%. Preoperative hypotension and perioperative blood transfusion were independent risk factors for both morbidity and mortality.

Conclusion

These results revealed that emergency colorectal surgeries are associated with significant morbidity and mortality. Furthermore, the independent risk factors for both morbidity and mortality in such patiients were preoperative hypotension and perioperative transfusion.

Citations

Citations to this article as recorded by

Effects of the COVID‐19 pandemic on short‐term postoperative outcomes for colorectal perforation: A nationwide study in Japan based on the National Clinical Database
Shimpei Ogawa, Hideki Endo, Masahiro Yoshida, Tomomitsu Tsuru, Michio Itabashi, Hiroyuki Yamamoto, Yoshihiro Kakeji, Hideki Ueno, Yuko Kitagawa, Taizo Hibi, Akinobu Taketomi, Norihiko Ikeda, Masaki Mori
Annals of Gastroenterological Surgery.2024; 8(3): 450. CrossRef
Effects of surgeon specialization on the outcome of emergency colorectal surgery
Nahar A. Alselaim, Ohood H. AlAamer, Mohammed M. Almalki, Abdualziz A. Al-osail, Sultanah F. Bin Gheshayan
Annals of Medicine & Surgery.2024; 86(12): 7010. CrossRef
Association between Intraoperative Early Warning Score and Mortality and In-Hospital Stay in Lower Gastrointestinal Spontaneous Perforation
Kazuya Takada, Yusuke Nagamine, Akira Ishii, Yan Shuo, Takumi Seike, Hanako Horikawa, Kentaro Matsumiya, Tetsuya Miyashita, Takahisa Goto, Ronald G. Pearl
Anesthesiology Research and Practice.2023; 2023: 1. CrossRef
Sigmoid colon cancer presenting as a left inguinal hernia: a case report
Mohammad E. Al Mohtasib, Mohammad N. Emar, Anan I. Al-jabari, Taima M. Aljabari, Islam H. Karajeh, Qutaiba Y. Al Jawabrah, Raghad M. Dghaish, Fahmi Jubran, Shadi Ruzayqat
Annals of Medicine & Surgery.2023; 85(11): 5653. CrossRef
Factors associated with 30-day mortality and morbidity in patients undergoing emergency colorectal surgery
Nahar A. Alselaim, Muhannad Abdulrahman Alsemari, Mesnad Alyabsi, Abrar M. Al-Mutairi
Annals of Saudi Medicine.2023; 43(6): 364. CrossRef
Efficiency of pre-operative preparation of intestines at treatment of sharp intestinal impassability tumoral genesis
H. Sh. Nazarov, Sh. К. Nazarov, N. Sh. Hasanov
Health care of Tajikistan.2022; (2): 59. CrossRef
Fluid management for critical patients undergoing urgent colectomy
Fabian Grass, Basile Pache, Fabio Butti, Josep Solà, Dieter Hahnloser, Nicolas Demartines, Martin Hübner
Journal of Evaluation in Clinical Practice.2020; 26(1): 109. CrossRef
Emergency surgery for gastrointestinal cancer: A nationwide study in Japan based on the National Clinical Database
Nobuaki Hoshino, Hideki Endo, Koya Hida, Nao Ichihara, Yoshimitsu Takahashi, Hiroshi Hasegawa, Toshimoto Kimura, Yuko Kitagawa, Yoshihiro Kakeji, Hiroaki Miyata, Takeo Nakayama, Yoshiharu Sakai
Annals of Gastroenterological Surgery.2020; 4(5): 549. CrossRef
Gestione delle complicanze infettive intra-addominali e delle peritoniti postoperatorie in chirurgia viscerale
A. Mancini, J. Abba, C. Arvieux
EMC - Tecniche Chirurgiche Addominale.2020; 26(4): 1. CrossRef
Tratamiento de las complicaciones infecciosas intraabdominales y de la peritonitis postoperatoria en cirugía visceral
A. Mancini, J. Abba, C. Arvieux
EMC - Técnicas Quirúrgicas - Aparato Digestivo.2020; 36(4): 1. CrossRef
Colonic stenting as a bridge to surgery in malignant large bowel obstruction: oncological outcomes
N. E. Donlon, M. E. Kelly, F. Narouz, P. H. McCormick, J. O. Larkin, B. J. Mehigan
International Journal of Colorectal Disease.2019; 34(4): 613. CrossRef

Case Report

Synchronous Primary Anorectal Melanoma and Sigmoid Adenocarcinoma: Inju Cho, Kyung Jong Kim, Sung-Chul Lim; Ann Coloproctol. 2016;32(5):190-194. Published online October 31, 2016; DOI: https://doi.org/10.3393/ac.2016.32.5.190

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49 Download
2 Web of Science
2 Citations

Abstract PDF

A primary anorectal malignant melanoma is a rare tumor. Moreover, cases involving a synchronous anorectal melanoma and colon adenocarcinoma are extremely rare. The authors report a case of a synchronous anorectal melanoma and sigmoid adenocarcinoma in an 84-year-old man. The regions of the anorectal melanoma showed melanocytic nevi in the adjacent mucosa of the anal canal and rectum. A dysplastic nevus was also identified in the anal mucosa. This case demonstrates that an anorectal melanoma can arise from pre-existing anorectal melanocytic lesions.

Citations

Citations to this article as recorded by

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma
Giovanni Paolino, Antonio Podo Brunetti, Carolina De Rosa, Carmen Cantisani, Franco Rongioletti, Andrea Carugno, Nicola Zerbinati, Mario Valenti, Domenico Mascagni, Giulio Tosti, Santo Raffaele Mercuri, Riccardo Pampena
Melanoma Research.2024; 34(6): 487. CrossRef
Endoscopic diagnosis of gastrointestinal melanoma
Sheng Wang, Siyu Sun, Xiang Liu, Nan Ge, Guoxin Wang, Jintao Guo, Wen Liu, Jinlong Hu
Scandinavian Journal of Gastroenterology.2020; 55(3): 330. CrossRef

Original Article

Outcomes and Risk Factors Affecting Mortality in Patients Who Underwent Colorectal Emergency Surgery: Nam Ho Oh, Kyung Jong Kim; Ann Coloproctol. 2016;32(4):133-138. Published online August 31, 2016; DOI: https://doi.org/10.3393/ac.2016.32.4.133

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56 Download
14 Web of Science
11 Citations

Abstract PDF

Purpose

Emergency colorectal surgery has a high risk of mortality and morbidity because of incomplete bowel preparation, bacterial proliferation, and contamination. In this study, we investigated the outcomes and the risk factors affecting mortality in patients who had undergone emergency surgery for the treatment of various colorectal diseases.

Methods

This study is a retrospective analysis of prospectively collected data to survey the clinical results for patients who had undergone emergency colorectal surgery from January 2014 to December 2014. We analyzed various clinicopathologic factors, which were divided into 3 categories: preoperative, intraoperative, and postoperative.

Results

A total of 50 patients had undergone emergency colorectal surgery during the time period covered by this study. Among them, 10 patients (20%) died during the postoperative period. A simple linear regression analysis showed that the risk factors for mortality were old age, preoperative hypotension, and a high American Society of Anesthesiologist (ASA) score. Moreover, a multiple linear regression analysis showed a high ASA score and preoperative hypotension to be independent risk factors.

Conclusion

In this study, emergency colorectal surgery showed a relatively high mortality rate. Furthermore, the independent risk factors for mortality were preoperative hypotension and high ASA score; thus, patients with these characteristics need to be evaluated more carefully and receive better care if the mortality rate is to be reduced.

Citations

Citations to this article as recorded by

Impact of Surgeon Specialization on Outcomes in Emergency Colorectal Surgery: A Systematic Review and Meta-analysis
Zachary Bunjo, Luke Traeger, Ishraq Murshed, Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Christopher Dobbins, Tarik Sammour
Diseases of the Colon & Rectum.2025; 68(1): 14. CrossRef
Postoperative hypotension following acute hip fracture surgery is a predictor of 30-day mortality
Neil Donald, Grace Eniola, Krisztian Deierl
The Bone & Joint Journal.2024; 106-B(2): 189. CrossRef
Emergent colectomy for colorectal cancer: A comparative analysis of open vs. minimally invasive approach
Hunter Jecius, Muhammad Khurrum, Erika Krall, Dynnika Tso, Afang Pefok, Ryan Silva, Emily Wusterbarth, Hina Arif, Mohammad Hamidi, Valentine Nfonsam
The American Journal of Surgery.2023; 225(4): 724. CrossRef
Surgical outcomes and prognostic factors associated with emergency left colonic surgery
Dauda Bawa, Yasser Mohammad Khalifa, Saleem Khan, Waddah Norah, Nibras Noman
Annals of Saudi Medicine.2023; 43(2): 97. CrossRef
Development and Evaluation of a Risk-Adjusted Measure of Intraoperative Hypotension in Patients Having Nonemergent, Noncardiac Surgery
Anna L. Christensen, Ethan Jacobs, Kamal Maheshwari, Fei Xing, Xiaohong Zhao, Samuel E. Simon, Karen B. Domino, Karen L. Posner, Alvin F. Stewart, Joseph A. Sanford, Daniel I. Sessler
Anesthesia & Analgesia.2021; 133(2): 445. CrossRef
Prediction of functional loss in emergency surgery is possible with a simple frailty screening tool
Davide Zattoni, Isacco Montroni, Nicole Marie Saur, Anna Garutti, Maria Letizia Bacchi Reggiani, Federico Ghignone, Giovanni Taffurelli, Giampaolo Ugolini
World Journal of Emergency Surgery.2021;[Epub] CrossRef
Fluid management for critical patients undergoing urgent colectomy
Fabian Grass, Basile Pache, Fabio Butti, Josep Solà, Dieter Hahnloser, Nicolas Demartines, Martin Hübner
Journal of Evaluation in Clinical Practice.2020; 26(1): 109. CrossRef
Procalcitonin as an early marker in the detection of anastomotic intestinal leak in a Universitary Hospital of Bogotá
Elkin Eduardo Benítez Navarrete, Tatiana Carolina Beltrán-García, María Fernanda Mosquera, Valeria Martinez Rojas, Daniel Alejandro Buitrago Medina, Carlos Edgar Figueroa Avendaño
Journal of Coloproctology.2020; 40(04): 376. CrossRef
Association of intra‐operative hypotension with acute kidney injury, myocardial injury and mortality in non‐cardiac surgery: A meta‐analysis
Ran An, Qian-Yun Pang, Hong‐Liang Liu
International Journal of Clinical Practice.2019;[Epub] CrossRef
Emergency Surgery Mortality (ESM) Score to Predict Mortality and Improve Patient Care in Emergency Surgery
Sirirat Tribuddharat, Thepakorn Sathitkarnmanee, Pavit Sappayanon
Anesthesiology Research and Practice.2019; 2019: 1. CrossRef
Emergent Colorectal Surgery: What Should Be Considered?
Chang-Nam Kim
Annals of Coloproctology.2016; 32(4): 124. CrossRef

Case Report

Giant Ascending Colonic Diverticulum Presenting With Intussusception: Ho Jin Kim, Jin Ha Kim, Ok In Moon, Kyung Jong Kim; Ann Coloproctol. 2013;29(5):209-212. Published online October 31, 2013; DOI: https://doi.org/10.3393/ac.2013.29.5.209

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55 Download
10 Citations

Abstract PDF

Diverticular disease of the colon is a common disease, and its incidence is increasing gradually. A giant colonic diverticulum (GCD) is a rare entity and is defined as a diverticulum greater than 4 cm in size. It mainly arises from the sigmoid colon, and possible etiology is a ball-valve mechanism permitting progressive enlargement. A plain abdominal X-ray can be helpful to make a diagnosis initially, and a barium enema and abdominal computed tomography may confirm the diagnosis. Surgical intervention is a definite treatment for a GCD. We report a case of an ascending GCD presenting with intussusception in a young adult.

Citations

Citations to this article as recorded by

Intussusception secondary to retroflexion of a proximal jejunal diverticulum, leading to Type 3 vagal indigestion with severe hypochloraemia in an adult Simmental bull (Bos taurus)
Liam A. Wilson, Rob F. Kelly, Adrian W. Philbey
Veterinary Record Case Reports.2024;[Epub] CrossRef
A case report of impacted fecalith within mucosal pouch: an unusual cause of colocolic intussusception
Douglas Greer, Adrian Fernandez
Annals of Coloproctology.2024; 40(Suppl 1): S15. CrossRef
Popping the Balloon: A Giant Colonic Diverticulum Complicated by Bladder Neck Compression
M. C. Ripoli, A. Lauro, S. Vaccari, G. Mastrocola, A. Lanci-Lanci, V. D’Andrea, I. R. Marino, M. Cervellera, V. Tonini
Digestive Diseases and Sciences.2021; 66(1): 41. CrossRef
Laparoscopic resection of a giant colonic diverticulum – the ‘lifting balloon’ sign – a video vignette
C. Rodríguez‐Otero Luppi, M. Rodríguez Blanco, J. Bollo Rodríguez, A. Méndez, J. Merlo Más
Colorectal Disease.2019; 21(9): 1096. CrossRef
Intussusception caused by an inverted colonic diverticulum: a case report
Bei Zhang, Jiping Wang, Xiaoguang Li, Zhuo Wang, Yangjiao Zhang, Hao Yang
Journal of Medical Case Reports.2018;[Epub] CrossRef
Adult intussusception secondary to diverticular disease
Habib Syed, Labib Syed, Umesh Parampalli, Mokhtar Uheba
BMJ Case Reports.2018; 2018: bcr-2018-226678. CrossRef
Laparoskopische Resektion eines Riesenkolondivertikels
P. J. Roch, T. Friedrich, R. Bönninghoff, D. Dinter, A. Rickert
Der Chirurg.2017; 88(8): 682. CrossRef
Giant colonic diverticulum: radiographic and MDCT characteristics
Abdel-Rauf Zeina, Ahmad Mahamid, Alicia Nachtigal, Itamar Ashkenazi, Mika Shapira-Rootman
Insights into Imaging.2015; 6(6): 659. CrossRef
Giant colonic diverticulum: Clinical presentation, diagnosis and treatment: Systematic review of 166 cases
Giuseppe Nigri
World Journal of Gastroenterology.2015; 21(1): 360. CrossRef
Giant Colonic Diverticulum: a Rare Diagnostic and Therapeutic Challenge of Diverticular Disease
Ryan Macht, Holly K. Sheldon, P. Marco Fisichella
Journal of Gastrointestinal Surgery.2015; 19(8): 1559. CrossRef

Original Article

Prognostic Implication of 15-Hydroxyprostaglandin Dehydrogenase Down-Regulation in Patients with Colorectal Cancer: Pil Sung Kang, Jin Ha Kim, Ok In Moon, Sung Chul Lim, Kyung Jong Kim; J Korean Soc Coloproctol. 2012;28(5):253-258. Published online October 31, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.5.253

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2 Citations

Abstract PDF

Purpose

Prostaglandin (PG) E2 is known to be closely related to cancer progression and is inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). 15-PGDH is shown to have tumor suppressor activity and to be down-regulated in various cancers, including colorectal cancer (CRC). Therefore, we evaluated the expression of 15-PGDH and its prognostic effect in patients with CRC.

Methods

15-PGDH expression was examined by using immunohistochemistry in 77 patients with CRC. Its prognostic significance was statistically evaluated.

Results

Negative 15-PGDH expression was noted in 55.8% of the 77 cases of CRC. 15-PGDH expression showed no correlation with any of the various clinicopathologic parameters. The status of lymph node metastasis, tumor-node-metastasis stages, and pre-operative carcinoembryonic antigen levels showed significant prognostic effect. However, univariate analysis revealed down-regulation of 15-PGDH not to be a predictor of poor survival. The 5-year overall survival rate was 71.7% in the group with positive expression of 15-PGDH and 67.1% in the group with negative expression of 15-PGDH, but this difference was not statistically significant (P = 0.751).

Conclusion

15-PGDH was down-regulated in 55.8% of the colorectal cancer patients. However, down-regulation of 15-PGDH showed no prognostic value in patients with CRC. Further larger scale or prospective studies are needed to clarify the prognostic effect of 15-PGDH down-regulation in patients with colorectal cancer.

Citations

Citations to this article as recorded by

The tumor suppressor role and epigenetic regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in cancer and tumor microenvironment (TME)
SubbaRao V. Tulimilli, Medha Karnik, Anjali Devi S. Bettadapura, Olga A. Sukocheva, Edmund Tse, Gowthamarajan Kuppusamy, Suma M. Natraj, SubbaRao V. Madhunapantula
Pharmacology & Therapeutics.2025; 268: 108826. CrossRef
Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials
Nagendra S. Yarla, Venkateshwar Madka, Gopal Pathuri, Chinthalapally V. Rao
International Journal of Molecular Sciences.2020; 21(24): 9609. CrossRef

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