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Dongjun Jeong 2 Articles
Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer
Han Jo Kim, Moo-Jun Baek, Dong Hyun Kang, Sang-Cheol Lee, Sang Byung Bae, Kyu Taek Lee, Namsu Lee, Hyungjoo Kim, Dongjun Jeong, Tae Sung Ahn, Moon Soo Lee, Dae Sik Hong, Jong-Ho Won
Ann Coloproctol. 2018;34(2):88-93.   Published online April 30, 2018
DOI: https://doi.org/10.3393/ac.2017.10.10
  • 5,727 View
  • 114 Download
  • 5 Web of Science
  • 4 Citations
AbstractAbstract PDF
Purpose
Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods
A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results
Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion
Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.

Citations

Citations to this article as recorded by  
  • Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression
    Ricella Souza da Silva, Eduardo M. Queiroga, Cynthia de Toledo Osório, Karin S. Cunha, Fabiana P. Neves, Julieth P. Andrade, Eliane P. Dias
    Pathobiology.2024; 91(2): 99.     CrossRef
  • Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography
    Giuseppe Floresta, Vincenzo Abbate
    Medicinal Research Reviews.2022; 42(4): 1588.     CrossRef
  • Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
    María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
    World Journal of Gastroenterology.2022; 28(26): 3177.     CrossRef
  • The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
    Seyed Mostafa Parizadeh, Reza Jafarzadeh‐Esfehani, Danial Fazilat‐Panah, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Majid Khazaei, Seyed Mohammad Reza Parizadeh, Majid Ghayour‐Mobarhan, Gordon A. Ferns, Amir Avan
    IUBMB Life.2019; 71(7): 802.     CrossRef
Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis
Jeong Yeon Kim, Dongjun Jeong, Tae Sung Ahn, Hyung Ju Kim, Doo San Park, So Yong Park, Sang Byung Bae, Sookyoung Lee, Sung Soo Lee, Moon Soo Lee, Hyun Deuk Cho, Moo Jun Baek
Ann Coloproctol. 2013;29(3):93-99.   Published online June 30, 2013
DOI: https://doi.org/10.3393/ac.2013.29.3.93
  • 6,283 View
  • 29 Download
  • 14 Web of Science
  • 10 Citations
AbstractAbstract PDF
Purpose

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods

The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results

The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion

These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

Citations

Citations to this article as recorded by  
  • CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy
    Keishi Yamashita, Yusuke Kumamoto
    International Journal of Molecular Sciences.2024; 25(11): 6003.     CrossRef
  • Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
    Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun, Raj Kumar Koiri
    PLOS ONE.2022; 17(8): e0273317.     CrossRef
  • SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression
    Qing Nian, Jingwei Li, ZhongYu Han, Qi Liang, Maoyu Liu, Chan Yang, Fernando Rodrigues-Lima, Tao Jiang, Liyun Zhao, Jinhao Zeng, Chi Liu, Jianyou Shi
    Biomedicine & Pharmacotherapy.2022; 153: 113519.     CrossRef
  • Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
    Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda Lopez-Moncada, Alexander Herrera, María José Torres, Exequiel Alonso, Norberto Ariel Gandini, Graciela Gigola, Hector R. Contreras, Claudia Gentili
    Molecular and Cellular Endocrinology.2021; 530: 111253.     CrossRef
  • Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
    Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen,
    eLife.2021;[Epub]     CrossRef
  • Secreted protein acidic and rich in cysteine gene variants: Impact on susceptibility and survival of hepatocellular carcinoma patients
    Samar Kamal Darweesh, Rasha Ahmed Abd Alziz, Heba Omar, Dina Sabry, Wael Fathy
    Journal of Gastroenterology and Hepatology.2019; 34(8): 1424.     CrossRef
  • Self‐Targeting, Immune Transparent Plasma Protein Coated Nanocomplex for Noninvasive Photothermal Anticancer Therapy
    Fwu‐Long Mi, Thierry Burnouf, Shih‐Yuan Lu, Yu‐Jen Lu, Kun‐Ying Lu, Yi‐Cheng Ho, Chang‐Yi Kuo, Er‐Yuan Chuang
    Advanced Healthcare Materials.2017;[Epub]     CrossRef
  • SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy
    Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
    Cancer Biomarkers.2017; 18(4): 459.     CrossRef
  • Tumor–stroma ratio is an independent predictor for survival in early cervical carcinoma
    Jing Liu, Juan Liu, Jinsong Li, Yingling Chen, Xiaoling Guan, Xiaojuan Wu, Chunyan Hao, Yanlin Sun, Yan Wang, Xiao Wang
    Gynecologic Oncology.2014; 132(1): 81.     CrossRef
  • Significance of Secreted Protein Acidic and Rich in Cysteine Expression in Colorectal Carcinoma
    Young Jin Kim
    Annals of Coloproctology.2013; 29(3): 87.     CrossRef

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