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Ha Kyung Park 2 Articles
Association Between a Close Distal Resection Margin and Recurrence After a Sphincter-Saving Resection for T3 Mid- or Low-Rectal Cancer Without Radiotherapy
Jae Woong Han, Min Jae Lee, Ha Kyung Park, Jae Ho Shin, Min Sung An, Tae Kwun Ha, Kwang Hee Kim, Ki Beom Bae, Tae Hyun Kim, Chang Soo Choi, Sang Hoon Oh, Min Kyung Oh, Mi Seon Kang, Kwan Hee Hong
Ann Coloproctol. 2013;29(6):231-237.   Published online December 31, 2013
DOI: https://doi.org/10.3393/ac.2013.29.6.231
  • 4,101 View
  • 23 Download
  • 7 Citations
AbstractAbstract PDF
Purpose

To maintain the patient's quality of life, surgeons strive to preserve the sphincter during rectal cancer surgery. This study evaluated the oncologic safety of a sphincter-saving resection with a distal resection margin (DRM) <1 cm without radiotherapy in T3, mid- or low-rectal cancer.

Methods

This retrospective study enrolled 327 patients who underwent a sphincter-saving resection for proven T3 rectal cancer located <10 cm from the anal verge and without radiotherapy between January 1995 and December 2011. The oncologic outcomes included the 5-year cancer-specific survival, the local recurrence, and the systemic recurrence rates.

Results

In groups A (DRM ≤1 cm) and B (DRM >1 cm), the 5-year cancer-specific survival rates were 81.57% and 80.03% (P = 0.8543), the 5-year local recurrence rates were 6.69% and 9.52% (P = 0.3981), and the 5-year systemic recurrence rates were 19.46% and 23.11% (P = 0.5750), respectively.

Conclusion

This study showed that the close DRM itself should not be a contraindication for a sphincter-saving resection for T3 mid- or low-rectal cancer without radiotherapy. However, a prospective randomized controlled trial including the effect of adjuvant therapy will be needed.

Citations

Citations to this article as recorded by  
  • The Impact of Narrow and Infiltrated Distal Margin After Proctectomy for Rectal Cancer on Patients’ Outcomes: a Systematic Review and Meta-analysis
    Islam H. Metwally, Mohammad Zuhdy, Omar Hamdy, Ahmed M. Fareed, Saleh S. Elbalka
    Indian Journal of Surgical Oncology.2022; 13(4): 750.     CrossRef
  • Association of levels of metabolites with the safe margin of rectal cancer surgery: a metabolomics study
    Shaopeng Zhang, Guoqiang Pan, Zhifeng Liu, Yuan Kong, Daguang Wang
    BMC Cancer.2022;[Epub]     CrossRef
  • Distal resection margins in rectal cancer specimens: differences in assessment between surgeons and pathologists and the influence of neoadjuvant chemoradiation
    T. L. Ghezzi, C. Tarta, P. C. Contu, A. R. Lazzaron, B. M. Contin, L. M. Kliemann, D. C. Damin
    Updates in Surgery.2021; 73(5): 1787.     CrossRef
  • Surgical margins in squamous cell carcinoma, different for the vulva?
    Noortje Pleunis, Maria E.J. Leermakers, Anneke A. van der Wurff, Paul J.J.M. Klinkhamer, Nicole P.M. Ezendam, Dorry Boll, Joanne A. de Hullu, Johanna M.A. Pijnenborg
    European Journal of Surgical Oncology.2018; 44(10): 1555.     CrossRef
  • Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis
    SooYoon Sung, Sung Hwan Kim, Joo Hwan Lee, Taek Keun Nam, Songmi Jeong, Hong Seok Jang, Jin Ho Song, Jeong Won Lee, Jung Min Bae, Jong Hoon Lee
    International Journal of Radiation Oncology*Biology*Physics.2017; 98(3): 647.     CrossRef
  • Efficacy and Safety of Low-Dose-Rate Endorectal Brachytherapy as a Boost to Neoadjuvant Chemoradiation in the Treatment of Locally Advanced Distal Rectal Cancer: A Phase-II Clinical Trial
    Shapour Omidvari, Shadi Zohourinia, Mansour Ansari, Leila Ghahramani, Mohammad Zare-Bandamiri, Ahmad Mosalaei, Niloofar Ahmadloo, Saeedeh Pourahmad, Hamid Nasrolahi, Sayed Hasan Hamedi, Mohammad Mohammadianpanah
    Annals of Coloproctology.2015; 31(4): 123.     CrossRef
  • Safe Distal Resection Margin in Patients With T3 Mid and Distal Rectal Cancer Who Underwent a Sphincter-Saving Resection Without Preoperative Radiotherapy
    Bong Hwa Lee, Hyoung Chul Park, Min Jeong Kin, Mi Young Jang
    Annals of Coloproctology.2013; 29(6): 219.     CrossRef
Prognostic Significance of the Decreased Rate of Perioperative Serum Carcinoembryonic Antigen Level in the Patients With Colon Cancer After a Curative Resection
Tae Doo Jung, Jong Han Yoo, Min Jae Lee, Ha Kyung Park, Jae Ho Shin, Min Sung An, Tae Kwun Ha, Kwang Hee Kim, Ki Beom Bae, Tae Hyeon Kim, Chang Soo Choi, Min Kyung Oh, Kwan Hee Hong
Ann Coloproctol. 2013;29(3):115-122.   Published online June 30, 2013
DOI: https://doi.org/10.3393/ac.2013.29.3.115
  • 3,505 View
  • 23 Download
  • 4 Citations
AbstractAbstract PDF
Purpose

The serum level of carcinoembryonic antigen (CEA) is a clinical prognostic factor in the follow-up evaluation of patients with colon cancer. We aimed to evaluate the prognostic significance of the rate of decrease of the perioperative serum CEA level in patients with colon cancer after a curative resection.

Methods

A total of 605 patients who underwent a curative resection for colon cancer between January 2000 and December 2007 were enrolled retrospectively. The rate of decrease was calculated using the following equation: ([preoperative CEA - postoperative CEA]/[preoperative CEA] ×100).

Results

In the group with a preoperative serum CEA level of >5 ng/mL, the normalized group with a postoperative serum CEA level of ≤5 ng/mL showed a better overall survival (OS) rate and disease-free survival (DFS) rate than those of the non-normalized group (P ≤ 0.0001). The "cutoff values" of the rate of decrease in the perioperative serum CEA that determined the OS and the DFS were 48.9% and 50.8%, respectively. In the multivariate analysis of preoperative serum CEA levels >5 ng/mL, the prognostic factors for the OS and the DFS were the cutoff value (P < 0.0001) and the pN stage (P < 0.0001).

Conclusion

A rate of decrease of more than 50% in the perioperative serum CEA level, as well as the normalization of the postoperative serum CEA level, may be useful factors for determining a prognosis for colon cancer patients with high preoperative CEA levels.

Citations

Citations to this article as recorded by  
  • Patients with T4N0 and T1‑3N1 colon cancer and a high preoperative carcinoembryonic antigen level benefit from adjuvant chemotherapy with oxaliplatin for 6 months
    Hiroyuki Inoue, Hiroki Shimizu, Yoshiaki Kuriu, Tomohiro Arita, Kenji Nanishi, Jun Kiuchi, Takuma Ohashi, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    Oncology Letters.2024;[Epub]     CrossRef
  • Metastasis of colorectal adenocarcinoma to the mandible
    Kushal CHATTERJEE, Aritra CHATTERJEE, Debarati BHOWMICK, Hrishikesh KUMAR, Arif HOSSAIN, Debabrata GAYEN
    European Journal of Oral and Maxillofacial Surgery.2021;[Epub]     CrossRef
  • Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer
    Jinsun Woo, Jungbin Kim, Inseok Park, Hyunjin Cho, Geumhee Gwak, Keun Ho Yang, Byung-Noe Bae, Ki Hwan Kim
    Annals of Coloproctology.2018; 34(1): 4.     CrossRef
  • Clinicopathologic features and oncologic outcomes of colorectal cancer patients with extremely high carcinoembryonic antigen
    Soo Young Lee, Jeong Seon Jo, Hun Jin Kim, Chang Hyun Kim, Jae-Kyun Ju, Young Jin Kim, Hyeong Rok Kim
    International Journal of Colorectal Disease.2015; 30(1): 63.     CrossRef
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