Annals of Coloproctology

Volume 27(5); October 2011

Editorials

Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?: Won-Kyung Kang; J Korean Soc Coloproctol. 2011;27(5):221-221. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.221

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The Synchronous Prevalence of Colorectal Neoplasms in Patients with Stomach Cancer: Ryung Ah Lee; J Korean Soc Coloproctol. 2011;27(5):222-223. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.222

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Lymph Node Ratio for Nodal Staging in Colorectal Cancer - a Promising, but Premature Tool: Kang Young Lee; J Korean Soc Coloproctol. 2011;27(5):224-225. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.224

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Citations

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CD169 identifies an activated CD8+T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients
Jiali Zhang, Jing Xu, Rong-xin Zhang, Yi Zhang, Qing-jian Ou, Jin-qing Li, Ze-zhou Jiang, Xiao-jun Wu, Yu-jing Fang, Limin Zheng
OncoImmunology.2016; 5(7): e1177690. CrossRef
Impact of nodal ratio on survival in recurrent nasopharyngeal carcinoma
Richie Chiu‐Lung Chan, Jimmy Yu Wai Chan
Head & Neck.2015; 37(1): 12. CrossRef

Review

Colorectal Cancer with Multiple Metastases: Is Palliative Surgery Needed?: Hong-Jo Choi, Jin Yong Shin; J Korean Soc Coloproctol. 2011;27(5):226-230. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.226

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In patients with symptomatic incurable metastatic colorectal cancer (mCRC), the goal of resection of the primary lesion is to palliate cancer-related morbidity, including obstruction, bleeding, or perforation. In patients with asymptomatic primary tumors and incurable metastatic disease, however, the necessity of primary tumor resection is less clear. Although several retrospective analyses suggest survival benefit in patients who undergo resection of the primary tumor, applying this older evidence to modern patients is out of date for several reasons. Modern chemotherapy regimens incorporating the novel cytotoxic agents oxaliplatin and irinotecan, as well as the target agents bevacizumab and cetuximab, have improved median survival from less than 1 year with the only available single-agent 5-fluorouracil until the mid-1990s to over 2 years. In addition to significant prolongation of overall survival, combinations of novel chemotherapeutic and target agents have allowed improved local and distant tumor control, decreasing the likelihood of local tumor-related complications requiring surgical resection. Resection of an asymptomatic primary tumor risks surgical complications and may postpone the administration of chemotherapy that may offer both systemic and local control. In conclusion, the morbidity and the mortality of unnecessary surgery or surgery that does not improve quality of life or survival in patients with mCRC of a limited life expectancy should be carefully evaluated. With the availability of effective combinations of chemotherapy and target agents, systemic therapy for the treatment of life-threatening metastases would be a preferable treatment strategy for unresectable asymptomatic patients with mCRC.

Citations

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Palliative laparoscopic bowel resection in stage IV colorectal cancer patients with unresectable metastasis
Kwan Mo Yang, Seok-Byung Lim, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Chang Sik Yu, Jin Cheon Kim
Korean Journal of Clinical Oncology.2013; 9(2): 134. CrossRef

Original Articles

Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer: Nam Won Kim, Chong Woo Chu, Tae Sung Ahn, Chang Jin Kim, Dong Jun Jung, Myoung Won Son, Sang Ho Bae, Moon Soo Lee, Chang Ho Kim, Moo Jun Baek; J Korean Soc Coloproctol. 2011;27(5):231-236. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.231

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Abstract PDF

Purpose

Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the relation of PRL-3 mRNA level in primary colorectal cancer to the corresponding stage and to other clinicopathologic factors.

Methods

Two hundred forty-five patients with histologically-proven colorectal cancer underwent surgery between January 2004 and December 2006. RNA was extracted and cDNA was prepared by using reverse transcription. Quantification of PRL-3 was done using a real-time polymerase chain reaction.

Results

Eighty-six cases with well-preserved specimens were enrolled: 53 males and 33 females. The mean age was 63.4 years. According to tumour node metastasis (TNM) stage of the American Joint Committee on Cancer (AJCC), stage I was 11 cases, stage II was 38 cases, stage III was 23 cases, and stage IV was 14 cases. Among stage IV cases, one case was combined with liver and lung metastases, and one case was combined with liver metastases and peritoneal dissemination. The remaining stage IV patients were combined with only liver metastases. There was a significant correlation in PRL-3 mRNA expression between primary colorectal cancer and corresponding tumor stage. PRL-3 mRNA expression was increased in the liver metastases cases. Lymphatic and vascular invasion were significantly related with PRL-3 mRNA levels.

Conclusion

Advanced stage prediction may be obtained by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Especially, the risk of liver metastases may be predicted by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Further study is required to confirm these preliminary results.

Citations

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Colorectal liver metastasis: molecular mechanism and interventional therapy
Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen, Yu Wen
Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef
A retrospective cohort study of clinical value of PRL-3 in stage III human colorectal cancer
Chuanyuan Liu, Wu Zhong, Laiyang Xia, Chuanfa Fang, Hongquan Liu, Xiaochun Liu
Medicine.2021; 100(17): e25658. CrossRef
Physiological and oncogenic roles of the PRL phosphatases
Serge Hardy, Elie Kostantin, Teri Hatzihristidis, Yevgen Zolotarov, Noriko Uetani, Michel L. Tremblay
The FEBS Journal.2018; 285(21): 3886. CrossRef
Biomarkers for predicting future metastasis of human gastrointestinal tumors
Lui Ng, Ronnie Tung Ping Poon, Roberta Pang
Cellular and Molecular Life Sciences.2013; 70(19): 3631. CrossRef
Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion
James J. Fiordalisi, Brian J. Dewar, Lee M. Graves, James P. Madigan, Adrienne D. Cox, Jung Weon Lee
PLoS ONE.2013; 8(5): e64309. CrossRef

Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?: Cheong Ho Lim, Hyeon Keun Shin, Wook Ho Kang, Seung Kyu Jeong, Hyung Kyu Yang; J Korean Soc Coloproctol. 2011;27(5):237-240. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.237

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Abstract PDF

Purpose

Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity.

Methods

The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject's serum and to compare the results with those for the control groups.

Results

Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 ± 0.78 pg/mL for male subjects and 1.16 ± 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow: 1.21 ± 0.44 pg/mL in group 1, 1.46 ± 0.83 pg/mL in group 2, and 1.20 ± 0.56 pg/mL in group 3 (P = 0.14).

Conclusion

Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance.

Citations

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Impact of Anal Fissure on Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness: A Case-Control Study
Paloma Luri-Prieto, Asunción Candela-Gomis, Antonio Palazón-Bru, Felipe Navarro-Cremades, Vicente Francisco Gil-Guillén, Antonio Fernando Compañ-Rosique
Visceral Medicine.2021; 37(2): 128. CrossRef
Anatomie und Pathogenese der Analfissur
Martin Mitteregger
coloproctology.2020; 42(6): 441. CrossRef
Cost considerations in the treatment of anal fissures
Giuseppe Brisinda, Giuseppe Bianco, Nicola Silvestrini, Giorgio Maria
Expert Review of Pharmacoeconomics & Outcomes Research.2014; 14(4): 511. CrossRef

Laparoscopic Versus Open Appendectomy for Appendicitis in Elderly Patients: Hyun Nam Baek, Yong Hwan Jung, Yong Hee Hwang; J Korean Soc Coloproctol. 2011;27(5):241-245. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.241

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Abstract PDF

Purpose

The appendectomy is the most common emergent surgical procedure in elderly patients. The increasing number of elderly persons has been accompanied by an increase in the number of cases of acute appendicitis in the elderly. In order to understand the clinical significance of a laparoscopic appendectomy for elderly patients with appendicitis, we investigated the results of a laparoscopic appendectomy for treating patients over 60 years of age with appendicitis and compared them with the results for an open technique.

Methods

We studied retrospectively patients over 60 years of age who underwent an appendectomy with either a laparoscopic (LA) or open (OA) technique for appendicitis between July 2007 and December 2009. There were 30 patients in the LA group and 47 patients in the OA group. The demographic data, operative time, length of the hospital stay, bowel movement, pain control, cost, complications and pre-existing disease were assessed.

Results

There were no significant differences between the LA and the OA groups with respect to pre-existing diseases, gender, age, American Society of Anesthesiologists (ASA) score and the number of cases of complicated appendicitis, operative time, length of hospital stay, and times of analgesics use. However, the proportion of early gas out (within POD #2) was significantly greater in the LA group (80% vs. 57%, P < 0.05), and postoperative complications were significantly lower in the LA group (7% vs. 32%, P < 0.01). The costs for the two groups were not significantly different.

Conclusion

A laparoscopic appendectomy is a safe and effective procedure in elderly patients and is not associated with any increase in morbidity. It can be recommended for routine use in treating elderly patients with appendicitis.

Citations

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EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults
Deborah S. Keller, Nathan Curtis, Holly Ann Burt, Carlo Alberto Ammirati, Amelia T. Collings, Hiram C. Polk, Francesco Maria Carrano, Stavros A. Antoniou, Nader Hanna, Laure-Meline Piotet, Sarah Hill, Anne C. M. Cuijpers, Patricia Tejedor, Marco Milone, E
Surgical Endoscopy.2024; 38(8): 4104. CrossRef
Laparoscopic and robotic surgery for colorectal cancer in older patients: a systematic review and meta-analysis
Carlo Alberto Ammirati, Roberto Passera, Elsa Beltrami, Chiara Peluso, Nader Francis, Alberto Arezzo
Minimally Invasive Therapy & Allied Technologies.2024; 33(5): 253. CrossRef
The Role of Basic Laboratory Parameters in Diagnosing Acute Appendicitis and Determining Disease Severity in the Elderly
Mustafa Yeni, Rıfat Peksöz
Turkish Journal of Colorectal Disease.2022; 32(2): 110. CrossRef
Comparison of Postoperative Acute Kidney Injury Between Laparoscopic and Laparotomy Procedures in Elderly Patients Undergoing Colorectal Surgery
Shun Huang, Zheng Li, Nan Zou, Ting Dai, Xiang Long Cao, Zhe Jia, Wen Ping Peng, Ning Yang, Rui Fang Jia, Ming Zhang Zuo
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2021; 31(2): 160. CrossRef
GERİATRİK AKUT APANDİSİTLERİN TANI VE TEDAVİSİNDEKİ FARKLILIKLAR: TEK MERKEZ DENEYİMİ
Ahmet TÜRKAN, Ahmet ERDOĞAN, Uğur KILINÇ
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi.2021; 23(1): 1. CrossRef
Acute Appendicitis in the Elderly: A Literature Review on an Increasingly Frequent Surgical Problem
Sintija Lapsa, Arturs Ozolins, Ilze Strumfa, Janis Gardovskis
Geriatrics.2021; 6(3): 93. CrossRef
Perforated vs. nonperforated acute appendicitis: evaluation of short-term surgical outcomes in an elderly population
Fabio Rondelli, Michele De Rosa, Paolo Stella, Marcello Boni, Graziano Ceccarelli, Ruben Balzarotti, Andrea Polistena, Alessandro Sanguinetti, Walter Bugiantella, Nicola Avenia
Minerva Chirurgica.2019;[Epub] CrossRef
Outcomes of appendectomy in elderly veteran patients
Oswaldo Renteria, Zain Shahid, Sergio Huerta
Surgery.2018; 164(3): 460. CrossRef
Independent Preoperative Predictors of Prolonged Length of Stay after Laparoscopic Appendectomy in Patients over 30 Years of Age: Experience from a Single Institution
Eric S. Wise, Stephen P. Gadomski, Annette M. Ilg, Camilo Bermudez, Emily W. Chan, Michelle L. Izmaylov, Samantha J. Gridley, Jessica V. Kaczmarek, Norman T. Melancon, Sarwat Ahmad, Kyle M. Hocking, Jose J. Diaz, Stephen M. Kavic
The American Surgeon™.2016; 82(11): 1092. CrossRef
Conventional Laparoscopic Appendicectomy and Laparoscope-Assisted Appendicectomy: a Comparative Study
Mayank Baid, Manoranjan Kar, Utpal De, Mrityunjay Mukhopadhyay
Indian Journal of Surgery.2015; 77(S2): 330. CrossRef
Acute appendicitis: position paper, WSES, 2013
Ferdinando Agresta, Luca Ansaloni, Fausto Catena, Luca Andrea Verza, Daniela Prando
World Journal of Emergency Surgery.2014;[Epub] CrossRef
Thirty-day outcomes of laparoscopic versus open appendectomy in elderly using ACS/NSQIP database
Ashkan Moazzez, Rodney J. Mason, Namir Katkhouda
Surgical Endoscopy.2013; 27(4): 1061. CrossRef

The Synchronous Prevalence of Colorectal Neoplasms in Patients with Stomach Cancer: Sang Su Lee, Woon Tae Jung, Cha Young Kim, Chang Yoon Ha, Hyun Ju Min, Hyun Jin Kim, Tae Hyo Kim; J Korean Soc Coloproctol. 2011;27(5):246-251. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.246

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Abstract PDF

Purpose

The association between stomach cancer and colorectal cancer is controversial. The purpose of this study was to determine the synchronous prevalence of colorectal neoplasms in patients with stomach cancer.

Methods

A total of 123 patients with stomach cancer (86 male) and 246 consecutive, age- and sex-matched persons without stomach cancer were analyzed from July 2005 to June 2010. All of them underwent colonoscopy within 6 months after undergoing gastroscopy.

Results

The prevalence of colorectal neoplasms was significantly higher in the stomach cancer group (35.8%) than in the control group (17.9%) (P < 0.001). Colorectal neoplasms were more prevalent in the patients with stomach cancer (odds ratio [OR], 3.10; 95% confidence interval [CI], 1.71 to 5.63). In particular, the difference in the prevalence of colorectal neoplasms was more prominent in the patients above 50 years old (OR, 3.54; 95% CI, 1.80 to 6.98).

Conclusion

The results showed that the synchronous prevalence of colorectal neoplasms was higher in patients with stomach cancer than in those without stomach cancer. Therefore, patients with stomach cancer should be regarded as a high-risk group for colorectal neoplasms, and colonoscopy should be recommended for screening.

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Colonoscopy plays an important role in detecting colorectal neoplasms in patients with gastric neoplasms
Xu-Rui Liu, Ze-Lin Wen, Fei Liu, Zi-Wei Li, Xiao-Yu Liu, Wei Zhang, Dong Peng
World Journal of Gastrointestinal Oncology.2024; 16(1): 133. CrossRef
Retrospective cohort study investigating association between precancerous gastric lesions and colorectal neoplasm risk
Hui Pan, Yu-Long Zhang, Chao-Ying Fang, Yu-Dai Chen, Li-Ping He, Xiao-Ling Zheng, Xiaowen Li
Frontiers in Oncology.2024;[Epub] CrossRef
Genetic analyses supporting colorectal, gastric, and prostate cancer syndromes
Karin Wallander, Wen Liu, Susanna von Holst, Jessada Thutkawkorapin, Vinaykumar Kontham, Anna Forsberg, Annika Lindblom, Kristina Lagerstedt‐Robinson
Genes, Chromosomes and Cancer.2019; 58(11): 775. CrossRef
Frequency and risk factors of colorectal adenoma in patients with early gastric cancer
Hyun H. Chung, Kyeong O. Kim, Si H. Lee, Byung I. Jang, Tae N. Kim
Internal Medicine Journal.2017; 47(10): 1184. CrossRef
Is Colonoscopic Screening Necessary for Patients Younger than 50 Years with Gastric Adenoma or Cancer?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Yoon Suk Jung
Journal of Korean Medical Science.2017; 32(8): 1281. CrossRef
Is Preoperative Work-Up Colonoscopy Necessary for Patient with Gastric Cancer?
Hee Chan Yang, Ju Hyung Lee, Sung Kyun Yim, Hong-Seon Son, Seung Young Seo, Seong Hun Kim, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Sang Wook Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2016; 16(4): 215. CrossRef
Short-term Outcomes of Laparoscopic Surgery for Synchronous Gastric and Colorectal Cancer
Ryoji Makizumi, Shinya Mikami, Kuniyasu Horikoshi, Tsukasa Shimamura, Shinjiro Kobayashi, Akira Hanai, Satoshi Tsukikawa, Yukihito Kokuba, Nobuyoshi Miyajima, Takehito Otsubo
Journal of St. Marianna University.2015; 6(2): 273. CrossRef
Clinical Significance of Colonoscopy in Patients with Upper Gastrointestinal Polyps and Neoplasms: A Meta-Analysis
Zhen-Jie Wu, Yuan Lin, Jun Xiao, Liu-Cheng Wu, Jun-Gang Liu, John Green
PLoS ONE.2014; 9(3): e91810. CrossRef
Role of Preoperative Colonoscopy in Patients with Gastric Cancer: A Case Control Study of the Prevalence of Coexisting Colorectal Neoplasms
Han Mo Yoo, Tae Geun Gweon, Ho Seok Seo, Jung Ho Shim, Sung Il Oh, Myung Gyu Choi, Kyo Young Song, Hae Myoung Jeon, Cho Hyun Park
Annals of Surgical Oncology.2013; 20(5): 1614. CrossRef

Prognostic Significance of Lymph Node Ratio in Stage III Rectal Cancer: Jin Yong Shin, Kwan Hee Hong; J Korean Soc Coloproctol. 2011;27(5):252-259. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.252

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Abstract PDF

Purpose

Although nodal metastasis is the most powerful prognostic factor in rectal cancer, marked heterogeneity exists within stage III rectal cancer. Recent studies of rectal cancer have shown a prognostic superiority of the lymph node ratio (LNR) compared with N stage. The purpose of this study was to investigate the prognostic value of the LNR in the era of the 7th edition of the TNM classification.

Methods

We included 190 patients who underwent a curative resection for rectal cancer with nodal metastasis. The patients were divided into four groups on the basis of statistically calculated cut-off values as 0.21, 0.32, and 0.61.

Results

The LNR was an independent risk factor for overall survival (OS; P = 0.008) and for systemic recurrence-free survival (SRFS; P = 0.002). However, the LNR was not a predictive factor for local recurrence. When the N stage of the sixth TNM staging system was separately analyzed as a covariate, the LNR was also found to be a predictive factor for both OS and SRFS (P = 0.012 and P = 0.004, respectively). A LNR value of 0.21 offered the best cut off to separate patients into two prognostic groups.

Conclusion

The defined cut-off values of the LNR were an independent risk factor for OS and distant metastasis-free survival in patients with rectal cancer, irrespective of the sixth or the seventh version of the TNM classification, and the LNR should be considered as a prognostic variable in any future staging system.

Citations

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Prognostic value of lymph node ratio in non-small-cell lung cancer: a meta-analysis
Jian Zhou, Zhangyu Lin, Mengyuan Lyu, Nan Chen, Hu Liao, Zihuai Wang, Jianqi Hao, Chunyi Yan, Lunxu Liu
Japanese Journal of Clinical Oncology.2020; 50(1): 44. CrossRef
Comparison of two novel staging systems with the TNM system in predicting stage III colon cancer survival
Richard Walker, Trevor Wood, Emily LeSouder, Michelle Cleghorn, Manjula Maganti, Andrea MacNeill, Fayez A. Quereshy
Journal of Surgical Oncology.2018; 117(5): 1049. CrossRef
The Prognostic Impact of the Metastatic Lymph Nodes Ratio in Colorectal Cancer
Chi-Hao Zhang, Yan-Yan Li, Qing-Wei Zhang, Alberto Biondi, Valeria Fico, Roberto Persiani, Xiao-Chun Ni, Meng Luo
Frontiers in Oncology.2018;[Epub] CrossRef
Log odds of positive lymph nodes is a superior prognostic indicator in stage III rectal cancer patients: A retrospective analysis of 17,632 patients in the SEER database
Ben Huang, Chen Chen, Mengdong Ni, Shaobo Mo, Guoxiang Cai, Sanjun Cai
International Journal of Surgery.2016; 32: 24. CrossRef
Clinical Significance of the Metastatic Lymph-Node Ratio in Rectal Cancer
Hyoung Chul Park
Annals of Coloproctology.2013; 29(3): 89. CrossRef
Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Rectal Cancer
Wafi Attaallah, Omer Gunal, Manuk Manukyan, Gulden Ozden, Cumhur Yegen
Annals of Coloproctology.2013; 29(3): 100. CrossRef
O índice de linfonodos comprometidos como um preditor para a ocorrência de recidivas tumorais no câncer de cólon estádio III
Tiago L. Dedavid e Silva, Daniel C. Damin
Revista do Colégio Brasileiro de Cirurgiões.2013; 40(6): 463. CrossRef

Clinical Significance of Lymph Node Ratio in Stage III Colorectal Cancer: Yo Han Park, Jae Im Lee, Jong Kyung Park, Hang Ju Jo, Won Kyung Kang, Chang Hyeok An; J Korean Soc Coloproctol. 2011;27(5):260-265. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.260

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Abstract PDF

Purpose

Recent literature has shown that lymph node ratio is superior to the absolute number of metastatic lymph nodes in predicting the prognosis in several malignances other than colorectal cancer. The aim of this study was to evaluate the prognostic significance of the lymph node ratio (LNR) in patients with stage III colorectal cancer.

Methods

We included 186 stage III colorectal cancer patients who underwent a curative resection over a 10-year period in one hospital. The cutoff point of LNR was chosen as 0.07 because there was significant survival difference at that LNR. The Kaplan-Meier and the Cox proportional hazard models were used to evaluate the prognostic effect according to LNR.

Results

There was statistically significant longer overall survival in the group of LNR > 0.07 than in the group of LNR ≤ 7 (P = 0.008). Especially, there was a survival difference for the N1 patients group (LN < 4) according to LNR (5-year survival of N1 patients was lower in the group of LNR > 0.07, P = 0.025), but there was no survival difference for the N2 group (4 ≥ LN) according to LNR. The multivariate analysis showed that the LNR is an independent prognostic factor.

Conclusions

LNR can be considered as a more accurate and potent modality for prognostic stratifications in patients with stage III colorectal cancer.

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The prognostic performance of the log odds of positive lymph nodes in patients with esophageal squamous cell carcinoma: A population study of the US SEER database and a Chinese single‐institution cohort
Hongdian Zhang, Wanyi Xiao, Peng Ren, Kai Zhu, Ran Jia, Yueyang Yang, Lei Gong, Zhentao Yu, Peng Tang
Cancer Medicine.2021; 10(17): 6149. CrossRef
Lymph Node Ratio and Liver Metachronous Metastases in Colorectal Cancer
Giovanni Li Destri, Giuseppe Privitera, Gaetano La Greca, Roberto Scilletta, Antonio Pesce, Teresa Rosanna Portale, Erminia Conti, Stefano Puleo
International Surgery.2021; 105(1-3): 122. CrossRef
Rectal cancers with microscopic circumferential resection margin involvement (R1 resections): Survivals, patterns of recurrence, and prognostic factors
Gianpiero Gravante, David Hemingway, James Andrew Stephenson, David Sharpe, Ahmed Osman, Melissa Haines, Vafa Pirjamali, Roberto Sorge, Justin Ming Yeung, Michael Norwood, Andrew Miller, Kirsten Boyle
Journal of Surgical Oncology.2016; 114(5): 642. CrossRef
Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Rectal Cancer
Wafi Attaallah, Omer Gunal, Manuk Manukyan, Gulden Ozden, Cumhur Yegen
Annals of Coloproctology.2013; 29(3): 100. CrossRef
Prognostic Value of Total Lymph Node Identified and Ratio of Lymph Nodes in Resected Colorectal Cancer
Leila Ghahramani, Leila Moaddabshoar, Samira Razzaghi, Sayed Hasan Hamedi, Saeedeh Pourahmad, Mohammad Mohammadianpanah
Annals of Colorectal Research.2013; 1(3): 81. CrossRef
Prognostic Value of Lymph Node Ratios in Node Positive Rectal Cancer Treated with Preoperative Chemoradiation
Jamal Jafari Nadoshan, Ramesh Omranipour, Omid Beiki, Kazem Zendedel, Abbas Alibakhshi, Habibollah Mahmoodzadeh
Asian Pacific Journal of Cancer Prevention.2013; 14(6): 3769. CrossRef
Proposal of a New Classification for Stage III Colorectal Cancer Based on the Number and Ratio of Metastatic Lymph Nodes
Li‐Ping Wang, Hong‐Yan Wang, Rui Cao, Cong Zhu, Xiong‐Zhi Wu
World Journal of Surgery.2013; 37(5): 1094. CrossRef
An appraisal of lymph node ratio in colon and rectal cancer: not one size fits all
M. Medani, Niall Kelly, George Samaha, G. Duff, Vourneen Healy, Elizabeth Mulcahy, Eoghan Condon, David Waldron, Jean Saunders, J. Calvin Coffey
International Journal of Colorectal Disease.2013; 28(10): 1377. CrossRef

Case Reports

Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports: Chun-Geun Ryu, Eun-Joo Jung, Gangmi Kim, Su Ran Kim, Dae-Yong Hwang; J Korean Soc Coloproctol. 2011;27(5):266-269. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.266

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Abstract PDF

Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.

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Kinnera Sahithi Urlapu, Dmitry Lvovsky
Cureus.2023;[Epub] CrossRef
Pulmonary Fibrosis Secondary to Oxaliplatin Treatment: From Rarity to Reality: A Case Study and Literature Review
Ana C. Moreira, João Portela, Carlos Couto, José Duarte, Natália Martins, Jorge Soares
Oncology and Therapy.2020; 8(2): 183. CrossRef
A case report of acute pulmonary hypertension after hyperthermic intraperitoneal chemotherapy (HIPEC) and review of the literature
Thomas S. Zajonz, Michael Sander, Winfried Padberg, Andreas Hecker, Ruediger Hörbelt, Christian Koch, Emmanuel Schneck
Annals of Medicine and Surgery.2018; 27: 26. CrossRef
Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient
Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens, Philippe G. Jorens
BMC Cancer.2017;[Epub] CrossRef
Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature
Mor Moskovitz, Mira Wollner, Nissim Haim
Case Reports in Oncological Medicine.2015; 2015: 1. CrossRef
Pulmonary Fibrosis Secondary to FOLFOX Chemotherapy: A Case Report
Wai Cheong Soon, Kate West, David Gibeon, Elizabeth Frances Bowen
Case Reports in Oncology.2014; 7(3): 662. CrossRef
Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Case Report
Dane Wildner, Frank Boxberger, Axel Wein, Kerstin Wolff, Heinz Albrecht, Gudrun Männlein, Rolf Janka, Kerstin Amann, Jürgen Siebler, Werner Hohenberger, Markus F. Neurath, Richard Strauß
Case Reports in Oncological Medicine.2013; 2013: 1. CrossRef

Recurrent Renal Leiomyosarcoma Mimicking a Colonic Submucosal Tumor: A Case Report: Yun Jeung Kim, Hee Seok Moon, Eaum Seok Lee, Jae Kyu Sung, Hyun Yong Jeong, Ji Yeon Kim, Dae Young Kang; J Korean Soc Coloproctol. 2011;27(5):270-274. Published online October 31, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.5.270

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A primary leiomyosarcoma of the kidney is a rare, but highly aggressive, neoplasm, accounting for only 0.1% of all invasive renal tumors. Local or systemic recurrence is common, but a leiomyosarcoma is difficult to diagnose preoperatively. We recently encountered an interesting case of an unusual recurrence of a renal leiomyosarcoma. A 57-year-old woman visited our hospital complaining of lower abdominal pain. Four years previously, she had undergone a left nephrectomy. She had a primary leiomyosarcoma of the kidney that had been misdiagnosed as a renal cell carcinoma. Colonoscopy revealed the presence of a lesion similar to a submucosal tumor in the descending colon. Postoperative pathologic examination confirmed that the mass was a recurrent leiomyosarcoma. We report this unusual case and present a review of the literature.

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A Rare Case of Colonic Leiomyosarcoma in Association with Ulcerative Colitis
Daisuke Akutsu, Yuji Mizokami, Hideo Suzuki, Masahiko Terasaki, Toshiaki Narasaka, Tsuyoshi Kaneko, Hirofumi Matsui, Tsuyoshi Enomoto, Taiki Sato, Ichinosuke Hyodo
Internal Medicine.2016; 55(19): 2799. CrossRef

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