Annals of Coloproctology

Skip Navigation: Skip to contents

SEARCH: Search

Advanced Search

mobile menu button

Page Path: HOME > Browse Articles

So Yong Park

1 Article

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis: Jeong Yeon Kim, Dongjun Jeong, Tae Sung Ahn, Hyung Ju Kim, Doo San Park, So Yong Park, Sang Byung Bae, Sookyoung Lee, Sung Soo Lee, Moon Soo Lee, Hyun Deuk Cho, Moo Jun Baek; Ann Coloproctol. 2013;29(3):93-99. Published online June 30, 2013; DOI: https://doi.org/10.3393/ac.2013.29.3.93

6,506 View
30 Download
14 Web of Science
10 Citations

Abstract PDF

Purpose

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods

The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results

The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion

These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

Citations to this article as recorded by

CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy
Keishi Yamashita, Yusuke Kumamoto
International Journal of Molecular Sciences.2024; 25(11): 6003. CrossRef
Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun, Raj Kumar Koiri
PLOS ONE.2022; 17(8): e0273317. CrossRef
SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression
Qing Nian, Jingwei Li, ZhongYu Han, Qi Liang, Maoyu Liu, Chan Yang, Fernando Rodrigues-Lima, Tao Jiang, Liyun Zhao, Jinhao Zeng, Chi Liu, Jianyou Shi
Biomedicine & Pharmacotherapy.2022; 153: 113519. CrossRef
Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda Lopez-Moncada, Alexander Herrera, María José Torres, Exequiel Alonso, Norberto Ariel Gandini, Graciela Gigola, Hector R. Contreras, Claudia Gentili
Molecular and Cellular Endocrinology.2021; 530: 111253. CrossRef
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen,
eLife.2021;[Epub] CrossRef
Secreted protein acidic and rich in cysteine gene variants: Impact on susceptibility and survival of hepatocellular carcinoma patients
Samar Kamal Darweesh, Rasha Ahmed Abd Alziz, Heba Omar, Dina Sabry, Wael Fathy
Journal of Gastroenterology and Hepatology.2019; 34(8): 1424. CrossRef
Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy
Fwu‐Long Mi, Thierry Burnouf, Shih‐Yuan Lu, Yu‐Jen Lu, Kun‐Ying Lu, Yi‐Cheng Ho, Chang‐Yi Kuo, Er‐Yuan Chuang
Advanced Healthcare Materials.2017;[Epub] CrossRef
SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy
Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
Cancer Biomarkers.2017; 18(4): 459. CrossRef
Tumor–stroma ratio is an independent predictor for survival in early cervical carcinoma
Jing Liu, Juan Liu, Jinsong Li, Yingling Chen, Xiaoling Guan, Xiaojuan Wu, Chunyan Hao, Yanlin Sun, Yan Wang, Xiao Wang
Gynecologic Oncology.2014; 132(1): 81. CrossRef
Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma
Young Jin Kim
Annals of Coloproctology.2013; 29(3): 87. CrossRef

TOP