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Minimally invasive surgery
Robotic surgery may lead to reduced postoperative inflammatory stress in colon cancer: a propensity score–matched analysis
Eun Ji Park, Gyong Tae Noh, Yong Joon Lee, Min Young Park, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Byung Soh Min
Ann Coloproctol. 2024;40(6):594-601.   Published online December 6, 2024
DOI: https://doi.org/10.3393/ac.2024.00171.0024
  • 3,397 View
  • 93 Download
  • 5 Web of Science
  • 6 Citations
AbstractAbstract PDFSupplementary Material
Purpose
Robot-assisted surgery is readily applied to every type of colorectal surgeries. However, studies showing the safety and feasibility of robotic surgery (RS) have dealt with rectal cancer more than colon cancer. This study aimed to investigate how technical advantages of RS can translate into actual clinical outcomes that represent postoperative systemic response.
Methods
This study retrospectively reviewed consecutive cases in a single tertiary medical center in Korea. Patients with primary colon cancer who underwent curative resection between 2006 and 2012 were included. Propensity score matching was done to adjust baseline patient characteristics (age, sex, body mass index, American Society of Anesthesiologists physical status, tumor profile, pathologic stage, operating surgeon, surgery extent) between open surgery (OS), laparoscopic surgery (LS), and RS groups.
Results
After propensity score matching, there were 66 patients in each group for analysis, and there was no significant differences in baseline patient characteristics. Maximal postoperative leukocyte count was lowest in the RS group and highest in the OS group (P=0.021). Similar results were observed for postoperative neutrophil count (P=0.024). Postoperative prognostic nutritional index was highest in the RS group and lowest in the OS group (P<0.001). The time taken to first flatus and soft diet resumption was longest in the OS group and shortest in the RS group (P=0.001 and P<0.001, respectively). Among all groups, other short-term postoperative outcomes such as hospital stay and complications did not show significant difference, and oncological survival results were similar.
Conclusion
Better postoperative inflammatory indices in the RS group may correlate with their faster recovery of bowel motility and diet resumption compared to LS and OS groups.

Citations

Citations to this article as recorded by  
  • Open, Laparoscopic, and robotic approaches in colorectal surgery: a comprehensive review with focus on colorectal cancer
    Farhad Shafiei, Fatemeh Kani, Nargess Porkar, Maede Mirzaee, Fatemeh Heidarzadeh, Mahdi Kolivand, Soheila Behdad, Amir Shokri
    Journal of Robotic Surgery.2026;[Epub]     CrossRef
  • Übergangsphase zur roboterassistierten Chirurgie beim kolorektalen Karzinom: eine vergleichende konsekutive Kohortenstudie
    U. A. Dietz, M. Kalisvaart, S. Maksimovic, R. Frey, M. Ramser, B. M. Erhart, U. Pfefferkorn
    Die Chirurgie.2025; 96(11): 942.     CrossRef
  • Comparative clinical efficacy of three surgical modalities for the treatment of malignant tumours of the left hemicolon
    Hao Chen, Dong-Ping Han, Jian-Yang Xiong, Zhen-Sheng Li, Teng-Cheng Hu, Zheng-Rong Li, Yi Cao
    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Comparison of the perioperative outcomes of robotic vs. open distal pancreatectomy: a meta-analysis of propensity-score-matched studies
    Junjie Wang, Yuanjun Liu, Yakun Wu
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Effectiveness of Guardix-SG in Preventing Postoperative Bowel Complications After Radical Cystectomy: A Single-Arm Prospective Observational Study
    Jiwoong Yu, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Seong Il Seo, Seong Soo Jeon, Byong Chang Jeong
    Journal of Urologic Oncology.2025; 23(3): 253.     CrossRef
  • Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis
    Xiaomei Jiang, Hang Zhou, Zhaoyang Zheng, Xiaodong Wang, Zongguang Zhou, Lie Yang
    Updates in Surgery.2025;[Epub]     CrossRef
Colorectal cancer
Long-term bowel functional outcomes following anal sphincter-preserving surgery for upper and middle rectal cancer: a single-center longitudinal study
Ahmad Sakr, Seung Yoon Yang, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2024;40(1):27-35.   Published online February 28, 2024
DOI: https://doi.org/10.3393/ac.2022.01067.0152
  • 5,673 View
  • 208 Download
  • 3 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
Despite advances in neoadjuvant chemoradiotherapy and anal sphincter-preserving surgery for rectal cancer, bowel dysfunction is still unavoidable and negatively affects patients’ quality of life. In this longitudinal study, we aimed to investigate the changes in bowel function with follow-up time and the effect of neoadjuvant chemoradiotherapy on bowel function following low anterior resection for rectal cancer.
Methods
In this study, 171 patients with upper or middle rectal cancer who underwent low anterior resection between 2012 and 2018 were included. Bowel function was assessed longitudinally with Memorial Sloan Kettering Cancer Center Bowel Function Instrument and Wexner scores every 6 months after restoration of bowel continuity. Patients with at least 2 follow-up visits were included.
Results
Overall, 100 patients received neoadjuvant chemoradiotherapy. Urgency, soilage, and fecal incontinence were noted within 24 months in the patients treated with neoadjuvant chemoradiotherapy. After 2 years of follow-up, significant bowel dysfunction and fecal incontinence were observed in the neoadjuvant chemoradiotherapy group. Low tumor level and neoadjuvant chemoradiotherapy were associated with delayed bowel dysfunction.
Conclusion
Neoadjuvant chemoradiotherapy in combination with low tumor level was significantly associated with delayed bowel dysfunction even after 2 years of follow-up. Therefore, careful selection and discussion with patients are paramount.

Citations

Citations to this article as recorded by  
  • Funktionelle Folgen von Radiotherapie, Chemotherapie und Operation bei der Behandlung des Rektumkarzinoms
    Philipp Rhode, Matthias Mehdorn, Undine Gabriele Lange, Sebastian Murad Rabe, Johannes Quart, Robert Nowotny, Patrick Sven Plum, Stefan Niebisch, Sigmar Stelzner
    Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie.2025; 150(04): 353.     CrossRef
  • Efficacy of Neoadjuvant Hypofractionated Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer: A Single-Center Retrospective Analysis
    Jae Seung Kim, Jaram Lee, Hyeung-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
    Cancers.2024; 16(24): 4280.     CrossRef
  • Beyond survival: a comprehensive review of quality of life in rectal cancer patients
    Won Beom Jung
    Annals of Coloproctology.2024; 40(6): 527.     CrossRef
Impact of Adjuvant Chemotherapy Completion on Oncologic Outcomes in ypTNMstage 2 Rectal Cancer Patients
Youn Young Park, Kang Young Lee, Nam Kyu Kim, Sat Byol Lee, Ga Ram Kim, Byung Soh Min, Seong-Taek Oh
Ann Coloproctol. 2019;35(6):335-341.   Published online December 31, 2019
DOI: https://doi.org/10.3393/ac.2019.03.10
  • 5,008 View
  • 64 Download
  • 3 Web of Science
  • 3 Citations
AbstractAbstract PDF
Purpose
Adjuvant chemotherapy (aCT) in rectal cancer patients who have undergone curative resection after neoadjuvant chemoradiation (nCRT) is controversial. We aimed to investigate the benefits of using aCT and the clinical impact of completing aCT in ypstage 2 rectal cancer patients.
Methods
We retrospectively reviewed clinicopathological data from patients who had undergone radical resection after nCRT between January 2006 and December 2012. In total, 152 patients with ypT3/4N0M0 rectal cancer were included. Of these patients, 139 initiated aCT, while 13 did not receive aCT (no-aCT). Among those who received aCT, 132 patients completed their planned cycles (aCT-completion) whereas 7 did not (aCT-incompletion). All patients received longcourse chemoradiation; a 5-fluorouracil-based regimen was used for nCRT in most patients. The prognostic factors affecting disease-free survival (DFS) and overall survival (OS) were analyzed.
Results
The median follow-up duration was 41 months. Demographic data did not differ significantly among the 3 groups. In multivariate analysis, open surgery, a tumor size >2 cm, retrieval of <12 lymph nodes, circumferential resection margin (CRM) positivity and aCT incompletion were independent prognostic factors for poor DFS. Old age (≥60 years), open surgery, CRM positivity, aCT incompletion, and lack of aCT initiation compared to aCT completion were independent prognostic factors for poor OS.
Conclusion
In ypstage 2 rectal cancer patients, aCT after nCRT and total mesorectal excision affected both DFS and OS; however, only patients who completed planned aCT exhibited survival benefits. Therefore, improving patients’ compliance with the completion of aCT is desirable.

Citations

Citations to this article as recorded by  
  • The Benefits of Adjuvant Chemotherapy for ypT3-4N0M0 Rectal Cancer Following Neoadjuvant Chemoradiation and Surgery
    Chih-Hsien Chang, Hung-Hsin Lin, Shih-Ching Chang, Jeng-Kai Jiang, Huann-Sheng Wang, Yuan-Tzu Lan
    Clinical Medicine Insights: Oncology.2025;[Epub]     CrossRef
  • Adjuvant chemotherapy in locally advanced rectal cancer after neo-adjuvant concurrent chemoradiotherapy and surgery: A retrospective study in Vietnamese patients
    Thang Tran, Huy Van Nguyen, Hoa Thi Nguyen, Hung Van Nguyen
    Annals of Medicine & Surgery.2023; 85(9): 4234.     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
Short-term Outcomes After Upfront Chemotherapy Followed by Curative Surgery in Metastatic Colon Cancer: A Comparison With Upfront Surgery Patients
Myung Hyun Han, Youn Young Park, Shiva Pratap, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2019;35(6):327-334.   Published online December 31, 2019
DOI: https://doi.org/10.3393/ac.2019.03.04.1
  • 4,965 View
  • 71 Download
  • 2 Web of Science
  • 2 Citations
AbstractAbstract PDF
Purpose
Upfront systemic chemotherapy with target agents has been recommended for patients with stage IV colon cancer. Some with partial response are considered for curative resection. There is high risk of developing postoperative complications following upfront systemic chemotherapy. We aimed to evaluate short-term perioperative outcomes of curative surgery after upfront chemotherapy in comparison with upfront surgery in patients with metastatic colon cancer.
Methods
Between January 2010 and October 2015, 146 patients (80 in the surgery first group, 66 in the upfront chemotherapy group) who underwent surgical resection before or after systemic chemotherapy for metastatic colon cancer were included in the present study. All decisions for treatment were made through a multidisciplinary team. Postoperative clinical outcomes and complications were analyzed to compare the groups.
Results
There was no difference between the 2 groups in terms of postoperative clinical outcomes. Overall complication rates were not different between the groups (surgery first group: 46.3% vs. upfront chemotherapy group: 60.6%; P = 0.084). When classified according to the Clavien-Dindo method, there was no difference between the 2 groups in terms of major complications (grade 3 or more) (surgery first group: 18.9% vs. upfront chemotherapy group: 27.5%; P = 0.374).
Conclusion
There was no significant increase in major postoperative complications in metastatic colon cancer patients who received upfront chemotherapy followed by curative surgery. Careful patient selection and treatment planning are important.

Citations

Citations to this article as recorded by  
  • Impact of preoperative chemotherapy on perioperative morbidity in combined resection of colon cancer and liver metastases
    Joy Z. Done, Angelos Papanikolaou, Miloslawa Stem, Shannon N. Radomski, Sophia Y. Chen, Chady Atallah, Jonathan E. Efron, Bashar Safar
    Journal of Gastrointestinal Surgery.2023; 27(11): 2380.     CrossRef
  • Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
    Young Jin Kim, Chang Hyun Kim
    Annals of Coloproctology.2021; 37(6): 425.     CrossRef
Single-center Experience of 24 Cases of Tailgut Cyst
Ahmad Sakr, Ho Seung Kim, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2019;35(5):268-274.   Published online October 31, 2019
DOI: https://doi.org/10.3393/ac.2018.12.18
  • 15,083 View
  • 331 Download
  • 37 Web of Science
  • 51 Citations
AbstractAbstract PDF
Purpose
Tailgut cysts are rare congenital or developmental lesions that arise from vestiges of the embryological hindgut. They are usually present in the presacral space. We report our single-center experience with managing tailgut cysts.
Methods
We conducted a retrospective analysis of 24 patients with tailgut cyst treated surgically at the Colorectal Surgery Department of Severance Hospital, Yonsei University, Seoul, South Korea, between 2007–2018.
Results
This study included 24 patients (18 females) with a median age of 51.5 years (range, 21–68 years). Ten cases were symptomatic and 14 were asymptomatic. Cysts were retrorectal in 21 patients. Cysts were below the coccyx level in 16 patients, opposite the coccyx in 6, and above the coccyx in 2. Cysts were supralevator in 5 patients, had a supra- and infralevator extension in 18 patients, and were infralevator in 1. Ten patients were managed using an anterior laparoscopic approach, 11 using a posterior approach, and 3 using a combined approach. Mean cyst size was 5.5 ± 2.7 cm. Postoperative complications were Clavien-Dindo (CD) classification grade II in 9 patients (37.5%) and CD grade III in 1 (4.2%). The posterior approach group showed the highest rate of complications (P = 0.021). Patients managed using a combined approach showed a larger cyst size (P < 0.001), longer operation times (P < 0.001), and a greater likelihood of tumor level above the coccyx (P = 0.002) compared to other approaches. The tumors of 2 male patients were malignant: 1 was a neuroendocrine tumor treated with radiotherapy, while the other was a closely followed adenocarcinoma. Median follow-up was 12 months (range, 1–66 months) with no recurrence.
Conclusion
Tailgut cysts are uncommon but can cause perineal or pelvic pain. Complete surgical excision via an appropriate approach according to tumor size, location, and correlation with adjacent pelvic floor muscles is the key treatment.

Citations

Citations to this article as recorded by  
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    International Journal of Surgery Case Reports.2026;[Epub]     CrossRef
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    P. Tsarkov, S. Barkhatov, D. Shlyk, L. Safyanov, V. Balaban, M. He
    Techniques in Coloproctology.2025;[Epub]     CrossRef
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    Masato Kitazawa, Seishu Karasawa, Satoshi Nakamura, Yuta Yamamoto, Yuji Soejima
    Cureus.2025;[Epub]     CrossRef
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    Hussein Abdallah, Stefan Heinrich, Matthias Birth
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    International Journal of Surgery Case Reports.2024; 120: 109912.     CrossRef
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    Jan Wojciechowski, Tomasz Skołozdrzy, Piotr Wojtasik, Maciej Romanowski
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  • The management of retrorectal tumors – a single-center analysis of 21 cases and overview of the literature
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    Histopathology.2023; 82(2): 232.     CrossRef
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  • Surgery of presacral cysts: case series analysis and literature review
    K. V. Stegnii, Zh. A. Rakhmonov, R. A. Goncharuk, M. A. Krekoten, E. R. Dvoinikova, E. V. Morova, M. О. Dmitriev
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  • Surgical treatment of retrorectal tumors: a plea for a laparoscopic approach
    Clara Galán, M. Pilar Hernández, M. Carmen Martínez, Anna Sánchez, Jesús Bollo, Eduardo Mª Targarona
    Surgical Endoscopy.2023; 37(12): 9080.     CrossRef
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  • Promoting Laparoscopic Anterior Approach for a Very Low Presacral Primary Neuroendocrine Tumor Arising in a Tailgut Cyst
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    Revista colombiana de Gastroenterología.2022; 37(3): 316.     CrossRef
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    Hajri Amal, Ahmed Elmi Abdirahim, Rachid Boufettal, Erguibi Driss, Saad Rifki El Jai, Farid Chehab
    European Journal of Medical and Health Sciences.2022; 4(5): 13.     CrossRef
  • Epidemiology, diagnostic approach and therapeutic management of tailgut cysts: A systematic review
    Aikaterini Mastoraki, Ilias Giannakodimos, Karmia Panagiotou, Maximos Frountzas, Dimosthenis Chrysikos, Stylianos Kykalos, Georgios E. Theodoropoulos, Dimitrios Schizas
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    Tamara Glyn, Peter Sagar, Frank Frizelle
    Colorectal Disease.2021; 23(11): 3027.     CrossRef
  • Multicenter Analysis of Presacral Neuroendocrine Neoplasms—Clinicopathological Characterization and Treatment Outcomes of a Rare Disease
    Sami Matrood, Leonidas Apostolidis, Jörg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kröcher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Surgical Management of Retrorectal Tumors
    Mathilde Aubert, Diane Mege, Yann Parc, Eric Rullier, Eddy Cotte, Guillaume Meurette, Philippe Zerbib, Bertrand Trilling, Bernard Lelong, Charles Sabbagh, Zaher Lakkis, Mehdi Ouaissi, Gil Lebreton, Philippe Rouanet, Gilles Manceau, Jean-Jacques Tuech, Gui
    Annals of Surgery.2021; 274(5): 766.     CrossRef
  • Isolated lumbar intradural tailgut cyst: A case report and review of the literature
    Antonio Colamaria, Matteo Sacco, Giovanni Parbonetti, Maria Blagia, Francesco Carbone, Matteo de Notaris
    Heliyon.2021; 7(10): e08223.     CrossRef
  • Prerectal tailgut cyst presenting with constipation and pseudo-rectal prolapse. A rare case presentation
    Allan Ngulube, Blessing Zambuko, Crispin O.M. Ntoto, Simbarashe Gift Mungazi, Derek Matsika
    Human Pathology Reports.2021; 26: 300557.     CrossRef
  • Anal Canal Duplication in an Adult Female—Case Report and Pathology Guiding
    Tudor Mateescu, Cristi Tarta, Paul Stanciu, Alis Dema, Fulger Lazar
    Medicina.2021; 57(11): 1205.     CrossRef
  • “The Innate Tail”: An Unusual Cause of Rectal Bleeding in an Adult Male
    Sujit Padmanabhan Nair, Sanjay Chandnani, Prasanta Debnath, Pravin M. Rathi, Parmeshwar Junare, Vinay Zanwar, Sangeeta Kini
    GE - Portuguese Journal of Gastroenterology.2021; 28(5): 349.     CrossRef
  • Robotic approach to large tailgut cyst with malignant transformation
    Alessandra Marano, Maria Carmela Giuffrida, Chiara Peluso, Valentina Testa, Paolo Bosio, Felice Borghi
    International Journal of Surgery Case Reports.2020; 77(D): S57.     CrossRef
  • Laparoscopic resection of a neuroendocrine tumor that almost fully replaced tailgut cysts: a case report
    Keita Kodera, Seiichiro Eto, Nei Fukasawa, Wataru Kai, Tomo Matsumoto, Tsuyoshi Hirabayashi, Hidejiro Kawahara, Nobuo Omura
    Surgical Case Reports.2020;[Epub]     CrossRef
  • Retrorectal tumors
    Giorgio La Greca, Giovanni Trombatore, Guido Basile, Pietro Conti
    International Journal of Surgery Case Reports.2020; 77(C): 726.     CrossRef
  • A Tailgut Cyst in the Ischiorectal Fossa—A Case Report—
    Ryo INADA, Eri KURODA, Ayako WATANABE, Toshiaki TOSHIMA, Kazuhide OZAKI, Yuichi SHIBUYA, Manabu MATSUMOTO, Jun IWATA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2020; 81(9): 1866.     CrossRef
  • Tailgut Cyst, Report of 24 Cases Single Center Experience
    Han Deok Kwak, Chang Hyun Kim
    Annals of Coloproctology.2019; 35(5): 227.     CrossRef
Case Report
A Granular Cell Tumor of the Rectum: A Case Report and Review of the Literature
Seung Yoon Yang, Byung Soh Min, Woo Ram Kim
Ann Coloproctol. 2017;33(6):245-248.   Published online December 31, 2017
DOI: https://doi.org/10.3393/ac.2017.33.6.245
  • 6,476 View
  • 69 Download
  • 7 Web of Science
  • 11 Citations
AbstractAbstract PDF

A granular cell tumor (GCT) is an uncommon mesenchymal lesion that rarely occurs in the colon and the rectum. We describe the case of 51-year-old man with a 2-cm-sized rectal GCT 10 cm above the anal verge that was incidentally detected after a screening colonoscopy. Preoperative radiologic studies demonstrated a suspicious submucosal rectal mass with mesorectal fat infiltration, but without circumferential resection margin threatening, extramural vessel invasion, and regional lymph-node enlargement. The tumor was resected by using a transanal endoscopic operation (TEO) without immediate postoperative complications. The final pathology revealed that the tumor consisted of a GCT that had invaded the subserosa with clear margins. It had no other risk factors for malignancy according to Fanburg-Smith criteria. We systematically reviewed the English literature by using PubMed and Google Scholar. This report may be the first documented case in the literature to describe a TEO for a GCT that had invaded the subserosa in the rectum.

Citations

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  • Granular Cell Tumor of the Anal Canal: Case Report and Literature Review
    Jorge Arche Prats, Diego García Prado, Gonzalo Campaña Villegas, Mónica Martínez Mardónez
    Journal of Coloproctology.2024; 44(04): e281.     CrossRef
  • Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection
    Michaelia S. Sunderland, Anthony Dakwar, Sowsan Rasheid
    The American Surgeon™.2023; 89(4): 1304.     CrossRef
  • Experience of surgical treatment in a granular cell tumor in the qscending colon: a case report
    In-Kyeong Kim, Young-Tae Ju, Han-Gil Kim, Jin-Kwon Lee, Dong-Chul Kim, Jae-Myung Kim, Jin Kyu Cho, Ji-Ho Park, Ju-Yeon Kim, Chi-Young Jeong, Soon-Chan Hong, Seung-Jin Kwag
    Annals of Coloproctology.2023; 39(3): 275.     CrossRef
  • Granular cell tumour. Case report.
    P. Leszczyńska, M. Sobocińska, K. Ustymowicz, W. Romańczyk
    Progress in Health Sciences.2023; 13(1): 107.     CrossRef
  • Granular cell tumor of the perineum (clinical case)
    R. R. Shakirov, O. Yu. Karpukhin, M. I. Ziganshin, I. S. Raginov
    Koloproktologia.2023; 22(4): 121.     CrossRef
  • A case report of rare granular cell tumor of the urinary bladder
    Saman Anwar Wahid, Han N. Mohammed Fadhl, Alaa Abbas Ali, Rebaz Karim Mohammed
    Urology Case Reports.2022; 42: 102034.     CrossRef
  • Granular cell tumor of the cecum
    Roberto Cantella, Giuseppe Evola, Carla Di Stefano, Ezio Trusso Zirna, Marianna Iudica, Luigi Piazza
    International Journal of Surgery Case Reports.2021; 87(C): 106397.     CrossRef
  • Granular Cell Tumor of the Perianal Region
    Marina Pérez-Flecha González, Enrique Revilla Sánchez, Carolina Ibarrola de Andrés, Ramón Gómez Sanz
    Journal of Gastrointestinal Surgery.2020; 24(4): 907.     CrossRef
  • A Rare Granular Cell Tumor with a Center Ulcer of the Rectum
    Jeonghun Lee, Younghye Kim
    Case Reports in Gastrointestinal Medicine.2020; 2020: 1.     CrossRef
  • Granular Cell Tumors of the Cecum: Report of Two Cases and Review of Literature
    Nam Yeol Cho, Yu-Ah Choi, Gye Sung Lee
    Keimyung Medical Journal.2020; 39(2): 86.     CrossRef
  • A rare case of tracheal granular cell tumor in a pediatric patient
    Bojiang Chen, Linrui Xu, Min Xie, Weimin Li, Fengming Luo
    Pediatric Pulmonology.2019; 54(8): 1101.     CrossRef
Original Articles
Single Center Experience With Hyperthermic Intraperitoneal Chemotherapy
Woo Ram Kim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2017;33(1):16-22.   Published online February 28, 2017
DOI: https://doi.org/10.3393/ac.2017.33.1.16
  • 5,882 View
  • 76 Download
  • 6 Web of Science
  • 4 Citations
AbstractAbstract PDF
Purpose

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been proposed for controlling peritoneal seeding metastasis in some kinds of cancers, including those of colorectal origin, but their safety and oncological benefits are subjects of debate. We present our early experience with those procedures.

Methods

Data were retrospectively collected from all patients with peritoneal carcinomatosis (PC) and pseudomyxoma peritonei (PMP) treated using CRS and HIPEC at Yonsei Cancer Center between July 2014 and July 2015. Short-term outcomes and risk factors for postoperative complications were analyzed.

Results

Twenty-three patients with PC (n = 18) and PMP (n = 5) underwent CRS and HIPEC. Median follow-up and age were 2 months and 54 years, respectively. The median peritoneal carcinomatosis index score was 15, and CC0-1 was achieved in 78.3% of all patients. The median operation time and bleeding loss were 590 minutes and 570 mL, respectively. Grade-IIIa/grade-IIIb complications occurred in 4.3% (n = 1)/26.1% (n = 6) of the patients within 30 days postoperatively, and no 30-day mortalities were reported. Factors related to postoperative complications with CRS and HIPEC were number of organ resection (P = 0.013), longer operation time (P < 0.001), and amount of blood loss (P = 0.003). All patients treated with cetuximab for recurred colorectal cancer had grade-III postoperative complication.

Conclusion

Our initial experience with CRS and HIPEC presented about 30% grade-III postoperative complications. Therefore, expert surgeons need to perform those procedures with great caution in selected patients who might benefit from it.

Citations

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  • Multisocietal Consensus on the Use of Cytoreductive Surgery and HIPEC for the Treatment of Diffuse Malignant Peritoneal Mesothelioma: A GRADE Approach for Evidence Evaluation and Recommendation
    Shigeki Kusamura, Michela Cinquini, David Morris, Pompiliu Piso, Hedy Kindler, Andreas Brandl, Edward Levine, Olivier Glehen, Vahan Kepenekian, Olivia Sgarbura, Paul H. Sugarbaker, Dario Baratti, Guaglio Marcello, Deraco Marcello
    Journal of Surgical Oncology.2025; 131(5): 810.     CrossRef
  • Pharmacologic Effects of Oxaliplatin Instability in Chloride-Containing Carrier Fluids on the Hyperthermic Intraperitoneal Chemotherapy to Treat Colorectal Cancer In Vitro and In Vivo
    Eun Jung Park, Junhyun Ahn, Sharif Md Abuzar, Kyung Su Park, Sung-Joo Hwang, Seung Hyuk Baik
    Annals of Surgical Oncology.2022; 29(13): 8583.     CrossRef
  • Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
    Young Jin Kim, Chang Hyun Kim
    Annals of Coloproctology.2021; 37(6): 425.     CrossRef
  • Is Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy a Safe and Effective Procedure for Treating Patients With a Peritoneal Surface Malignancy?
    Dong-Guk Park
    Annals of Coloproctology.2017; 33(1): 3.     CrossRef
Prognostic Impact of Immunonutritional Status Changes During Preoperative Chemoradiation in Patients With Rectal Cancer
Yong Joon Lee, Woo Ram Kim, Jeonghee Han, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
Ann Coloproctol. 2016;32(6):208-214.   Published online December 31, 2016
DOI: https://doi.org/10.3393/ac.2016.32.6.208
  • 6,036 View
  • 57 Download
  • 19 Web of Science
  • 16 Citations
AbstractAbstract PDF
Purpose

Previous studies have demonstrated the prognostic impact of the prognostic nutritional index (PNI), a proposed indicator of immunonutritional statuses of surgical patients, on patients with various gastrointestinal cancers. Although the prognostic impact of the PNI on patients with colorectal cancer has been well established, its value has not been studied in patients treated with preoperative chemoradiation (pCRT). This study aimed to evaluate the prognostic impact of PNI on patients receiving pCRT for locally advanced rectal cancer (LARC).

Methods

Patients with LARC who underwent curative pCRT followed by surgical resection were enrolled. The PNI was measured in all patients before and after pCRT, and the difference in values was calculated as the PNI difference (dPNI). Patients were classified according to dPNI (<5, 5–10, and >10). Clinicopathologic parameters and long-term oncologic outcomes were assessed according to dPNI classification.

Results

No significant intergroup differences were observed in clinicopathologic parameters such as age, histologic grade, tumor location, tumor-node-metastasis stage, and postoperative complications. Approximately 53% of the patients had a mild dPNI (<5); only 15% had a high dPNI (>10). Univariate and multivariate analyses identified the dPNI as an independent prognostic factor for disease-free status (P < 0.01; hazard ratio [HR], 2.792; 95% confidence interval [CI], 1.577–4.942) and for cancer-specific survival (P = 0.012; HR, 2.469; 95%CI, 1.225–4.978).

Conclusion

The dPNI is predictive of long-term outcomes in pCRT-treated patients with LARC. Further prospective studies should investigate whether immune-nutritional status correction during pCRT would improve oncologic outcomes.

Citations

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  • Multidisciplinary Preoperative Immunonutrition Initiative in Colon and Rectal Surgery
    Christopher Zammitti, Olajumoke Megafu, Samantha Lee, QuynhAnh Phan, Karim Alavi, Paul Sturrock, Justin Maykel, Tess Aulet
    Journal of Surgical Research.2025; 316: 254.     CrossRef
  • Novel Index Based on Inflammatory Markers Correlates with Treatment Efficacy of Nivolumab for Recurrent/Metastatic Head and Neck Cancer
    Hiroe Tada, Reika Kawabata-Iwakawa, Hideyuki Takahashi, Kazuaki Chikamatsu
    Oncology.2024; 103(8): 714.     CrossRef
  • Preoperative albumin-to-globulin ratio and prognostic nutritional index predict the prognosis of colorectal cancer: a retrospective study
    JunHu Li, Na Zhu, Cheng Wang, LiuPing You, WenLong Guo, ZhiHan Yuan, Shuai Qi, HanZheng Zhao, JiaYong Yu, YueNan Huang
    Scientific Reports.2023;[Epub]     CrossRef
  • The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
    Atsushi Shimada, Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri, Yoshihiro Kakeji
    Scientific Reports.2023;[Epub]     CrossRef
  • Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery
    Ali Guner, Minah Cho, Yoo-Min Kim, Jae-Ho Cheong, Woo Jin Hyung, Hyoung-Il Kim
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Pelvimetric and Nutritional Factors Predicting Surgical Difficulty in Laparoscopic Resection for Rectal Cancer Following Preoperative Chemoradiotherapy
    Yanwu Sun, Jianhua Chen, Chengwei Ye, Huiming Lin, Xingrong Lu, Ying Huang, Pan Chi
    World Journal of Surgery.2021; 45(7): 2261.     CrossRef
  • Inflammation‐nutritional markers of peripheral blood could predict survival in advanced non‐small‐cell lung cancer patients treated with PD‐1 inhibitors
    Dan Pu, Qian Xu, Lai‐Yan Zhou, Yu‐Wen Zhou, Ji‐Yan Liu, Xue‐Lei Ma
    Thoracic Cancer.2021; 12(21): 2914.     CrossRef
  • Preoperative change of modified Glasgow prognostic score after stenting predicts the long-term outcomes of obstructive colorectal cancer
    Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Takaho Okada, Tomoya Abe, Takashi Yazawa, Haruyuki Tsuchiya, Naoya Akazawa, Masaki Sato, Tetsuya Ohira, Yoshihiro Harada, Haruka Okano, Kei Ito, Noriaki Ohuchi, Takashi Tsuchiya
    Surgery Today.2020; 50(3): 232.     CrossRef
  • Prognostic impact of preoperative immunonutritional status in rectal mucinous adenocarcinoma
    Yanwu Sun, Zhekun Huang, Huiming Lin, Pan Chi
    Future Oncology.2020; 16(8): 339.     CrossRef
  • Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy


    Yurday Ozdemir, Erkan Topkan, Huseyin Mertsoylu, Ugur Selek
    Cancer Management and Research.2020; Volume 12: 1959.     CrossRef
  • Peripheral blood markers predictive of outcome and immune-related adverse events in advanced non-small cell lung cancer treated with PD-1 inhibitors
    Lihong Peng, Yong Wang, Fen Liu, Xiaotong Qiu, Xinwei Zhang, Chen Fang, Xiaoyin Qian, Yong Li
    Cancer Immunology, Immunotherapy.2020; 69(9): 1813.     CrossRef
  • The prognostic value of the prognostic nutritional index and inflammation-based markers in obstructive colorectal cancer
    Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Takaho Okada, Tomoya Abe, Takashi Yazawa, Haruyuki Tsuchiya, Naoya Akazawa, Masaki Sato, Tetsuya Ohira, Yoshihiro Harada, Haruka Okano, Kei Ito, Takashi Tsuchiya
    Surgery Today.2020; 50(10): 1272.     CrossRef
  • Preoperative Fibrinogen-Albumin Ratio Index (FARI) is a Reliable Prognosis and Chemoradiotherapy Sensitivity Predictor in Locally Advanced Rectal Cancer Patients Undergoing Radical Surgery Following Neoadjuvant Chemoradiotherapy


    Siyi Lu, Zhenzhen Liu, Xin Zhou, Bingyan Wang, Fei Li, Yanpeng Ma, Wendong Wang, Junren Ma, Yuxia Wang, Hao Wang, Wei Fu
    Cancer Management and Research.2020; Volume 12: 8555.     CrossRef
  • Immunonutritional status and pulmonary cavitation in patients with tuberculosis: A revisit with an assessment of neutrophil/lymphocyte ratio
    Makoto Nakao, Hideki Muramatsu, Sosuke Arakawa, Yusuke Sakai, Yuto Suzuki, Kohei Fujita, Hidefumi Sato
    Respiratory Investigation.2019; 57(1): 60.     CrossRef
  • Temporal changes in immune cell composition and cytokines in response to chemoradiation in rectal cancer
    Yong Joon Lee, Sat Byol Lee, Suk Kyung Beak, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
    Scientific Reports.2018;[Epub]     CrossRef
  • Impairment of Immunonutritional Status During Treatment is a Factor Associated With Oncologic Outcomes in Patients With Rectal Cancer Treated With Preoperative Chemoradiotherapy
    In Ja Park
    Annals of Coloproctology.2016; 32(6): 201.     CrossRef
Editorial
Intestinal Perforation: A Surgeon's Nightmare Enlightened by Scientific Research
Byung Soh Min
Ann Coloproctol. 2016;32(6):205-205.   Published online December 31, 2016
DOI: https://doi.org/10.3393/ac.2016.32.6.205
  • 4,029 View
  • 43 Download
  • 1 Citations
PDF

Citations

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  • Comparison of a Subtotal Colectomy With Self-Expandable Metallic Stent in the Management of Patients With Obstructive Left Colon Cancer
    Byung Chun Kim
    Annals of Coloproctology.2016; 32(6): 203.     CrossRef
Case Report
Efficacy of Immunohistochemical Staining in Differentiating a Squamous Cell Carcinoma in Poorly Differentiated Rectal Cancer: Two Case Reports
Sairafi Rami, Yoon Dae Han, Mi Jang, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Ann Coloproctol. 2016;32(4):150-155.   Published online August 31, 2016
DOI: https://doi.org/10.3393/ac.2016.32.4.150
  • 7,561 View
  • 37 Download
  • 1 Web of Science
  • 1 Citations
AbstractAbstract PDF

A rectal carcinoma, including primary an adenosquamous and a squamous cell carcinoma (SCC), is a very rare disease, accounting for 0.025% to 0.20% of all large-bowel malignant tumors. Because SCCs have a higher mortality than adenosquamous carcinomas, determining whether the primary rectal cancer exhibits an adenomatous component or a squamous component is important. While differentiating between these 2 components, especially in poorly differentiated rectal cancer, is difficult, specific immunohistochemical stains enable accurate diagnoses. Here, we report the use of immunohistochemical stains to distinguish between the adenomatous and the squamous components in 2 patients with low rectal cancer, a 58-year-old man and a 73-year-old woman, who were initially diagnosed using the histopathologic results for a poorly differentiated carcinoma. These data suggest that using these immunohistochemical stains will help to accurately diagnose the type of rectal cancer, especially for poorly differentiated carcinomas, and will provide important information to determine the proper treatment for the patient.

Citations

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  • Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review
    Elena Popa, Vanesa Tomatis, Esther Quick, Paul Mitchell, Chrisovalantis Tsimiklis, Annika Mascarenhas
    Oncology Letters.2025; 30(1): 1.     CrossRef
Original Article
Short-term Outcomes of an Extralevator Abdominoperineal Resection in the Prone Position Compared With a Conventional Abdominoperineal Resection for Advanced Low Rectal Cancer: The Early Experience at a Single Institution
Seungwan Park, Hyuk Hur, Byung Soh Min, Nam Kyu Kim
Ann Coloproctol. 2016;32(1):12-19.   Published online February 29, 2016
DOI: https://doi.org/10.3393/ac.2016.32.1.12
  • 7,345 View
  • 46 Download
  • 11 Web of Science
  • 10 Citations
AbstractAbstract PDF
Purpose

This study compared the perioperative and pathologic outcomes between an extralevator abdominoperineal resection (APR) in the prone position and a conventional APR.

Methods

Between September 2011 and March 2014, an extralevator APR in the prone position was performed on 13 patients with rectal cancer and a conventional APR on 26 such patients. Patients' demographics and perioperative and pathologic outcomes were obtained from the colorectal cancer database and electronic medical charts.

Results

Age and preoperative carcinoembryonic antigen (CEA) level were significantly different between the conventional and the extralevator APR in the prone position (median age, 65 years vs. 55 years [P = 0.001]; median preoperative CEA level, 4.94 ng/mL vs. 1.81 ng/mL [P = 0.011]). For perioperative outcomes, 1 (3.8%) intraoperative bowel perforation occurred in the conventional APR group and 2 (15.3%) in the extralevator APR group. In the conventional and extralevator APR groups, 12 (46.2%) and 6 patients (46.2%) had postoperative complications, and 8 (66.7%) and 2 patients (33.4%) had major complications (Clavien-Dindo III/IV), respectively. The circumferential resection margin involvement rate was higher in the extralevator APR group compared with the conventional APR group (3 of 13 [23.1%] vs. 3 of 26 [11.5%]).

Conclusion

The extralevator APR in the prone position for patients with advanced low rectal cancer has no advantages in perioperative and pathologic outcomes over a conventional APR for such patients. However, through early experience with a new surgical technique, we identified various reasons for the lack of favorable outcomes and expect sufficient experience to produce better peri- or postoperative outcomes.

Citations

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  • Abdominoperineal Resection in Prone Versus Supine Position: A Systematic Review and Meta-Analysis
    Bernardo Fontel Pompeu, Eric Pasqualotto, Beatriz D'Andrea Pigossi, Matheus Reginato Araujo, Lucas Monteiro Delgado, Lucas Soares de Souza Pinto Guedes, Sergio Mazzola Poli de Figueiredo, Fernanda Bellotti Formiga
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2025; 35(3): 224.     CrossRef
  • Management of left-sided malignant colorectal obstructions with curative intent: a network meta-analysis
    Tyler McKechnie, Jeremy E. Springer, Zacharie Cloutier, Victoria Archer, Karim Alavi, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu
    Surgical Endoscopy.2023; 37(6): 4159.     CrossRef
  • Prone Versus Supine Position in Abdominoperineal Resection: Outcomes in the Laparoscopic Era
    Cecilia Ferrari, Carmen Martinez Sanchez, Jesus Bollo, Pilar Hernandez, Lorena Cambeiro, Claudia Codina, Eduardo Targarona
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(4): 382.     CrossRef
  • Surgical Treatment of Low-Lying Rectal Cancer: Updates
    Cristopher Varela, Nam Kyu Kim
    Annals of Coloproctology.2021; 37(6): 395.     CrossRef
  • Perioperative and oncological outcomes of abdominoperineal resection in the prone position vs the classic lithotomy position: A systematic review with meta‐analysis
    Jose Wilson B. Mesquita‐Neto, Hassan Mouzaihem, Francisco Igor B. Macedo, Lance K. Heilbrun, Donald W. Weaver, Steve Kim
    Journal of Surgical Oncology.2019; 119(7): 979.     CrossRef
  • Prone Compared With Lithotomy for Abdominoperineal Resection: A Systematic Review and Meta-analysis
    Tyler McKechnie, Yung Lee, Jeremy E. Springer, Aristithes G. Doumouras, Dennis Hong, Cagla Eskicioglu
    Journal of Surgical Research.2019; 243: 469.     CrossRef
  • Perineal Wound Complications After Extralevator Abdominoperineal Excision for Low Rectal Cancer
    Jia Gang Han, Zhen Jun Wang, Zhi Gang Gao, Guang Hui Wei, Yong Yang, Zhi Wei Zhai, Bao Cheng Zhao, Bing Qiang Yi
    Diseases of the Colon & Rectum.2019; 62(12): 1477.     CrossRef
  • Critical and Challenging Issues in the Surgical Management of Low-Lying Rectal Cancer
    Aeris Jane D. Nacion, Youn Young Park, Seung Yoon Yang, Nam Kyu Kim
    Yonsei Medical Journal.2018; 59(6): 703.     CrossRef
  • EXTRALEVATOR ABDOMINOPERINEAL EXCISION OF THE RECTUM: SHORT-TERM OUTCOMES IN COMPARISON WITH CONVENTIONAL SURGERY
    R. A. Murashko, I. B. Uvarov, E. A. Ermakov, V. B. Kaushanskiy, R. V. Konkov, D. D. Sichinava, B. N. Sadikov
    Koloproktologia.2017; (4): 34.     CrossRef
  • Extralevator Abdominoperineal Resection in the Prone Position
    Young Jin Kim
    Annals of Coloproctology.2016; 32(1): 1.     CrossRef
Case Report
Colon Stricture After Ischemia Following a Robot-Assisted Ultra-Low Anterior Resection With Coloanal Anastomosis
Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim
Ann Coloproctol. 2015;31(4):157-162.   Published online August 31, 2015
DOI: https://doi.org/10.3393/ac.2015.31.4.157
  • 7,397 View
  • 52 Download
  • 6 Web of Science
  • 9 Citations
AbstractAbstract PDF

Four consecutive cases of a colonic stricture following a da Vinci robot-assisted ultra-low anterior resection (LAR) with coloanal anastomosis and diverting ileostomy for the treatment of rectal cancer are reported. The colonic strictures developed after early proximal colonic ischemia without anastomotic site leakage or disruption. All patients were treated with preoperative chemoradiation therapy. During the postoperative recovery period, patients developed colonic ischemia, presenting with a high, spiking fever, but without any symptoms of peritonitis. Patients were treated with conservative management (antibiotic therapy) and discharged after two weeks when in good condition. Several months after discharge, all four patients developed a long-segment colonic stricture from the anastomosis site to the distal colon. Management of the colon strictures, including the anastomotic site, involved colonic dilation with a Hegar dilator in an outpatient clinic for several months. The ileostomies in three patients could not be closed.

Citations

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  • Laparoscopic Abdominoperineal Resection for Ischemic Colitis after Laparoscopic Partial Resection of the Descending Colon: Case Report
    Mitsuki Yokota, Hidekazu Takahashi, Asako Mike, Kei Fukumori, Yuka Iwami, Juavijitjan Watsapol, Satoshi Ishikawa, Shohei Takaichi, Masakatsu Paku, Kazuya Iwamoto, Tomofumi Ohashi, Yujiro Nakahara, Kohei Murakami, Tadafumi Asaoka, Ichiro Takemasa, Takeshi
    Surgical Case Reports.2026; 12(1): n/a.     CrossRef
  • Pathophysiology of anastomotic stricture following rectal anastomosis: Insights into mechanisms, risk factors, and preventive strategies
    Ahmet Yavuz, Hikmet Pehlevan-Özel, Mesut Tez
    World Journal of Gastrointestinal Pathophysiology.2025;[Epub]     CrossRef
  • Comment on “Risk Factors for Benign Anastomotic Stenosis After Esophagectomy for Cancer”
    Rachana Mehta, Ranjana Sah
    Annals of Surgical Oncology.2025; 32(12): 9306.     CrossRef
  • Magnetic resonance imaging in the diagnosis of necrosis of a pulled-through colon segment after abdomino-anal resection of the rectum for cancer
    Sofiya A. Myalina, Ksenia I. Paziuk, Tatiana P. Berezovskaya, Alexey A. Nevolskikh, Aleksandr L. Potapov, Sergey A. Ivanov
    Digital Diagnostics.2023; 4(1): 61.     CrossRef
  • Prolonged ischemia of the ileum and colon after surgical mucosectomy explains contraction and failure of “mucus free” bladder augmentation
    Dániel Urbán, Gabriella Varga, Dániel Érces, Mahmoud Marei Marei, Raimondo Cervellione, David Keene, Anju Goyal, Tamás Cserni
    Journal of Pediatric Urology.2022; 18(4): 500.e1.     CrossRef
  • Robotic Intersphincteric Resection for Low Rectal Cancer: Technical Controversies and a Systematic Review on the Perioperative, Oncological, and Functional Outcomes
    Guglielmo Niccolò Piozzi, Seon Hahn Kim
    Annals of Coloproctology.2021; 37(6): 351.     CrossRef
  • Surgical specimen extraction via a prophylactic ileostomy procedure: A minimally invasive technique for laparoscopic rectal cancer surgery
    Peng Wang, Jian-Wei Liang, Hai-Tao Zhou, Zheng Wang, Zhi-Xiang Zhou
    World Journal of Gastroenterology.2018; 24(1): 104.     CrossRef
  • Risk factors including the presence of inflammation at the resection margins for colorectal anastomotic stenosis following surgery for diverticular disease
    A. Bressan, L. Marini, M. Michelotto, A. C. Frigo, G. Da Dalt, S. Merigliano, L. Polese
    Colorectal Disease.2018; 20(10): 923.     CrossRef
  • Vascular anatomy of inferior mesenteric artery in laparoscopic radical resection with the preservation of left colic artery for rectal cancer
    Ke-Xin Wang, Zhi-Qiang Cheng, Zhi Liu, Xiao-Yang Wang, Dong-Song Bi
    World Journal of Gastroenterology.2018; 24(32): 3671.     CrossRef
Original Article
Reduced-Port Laparoscopic Surgery for a Tumor-Specific Mesorectal Excision in Patients With Colorectal Cancer: Initial Experience With 20 Consecutive Cases
Sung Uk Bae, Se Jin Baek, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim, Hyuk Hur
Ann Coloproctol. 2015;31(1):16-22.   Published online February 28, 2015
DOI: https://doi.org/10.3393/ac.2015.31.1.16
  • 8,835 View
  • 36 Download
  • 30 Web of Science
  • 26 Citations
AbstractAbstract PDF
Purpose

Single-port plus one-port, reduced-port laparoscopic surgery (RPLS) may decrease collisions between laparoscopic instruments and the camera in a narrow, bony, pelvic cavity while maintaining the cosmetic advantages of single-incision laparoscopic surgery. The aim of this study is to describe our initial experience with and to assess the feasibility and safety of RPLS for tumor-specific mesorectal excisions (TSMEs) in patients with colorectal cancer.

Methods

Between May 2010 and August 2012, RPLS for TSME was performed in 20 patients with colorectal cancer. A single port with four channels through an umbilical incision and an additional port in the right lower quadrant were used for RPLS.

Results

The median operation time was 231 minutes (range, 160-347 minutes), and the estimated blood loss was 100 mL (range, 50-500 mL). We transected the rectum with one laparoscopic stapler in 17 cases (85%). The median time to soft diet was 4 days (range, 3-6 days), and the length of hospital stay was 7 days (range, 5-45 days). The median total number of lymph nodes harvested was 16 (range, 7-36), and circumferential resection margin involvement was found in 1 case (5%). Seven patients (35%) developed postoperative complications, and no mortalities occurred within 30 days. During the median follow-up period of 20 months (range, 12-40 months), liver metastasis occurred in 1 patient 10 months after surgery, and local recurrence was nonexistent.

Conclusion

RPLS for TSME in patients with colorectal cancer is technically feasible and safe without compromising oncologic safety. However, further studies comparing RPLS with a conventional, laparoscopic low-anterior resection are needed to prove the advantages of the RPLS procedure.

Citations

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Case Report
Perianal Paget's Disease
Chang Woo Kim, Yon Hee Kim, Min Soo Cho, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim
Ann Coloproctol. 2014;30(5):241-244.   Published online October 28, 2014
DOI: https://doi.org/10.3393/ac.2014.30.5.241
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AbstractAbstract PDF

The incidence of extramammary Paget's disease (EMPD) is very low. An 84-year-old Korean man was treated with topical and oral medications at a local dermatologic clinic for a year, but the symptoms did not improve. He visited Severance Hospital and underwent a perianal skin biopsy and was finally diagnosed with EMPD. The authors performed a wide local excision according to a 1-cm margin around the lesion. For the skin and the soft tissue defects, bilateral inferior gluteal artery perforator flap transpositions were performed. The size of the lesion was 14 cm2 × 9 cm2, and the lateral and the basal margins were all disease free.

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Original Articles
Safety and Feasibility of a Laparoscopic Colorectal Cancer Resection in Elderly Patients
Duck Hyoun Jeong, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim
Ann Coloproctol. 2013;29(1):22-27.   Published online February 28, 2013
DOI: https://doi.org/10.3393/ac.2013.29.1.22
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  • 21 Citations
AbstractAbstract PDF
Purpose

The aim of this study is to assess the effects of age on the short-term outcomes of a laparoscopic resection of colorectal cancer in elderly (≥75 years old), as compared with younger (<75 years old), patients.

Methods

A retrospective analysis of patients who underwent laparoscopic surgery for colorectal cancer between January 2007 and December 2009 was performed. There were two groups: age <75 years old (group A) and age ≥75 years old (group B). The perioperative outcomes between group A and group B were compared.

Results

The study included 824 patients in group A and 92 patients in group B. The body mass index (BMI) and the American Society of Anesthesiologists (ASA) score were significantly different between group B and group A (BMI: 22.5 vs. 23.5, P = 0.002; ASA score: 1.88 vs. 1.48, P = 0.001). Mean operating times were similar between the groups (325.4 minutes vs. 351.6 minutes, P = 0.07). We observed a higher overall complication rate in group B than in group A (12.0% vs. 6.2%, P = 0.047), but the number of severe complications of Accordion Severity Classification ≥3 (those that required an invasive procedure) was not significantly different between the two groups (6.5% vs. 3.4%, P = 0.142). There was no significant difference in the length of hospital stay (13.0 days vs. 12.0 days, P = 0.053).

Conclusion

Although the elderly patients had a significantly higher overall postoperative complication rate, no significant difference was seen in either the number of severe complications of Accordion Severity Classification ≥3 or in the length of hospital stay. A laparoscopic colorectal cancer resection in elderly patients, especially those aged 75 years or older, is safe and feasible.

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Oncologic Outcomes of a Laparoscopic Right Hemicolectomy for Colon Cancer: Results of a 3-Year Follow-up
Jung Hoon Cho, Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
J Korean Soc Coloproctol. 2012;28(1):42-48.   Published online February 29, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.1.42
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AbstractAbstract PDF
Purpose

The purpose of the study is to evaluate the oncologic outcomes of a laparoscopic-assisted right hemicolectomy for the treatment of colon cancer and compare the results with those of previous randomized trials.

Methods

From June 2006, to December 2008, 156 consecutive patients who underwent a laparoscopic right hemicolectomy with a curative intent for colon cancer were evaluated. The clinicopatholgic outcomes and the oncologic outcomes were evaluated retrospectively by using electronic medical records.

Results

There were 84 male patients and 72 female patients. The mean possible length of stay was 7.0 ± 1.5 days (range, 4 to 12 days). The conversion rate was 3.2%. The total number of complications was 30 (19.2%). Anastomotic leakage was not noted. There was no mortality within 30 days. The 3-year overall survival rate of all stages was 93.3%. The 3-year overall survival rates according to stages were 100% in stage I, 97.3% in stage II, and 84.8% in stage III. The 3-year disease-free survival rate of all stages was 86.1%. The 3-year disease-free survival rates according to stage were 96.2% in stage I, 90.3% in stage II, and 75.6% in stage III. The mean follow-up period was 36.3 (3 to 60) months.

Conclusion

A laparoscopic right hemicolectomy for the treatment of colon cancer is technically feasible and safe to perform in terms of oncologic outcomes. The present data support previously reported randomized trials.

Citations

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  • Short-term outcomes and the learning curve for laparoscopic right hemicolectomy using the ArtiSential: a multicenter pooled analysis
    Seijong Kim, Jaeim Lee, Heung-Kwon Oh, Dae Hee Pyo, Yoon Suk Lee, Yong Sik Yoon, Dong Hwan Bae, Byung Soh Min, Chang Hyun Kim, Jung Wook Huh
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    Seung Yoon Yang, Youn Young Park, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
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Case Report
Efficacy of Imatinib Mesylate Neoadjuvant Treatment for a Locally Advanced Rectal Gastrointestinal Stromal Tumor
Kyu Jong Yoon, Nam Kyu Kim, Kang Young Lee, Byung Soh Min, Hyuk Hur, Jeonghyun Kang, Sarah Lee
J Korean Soc Coloproctol. 2011;27(3):147-152.   Published online June 30, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.3.147
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  • 10 Citations
AbstractAbstract PDF

Surgery is the standard treatment for a primary gastrointestinal stromal tumor (GIST); however, surgical resection is often not curative, particularly for large GISTs. In the past decade, with imatinib mesylate (IM), management strategies for GISTs have evolved significantly, and now IM is the standard care for patients with locally advanced, recurrent or metastatic GISTs. Adjuvant therapy with imatinib was recently approved for use, and preoperative imatinib is an emerging treatment option for patients who require cytoreductive therapy. IM neoadjuvant therapy for primary GISTs has been reported, but there is no consensus on the dose of the drug, the duration of treatment and the optimal time of surgery. These are critical because drug resistance or tumor progression can develop with a prolonged treatment. This report describes two cases of large rectal malignant GISTs, for which a abdominoperineal resection was initially anticipated. The two patients received IM preoperative treatment; we followed-up with CT or magnetic resonance imaging to access the response. After 9 months of treatment, a multi-disciplinary consensus that maximal benefit from imatinib had been achieved was reached. We determined the best time for surgical intervention and successfully performed sphincter-preserving surgery before resistance to imatinib or tumor progression occurred. We believe that a multidisciplinary team approach, considerating the optimal duration of therapy and the timing of surgery, is required to optimize treatment outcome.

Citations

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Original Article
Clinical Impact of Tumor Regression Grade after Preoperative Chemoradiation for Locally Advanced Rectal Cancer: Subset Analyses in Lymph Node Negative Patients
Byung Soh Min, Nam Kyu Kim, Ju Yeon Pyo, Hoguen Kim, Jinsil Seong, Ki Chang Keum, Seung Kook Sohn, Chang Hwan Cho
J Korean Soc Coloproctol. 2011;27(1):31-40.   Published online February 28, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.1.31
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AbstractAbstract PDF
Background

We investigated the prognostic significance of tumor regression grade (TRG) after preoperative chemoradiation therapy (preop-CRT) for locally advanced rectal cancer especially in the patients without lymph node metastasis.

Methods

One-hundred seventy-eight patients who had cT3/4 tumors were given 5,040 cGy preoperative radiation with 5-fluorouracil/leucovorin chemotherapy. A total mesorectal excision was performed 4-6 weeks after preop-CRT. TRG was defined as follows: grade 1 as no cancer cells remaining; grade 2 as cancer cells outgrown by fibrosis; grade 3 as a minimal presence or absence of regression. The prognostic significance of TRG in comparison with histopathologic staging was analyzed.

Results

Seventeen patients (9.6%) showed TRG1. TRG was found to be significantly associated with cancer-specific survival (CSS; P = 0.001) and local recurrence (P = 0.039) in the univariate study, but not in the multivariate analysis. The ypN stage was the strongest prognostic factor in the multivariate analysis. Subgroup analysis revealed TRG to be an independent prognostic factor for the CSS of ypN0 patients (P = 0.031). TRG had a stronger impact on the CSS of ypN (-) patients (P = 0.002) than on that of ypN (+) patients (P = 0.521). In ypT2N0 and ypT3N0, CSS was better for TRG2 than for TRG3 (P = 0.041, P = 0.048), and in ypN (-) and TRG2 tumors, CSS was better for ypT1-2 than for ypT3-4 (P = 0.034).

Conclusion

TRG was found to be the strongest prognostic factor in patients without lymph node metastasis (ypN0), and different survival was observed according to TRG among patients with a specific histopathologic stage. Thus, TRG may provide an accurate prediction of prognosis and may be used for f tailoring treatment for patients without lymph node metastasis.

Citations

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