- Does T3 Subdivision Correlate with Nodal or Distant Metastasis in Colorectal Cancer?
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Hong Yeol Yoo, Rumi Shin, Heon-Kyun Ha, Heung-Kwon Oh, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Woo Ho Kim, Jae-Gahb Park
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J Korean Soc Coloproctol. 2012;28(3):160-164. Published online June 30, 2012
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DOI: https://doi.org/10.3393/jksc.2012.28.3.160
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We analyzed the clinical data of T3 colorectal cancer patients to assess whether T3 subdivision correlates with node (N) or metastasis (M) staging and stage-independent factors. MethodsFive hundred fifty-five patients who underwent surgery for primary colorectal cancer from January 2003 to December 2009 were analyzed for T3 subdivision. T3 subdivision was determined by the depth of invasion beyond the outer border of the proper muscle (T3a, <1 mm; T3b, 1 to 5 mm; T3c, >5 to 15 mm; T3d, >15 mm). We investigated the correlation between T3 subdivision and N, M staging and stage-independent prognostic factors including angiolymphatic invasion (ALI), venous invasion (VI) and perineural invasion (PNI). ResultsThe tumors of the 555 patients were subclassified as T3a in 86 patients (15.5%), T3b in 209 patients (37.7%), T3c in 210 patients (37.8%) and T3d in 50 patients (9.0%). The nodal metastasis rates were 39.5% for T3a, 56.5% for T3b, 75.7% for T3c and 74.0% for T3d. The distant metastasis rates were 7.0% for T3a 9.1% for T3b, 27.1% for T3c and 40.0% for T3d. Both N and M staging correlated with T3 subdivision (Spearman's rho = 0.288, 0.276, respectively; P < 0.001). Other stage-independent prognostic factors correlated well with T3 subdivision (Spearman's rho = 0.250, P < 0.001 for ALI; rho = 0.146, P < 0.001 for VI; rho = 0.271, P < 0.001 for PNI). ConclusionSubdivision of T3 colorectal cancer correlates with nodal and metastasis staging. Moreover, it correlates with other prognostic factors for colorectal cancer.
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Citations
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Arnaud Ronfaut, Christophe Attencourt, Jean-Rene Tesson, Charles Sabbagh, Jean-Marc Regimbeau, Denis Chatelain
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John D. Paulsen, Alexandros D. Polydorides
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M.R.S. Siddiqui, C. Simillis, J. Bhoday, N.J. Battersby, J. Mok, S. Rasheed, P. Tekkis, A.M. Abulafi, G. Brown
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Yoshito Akagi, Kazuo Shirouzu, Tetsushi Kinugasa
Journal of Surgical Oncology.2013; 108(6): 358. CrossRef - T3 Subdivision Correlation with Nodal or Distant Metastasis in Colorectal Cancer; Is It Practically Useful?
Nam Kyu Kim
Journal of the Korean Society of Coloproctology.2012; 28(3): 119. CrossRef
- Clinical Features of Colorectal Cancer Detected by the National Cancer Screening Program
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Dae-Do Park, Rumi Shin, Ji-Sun Kim, Heung-Kwon Oh, Seung-Yong Jeong, Kyu Joo Park, Jae-Gahb Park
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J Korean Soc Coloproctol. 2010;26(6):420-423. Published online December 31, 2010
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DOI: https://doi.org/10.3393/jksc.2010.26.6.420
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3,471
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Since 2004, the National Cancer Screening Program of Korea has included colorectal cancer screening based on primary screening with the fecal occult blood test (FOBT). We report on the clinical features of colorectal cancer detected by the National Cancer Screening Program. MethodsWe retrospectively analyzed 577 patients who underwent elective surgery for colorectal cancer at the Seoul National University Hospital between January 2008 and December 2009. We compared the clinical features of colorectal cancers detected by the National Cancer Screening Program (NCSP group) with those of the control group in terms of age, gender, preoperative symptom, location of the tumor, surgical technique and tumor-node-metastasis (TNM) stage. ResultsAge, gender, location of the tumor and operation types were not different between the two groups. The proportion of asymptomatic patients was significantly higher in the NCSP group than it was in the control group (86.5% vs. 20.0%; P < 0.001). The proportion of less invasive lesions (T1 or T2) was significantly higher in the NCSP group (46.3% vs. 27.7%; P = 0.002). The pathologic stages of the colorectal cancers in the NCSP group were I, 40.3%; II, 17.9%; III, 40.3% and IV, 1.5% whereas in the control group, they were I, 20.8%; II, 32.9%; III, 34.9% and IV, 11.4%. The proportion of stage I cancer was significantly higher in the NCSP group than in the control group (40.3% vs. 20.8%; P = 0.006). ConclusionOur study demonstrates the FOBT in the NCSP is effective in early detection of colorectal cancer.
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Citations
Citations to this article as recorded by - Clinicopathological Characteristics of Colorectal Adenomas and Cancers Detected by FIT-positive Colonoscopy
Seiji Kimura, Shinichiro Yamagishi, Shinsaku Fukuda
Nippon Daicho Komonbyo Gakkai Zasshi.2020; 74(1): 6. CrossRef - Predictive Nomogram for Recurrence of Stage I Colorectal Cancer After Curative Resection
Chan Kim, Woo Ram Kim, Ki-Yeol Kim, Hong Jae Chon, Seung Hoon Beom, Hyojoong Kim, Minkyu Jung, Sang Joon Shin, Nam Kyu Kim, Joong Bae Ahn
Clinical Colorectal Cancer.2018; 17(3): e513. CrossRef - Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis
Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon
Korean Journal of Pathology.2013; 47(3): 245. CrossRef - Clinicopathologic Factors Affecting Recurrence after Curative Surgery for Stage I Colorectal Cancer
Min Ae Keum, Seok-Byung Lim, Sun A Kim, Yong Sik Yoon, Chan Wook Kim, Chang Sik Yu, Jin Cheon Kim
Journal of the Korean Society of Coloproctology.2012; 28(1): 49. CrossRef
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