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Seong Woo Jeon 1 Article
Regression of Colonic Adenomas After Treatment With Sulindac in Familial Adenomatous Polyposis: A Case With a 2-Year Follow-up Without a Prophylactic Colectomy
Kyu Young Kim, Seong Woo Jeon, Jung Gil Park, Chung Hoon Yu, Se Young Jang, Jae Kwang Lee, Hee Young Hwang
Ann Coloproctol. 2014;30(4):201-204.   Published online August 26, 2014
DOI: https://doi.org/10.3393/ac.2014.30.4.201
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  • 7 Web of Science
  • 6 Citations
AbstractAbstract PDF

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by hundreds of colorectal adenomatous polyps that progress to colorectal cancer. Management of patients with FAP is with a total colectomy. Chemopreventive strategies have been studied in FAP patients in an effort to delay the development of adenomas in the upper and the lower gastrointestinal tract and to prevent recurrence of adenomas in the retained rectum of patients after prophylactic surgery. Sulindac, a nonsteroidal anti-inflammatory drug, causes regression of colorectal adenomas in the retained rectal segment of FAP patients. However, evidence regarding long-term use of this therapy and its effect on the intact colon has been insufficient. We report a case in which the long-term use of sulindac was effective in reducing the size and the number of colonic polyps in patients with FAP without a prophylactic colectomy and polypectomy; we also present a review of the literature.

Citations

Citations to this article as recorded by  
  • Surgical Decision-Making in Familial Adenomatous Polyposis
    Allie E. Steinberger, Maggie L. Westfal, Paul E. Wise
    Clinics in Colon and Rectal Surgery.2024; 37(03): 191.     CrossRef
  • Chemoprevention in hereditary digestive neoplasia: A comprehensive review
    Eugénie Chevalier, Robert Benamouzig
    Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
  • Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model
    Khalid Asadi, Lynnette R. Ferguson, Martin Philpott, Nishi Karunasinghe
    Journal of Cancer Prevention.2017; 22(3): 135.     CrossRef
  • Endogenous conversion of ω-6 to ω-3 polyunsaturated fatty acids infat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/β-catenin signaling or activating 15-PGDH/IL-18
    Young-Min Han, Jong-Min Park, Ji-Young Cha, Migyeong Jeong, Eun-Jin Go, Ki Baik Hahm
    International Journal of Cancer.2016; 138(9): 2247.     CrossRef
  • NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties
    Khosrow Kashfi, Mitali Chattopadhyay, Ravinder Kodela
    Redox Biology.2015; 6: 287.     CrossRef
  • Sulindac

    Reactions Weekly.2015; 1570(1): 198.     CrossRef

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