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Eun Jung Jang 1 Article
Value and Interpretation of Resection Margin after a Colonoscopic Polypectomy for Malignant Polyps
Eun Jung Jang, Dae Dong Kim, Chang Ho Cho
J Korean Soc Coloproctol. 2011;27(4):194-201.   Published online August 31, 2011
DOI: https://doi.org/10.3393/jksc.2011.27.4.194
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AbstractAbstract PDF
Purpose

This study was designed to compare the clinicopathologic findings of an endoscopic polypectomy for malignant polyps with subsequent surgery and to evaluate the appropriateness of the pathologic finding criterion of the resection margin as an indicator for surgery in cases of malignant colorectal polyps.

Methods

We examined the clinicopathologic characteristics, complications and prognoses among the patients who underwent a colonoscopic polypectomy in both our hospitals and at other hospitals from April 2003 and April 2010. These patients were divided into two groups, the group (non-operation group) that only underwent a polypectomy (n = 37) and the group (operation group) that underwent a polypectomy with subsequent surgery (n = 33).

Results

There were no differences between two groups in the ratios of the number of men to the number of women, the ages or the comorbidities. In terms of endoscopic findings, we found no differences between the two groups in the locations of the polyps, the sizes of the polyps, or the presence of stalks. However, ulceration of polyps was higher in the non-operation group (51.5% vs. 21.6%; P = 0.009), as was the case with submucosal invasion (75.8% vs. 16.2%; P < 0.005). When an endoscopic polypectomy was performed, incomplete resection margins and specimens with margins involved occurred more frequently in the operation group (93.9% vs. 51.4%; P < 0.005), but no residual tumor was detected in 31 of 33 (93.9%) patients in that group. One pathologist reviewed the specimens of 54 patients (operation group, 19; non-operation group, 36). Six of the 19 polyps (31.6%) in the operation group and fifteen of the 36 polyps (41.7%) in the non-operation group had a margin without cancer cells.

Conclusion

We may accept the criterion of a safe margin, including a coagulation zone. A multidisciplinary approach has to be developed by surgeons, endoscopists and pathologists based on a discussion of the risk factors for the patient before making a decision on the treatment treatment.

Citations

Citations to this article as recorded by  
  • Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
    Goran Mohammed Raouf Abdulqader
    Open Medicine.2024;[Epub]     CrossRef
  • Factors Predicting Malignant Occurrence and Polyp Recurrence after the Endoscopic Resection of Large Colorectal Polyps: A Single Center Experience
    Olga Mandic, Igor Jovanovic, Mirjana Cvetkovic, Jasmina Maksimovic, Tijana Radonjic, Maja Popovic, Novica Nikolic, Marija Brankovic
    Medicina.2022; 58(10): 1440.     CrossRef
  • Near-infrared photoimmunotherapy is effective treatment for colorectal cancer in orthotopic nude-mouse models
    Hannah M. Hollandsworth, Siamak Amirfakhri, Filemoni Filemoni, Justin Molnar, Robert M. Hoffman, Paul Yazaki, Michael Bouvet, Irina V. Lebedeva
    PLOS ONE.2020; 15(6): e0234643.     CrossRef
  • Surgical treatment of malignant colon polyps
    Nuno Telo Preto Ramos, André Gonçalves, Pedro Correia da Silva, José Barbosa
    Journal of Coloproctology.2018; 38(04): 260.     CrossRef

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