- Difference in Tumor Area as a Predictor of a Pathological Complete Response for Patients With Locally Advanced Rectal Cancer
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Ji Hyeong Song, Yo-Han Park, Sang Hyuk Seo, Anbok Lee, Kwang Hee Kim, Min Sung An, Ki Beom Bae, Kwan Hee Hong, Jin Won Hwang, Ji Hyun Kim, Hyun Seok Jung, Ki Jung Ahn
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Ann Coloproctol. 2017;33(6):219-226. Published online December 31, 2017
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DOI: https://doi.org/10.3393/ac.2017.33.6.219
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This study was conducted to discover the clinical factors that can predict pathologically complete remission (pCR) after neoadjuvant chemoradiotherapy (CRT), so that those factors may help in deciding on a treatment program for patients with locally advanced rectal cancer. MethodsA total of 137 patients with locally advanced rectal cancer were retrospectively enrolled in this study, and data were collected retrospectively. The patients had undergone a total mesorectal excision after neoadjuvant CRT. Histologic response was categorized as pCR vs. non-pCR. The tumor area was defined as (tumor length) × (maximum tumor depth). The difference in tumor area was defined as pre-CRT tumor area – post-CRT tumor area. Univariate and multivariate logistic regression analyses were conducted to find the factors affecting pCR. A P-value < 0.05 was considered significant. ResultsTwenty-three patients (16.8%) achieved pCR. On the univariate analysis, endoscopic tumor circumferential rate <50%, low pre-CRT T & N stage, low post-CRT T & N stage, small pretreatment tumor area, and large difference in tumor area before and after neoadjuvant CRT were predictive factors of pCR. A multivariate analysis found that only the difference in tumor area before and after neoadjuvant CRT was an independent predictor of pCR (P < 0.001). ConclusionThe difference in tumor area, as determined using radiologic tools, before and after neoadjuvant CRT may be important predictor of pCR. This clinical factor may help surgeons to determine which patients who received neoadjuvant CRT for locally advanced rectal cancer should undergo surgery.
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- Particular aspects of treating rectal cancer: The watch and wait approach
Diana Andreea Draghici, Alexandru Rares Stoian, Vlad Andrei Porojan, Oana Ilona David, Ştefan Bedereag, Anda Natalia Ciuhu, Andrei Haidar, Dragoş Crețoiu, Carmen Elena Condrat, Valentin Titus Grigorean Journal of Cancer Research and Therapeutics.2023; 19(2): 461. CrossRef - Predicting stage ypT0–1N0 for nonradical management in patients with middle or low rectal cancer who undergo neoadjuvant chemoradiotherapy: a retrospective cohort study
Jeehye Lee, In Jun Yang, Jung Wook Suh, Hong-min Ahn, Heung-Kwon Oh, Duck-Woo Kim, Young-Hoon Kim, Kyoung Ho Lee, Sung-Bum Kang Annals of Surgical Treatment and Research.2022; 103(1): 32. CrossRef - Radiotherapy after local excision of rectal cancer may offer reduced local recurrence rates
H. J. S. Jones, S. Goodbrand, R. Hompes, N. Mortensen, C. Cunningham Colorectal Disease.2019; 21(4): 451. CrossRef - ‘Watch and wait’ in rectal cancer: summary of the current evidence
Jason On, Emad H Aly International Journal of Colorectal Disease.2018; 33(9): 1159. CrossRef
- Risk Factors of a Pulmonary Thromboembolism After Colorectal Surgery
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Junyub Kim, Byung-Noe Bae, Hyun Seok Jung, Inseok Park, Hyunjin Cho, Geumhee Gwak, Kiwhan Kim, Hong-Joo Kim, Young Duk Kim
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Ann Coloproctol. 2015;31(5):187-191. Published online October 31, 2015
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DOI: https://doi.org/10.3393/ac.2015.31.5.187
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4,127
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Previous studies have revealed that predictors and risk factors of pulmonary thromboembolism (PTE) are malignancy, immobilization, diabetes, and obesity in the postoperative patients. However, in patients undergoing colorectal cancer, studies of PTE have not been enough. Thus, we investigated the risk factors of PTE related to colorectal surgery. MethodsFrom January 2009 to October 2014, 312 patients received colorectal surgery without other organ resection. The postoperative patients with PTE were 14 (4.5%), and they were classified by sex, age, and stage as a 1:3 paired match to the control group. A multiple logistic regression was performed to identify which factors were associated with PTE. ResultsOne patient was in stage I, 3 in stage II, 9 in stage III, and 1 in stage IV. In the binary logistic regression analysis, history of diabetes mellitus (odds ratio, 6.498; P = 0.031) and being overweight (odds ratio, 10.018; P = 0.014) were independent risk factors for PTE in patients undergoing colorectal cancer. ConclusionA history of diabetes mellitus and being overweight were independent risk factors of PTE after colorectal cancer.
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Citations
Citations to this article as recorded by 
- Could Preoperative Unintended Weight Loss Predispose to Postoperative Thrombosis in Patients Undergoing Colorectal Cancer Surgery? An Analysis of the NSQIP Data
Sally Temraz, Hani Tamim, Aurelie Mailhac, Farah Nassar, Nour Moukalled, Faek Jamali, Ali Taher Journal of the American College of Nutrition.2021; 40(2): 141. CrossRef - Venous Thromboembolic Complications in Colorectal Surgery
Jung Wook Huh Annals of Coloproctology.2015; 31(5): 172. CrossRef
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