Annals of Coloproctology

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Original Article

Malignant disease,Colorectal cancer,Prognosis,Epidemiology & etiology

Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer: Hyundo Lee, Hae Won Lee, Eun Jung Park, Jeonghyun Kang, Seung Hyuk Baik; Ann Coloproctol. 2022;38(3):197-206. Published online October 18, 2021; DOI: https://doi.org/10.3393/ac.2021.00640.0091

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2 Citations

Purpose
This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC).
Methods
Between 1996 and 2019, patients who were diagnosed with both BrC and CRC were evaluated retrospectively. Patients with distant metastasis, palliative resection, and previous cancer histories except for BrCs or CRCs were excluded. Altogether, 105 patients were divided into the B=C group (n=21), B-first group (n=40), and C-first group (n=44) according to the definition of synchronous and metachronous cancers. The clinicopathologic features and overall survival were evaluated.
Results
TNM stages and histologic types were comparable among the 3 groups (P=0.434). The interval of diagnosis was 67.1±40.4 and 59.3±47.2 months in the B- and C-first groups, respectively. The incidence of adjuvant chemotherapy in the B-first group was 57.5%, which was higher than the B=C and C-first groups (P<0.001). The estrogen receptor, progesterone receptor, Ki-67, and HER-2 molecular markers were not significantly different among the groups. The overall survival of the B-first group showed lower survival rates than the C-first group (P=0.039). In the logistic regression, HER-2 status (hazard ratio [HR], 11.9; P=0.032) and lymph node metastasis of CRC (HR, 5.8; P=0.036) were prognostic factors affecting overall survival.
Conclusion
B-first group had poorer survival outcomes than the C-first group in patients with the metachronous BrC and CRC. HER2 positivity and CRC lymph node metastasis may be prognostic factors that affect overall survival in these patients. The findings support that a colorectal cancer screening program should be included during BrC surveillance.

Citations

Citations to this article as recorded by

Synchronous or metachronous breast and colorectal cancers in younger-than-average-age patients: a case series
Jordyn Silverstein, Francis Wright, Dalila Stanfield, Amy Jo Chien, Jasmine M Wong, John W Park, Amie Blanco, Katherine Van Loon, Chloe E Atreya
The Oncologist.2024; 29(9): e1159. CrossRef
Synchronous Breast and Colorectal Malignant Tumors—A Systematic Review
Cristian Iorga, Cristina Raluca Iorga, Alexandru Grigorescu, Iustinian Bengulescu, Traian Constantin, Victor Strambu
Life.2024; 14(8): 1008. CrossRef

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