- Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report
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Yo Na Kim, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Dong Geun Lee, Ho Lee, Min Ro Lee, Kyung Ryoul Kim
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J Korean Soc Coloproctol. 2011;27(3):157-161. Published online June 30, 2011
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DOI: https://doi.org/10.3393/jksc.2011.27.3.157
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Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 × 5.1 cm ulcerative fungating lesion, and the other was a 2.8 × 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.
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- Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas
Inayat GILL, Christienne SHAMS, Elisa QUIROZ, Subhashree M. KRISHNAN, Susanna GAIKAZIAN Gazzetta Medica Italiana Archivio per le Scienze Mediche.2021;[Epub] CrossRef - Large cell neuroendocrine carcinoma of the colon with brain metastasis: A case report
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Kunihiko Suga, Hiroomi Ogawa, Makoto Sohda, Chika Katayama, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Takuya Shiraishi, Ryuji Katoh, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki Surgical Case Reports.2020;[Epub] CrossRef - Colorectal neuroendocrine carcinoma: A case report and review of the literature
Tomoaki Yoshida, Kenya Kamimura, Kazunori Hosaka, Koji Doumori, Hiromitsu Oka, Akito Sato, Yasuo Fukuhara, Shoji Watanabe, Tomomi Sato, Akira Yoshikawa, Takashi Tomidokoro, Shuji Terai World Journal of Clinical Cases.2019; 7(14): 1865. CrossRef - Neuroendocrine tumor mixed with adenoma in rectum: a case report and literature review
Jiancong Hu, Xiaochuan Chen, Dezheng Lin, Zhaoliang Yu, Juan Li, Xuefeng Guo International Journal of Surgery Oncology.2019; 4(6): e79. CrossRef - Large Cell Neuroendocrine Carcinoma of the Rectum with Long Recurrence-free Survival after Radical Surgery and Adjuvant Chemotherapy
Kukiko SAKIHAMA, Kinuko NAGAYOSHI, Hayato FUJITA, Shuntaro NAGAI, Yoshinao ODA, Masafumi NAKAMURA Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2018; 79(12): 2463. CrossRef - Synchronous Small Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Colon: A Link for Common Stem Cell Origin?
Seth Lipka, Jorge Hurtado-Cordovi, Boris Avezbakiyev, Lester Freedman, Toshimasa Clark, Kaleem Rizvon, Paul Mustacchia ACG Case Reports Journal.2014; 1(2): 96. CrossRef - Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon
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- Effects of Delay in the Snap Freezing of Colorectal Cancer Tissues on the Quality of DNA and RNA
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Sang Hyun Hong, Hyun Ah Baek, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Ho Sung Park
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J Korean Soc Coloproctol. 2010;26(5):316-323. Published online October 31, 2010
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DOI: https://doi.org/10.3393/jksc.2010.26.5.316
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The success of basic molecular research using biospecimens strongly depends on the quality of the specimen. In this study, we evaluated the effects of delayed freezing time on the stability of DNA and RNA in fresh frozen tissue from patients with colorectal cancer. MethodsTissues were frozen at 10, 30, 60, and 90 minutes after extirpation of colorectal cancer in 20 cases. Absorbance ratio of 260 to 280 nm (A260/A280) and agarose gel electrophoresis were evaluated. In addition, the RNA integrity number (RIN) was assayed for the analysis of the RNA integrity. ResultsRegardless of delayed freezing time, all DNA and RNA samples revealed A260/A280 ratios of more than 1.9, and all DNA samples showed a discrete, high-molecular-weight band on agarose gel electrophoresis. The RINs were 7.53 ± 2.04, 6.70 ± 1.88, 6.47 ± 2.58, and 4.22 ± 2.34 at 10, 30, 60, and 90 minutes, respectively. Though the concentration of RNA was not affected by delayed freezing, the RNA integrity was decreased with increasing delayed freezing time. ConclusionAccording to the RIN results, we recommend that the collection of colorectal cancer tissue should be done within 10 minutes for studies requiring RNA of high quality and within 30 minutes for usual RNA studies.
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