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Tae Doo Jung 1 Article
Prognostic Significance of the Decreased Rate of Perioperative Serum Carcinoembryonic Antigen Level in the Patients With Colon Cancer After a Curative Resection
Tae Doo Jung, Jong Han Yoo, Min Jae Lee, Ha Kyung Park, Jae Ho Shin, Min Sung An, Tae Kwun Ha, Kwang Hee Kim, Ki Beom Bae, Tae Hyeon Kim, Chang Soo Choi, Min Kyung Oh, Kwan Hee Hong
Ann Coloproctol. 2013;29(3):115-122.   Published online June 30, 2013
DOI: https://doi.org/10.3393/ac.2013.29.3.115
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  • 4 Citations
AbstractAbstract PDF
Purpose

The serum level of carcinoembryonic antigen (CEA) is a clinical prognostic factor in the follow-up evaluation of patients with colon cancer. We aimed to evaluate the prognostic significance of the rate of decrease of the perioperative serum CEA level in patients with colon cancer after a curative resection.

Methods

A total of 605 patients who underwent a curative resection for colon cancer between January 2000 and December 2007 were enrolled retrospectively. The rate of decrease was calculated using the following equation: ([preoperative CEA - postoperative CEA]/[preoperative CEA] ×100).

Results

In the group with a preoperative serum CEA level of >5 ng/mL, the normalized group with a postoperative serum CEA level of ≤5 ng/mL showed a better overall survival (OS) rate and disease-free survival (DFS) rate than those of the non-normalized group (P ≤ 0.0001). The "cutoff values" of the rate of decrease in the perioperative serum CEA that determined the OS and the DFS were 48.9% and 50.8%, respectively. In the multivariate analysis of preoperative serum CEA levels >5 ng/mL, the prognostic factors for the OS and the DFS were the cutoff value (P < 0.0001) and the pN stage (P < 0.0001).

Conclusion

A rate of decrease of more than 50% in the perioperative serum CEA level, as well as the normalization of the postoperative serum CEA level, may be useful factors for determining a prognosis for colon cancer patients with high preoperative CEA levels.

Citations

Citations to this article as recorded by  
  • Patients with T4N0 and T1‑3N1 colon cancer and a high preoperative carcinoembryonic antigen level benefit from adjuvant chemotherapy with oxaliplatin for 6 months
    Hiroyuki Inoue, Hiroki Shimizu, Yoshiaki Kuriu, Tomohiro Arita, Kenji Nanishi, Jun Kiuchi, Takuma Ohashi, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    Oncology Letters.2024;[Epub]     CrossRef
  • Metastasis of colorectal adenocarcinoma to the mandible
    Kushal CHATTERJEE, Aritra CHATTERJEE, Debarati BHOWMICK, Hrishikesh KUMAR, Arif HOSSAIN, Debabrata GAYEN
    European Journal of Oral and Maxillofacial Surgery.2021;[Epub]     CrossRef
  • Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer
    Jinsun Woo, Jungbin Kim, Inseok Park, Hyunjin Cho, Geumhee Gwak, Keun Ho Yang, Byung-Noe Bae, Ki Hwan Kim
    Annals of Coloproctology.2018; 34(1): 4.     CrossRef
  • Clinicopathologic features and oncologic outcomes of colorectal cancer patients with extremely high carcinoembryonic antigen
    Soo Young Lee, Jeong Seon Jo, Hun Jin Kim, Chang Hyun Kim, Jae-Kyun Ju, Young Jin Kim, Hyeong Rok Kim
    International Journal of Colorectal Disease.2015; 30(1): 63.     CrossRef

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