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Original Article
Anorectal physioloy
Risk factors associated with low anterior resection syndrome: a cross-sectional study
See Liang Lim, Wan Zainira Wan Zain, Zalina Zahari, Andee Dzulkarnaen Zakaria, Mohd Nizam Md Hashim, Michael Pak-Kai Wong, Zaidi Zakaria, Rosnelifaizur Ramely, Ahmad Shanwani Mohamed Sidek
Ann Coloproctol. 2023;39(5):427-434.   Published online June 3, 2022
DOI: https://doi.org/10.3393/ac.2022.00227.0032
  • 10,229 View
  • 212 Download
  • 10 Web of Science
  • 8 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
Purpose
Oncological outcomes following rectal cancer surgery have improved significantly over recent decades with lower recurrences and longer overall survival. However, many of the patients experienced low anterior resection syndrome (LARS). This study identified the prevalence and risk factors associated with the development of LARS.
Methods
This cross-sectional study involved patients who were diagnosed with rectal cancer and had undergone sphincter-preserving low anterior resection from January 2011 to December 2020. Upon clinic follow-up, patients were asked to complete an interviewed based questionnaire (LARS score) designed to assess bowel dysfunction after rectal cancer surgery.
Results
Out of 76 patients, 25 patients (32.9%) had major LARS, 10 patients (13.2%) had minor LARS, and 41 patients (53.9%) had no LARS. The height of tumor from anal verge showed an association with the development of major LARS (P=0.039). Those patients with less than 8 cm tumor from anal verge had an increased risk of LARS by 3 times compared to those with 8 cm and above (adjusted odds ratio, 3.11; 95% confidence interval, 1.06–9.13).
Conclusion
Results from our study show that low tumor height was a significant risk factor that has a negative impact on bowel function after surgery. The high prevalence of LARS emphasizes the need for study regarding risk factors and the importance of understanding the pathophysiology of LARS, in order for us to improve patient bowel function and quality of life after rectal cancer surgery.

Citations

Citations to this article as recorded by  
  • Score assessment and treatment in patients presenting with low anterior resection syndrome after sphincter-sparing rectal cancer surgery
    R. Sguinzi, J. Fiechter, L. Bafumi, B. Gremaud, B. Geng, P. Janiak, L. Bühler, B. Egger
    International Journal of Colorectal Disease.2025;[Epub]     CrossRef
  • A randomized controlled trial of a digital lifestyle intervention involving postoperative patients with colorectal cancer
    Young Il Kim, In Ja Park, Jun-Soo Ro, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Yura Lee, Yae Won Tak, Seockhoon Chung, Kyung Won Kim, Yousun Ko, Sung-Cheol Yun, Min-Woo Jo, Jong Won Lee
    npj Digital Medicine.2025;[Epub]     CrossRef
  • Impact of low anterior resection syndrome after rectal surgery on sleep quality
    Akira Toyoshima, Toshihiro Nishizawa, Osamu Toyoshima, Ryuji Akai, Manabu Kaneko, Shin Sasaki
    Surgery Today.2025; 55(12): 1868.     CrossRef
  • Evaluation of the utility of a nomogram for predicting lymph node metastasis in T1 colorectal cancer in shared decision-making in clinical practice: a survey-based study
    Hyeon Seung Kim, Kyung Su Han, Min Wan Lee, Dae Kyung Sohn, Chang Won Hong, Dong Woon Lee, Kiho You, Sung Chan Park, Byung Chang Kim, Bun Kim, Jae Hwan Oh
    Annals of Coloproctology.2025; 41(4): 303.     CrossRef
  • Comparative analysis of organ preservation attempt and radical surgery in clinical T2N0 mid to low rectal cancer
    Hyeung-min Park, Jaram Lee, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
    International Journal of Colorectal Disease.2024;[Epub]     CrossRef
  • Beyond survival: a comprehensive review of quality of life in rectal cancer patients
    Won Beom Jung
    Annals of Coloproctology.2024; 40(6): 527.     CrossRef
  • Organ preservation for early rectal cancer using preoperative chemoradiotherapy
    Gyung Mo Son
    Annals of Coloproctology.2023; 39(3): 191.     CrossRef
  • Low anterior resection syndrome: is it predictable?
    Dong Hyun Kang
    Annals of Coloproctology.2023; 39(5): 373.     CrossRef
Case Report
Multiple gastrointestinal melanoma causing small bowel intussusception
Jian Yang Eng, Salehah Tahkin, Huzairi Yaacob, Nor Hayati Yunus, Ahmad Shan Wani Mohamed Sidek, Michael Pak-Kai Wong
Ann Coloproctol. 2023;39(1):85-88.   Published online July 21, 2021
DOI: https://doi.org/10.3393/ac.2021.00143.0020
  • 6,077 View
  • 147 Download
  • 2 Web of Science
  • 3 Citations
AbstractAbstract PDF
A 61-year-old gentleman presented with small bowel intussusception from small bowel melanoma intussusceptum. He complains of intermittent abdominal distension but no history of intestinal obstruction. Apart from this, he was also symptomatic anemia which required repeated transfusion for the past few months. The contrast-enhanced computed tomography of the abdomen shows an omental mass with small bowel intussusception. He then underwent an exploratory laparotomy with segmental resection of the affected segment. Histopathological examination confirmed primary gastrointestinal melanoma. Multiple small bowel malignant melanoma is a rare disease. It remains a controversial diagnosis as it may be a primary or metastasis from an unidentified or regressed primary cutaneous melanoma. Prompt surgical intervention enables us to obtain tissue diagnosis, prevent complete intestinal obstruction and strategize the goals of treatment for the patient.

Citations

Citations to this article as recorded by  
  • Primary melanoma of the gastrointestinal tract
    Paola De Nardi, Stefania Guida, Giuseppe Damiano, Nathalie Rizzo, Ana Maria Samanes Gajate, Silvia Teresa Riva, Giovanni Paolino, Michele Colombo, Roberta Tummineri, Franco Rongioletti, Santo Raffaele Mercuri, Arturo Chiti, Pierpaolo Sileri, Vincenzo Russ
    World Journal of Gastroenterology.2026;[Epub]     CrossRef
  • Small bowel melanoma causing obstruction: A case report and a literature review
    Ammar Mattit, Ibrahim Marrawi, Safouh Kheir, Taha Khamis, Safaa Qatleesh, Muhammad Ali Ousta
    International Journal of Surgery Case Reports.2024; 116: 109388.     CrossRef
  • Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis
    Niraj James Shah, Mark M. Aloysius, Eldrin Bhanat, Shweta Gupta, Ganesh Aswath, Savio John, Shou-Jiang Tang, Hemant Goyal
    BMC Gastroenterology.2022;[Epub]     CrossRef
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