Annals of Coloproctology

Volume 26(4); August 2010

Editorials

Survivin may be a Key Target for Oxaliplatin: Moo Jun Baek; J Korean Soc Coloproctol. 2010;26(4):239-239. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.239

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A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer
James P. Madigan, Robert W. Robey, Joanna E. Poprawski, Huakang Huang, Christopher J. Clarke, Michael M. Gottesman, Myles C. Cabot, Daniel W. Rosenberg
Experimental Cell Research.2020; 388(2): 111860. CrossRef

Cessation or dose reduction of Capecitabine due to Complications in Patients with Colon Cancer: Seung Kook Sohn; J Korean Soc Coloproctol. 2010;26(4):240-240. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.240

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Review

Right Colonic Diverticulitis: In Kyu Lee; J Korean Soc Coloproctol. 2010;26(4):241-245. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.241

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Although right colonic diverticultis (RCD) has been reported to be a rare disease in Western countries, RCD is a common diagnosis, with an incidence per 2.9-17 case of appendicitis, in Korea. Many Western studies have reported that it is difficult to differentiate the presenting symptoms of RCD from those of appendicitis before surgery because the signs and symptoms are similar. However, performing a computed tomography scan after the application of the diagnostic criteria for RCD has increased the preoperative RCD diagnostic rate. Treatment strategies have been difficult to define for this condition due to its low preoperative diagnosis rate. However, recent reports have shown that conservative medical treatment of uncomplicated RCD can be recommended and that such treatment is effective due to the benign and self-limited natural history of RCD. Therefore, in this review, we discuss the controversies surrounding RCD management.

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Beyond the Norm: Acute Multifocal Diverticulitis
Bianca Thakkar, Jasmine Tidwell, Minh Thu T. Nguyen, Gengsheng Yu, Neil Parikh
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Isolated Cecal Diverticulitis in a Non-Asian Patient With Strong Family History of Colon Adenocarcinoma
Reynold Henry, Benjamin Tam, Nicholas Serniak, Glenn Ault
The American Surgeon™.2023; 89(4): 1054. CrossRef
Right-sided acute diverticulitis in the West: experience at a university hospital in Argentina
René M. Palacios Huatuco, Diana A. Pantoja Pachajoa, Julian E. Liaño, Héctor A. Picón Molina, Rafael Palencia, Alejandro M. Doniquian, Matías Parodi
Annals of Coloproctology.2023; 39(2): 123. CrossRef
Case Series of Right Colon Diverticulitis in the West: A Neglected Disease?
Lucas Faraco Sobrado, Tarsila Gomes Caldas, Carolina Graciolli Facanali, Leonardo Bustamente-Lopez, Carlos Walter Sobrado
Journal of Coloproctology.2022; 42(04): 302. CrossRef
Seeking outpatient management of right-sided diverticulitis
María Savoie-Hontoria, Rafael José Orti-Rodríguez, Miguel Ángel García Bello, Antonio Dámaso Pérez Álvarez, Manuel Ángel Barrera Gómez
European Surgery.2021; 53(6): 305. CrossRef
Laparoscopic diverticulectomy versus non-operative treatment for uncomplicated right colonic diverticulitis
Le Huy Luu, Nguyen Lam Vuong, Vo Thi Hong Yen, Do Thi Thu Phuong, Bui Khac Vu, Nguyen Viet Thanh, Nguyen Thien Khanh, Nguyen Van Hai
Surgical Endoscopy.2020; 34(5): 2019. CrossRef
Diverticulitis aguda del ángulo hepático simulando un cuadro de colecistitis aguda
M. Gonzalez-Urquijo, A. Baca-Arzaga, G. Lozano-Balderas
Revista de Gastroenterología de México.2020; 85(4): 484. CrossRef
Acute diverticulitis of the hepatic flexure mimicking acute cholecystitis
M. Gonzalez-Urquijo, A. Baca-Arzaga, G. Lozano-Balderas
Revista de Gastroenterología de México (English Edition).2020; 85(4): 484. CrossRef
Perforated cecal diverticulitis with CT diagnosis and medical management
Caleb Tsetse, Shazia Rahat Chaudhry, Feraas Jabi, Jennifer Nicole Taylor
Radiology Case Reports.2019; 14(1): 30. CrossRef
Long-term outcome and management of right colonic diverticulitis in western countries: Multicentric Retrospective Study
L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
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Résultats à long terme et prise en charge des diverticulites du colon droit dans les pays occidentaux : étude rétrospective multicentrique
L. Courtot, V. Bridoux, Z. Lakkis, G. Piessen, G. Manceau, A. Mulliri, G. Meurette, A. Bouayed, A. Vénara, B. Blanc, N. Tabchouri, E. Salamé, M. Ouaïssi
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Novel swine model of colonic diverticulosis
Xiaomei Guo, Bhavesh Patel, Ling Han, Hiba Al-Dulaimi, William G. Van Alstine, Jillian N. Noblet, Sean Chambers, Ghassan S Kassab
American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 317(1): G51. CrossRef
Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study
Yosuke Sasaki, Fumiya Komatsu, Naoyasu Kashima, Takahiro Sato, Ikutaka Takemoto, Sho Kijima, Tadashi Maeda, Takamasa Ishii, Taito Miyazaki, Yoshiko Honda, Nagato Shimada, Yoshihisa Urita
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A Rare Case of Acute Right-Sided Colonic Diverticulitis Presenting as Pancreatitis
Maria de Lourdes Ladino Sturchler, Evan A. Rusoja, Arun Nagdev, Barry C. Simon
The Journal of Emergency Medicine.2018; 54(4): e77. CrossRef
An Atypical Case of Transverse Diverticulitis and the Changing Management of Diverticular Disease
Andrew C. Ostosh, Adeeb Saleh, Kevin M. Boehm
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Right-Sided Colonic Diverticulitis: Clinical Features, Sonographic Appearances, and Management
Tse-Cheng Chiu, Yi-Hong Chou, Chui-Mei Tiu, Hong-Jen Chiou, Hsin-Kai Wang, Yi-Chen Lai, Yi-You Chiou
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Right-sided acute diverticulitis: A single Western center experience
Francesco Monari, Maurizio Cervellera, Basilio Pirrera, Umberto D'Errico, Samuele Vaccari, Laura Alberici, Valeria Tonini
International Journal of Surgery.2017; 44: 128. CrossRef
Acute Bowel Computed Tomography
Abdulmalik Dredar, Prem Thanaratnam, Kaiser Hussain, Seth Andrews, Edward Mtui, Tara Catanzano
Seminars in Ultrasound, CT and MRI.2017; 38(4): 399. CrossRef
Reste-t-il des indications pour la chirurgie à froid ?
B. Schiltz, C. Dumont, N. C. Buchs, Ph. Morel, F. Ris
Côlon & Rectum.2017; 11(1): 25. CrossRef
Diagnóstico y tratamiento de la enfermedad diverticular del colon derecho: revisión de conjunto
Francesco Ferrara, Jesús Bollo, Letizia V Vanni, Eduardo M Targarona
Cirugía Española.2016; 94(10): 553. CrossRef
Diagnosis and Management of Right Colonic Diverticular Disease: A Review
Francesco Ferrara, Jesús Bollo, Letizia V. Vanni, Eduardo M. Targarona
Cirugía Española (English Edition).2016; 94(10): 553. CrossRef
Evaluating Suspected Appendicitis
Winson Jianhong Tan, Hock Soo Ong
Journal of the American College of Surgeons.2015; 221(2): 635. CrossRef
Computed Tomography of Colonic and Appendiceal Emergencies
Vincent M. Mellnick, Christine O. Menias
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Diagnosis and Treatment of Colon Diverticulitis
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Korean Journal of Medicine.2013; 85(6): 563. CrossRef

Original Articles

Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells: Won Jun Sohn, Jung Won Lee, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):246-253. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.246

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Abstract PDF

Purpose

Oxaliplatin is a third-generation platinum compound, and it has no nephrotoxicity and has reduced bone marrow toxicity. Cancer cells that are resistant to cisplatin are sensitive to oxaliplatin. Oxaliplatin is used widely for the treatment of colon cancers. Recently, oxaliplatin was reported to inhibit the expression of survivin, which protects cell apoptosis. However, there are no reports on the expressions of survivin variants and the changes in intracellular localization of survivin in cancer cells. We studied the expression of survivin caused by oxaliplatin in HCT116 colon cancer cells, and we observed the localization of survivin in the mitotic phase.

Methods

We treated the HCT116 colon cancer cells with 2.0 µM of oxaliplatin, and we studied the expressions of survivin protein, and survivin mRNA variants, as well as the changes in intracellular localization, by using the Western blot method, RT-PCR, immunocytochemistry, and flowcytometry.

Results

Oxaliplatin inhibits the expression of the survivin protein and survivin mRNA in HCT116 colon cancer cells. The expression of the survivin-2B variants, which have no antiapoptotic activity but control cell mitosis by localization on a microtubule, is reduced continuously 2 days after treatment with oxaliplatin. In immunocytochemistry, expression of survivin in the cytoplasm is reduced and especially is not expressed in microtubules and contractile rings.

Conclusion

One of the mechanisms of oxaliplatin is to inhibit the expression of and to change the localization of survivin. Based on these results, we suggest that changes in the expression of survivin variants and in their localization are two effects of oxaliplatin.

Citations

Citations to this article as recorded by

Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial
M Verstraete, A Debucquoy, J Dekervel, J van Pelt, C Verslype, E Devos, G Chiritescu, K Dumon, A D'Hoore, O Gevaert, X Sagaert, E Van Cutsem, K Haustermans
British Journal of Cancer.2015; 112(8): 1314. CrossRef
Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
Dong-Guk Park
Annals of Surgical Treatment and Research.2014; 86(2): 68. CrossRef

Effects of DCA on Cell Cycle Proteins in Colonocytes: Yun-Hyung Ha, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):254-259. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.254

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Abstract PDF

Purpose

Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous studies have been based on studies on colon cancer cell lines, the effect of DCA on normal colonocytes is unknown.

Methods

Normal colonocytes and Caco-2 and HCT116 cells were treated with 20 µM and 250 µM of DCA, and the effect of different concentrations of DCA was measured based on the expression of cell-cycle-related proteins by using Western blots.

Results

The expressions of CDK2 and cyclin D1 for different concentrations of DCA in normal colonocytes and colon cancer cells were similar, but the expressions of cyclin E and A were significantly different. In HCT116 colon cancer cells, the expression of cyclin E increased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin E was not changed or decreased. In HCT116 colon cancer cells, the expression of cyclin A was not changed or decreased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin A was increased at a DCA concentration of 20 µM.

Conclusion

The effect of DCA on stimulating cell proliferation suggests that DNA synthesis is stimulated by an increased expression of cyclin E in colon cancer cells. Our results suggest that a low dose of DCA induces cellular proliferation through increased expression of cyclin A and that a high dose of DCA induces decreased expression of cyclin E and CDK2 in normal colonocytes.

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Implication of gut microbes and its metabolites in colorectal cancer
Arun Kumar, Asgar Ali, Raj Kishore Kapardar, Ghulam Mehdi Dar, Nimisha, Apurva, Abhay Kumar Sharma, Renu Verma, Real Sumayya Abdul Sattar, Ejaj Ahmad, Bhawna Mahajan, Sundeep Singh Saluja
Journal of Cancer Research and Clinical Oncology.2023; 149(1): 441. CrossRef
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer
Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar, Rob Van Houdt
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner
Wei Zhu, Yan Si, Jun Xu, Yu Lin, Jing‐Zi Wang, Mengda Cao, Shanwen Sun, Qiang Ding, Lingjun Zhu, Ji‐Fu Wei
Journal of Cellular and Molecular Medicine.2020; 24(6): 3521. CrossRef
Microbiota in cancer development and treatment
Muhammad Hassan Raza, Kamni Gul, Abida Arshad, Naveeda Riaz, Usman Waheed, Abdul Rauf, Fahad Aldakheel, Shatha Alduraywish, Maqbool Ur Rehman, Muhammad Abdullah, Muhammad Arshad
Journal of Cancer Research and Clinical Oncology.2019; 145(1): 49. CrossRef
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer
Huawei Zeng, Shahid Umar, Bret Rust, Darina Lazarova, Michael Bordonaro
International Journal of Molecular Sciences.2019; 20(5): 1214. CrossRef
Dysbiosis of gut microbiota in promoting the development of colorectal cancer
Shaomin Zou, Lekun Fang, Mong-Hong Lee
Gastroenterology Report.2018; 6(1): 1. CrossRef
Oxidative stress: a key regulator of leiomyoma cell survival
Nicole M. Fletcher, Mohammed S. Abusamaan, Ira Memaj, Mohammed G. Saed, Ayman Al-Hendy, Michael P. Diamond, Ghassan M. Saed
Fertility and Sterility.2017; 107(6): 1387. CrossRef
Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53-mediated pathway
HAI-BO YANG, WEI SONG, MEI-DIE CHENG, HAI-FANG FAN, XU GU, YING QIAO, XIN LU, RUI-HE YU, LAN-YING CHEN
Molecular Medicine Reports.2015; 11(4): 2749. CrossRef
Differential Regulation of EGFR–MAPK Signaling by Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in Colon Cancer
Sara M. Centuori, Jesse D. Martinez
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Bile acids in the colon, from healthy to cytotoxic molecules
Juan I. Barrasa, Nieves Olmo, Ma Antonia Lizarbe, Javier Turnay
Toxicology in Vitro.2013; 27(2): 964. CrossRef
Sodium deoxycholate inhibits chick duodenal calcium absorption through oxidative stress and apoptosis
María A. Rivoira, Ana M. Marchionatti, Viviana A. Centeno, Gabriela E. Díaz de Barboza, María E. Peralta López, Nori G. Tolosa de Talamoni
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2012; 162(4): 397. CrossRef

Laparoscopic Appendectomy with a Single Incision in a Single Institute: Jin A Lee, Ki Young Sung, Jun Hyun Lee, Do Sang Lee; J Korean Soc Coloproctol. 2010;26(4):260-264. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.260

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Abstract PDF

Purpose

The laparoscopic appendectomy has become popular for the treatment of acute appendicitis. A single-incision laparoscopic appendectomy offers better cosmesis. We present the results of single-incision laparoscopic appendectomies in our hospital as initial experience.

Methods

A single-incision laparoscopic appendectomy was performed in 75 patients at The Catholic University of Korea, Bucheon St. Mary's hospital. The operating time, operation type, hospital stay, surgical morbidities, and body mass index were compared.

Results

This retrospective study revealed equal operation times in both the suppurative and the perforated appendicitis group. There was an increase in the hospital stay in the perforated appendicitis group. The postoperative complication rate was 4%, and the median operation time was 58.55 ± 31.79 minutes.

Conclusion

The single-incision laparoscopic appendectomy was easy and safe procedure for treating acute appendicitis. There were no differences in degree of inflammation and body mass index.

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A Comparative Study Between Single-Incision Laparoscopic Appendicectomy Using Conventional Instruments and Glove-Port (SILACIG) and Conventional Multiport Laparoscopic Appendicectomy (CMLA)
Ahamed Muneef, Uday Kumbhar, Chellappa Vijayakumar, Oseen Shaikh
Cureus.2020;[Epub] CrossRef
Feasibility of Single Port Laparoscopic Surgery in Patients with Perforated Appendicitis
Byung Seo Choi, Geon Young Byun, Seong Bae Hwang, Sung Ryul Lee
The Journal of Minimally Invasive Surgery.2016; 19(1): 19. CrossRef
A COMPARATIVE STUDY BETWEEN SINGLE INCISION MULTIPORT LAPAROSCOPIC APPENDICECTOMY AND CONVENTIONAL LAPAROSCOPIC APPENDECTOMY
Karunamoorthy Rajachidambaram, Dhinakaran Kaarthesan
Journal of Evolution of Medical and Dental Sciences.2016; 5(39): 2372. CrossRef
The Twin Forceps: A New Instrument for SILS
Antonia Rizzuto, Mario Donnici, Paola Nudo, Basilio Sinopoli, Rosario Sacco, Guido Danieli
BioMed Research International.2015; 2015: 1. CrossRef
Estudio comparativo prospectivo aleatorizado entre apendicectomía laparoscópica por puerto único y apendicectomía laparoscópica convencional
Rafael Villalobos Mori, Jordi Escoll Rufino, Fernando Herrerías González, M.Carmen Mias Carballal, Alfredo Escartin Arias, Jorge Juan Olsina Kissler
Cirugía Española.2014; 92(7): 472. CrossRef
Prospective, Randomized Comparative Study Between Single-port Laparoscopic Appendectomy and Conventional Laparoscopic Appendectomy
Rafael Villalobos Mori, Jordi Escoll Rufino, Fernando Herrerías González, M. Carmen Mias Carballal, Alfredo Escartin Arias, Jorge Juan Olsina Kissler
Cirugía Española (English Edition).2014; 92(7): 472. CrossRef
Surgical Outcomes of Single-port Laparoscopic Appendectomy versus Conventional Laparoscopic Appendectomy in Children: Preliminary Report of a Prospective Randomized Trial
Jung Rae Cho, Won Me Kang, Soo Min Ahn
Journal of the Korean Association of Pediatric Surgeons.2014; 20(2): 48. CrossRef
Single-incision laparoscopic appendectomy versus traditional three-port laparoscopic appendectomy: an analysis of outcomes at a single institution
F. Paul Buckley, Hannah Vassaur, Sharon Monsivais, Daniel Jupiter, Rob Watson, John Eckford
Surgical Endoscopy.2014; 28(2): 626. CrossRef
Comparison between single-incision and conventional three-port laparoscopic appendectomy: a meta-analysis from eight RCTs
Jun Gao, Ping Li, Qingguo Li, Dong Tang, Dao-Rong Wang
International Journal of Colorectal Disease.2013; 28(10): 1319. CrossRef
Single-Port Laparoscopic Appendectomy Versus Conventional Laparoscopic Appendectomy
Won-Suk Lee, Sang Tae Choi, Jung Nam Lee, Keon Kug Kim, Yeon Ho Park, Woon Kee Lee, Jeong-Heum Baek, Tae-Hoon Lee
Annals of Surgery.2013; 257(2): 214. CrossRef
Comparative Study Between Single-Incision and Three-Port Laparoscopic Appendectomy: A Prospective Randomized Trial
Bong-Hyeon Kye, Junhyun Lee, Wook Kim, Dongjae Kim, Dosang Lee
Journal of Laparoendoscopic & Advanced Surgical Techniques.2013; 23(5): 431. CrossRef
Outcomes of Single-Incision Laparoscopic Appendectomy at a Single Center
Takahiro Watanabe, Hidetosi Wada, Masanori Sato, Yuichirou Miyaki, Junpei Tochikubo, Norihiko Shiiya
Surgical Science.2013; 04(10): 426. CrossRef
A Review of Minimally Invasive Single-Port/Incision Laparoscopic Appendectomy
Haroon Rehman, Tim Mathews, Irfan Ahmed
Journal of Laparoendoscopic & Advanced Surgical Techniques.2012; 22(7): 641. CrossRef
Single incision versus conventional multi-incision appendicectomy for suspected appendicitis
Haroon Rehman, Ahsan M Rao, Irfan Ahmed
Cochrane Database of Systematic Reviews.2011;[Epub] CrossRef
Single port laparoscopic appendectomy: are we pursuing real advantages?
Nereo Vettoretto, Vincenzo Mandalà
World Journal of Emergency Surgery.2011; 6(1): 25. CrossRef
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H Rehman, I Ahmed
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Risk Factors for Anastomotic Leakage after Laparoscopic Rectal Resection: Dong Hyun Choi, Jae Kwan Hwang, Yong Tak Ko, Han Jeong Jang, Hyeon Keun Shin, Young Chan Lee, Cheong Ho Lim, Seung Kyu Jeong, Hyung Kyu Yang; J Korean Soc Coloproctol. 2010;26(4):265-273. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.265

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Abstract PDF

Purpose

The anastomotic leakage rate after rectal resection has been reported to be approximately 2.5-21 percent, but most results were associated with open surgery. The aim of this study was to identify risk factors and their relationship to the experience of the surgeon for anastomotic leakage after laparoscopic rectal resection.

Methods

Between March 2003 and December 2008, 156 patients underwent a laparoscopic rectal resection without a diverting ileostomy. The patients' characteristics, the details of treatment, the intraoperative results, and the postoperative results were recorded prospectively. Univariate and multivariate analyses were applied to identify risk factors for anastomotic leakage.

Results

The majority of operations were performed for malignant disease (n = 150; 96.2%), and 96 patients (61.5%) were males. Conversion to open surgery occurred in 1 case (0.6%). The anastomotic leak rate was 10.3% (16/156), and there were no mortalities. In the univariate analysis, tumor location, anastomotic level, intraoperative events, and operation time were associated with increased anastomotic leakage rate. In the multivariate analysis, anastomotic level (odds ratio [OR], 6.855; 95% confidence interval [CI], 1.271 to 36.964) and operation time (OR, 8.115; 95% CI, 1.982 to 33.222) were significantly associated with anastomotic leakage.

Conclusion

The important risk factors for anastomotic leakage after laparoscopic rectal resection without a diverting ileostomy were low anastomosis and long operation time. An additional procedure, such as diverting stoma, may reduce the anastomotic leakage if it is selectively applied in cases with these risk factors.

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Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
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Jiawen Zhang, Linhua Jiang, Xinguo Zhu
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Enesh Shiwakoti, Jianning Song, Jun Li, Shanshan Wu, Zhongtao Zhang
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Sarath Sujatha-Bhaskar, Matthew Whealon, Colette S. Inaba, Christina Y. Koh, Mehraneh D. Jafari, Steven Mills, Alessio Pigazzi, Michael J. Stamos, Joseph C. Carmichael
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Indian Journal of Surgery.2017; 79(6): 555. CrossRef
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British Journal of Surgery.2013; 100(12): 1579. CrossRef
Systematic Review of Anastomotic Leakage Rate According to an International Grading System Following Anterior Resection for Rectal Cancer
Zhi-Jie Cong, Liang-Hao Hu, Zheng-Qian Bian, Guang-Yao Ye, Min-Hao Yu, Yun-He Gao, Zhao-Shen Li, En-Da Yu, Ming Zhong, Georgina L Hold
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The American Journal of Surgery.2013; 205(4): 447. CrossRef
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William Kondo, Reitan Ribeiro, Carlos Henrique Trippia, Monica Tessmann Zomer
Case Reports in Obstetrics and Gynecology.2013; 2013: 1. CrossRef
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Torben Glatz, Gabriel Seifert, Philipp A. Holzner, S. Chikhladze, Birte Kulemann, Olivia Sick, Jens Höppner, Ulrich Theodor Hopt, Goran Marjanovic
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Ghost Ileostomy with or without abdominal parietal split
Michele Cerroni, Roberto Cirocchi, Umberto Morelli, Stefano Trastulli, Jacopo Desiderio, Mario Mezzacapo, Chiara Listorti, Luigi Esperti, Diego Milani, Nicola Avenia, Nino Gullà, Giuseppe Noya, Carlo Boselli
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Intraoperative Radiotherapy for Locally Advanced Rectal Cancer: Min Kyu Kang, Myung Se Kim, Jae Hwang Kim; J Korean Soc Coloproctol. 2010;26(4):274-278. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.274

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Abstract PDF

Purpose

Although intraoperative radiotherapy (IORT) is known to be a method that can reduce local recurrence in locally advanced colorectal cancer, it is not widely used. The aim of this study was to report our experience with IORT for locally advanced rectal cancer.

Methods

From 1991 to 1994, nine patients with locally advanced rectal cancer received IORT. External beam radiotherapy was given postoperatively in five patients and preoperatively in three. Seven patients received chemotherapy. IORT was done with 6-MeV or 9-MeV electrons, and 12 Gy was irradiated at the tumor bed. The median follow-up period was 84 months (range, 15 to 208 months).

Results

The median age of patients was 51 years (range, 42 to 73 years). All patients had advanced clinical T-stage (cT3/4) cancer. The overall and the disease-free survival rates were 66.7% and 66.7% at 5 years, respectively. One patient developed a local recurrence near the anastomosis site, which was out of the IORT field. Four patients died before the last follow-up; three from distant metastasis and one from secondary primary cancer. Adverse effects related to IORT did not occur.

Conclusion

Although the number of patients was small in this study, IORT is thought to be safe and effective in reducing local recurrence in locally advanced rectal cancer. However, the role of IORT should be refined in the era of preoperative radio-chemotherapy followed by total mesorectal excision.

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Laparoscopic abdominoperineal resection with intraoperative radiotherapy for locally advanced low rectal cancer
Matej Skrovina, Renata Soumarova, Miloslav Duda, Roman Bezdek, Jiri Bartos, Adam Wendrinski, Petr Andel, Javed Parvez, Martin Straka, Lukas Adamcik
Biomedical Papers.2014; 158(3): 447. CrossRef
Laparoscopic Resection with Intraoperative Radiotherapy for Local Advanced Rectal Cancer: A Preliminary Case Report
Yimei Jiang, Xiaopin Ji, Shengguang Zhao, Ren Zhao, Yening Jin
Journal of Laparoendoscopic & Advanced Surgical Techniques.2013; 23(3): 267. CrossRef
A review of the logistic role of l‐carnitine in the management of radiation toxicity and radiotherapy side effects
Haseeb Ahmad Khan, Abdullah Saleh Alhomida
Journal of Applied Toxicology.2011; 31(8): 707. CrossRef

Clinical Significance of Tumor Regression Grade in Rectal Cancer with Preoperative Chemoradiotherapy: Young Joo Park, Byung Ryul Oh, Sang Woo Lim, Jung Wook Huh, Jae Kyun Joo, Young Jin Kim, Hyeong Rok Kim; J Korean Soc Coloproctol. 2010;26(4):279-286. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.279

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Abstract PDF

Purpose

Neoadjuvant chemoradiotherapy applied to the locally advanced rectal cancer reduces local recurrence and improves survival. We assessed tumor regression grade (TRG) and its influence on survival in rectal cancer patients treated with chemoradiotherapy followed by surgical resection.

Methods

We studied 108 patients that were seen at our hospital between August 2004 and December 2008. Patients received preoperative chemoradiotherapy consisting of 5-fluorouracil and leucovorin by continous infusion during the first and fifth week, delivered with concurrent pelvic radiation of 50.4 Gy, followed by radical surgery at 6-8 weeks. The TRG was determined by the amount of fibrosis in the tumor embedding area and was divided into 5 grades based on the relative amount of fibrosis. We analyzed all preoperative clinicopathologic factors, postoperative pathologic stages, TRG and prognosis, retrospectively.

Results

Downstaging of rectal cancer through neoadjuvant chemoradiotherapy occurred in 64 (59%) patients. The numbers of total regressions (TRG4), good regressions (TRG3), moderate regressions (TRG2), minor regressions (TRG1), and no regression (TRG0) were 19 (18%), 65 (60%), 17 (16%), 6 (5%), and 1 (1%) respectively. The TRG was inversely correlated with perineural invasion and lymphovascular invasion (P = 0.008, P = 0.032). The local recurrence rate declined as the tumor regression grade increased (P = 0.032). The 19 patients with TRG4 had a better three-year disease free survival than the 89 patients with TRG0-3 (P = 0.034). The 16 patients with pathologic complete remission (pCR) had a better three-year disease free survival than the 92 patients with non-pCR (P = 0.025).

Conclusion

Higher TRG after preoperative chemoradiotherapy for rectal cancer closely correlates with better survival and low local recurrence. The TRG is considered to be a significant prognostic factor.

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An investigation into tumor regression grade as a parameter for locally advanced rectal cancer and 5-year overall survival rate
Supparerk Laohawiriyakamol, Wongsakorn Chaochankit, Worawit Wanichsuwan, Kanet Kanjanapradit, Teeranan Laohawiriyakamol
Annals of Coloproctology.2023; 39(1): 59. CrossRef
Rezultate preliminare ale markerilor ca predictori ai răspunsului tisular la radiochimioterapie în cancerul rectal
Sânziana Ionescu, Petre Radu, Octavia Luciana Madge, Victor Strâmbu
Oncolog-Hematolog.ro.2022; 1(58): 8. CrossRef
Clinical Implication of Perineural and Lymphovascular Invasion in Rectal Cancer Patients Who Underwent Surgery After Preoperative Chemoradiotherapy
Young Il Kim, Chan Wook Kim, Jong Hoon Kim, Jihun Kim, Jun-Soo Ro, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Diseases of the Colon & Rectum.2022; 65(11): 1325. CrossRef
Downstaging in Advanced Rectal Cancers: A Propensity-Matched Comparison Between Short-Course Radiotherapy Followed by Chemotherapy and Long-Course Chemoradiotherapy
Praveen S. Kammar, Niharika R. Garach, Sivasanker Masillamany, Ashwin de’Souza, Vikas Ostwal, Avanish P. Saklani
Diseases of the Colon & Rectum.2022; 65(10): 1215. CrossRef
Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
Wan-Shan Li, Chih-I Chen, Hsin-Pao Chen, Kuang-Wen Liu, Chia-Jen Tsai, Ching-Chieh Yang
Diagnostics.2021; 11(11): 2132. CrossRef
How to measure tumour response in rectal cancer? An explanation of discrepancies and suggestions for improvement
Iris D. Nagtegaal, Rob Glynne-Jones
Cancer Treatment Reviews.2020; 84: 101964. CrossRef
Neoadjuvant chemoradiotherapy might provide survival benefit in patients with stage IIIb/IIIc locally advanced rectal cancer: A retrospective single‐institution study with propensity score‐matched comparative analysis
Xi‐yu Sun, Song‐hua Cai, Lai Xu, Dan Luo, Hui‐zhong Qiu, Bin Wu, Guo‐le Lin, Jun‐yang Lu, Guan‐nan Zhang, Yi Xiao
Asia-Pacific Journal of Clinical Oncology.2020; 16(3): 142. CrossRef
Prognostic value of tumour regression grade in locally advanced rectal cancer: a systematic review and meta‐analysis
J. C. Kong, G. R. Guerra, S. K. Warrier, A. Craig Lynch, M. Michael, S. Y. Ngan, W. Phillips, G. Ramsay, A. G. Heriot
Colorectal Disease.2018; 20(7): 574. CrossRef
UEG Week 2018 Poster Presentations

United European Gastroenterology Journal.2018;[Epub] CrossRef
Prognostic significance of tumour regression grade after neoadjuvant chemoradiotherapy for a cohort of patients with locally advanced rectal cancer: an 8‐year retrospective single‐institutional study
L. Xu, S. Cai, T. Xiao, Y. Chen, H. Qiu, B. Wu, G. Lin, X. Sun, J. Lu, W. Zhou, Y. Xiao
Colorectal Disease.2017;[Epub] CrossRef
Magnetic resonance tumor regression grade (MR-TRG) to assess pathological complete response following neoadjuvant radiochemotherapy in locally advanced rectal cancer
Marco Rengo, Simona Picchia, Simona Marzi, Davide Bellini, Damiano Caruso, Mauro Caterino, Maria Ciolina, Domenico De Santis, Daniela Musio, Vincenzo Tombolini, Andrea Laghi
Oncotarget.2017; 8(70): 114746. CrossRef
Oncologic impact of pathologic response on clinical outcome after preoperative chemoradiotherapy in locally advanced rectal cancer
Wook Hyeon Yoon, Hun Jin Kim, Chang Hyun Kim, Jae Kyoon Joo, Young Jin Kim, Hyeong Rok Kim
Annals of Surgical Treatment and Research.2015; 88(1): 15. CrossRef
Low Lymph Node Retrieval After Preoperative Chemoradiation for Rectal Cancer is Associated with Improved Prognosis in Patients with a Good Tumor Response
Hun Jin Kim, Jeong Seon Jo, Soo Young Lee, Chang Hyun Kim, Young Jin Kim, Hyeong Rok Kim
Annals of Surgical Oncology.2015; 22(6): 2075. CrossRef
Clinical Prediction of Pathological Complete Response After Preoperative Chemoradiotherapy for Rectal Cancer
Jung Wook Huh, Hyeong Rok Kim, Young Jin Kim
Diseases of the Colon & Rectum.2013; 56(6): 698. CrossRef
Prognostic Significance of Partial Tumor Regression After Preoperative Chemoradiotherapy for Rectal Cancer
Yen-Chien Lee, Chung-Cheng Hsieh, Jen-Pin Chuang
Diseases of the Colon & Rectum.2013; 56(9): 1093. CrossRef
Prognostic Role of p53 Messenger Ribonucleic Acid Expression in Patients after Curative Resection for Stage I to III Colorectal Cancer: Association with Colon Cancer Stem Cell Markers
Jung Wook Huh, Hyeong Rok Kim, Young Jin Kim
Journal of the American College of Surgeons.2013; 216(6): 1063. CrossRef
A phase II study of neoadjuvant chemoradiotherapy with oxaliplatin and capecitabine for rectal cancer
Lin Zhao, Chunmei Bai, Yajuan Shao, Mei Guan, Ning Jia, Yi Xiao, Huizhong Qiu, Fuquan Zhang, Ti Yang, Guangxi Zhong, Shuchang Chen
Cancer Letters.2011; 310(2): 134. CrossRef
Oncologic outcomes of pathologic stage I lower rectal cancer with or without preoperative chemoradiotherapy: Are they comparable?
Jung Wook Huh, Chang Hyun Kim, Hyeong Rok Kim, Young Jin Kim
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Oncologic Outcome after Cessation or Dose Reduction of Capecitabine in Patients with Colon Cancer: Jung-A Yun, Hee Cheol Kim, Hyun-Sook Son, Hyoung Ran Kim, Hae Ran Yun, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun; J Korean Soc Coloproctol. 2010;26(4):287-292. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.287

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Abstract PDF

Purpose

Oral capecitabine has been used as adjuvant therapy for colorectal cancer patients since the 1990s. Patient-initiated cessation or reduced use of capecitabine occurs widely for various reasons, yet the consequences of these actions are unclear. The present study sought to clarify treatment outcomes in such patients.

Methods

The study included 173 patients who had been diagnosed with stage II or III colon cancer according to the pathologic report after radical surgery at Samsung Medical Center from May 2005 to June 2007 and who had received capecitabine as adjuvant therapy. The patients were divided into groups according to whether the dose was reduced (I, dose maintenance; II, dose reduction) or stopped (A, cycle completion; B, cycle cessation). Recurrence and disease-free survival rates between the two groups each were analyzed.

Results

Of the 173 patients, 128 (74.6%) experienced complications, most frequently hand-foot syndrome (n = 114). Reduction (n = 35) or cessation (n = 18) of medication was most commonly due to complications. Concerning reduced dosage, both groups displayed no statistically significant differences in recurrence rate and 3-year disease-free survival rate. Concerning discontinued medication use, the cycle completion group showed an improved recurrence rate (P = 0.048) and 3-year disease-free survival rate (P = 0.028).

Conclusion

The results demonstrate that maintaining compliance with capecitabine as an adjuvant treatment for colon cancer to preventing complications positively affects patient prognosis.

Citations

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The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients
Doreen Z. Mhandire, Andrew K. L. Goey
Molecular Diagnosis & Therapy.2022; 26(2): 137. CrossRef
Global Cancer Burden and Natural Disasters: A Focus on Asia’s Vulnerability, Resilience Building, and Impact on Cancer Care
Roselle De Guzman, Monica Malik
Journal of Global Oncology.2019; (5): 1. CrossRef
Association Between Adjuvant Chemotherapy Duration and Survival Among Patients With Stage II and III Colon Cancer
Devon J. Boyne, Colleen A. Cuthbert, Dylan E. O’Sullivan, Tolulope T. Sajobi, Robert J. Hilsden, Christine M. Friedenreich, Winson Y. Cheung, Darren R. Brenner
JAMA Network Open.2019; 2(5): e194154. CrossRef
5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT Cell Line
Jan Hartinger, Pavel Veselý, Martin Šíma, Irena Netíková, Eva Matoušková, Luboš Petruželka
Prague Medical Report.2017; 118(4): 128. CrossRef
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Annie Law, Sue Dyson, Denis Anthony
Journal of Advanced Nursing.2015; 71(8): 1825. CrossRef

Significance of Follow-up in Detection of Pulmonary Metastasis of Colorectal Cancer: Jae Won Shin, Sun Il Lee, Hong Young Moon; J Korean Soc Coloproctol. 2010;26(4):293-297. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.293

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3 Citations

Abstract PDF

Purpose

This study was performed to evaluate the effectiveness of conventional chest radiography, carcinoembrionic antigen (CEA) level and abdominal computed tomography (CT) or chest CT for early detection of pulmonary metastasis after a curative resection of colorectal cancer.

Methods

We retrospectively reviewed 84 cases of pulmonary metastasis from a group of colorectal cancer patients who had a curative surgical resection from 2000 to 2006 at the Korea University Medical Center.

Results

Stage I tumors were detected in 4 patients, stage II tumors in 18, stage III tumors in 43 and stage IV tumors in 19. The detection rates for pulmonary metastasis were 28.5% by conventional chest radiography, 40.5% by increased CEA level and 28.5% by abdominal CT or chest CT. Among them, fourteen patients underwent a radical pneumonectomy. After detection of pulmonary metastasis, the survival outcome for the patients who underwent a resection of the lung was superior to the survival outcome of the patients who did not undergo a resection of the lung (43.7 months vs. 17.4 months, P = 0.001). For patients who underwent resections of the lung, pulmonary metastasis was detected by conventional chest radiography in 2 (14%) patients, by elevated CEA level in 6 (42%) patients, and by abdominal CT or chest CT in 6 (42%) patients.

Conclusion

Conventional chest radiography is no more useful in detecting early pulmonary metastasis after a curative colorectal surgery than a routine chest CT. Thus, we propose the use of routine chest CT for screening for lung metastasis.

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A novel diagnostic model for differentiation of lung metastasis from primary lung cancer in patients with colorectal cancer
Rui Guo, Shi Yan, Fei Wang, Hua Su, Qing Xie, Wei Zhao, Zhi Yang, Nan Li, Jiangyuan Yu
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Simultaneous laparoscopic colorectal resection and pulmonary resection by minithoracotomy: Report of four cases
Tetsuo Tsukahara, Seiichiro Yamamoto, Taihei Oshiro, Shin Fujita, Hiroyuki Sakurai, Shun‐ichi Watanabe
Asian Journal of Endoscopic Surgery.2014; 7(2): 160. CrossRef
Clinical Characteristics of Patients With Solitary Pulmonary Mass After Radical Treatment for Primary Cancers: Pulmonary Metastasis or Second Primary Lung Cancer?
Jun Ge, Hong-Feng Gou, Ye Chen, Ke Cheng, Long-Hao Li, Hang Dong, Feng Gao, Feng Zhao, Hai-Tao Men, Qiu Li, Meng Qiu, Jing-Mei Su, Feng Xu, Feng Bi, Ji-Yan Liu
Cancer Investigation.2013; 31(6): 397. CrossRef

Case Reports

Impaction of a Foreign Body in the Rectum by Improper Use of a (Electronic) Massager: A Case Report: Eun-Joo Jung, Chun-Geun Ryu, Gangmi Kim, Dae-Yong Hwang; J Korean Soc Coloproctol. 2010;26(4):298-301. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.298

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Abstract PDF

A male, 67 years old, visited the emergency room because of a foreign body impacted in his rectum. While he was being treated for grade-II hemorrhoids conservatively, he heard that massage of the peri-anal area could be helpful for preventing hemorrhoids. Thus, while using an electronic massager after placing the head of the machine into a short round bar, the head became separated from the machine, and this was inserted into the anus and impacted. The patient had anal discomfort without abdominal pain. His vital signs were stable, and no abnormal physical findings were found for the abdomen. On digital rectal examination, the rim of the foreign body was palpated about 8 cm from the anal verge. Anal bleeding, abnormal discharge, or foul odor was not found. On a simple abdominal X-ray, a radio-opaque foreign body was observed in the pelvic cavity, and mild leukocytosis was noted on the laboratory test. To avoid injury to the anal sphincter, we tried to remove the foreign body under the spinal anesthesia. After anesthesia had been administered, the foreign body was palpated more distally at 5-6 cm from the anal verge by digital examination, and the foreign body was found to have a hole in its center. This was held using a Kelly clamp, and with digital guiding, was removed through the anus. After removal, an anoscopic examination was performed to determine if mucosal injury had occurred in the rectum or anal canal. The patient was discharged without complication after 24 hours of close observation.

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Rectal perforation caused by a sharp pig backbone in a middle-aged patient with mild depression
Hyeong Ju Sun, Jeonghun Lee, Dong Min Kim, Myeong-Su Chu, Kyoung Sun Park, Dong Jin Choi
Yeungnam University Journal of Medicine.2015; 32(1): 31. CrossRef

Laparoscopic Approach to a Case of Appendicular Schwannoma: Suk Won Suh, Joong Min Park, Yoo Shin Choi, Sung Jae Cha, In Taik Chang, Beom Gyu Kim; J Korean Soc Coloproctol. 2010;26(4):302-306. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.302

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10 Citations

Abstract PDF

Appendicular schwannoma is a rare tumor originating from Schwann's cells in the Auerbach plexus. The preoperative diagnosis is difficult because the clinical features are nonspecific, and it is mostly found accidentally via a radiologic image as a tumor, mimicking malignancy. We report a case of an appendicular schwannoma coexisting with an adenocarcinoma in the lung. A laparoscopic appendectomy was done with a clear resection margin, and the immunohistochemical staining showed positive S-100 protein, which confirmed the schwannoma. The patient also underwent a left upper lobectomy of the lung. The patient has been free of recurrence for the 6 months since the operation. The laparoscopic approach could be available for treatment of an appendicular schwannoma, thus avoiding an unnecessary laparotomy.

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Appendicular schwannoma presenting as vague abdominal pain
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Journal of Surgical Case Reports.2018;[Epub] CrossRef
Laparoscopic Resection of Appendiceal Schwannoma
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(1): 78. CrossRef
A Case of Appendiceal Schwannoma
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Schwannoma of ascending colon treated by laparoscopic right hemicolectomy
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World Journal of Surgical Oncology.2012;[Epub] CrossRef

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