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Sun Hee Jee 3 Articles
Is Microsatellite Instability Really a Good Prognostic Factor of Colorectal Cancer?
Ui Sup Shin, Sang Sik Cho, Sun Mi Moon, Sun Hoo Park, Sun Hee Jee, Eun-Joo Jung, Dae-Yong Hwang
Ann Coloproctol. 2014;30(1):28-34.   Published online February 28, 2014
DOI: https://doi.org/10.3393/ac.2014.30.1.28
  • 4,977 View
  • 43 Download
  • 33 Web of Science
  • 25 Citations
AbstractAbstract PDF
Purpose

The aim of this study was to investigate the clinicopathologic features of and the prognosis for colorectal cancers (CRCs) with microsatellite instabilities (MSIs).

Methods

Between 2006 and 2009, genotyping was performed on 245 patients with stage II/III CRCs to establish the MSI status. The clinicopathologic differences and the prognostic value of MSI were analyzed. The median follow-up period was 38 months (range, 7-68 months).

Results

Of the total 245 patients, 20 (8.2%) had MSI-high (H) and 225 (91.8%) had MSI-low (L) or stable (S) CRCs. Adjuvant chemotherapies were performed on 101 stage II (87.8%) and 107 stage III patients (82.3%). Patients with MSI-H CRCs more frequently had a family history of colon cancer (10% vs. 2.7%, P = 0.003), more frequently had a cancer located at the proximal colon (90.0% vs. 19.1%, P < 0.0001), and more often showed a mucinous phenotype or poor differentiation (35.0% vs. 7.1%, P = 0.001). Despite less frequent lymph node metastasis (25% vs. 55.6%, P = 0.01), the number of retrieved lymph nodes was higher (26.3 ± 13.1 vs. 20.7 ± 1.2, P = 0.04) in the MSI-H group. The overall survival and the disease-free survival (DFS) did not differ with respect to MSI status. However, in the stage II subgroup, the DFS for patients with MSI-H CRCs was significantly worse (72.2% vs. 90.7%, P = 0.03). The multivariate analysis performed on this subgroup revealed that MSI-H was an independent poor prognostic factor (adjusted hazard ratio, 4.0; 95% confidence interval, 1.0-15.6, P = 0.046).

Conclusion

MSI-H CRCs had distinct clinicopathologic features, and MSI-H was an independent poor prognostic factor in stage II CRCs. Considering the majority of stage II patients were administrated adjuvant chemotherapy, the efficacy of adjuvant chemotherapy for treating MSI CRCs might be different from that for treating MSI-L/S tumors.

Citations

Citations to this article as recorded by  
  • Prognostic significance of negative lymph node count in microsatellite instability-high colorectal cancer
    Xuan Dai, Zhujiang Dai, Jihong Fu, Zhonglin Liang, Peng Du, Tingyu Wu
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer
    Wen-Xuan Fan, Fei Su, Yan Zhang, Xiao-Ling Zhang, Yun-Yi Du, Yang-Jun Gao, Wei-Ling Li, Wen-Qing Hu, Jun Zhao
    Biomarker Research.2024;[Epub]     CrossRef
  • Exploring the value of multiple preprocessors and classifiers in constructing models for predicting microsatellite instability status in colorectal cancer
    Yi Ma, Zhihao Shi, Ying Wei, Feng Shi, Guochu Qin, Zhengyang Zhou
    Scientific Reports.2024;[Epub]     CrossRef
  • The prognostic significance of microsatellite instability in colorectal cancer: a Swedish multi-center study
    Petri Rantanen, Anne Keränen, Shabane Barot, Sam Ghazi, Annelie Liljegren, Caroline Nordenvall, Annika Lindblom, Ulrik Lindforss
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Preoperative albumin–bilirubin score as a prognostic indicator in patients with stage III colon cancer
    Hyun Gu Lee, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Jin Cheon Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Radiomics features based on internal and marginal areas of the tumor for the preoperative prediction of microsatellite instability status in colorectal cancer
    Yi Ma, Changsong Lin, Song Liu, Ying Wei, Changfeng Ji, Feng Shi, Fan Lin, Zhengyang Zhou
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Anatomical Distribution of Colon Cancer: A Retrospective 10-Year Study to Evaluate Rightward Shift in Two Referral Hospitals in Iran
    Ahmad R Mafi, Shima Azimi Oliaei, Ramin Heshmat, Hossein Yahyazadeh, Ali G Motlagh
    International Journal of Cancer Management.2022;[Epub]     CrossRef
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    James W. T. Toh, Hema Mahajan, Pierre Chapuis, Kevin Spring
    Cancer Reports.2021;[Epub]     CrossRef
  • Rate of dissemination and prognosis in early and advanced stage colorectal cancer based on microsatellite instability status: systematic review and meta-analysis
    James W. T. Toh, Kevin Phan, Faizur Reza, Pierre Chapuis, Kevin J. Spring
    International Journal of Colorectal Disease.2021; 36(8): 1573.     CrossRef
  • Computed Tomography-Based Radiomics Model to Preoperatively Predict Microsatellite Instability Status in Colorectal Cancer: A Multicenter Study
    Zhi Li, Qi Zhong, Liang Zhang, Minhong Wang, Wenbo Xiao, Feng Cui, Fang Yu, Chencui Huang, Zhan Feng
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Colon cancer patients with mismatch repair deficiency are more likely to present as acute surgical cases
    Ioannis Gkekas, Jan Novotny, Tuomas Kaprio, Ines Beilmann-Lehtonen, Pavel Fabian, Sofia Edin, Karin Strigård, Tomas Svoboda, Jaana Hagström, Lucie Barsova, Tomas Jirasek, Caj Haglund, Richard Palmqvist, Ulf Gunnarsson
    European Journal of Cancer.2021; 157: 1.     CrossRef
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    Kabytto Chen, Geoffrey Collins, Henry Wang, James Wei Tatt Toh
    Current Oncology.2021; 28(6): 5356.     CrossRef
  • Prognostic and predictive role of DNA mismatch repair status in stage II‐III colorectal cancer: A systematic review and meta‐analysis
    Zhujun Deng, Yun Qin, Jing Wang, Gang Wang, Xiaoqiang Lang, Juan Jiang, Kang Xie, Wengeng Zhang, Heng Xu, Yang Shu, Yan Zhang
    Clinical Genetics.2020; 97(1): 25.     CrossRef
  • Implication of Microsatellite Instability in Chinese Cohort of Human Cancers


    Meiying Cui, Pan Li, Ying Mao, Lan Zhang, Peiyi Xia, Enjie Liu, Weiwei Wang, Jianying Zhang, Guozhong Jiang, Wencai Li
    Cancer Management and Research.2020; Volume 12: 10287.     CrossRef
  • Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
    Robin Mjelle, Wenche Sjursen, Liv Thommesen, Pål Sætrom, Eva Hofsli
    BMC Cancer.2019;[Epub]     CrossRef
  • Evaluation of Long-Term Outcomes of Microsatellite Instability Status in an Asian Cohort of Sporadic Colorectal Cancers
    Winson Jianhong Tan, Julie Liana Hamzah, Sanchalika Acharyya, Fung Joon Foo, Kiat Hon Lim, Iain Bee Huat Tan, Choong Leong Tang, Min Hoe Chew
    Journal of Gastrointestinal Cancer.2018; 49(3): 311.     CrossRef
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    Jeong Mo Bae, Jung Ho Kim, Yoonjin Kwak, Dae-Won Lee, Yongjun Cha, Xianyu Wen, Tae Hun Lee, Nam-Yun Cho, Seung-Yong Jeong, Kyu Joo Park, Sae Won Han, Hye Seung Lee, Tae-You Kim, Gyeong Hoon Kang
    British Journal of Cancer.2017; 116(8): 1012.     CrossRef
  • Investigation of correlation between mutational status in key EGFR signaling genes and prognosis of stage II colorectal cancer
    Li Li, Bei-Bei Ni, Qing-Hua Zhong, Yan-Hui Liu, Ming-Hui Zhang, Ke-Ping Zhang, Dai-Ci Chen, Lei Wang
    Future Oncology.2017; 13(17): 1473.     CrossRef
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    Dae Ro Lim, Jung Kul Kuk, Taehyung Kim, Eung Jin Shin
    Medicine.2017; 96(42): e8241.     CrossRef
  • Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma
    Jeong Mo Bae, Jung Ho Kim, Hyeon Jeong Oh, Hye Eun Park, Tae Hun Lee, Nam-Yun Cho, Gyeong Hoon Kang
    Modern Pathology.2017; 30(2): 267.     CrossRef
  • Prognostic relevance of microsatellite instability in pT3N0M0 colon cancer: a population-based study
    Francesco Iachetta, Federica Domati, Luca Reggiani-Bonetti, Valeria Barresi, Giulia Magnani, Luigi Marcheselli, Claudia Cirilli, Monica Pedroni
    Internal and Emergency Medicine.2016; 11(1): 41.     CrossRef
  • Clinical, histological, and molecular risk factors for cancer recurrence in patients with stage II colon cancer
    Yann Touchefeu, Marie Provost-Dewitte, Thierry Lecomte, Alain Morel, Isabelle Valo, Jean-François Mosnier, Céline Bossard, Juliette Eugène, Emilie Duchalais, Jérôme Chetritt, Serge Guyetant, Stéphane Bézieau, Hélène Senellart, Morgane Caulet, Estelle Cauc
    European Journal of Gastroenterology & Hepatology.2016; 28(12): 1394.     CrossRef
  • Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer
    H.M. Mohan, E. Ryan, I. Balasubramanian, R. Kennelly, R. Geraghty, F. Sclafani, D. Fennelly, R. McDermott, E.J. Ryan, D. O'Donoghue, J.M.P. Hyland, S.T. Martin, P.R. O'Connell, D. Gibbons, Des Winter, K. Sheahan
    European Journal of Surgical Oncology (EJSO).2016; 42(11): 1680.     CrossRef
  • Different treatment strategies and molecular features between right-sided and left-sided colon cancers
    Hong Shen
    World Journal of Gastroenterology.2015; 21(21): 6470.     CrossRef
  • Is a Microsatellite Instability Still Useful for Tailored Treatment in Stage II and III Colon Cancer?
    Nam Kyu Kim
    Annals of Coloproctology.2014; 30(1): 5.     CrossRef
Incidence and Risk Factors of Parastomal Hernia
Yeun Ju Sohn, Sun Mi Moon, Ui Sup Shin, Sun Hee Jee
J Korean Soc Coloproctol. 2012;28(5):241-246.   Published online October 31, 2012
DOI: https://doi.org/10.3393/jksc.2012.28.5.241
  • 5,026 View
  • 58 Download
  • 55 Citations
AbstractAbstract PDF
Purpose

Among the various stoma complications, the parastomal hernia (PSH) is the most common. Prevention of PSH is very important to improve the quality of life and to prevent further serious complications. The aim of this study was to analyze the incidence and the risk factors of PSH.

Methods

From January 2002 and October 2008, we retrospectively reviewed 165 patients who underwent an end colostomy. As a routine oncologic follow-up, abdomino-pelvic computed tomography was used to examine the occurrence of the PSH. The associations of age, sex, body mass index (BMI), history of steroid use and comorbidities to the development of the PSH were analyzed. The median duration of the follow-up was 36 months (0 to 99 months).

Results

During follow-up, 50 patients developed a PSH and the 5-year cumulative incidence rate of a PSH, obtained by using the Kaplan-Meier method, was 37.8%. In the multivariate COX analysis, female gender (hazard ratio [HR], 3.29; 95% confidence interval [CI], 1.77 to 6.11; P < 0.0001), age over 60 years (HR, 2.37; 95% CI, 1.26 to 4.46; P = 0.01), BMI more than 25 kg/m2 (HR, 1.8; 95% CI, 1.02 to 3.16; P = 0.04), and hypertension (HR, 2.08; 95% CI, 1.14 to 3.81; P = 0.02) were all independent risk factors for the development of a PSH.

Conclusion

The 5-year incidence rate of a PSH was 37.8%. The significant risk factors of a PSH were as follows: female gender, age over 60 years, BMI more than 25 kg/m2, and hypertension. Using a prophylactic mesh during colostomy formation might be advisable when the patients have these factors.

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    Sherif Abolfotouh, Tero Rautio, Kai Klintrup, Ilona Helavirta, Jyrki Mäkelä
    Scandinavian Journal of Gastroenterology.2017; 52(10): 1078.     CrossRef
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    Sebastian Barber-Millet, Salvador Pous, Vicente Navarro, Jose Iserte, Eduardo García-Granero
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Effectiveness of Adjuvant Chemotherapy with 5-FU/Leucovorin and Prognosis in Stage II Colon Cancer
Sun Hee Jee, Sun Mi Moon, Ui Sup Shin, Hoe Min Yang, Dae-Yong Hwang
J Korean Soc Coloproctol. 2011;27(6):322-328.   Published online December 31, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.6.322
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AbstractAbstract PDF
Purpose

The aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemotherapy in stage II colon cancer in the sparsity of Korean data.

Methods

From 1993 to 2006, 363 curatively resected pathologic stage II colon cancer patients were enrolled. Six cycles of adjuvant chemotherapy was performed: intravenous bolus 5-fluorouracil (5-FU) 500 mg/m2 with leucovorin 20 mg/m2 for 2 hours daily for 5 days, followed by a 3-week resting period (n = 308). Fifty-five patients received only curative surgery. A high risk of recurrence was defined as the presence of one or more of the following factors: T4 tumor, lympho-vascular invasion, perineural invasion, perforation, obstruction, retrieved lymph node < 12, and poorly differention. The median follow-up period was 68 months (1 to 205 months).

Results

The five-year overall survival (OS) rate was 90.1%, and the five-year disease-free survival (DFS) rate was 84.7%. Among high-risk patients, the OS and the DFS rates of the treatment group were significantly higher than those of the non-treatment group (OS: 90.6% vs. 69.1%, P < 0.0001; DFS: 85.9% vs. 54.1%, P < 0.0001). Among low-risk patients, the survival results of the treatment group were also significantly superior (OS: 97.7% vs. 88.2%, P < 0.0001; DFS: 93.0% vs. 80.0%, P = 0.001). In the multivariate analysis, adjuvant chemotherapy was a significantly favorable prognostic factor for overall survival (hazard ratio, 0.41; 95% confidence interval, 0.22 to 0.75; P = 0.004).

Conclusion

In our population, adjuvant chemotherapy showed superior survival to curative surgery alone and significantly reduced the risk of death. A nationwide multicenter randomized trial is needed.

Citations

Citations to this article as recorded by  
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