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Dong-Guk Park

8 Articles

Metastasis

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report: Sungchul Lee, Euitae Kim, Dong-Guk Park; Ann Coloproctol. 2024;40(Suppl 1):S18-S22. Published online November 21, 2022; DOI: https://doi.org/10.3393/ac.2022.00339.0048

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A 61-year-old man presented with abdominal distension without any symptoms. On colonoscopy and computed tomography findings, it was clinically diagnosed as peritoneal metastasis of sigmoid colon cancer, and diagnostic laparoscopy was performed. Only the peritoneum was partially resected, and the pathology was signet ring cell carcinoma with predominantly local mucinous carcinoma component. However, the patient complained of persistent symptoms and, despite the progress of chemotherapy, the peritoneal dissemination worsened, and additional cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) was performed. Mixed adenoneuroendocrine carcinomas (MANECs) were reported in the appendix with perforated visceral peritoneum. After additional chemotherapy, the patient was discharged. Patients with advanced MANEC with peritoneal spreading may benefit from aggressive treatment by cytoreduction surgery with HIPEC, followed by intravenous chemotherapy.

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Mixed neuroendocrine non-neuroendocrine neoplasms in gastroenteropancreatic tract
Sebastián Díaz-López, Jerónimo Jiménez-Castro, Carlos Enrique Robles-Barraza, Carlos Ayala-de Miguel, Manuel Chaves-Conde
World Journal of Gastrointestinal Oncology.2024; 16(4): 1166. CrossRef

Urinary Bladder Injury During Colonoscopy Without Colon Perforation: Jung Wook Suh, Jun Won Min, Hwan Namgung, Dong-Guk Park; Ann Coloproctol. 2017;33(3):112-114. Published online June 30, 2017; DOI: https://doi.org/10.3393/ac.2017.33.3.112

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We report a case of urinary bladder perforation during colonoscopy. A 67-year-old female, who had undergone a transabdominal hysterectomy for uterine myomas 15 years ago, visited the emergency department with complaint of abdominal pain after a screening colonoscopy. Laparoscopic examination revealed severe adhesion between the sigmoid colon and the urinary bladder. The urinary bladder wall was weakened, and several perforation sites were found. The surgery was converted to a laparotomy. After a thorough examination, we performed primary repair for the perforation sites, followed by an omentopexy.

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Trauma to the solid abdominal organs: The missed dark box of colonoscopy
Mohamed H Emara, Usama Mazid, Yasmine A Elshaer, Mahmoud A Elkerdawy, Dilaver Farooq Malik, Aya M Mahros
World Journal of Gastroenterology.2024; 30(7): 624. CrossRef
Mesenteric laceration of the sigmoid colon after colonoscopy: A rare complication
Min Wu, Yonghua Lin, Zhichao Chen, Jianfeng Wei
Asian Journal of Surgery.2023; 46(11): 5391. CrossRef
Massive retroperitoneal hematoma following colonoscopy
Reo Ohtsuka, Hodaka Amano, Kei Niida, Takeaki Yoshino, Michiyo Owari, Ryotaro Takano, Yuichi Akama, Yohei Watanabe, Toshiyasu Iwao
Medicine.2018; 97(31): e11723. CrossRef

Is Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy a Safe and Effective Procedure for Treating Patients With a Peritoneal Surface Malignancy?: Dong-Guk Park; Ann Coloproctol. 2017;33(1):3-4. Published online February 28, 2017; DOI: https://doi.org/10.3393/ac.2017.33.1.3

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Albumin Leakage Level during Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Associated with Major Complications
Hyun-Chang Kim, Dong Woo Han, Eun Jung Park, Yeon Hwa Hong, Young Song
Cancers.2024; 16(16): 2874. CrossRef
Analgesic effects of combined transversus abdominis plane block and intramuscular electrical stimulation in patients undergoing cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy: a randomized controlled trial
Hyun-Chang Kim, Jinyoung Park, Jinyoung Oh, Minjae Kim, Eun Jung Park, Seung Hyuk Baik, Young Song
International Journal of Surgery.2023; 109(5): 1199. CrossRef

Peritoneal Metastatic Goblet-Cell Carcinoid Tumor Treated With Cytoreductive Surgery and Intraperitoneal Chemotherapy: Sang Il Youn, Hwan Namgung, Jeong Seok Yun, Yun Jun Park, Dong-Guk Park; Ann Coloproctol. 2015;31(2):74-78. Published online April 30, 2015; DOI: https://doi.org/10.3393/ac.2015.31.2.74

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We report a case of a goblet-cell carcinoid tumor of the appendix which metastasized to the peritoneum and was treated by using cytoreductive surgery (CRS) with intraperitoneal chemotherapy. A 47-year-old male presented with chronic constipation and was diagnosed as having a rectal adenocarcinoma with a signet-ring-cell component under colonoscopy. Computed tomography suggested peritoneal metastases with diffuse nodular parietal peritoneal thickening of the entire abdomen and focal invasion of the upper rectum by a seeding mass. CRS with intraperitoneal chemotherapy was done under the diagnosis of a rectal adenocarcinoma with peritoneal metastases. The pathologic diagnosis was a goblet-cell carcinoid tumor of the appendix with peritoneal metastasis. The histological discrepancy between a peritoneal metastatic mass and a rectal mass was due to the mixed histological pattern of a goblet-cell carcinoid tumor. A metastatic mass may not share identical immunohistochemical characteristics from its origin. This histologic discrepancy necessitates caution in diagnosing a distant metastasis of a goblet-cell carcinoid tumor.

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Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report
Sungchul Lee, Euitae Kim, Dong-Guk Park
Annals of Coloproctology.2024; 40(Suppl 1): S18. CrossRef
Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum—A Case Report and Brief Review of the Literature
Alexandra Dinu, Mariana Aşchie, Gabriela Isabela Bălţătescu, Manuela Enciu, Ionuţ Burlacu
Reports.2024; 8(1): 1. CrossRef
Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall
Faten Limaiem, Sahir Omrani, Mohamed Hajri
Clinical Case Reports.2023;[Epub] CrossRef
Mixed Neuroendocrine Non-neuroendocrine Neoplasm of Anorectum with Goblet Cell Morphology
Sandhya Biswal, Anirban Kundu, Ankit Sahoo, Prakash Kumar Sasmal, Biswajit Sahoo, Suvradeep Mitra
Journal of Gastrointestinal Cancer.2021; 52(3): 1093. CrossRef
Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
Santosh Shenoy
World Journal of Gastrointestinal Surgery.2016; 8(10): 660. CrossRef

Bezoar-induced Small Bowel Obstruction: Se Heon Oh, Hwan Namgung, Mi Hyun Park, Dong-Guk Park; J Korean Soc Coloproctol. 2012;28(2):89-93. Published online April 30, 2012; DOI: https://doi.org/10.3393/jksc.2012.28.2.89

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Purpose

The aim of this study was to observe the clinical features of a bezoar-induced small bowel obstruction and to investigate the role of abdominal computed tomography (CT) in establishing the diagnosis.

Methods

We retrospectively reviewed 20 cases of bezoar-induced small bowel obstruction in our hospital from 1996 to 2010.

Results

Thirteen patients (65%) had a history of abdominal surgery. Nine patients (45%) were diagnosed with a bezoar before surgery, seven patients were diagnosed by using abdominal CT, and two patients were diagnosed with a small bowel series. Abdominal CT was performed in 15 patients, and the diagnostic accuracy was 47% (7/15). Surgery revealed ten bezoars in the jejunum and 11 in the ileum. Two patients had bezoars found concurrently in the stomach. Spontaneous removal took place in two patients. An enterotomy and bezoar extraction was performed in 15 patients. Fragmentation and milking, a small bowel resection, and a Meckel's diverticulectomy were performed in one patient each. Early operative treatment was possible (P = 0.036) once the bezoar had been diagnosed by using abdominal CT. There tended to be fewer postoperative complications in patients who were diagnosed with a bezoar by using abdominal CT, but the result was not statistically significant (P = 0.712).

Conclusion

A preoperative diagnosis of bezoar-induced small bowel obstruction by using clinical features was difficult. Increased use of abdominal CT led to a more accurate diagnosis and to earlier surgery for bezoar-induced small bowel obstructions, thereby reducing the rate of complications.

Citations

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Small intestinal obstruction caused by the gastric bezoars in elderly diabetic patients: A case report
Yifan Huang, Jie Meng, Shuo Zhang
International Journal of Surgery Case Reports.2025; 127: 110761. CrossRef
Small bowel obstruction caused by dehydrated apple ingestion: the challenges of preoperative radiological diagnosis and surgical management
Rama Hala Gamal Mikhail, Siobhan McKay, Mark Goodwin, Osamu Yoshino
BMJ Case Reports.2024; 17(2): e256710. CrossRef
Small bowel obstruction due to a meat bolus bezoar: the second case report in literature
Ammar Albostani, Fadi Kfelati, Wafaa Alsaadi, Rufaida Ahmad Faraman, Aasem Farman
Annals of Medicine & Surgery.2024; 86(2): 1139. CrossRef
Endoscopic lithotripsy combined with drug lithotripsy vs. drug lithotripsy for the treatment of phytobezoars: analysis of 165 cases
Xiao Zheng, Bin Qiu, Xiao-wei Jin, Lin-na Liu, Peng Wang, Hai-jing Yu, Juan Zhang, Wen-jing Geng, Rui Wang, Hua Liu
Surgical Endoscopy.2024; 38(5): 2788. CrossRef
A Rare Case of Gastric Phytobezoar (Diospyrobezoar) in a Healthy Adult
Ahmed M Odeh, Ahmed A Alkhalifa, Mohammed A AlHajji, Alwayah J Alahmed, Jawad H Alsalman, Abdulrahman M AlMulhem, Mohammed S AlGhadeer, Ezzeddin Kurdi, Fatima S Albader, Abdulmohsen Alsuwaigh, Mohammad A Khan
Cureus.2024;[Epub] CrossRef
Evaluation of the location, number and diameter of bezoars in patients with a history of previous gastrointestinal surgery
Ali Muhtaroğlu, Merve Yiğit, Hakan Demir, Uğur Dülger, Muhammed Doğangün, İbrahim Furkan Küçük, Fatih Altintoprak
European Journal of Trauma and Emergency Surgery.2023; 49(4): 1783. CrossRef
Diagnosis of a rare pediatric case of small-bowel obstruction secondary to a phytobezoar in a Meckel’s diverticulum aided by point-of-care ultrasound
Anastasia Zello, David Kirschner
Canadian Journal of Emergency Medicine.2023; 25(3): 244. CrossRef
Phytobezoar-Induced Mechanical Ileus and Incipient Intussusception: A Case Report
Christoforos S. Kosmidis, Chrysi Maria Mystakidou, Nikolaos Varsamis, Charilaos Koulouris, Christina Sevva, Konstantina Papadopoulou, Christina Michael, Nikolaos Iason Katsios, Vasiliki Theodorou, Petrina Miltiadous, Konstantinos Papadopoulos, Konstantino
Medicina.2023; 59(7): 1227. CrossRef
Small Bowel Obstruction by a Phytobezoar in a Patient With Previous Antrectomy and Billroth II Reconstruction
Alberto Abreu da Silva, Jéssica Ricardo, Andreia Ferreira, Diogo Sousa, José Augusto Martins
Cureus.2023;[Epub] CrossRef
Intestinal bezoar aggravated by hypomotility of ischemic small intestine: A case report
Ting‐Hsuan Chiang, Hsing‐Jung Yeh, Chun‐Chao Chang, Kuan‐Chieh Fang
Advances in Digestive Medicine.2022; 9(1): 52. CrossRef
Khat induced bezoar; a rare cause of small bowel obstruction:a case report
Badhaasaa Beyene, Burka Mohammadsani, Minewor Abdlhadi, Kedest Getachew, Hatae Ahmedin
International Journal of Surgery Case Reports.2022; 91: 106811. CrossRef
Impending perforation near ileocecal junction due to phytobezoar impaction and intraluminal polyp: a case report
Mehwish Mooghal, Asrar Ahmad, Adnan Safi, Wajiha Khan, Naveed Ahmad
Journal of Medical Case Reports.2022;[Epub] CrossRef
Inflammation and Obstruction of the Small Intestine Due to Phytobezoar: a Case Report
Van Trung Hoang, The Huan Hoang, Ngoc Trinh Thi Pham, Vichit Chansomphou, Duc Thanh Hoang
SN Comprehensive Clinical Medicine.2022;[Epub] CrossRef
Small bowel obstruction secondary to a plastic bezoar
Sarah Li-Ling Goh, Christopher Steen, Enoch Wong, Monique Scott
BMJ Case Reports.2022; 15(11): e251438. CrossRef
Small Bowel Obstruction Caused by an Aggressive Weight Loss Diet in a Patient With No Predisposing Factors
Samara C Hassranah, Aryaa Ramnarine, Sangeeta Parbhu, Vijay Naraynsingh
Cureus.2022;[Epub] CrossRef
Hematological manifestations of trichobezoar in a child
S.O. Nykytyuk, R.V. Bodnarchuk, O.R. Boyarchuk, S.S. Levenets, M.V. Dolynna
CHILD`S HEALTH.2022; 16(6): 435. CrossRef
Clinical characteristics and indications for surgery for bezoar-induced small bowel obstruction
Shuai Wang, Xiaohui Yang, Yixiong Zheng, Yulian Wu
Journal of International Medical Research.2021;[Epub] CrossRef
When eating makes you sick – Gastric stump obstruction caused by a phytobezoar. A case report and literature review
Mariana Claro, Daniel Costa Santos, Alberto Abreu Silva, Cláudia Deus, João Grilo, Diogo Sousa, José Augusto Martins
International Journal of Surgery Case Reports.2021; 79: 263. CrossRef
Phytobezoar: A train can hide another
Atef Mejri, Emna Trigui
International Journal of Surgery Case Reports.2021; 81: 105814. CrossRef
From Blocking Shots to Blocking GI Transit, This Professional Basketball Player Does It All: A Case Report on Small Bowel Obstruction
Emily L. DeMaio, Richard C. Jarvis, Jessica A. Cohen, Courtney N. Gleason, Aristomenis K. Exadaktylos
Case Reports in Medicine.2021; 2021: 1. CrossRef
Intestinal Obstruction Secondary to Multiple Gastrointestinal phytobezoars, A Rare presentation
Abdullah G. Alsahwan, Ameen M. Almarhoon, Jihad AlSafwani, Hanan Alsahwan, Neamat Alturki
International Journal of Surgery Case Reports.2021; 83: 106004. CrossRef
Bezoar as a cause of jejunal afferent loop mass after pylorus preserving pancreaticoduodedectomy: A case report
Woo Yong Lee
International Journal of Surgery Case Reports.2021; 85: 106177. CrossRef
A rare giant gastric trichobezoar in a young female patient: Case report and review of the literature
Dimitra G. Delimpaltadaki, Ioannis G. Gkionis, Mathaios E. Flamourakis, Andreas F. Strehle, Emmanouil N. Bachlitzanakis, Michail I. Giakoumakis, Manousos S. Christodoulakis, Konstantinos G. Spiridakis
Clinical Case Reports.2021;[Epub] CrossRef
A case series of intestinal obstruction secondary to shiitake mushroom intake during Chinese New Year
Gaik Huey Ng, Li Ying Teoh, Mei Sze Teh, Suniza Jamaris, Mee Hoong See
Journal of Surgical Case Reports.2020;[Epub] CrossRef
Clinical Case of a Patient with Small Bowel Obstruction and Multiple Diospirobesoaras of the Gastrointestinal Tract
A. S. Harutyunyan, V. D. Levitsky, V. V. Kiselev, P. A. Yartsev, A. V. Vodyasov, N. V. Shavrina
Russian Sklifosovsky Journal "Emergency Medical Care".2020; 9(2): 281. CrossRef
Adhesive small bowel obstruction – an update
Jia Wei Valerie Tong, Pravin Lingam, Vishalkumar Girishchandra Shelat
Acute Medicine & Surgery.2020;[Epub] CrossRef
Intestinal obstruction by a phytobezoar in a patient with a history of gastroplasty
Luiz de Abreu Junior, Gustavo Garcia Marques, Ingredy Tavares da Silva, Flávia Munhos Granja, Marcelo Zindel Salem
Radiologia Brasileira.2019; 52(2): 133. CrossRef
Parsnip phytobezoar causing small bowel obstruction
Denise I. Garcia, William Taylor Head, Aaron P. Lesher
Journal of Pediatric Surgery Case Reports.2019; 47: 101227. CrossRef
Clinics in diagnostic imaging (198)
YQA Soon, HM Low, CWT Huey, GKL Wansaicheong
Singapore Medical Journal.2019; 60(8): 397. CrossRef
When a cure becomes the pathology: mechanical bowel obstruction due to herbal pharmacobezoar. A case report with review of literature
Saurabh Gandhi, Eham Arora, Ajay Bhandarwar, Arun Patil, Amol Wagh, Shubham Gupta
Clinical Journal of Gastroenterology.2018; 11(5): 396. CrossRef
An unusual cause of small bowel obstruction due to an ingested mango seed: a case report
A. R. Fernando, R. Bulathsinghela, D. N. Samarasekera
BMC Research Notes.2017;[Epub] CrossRef
Small Bowel Obstruction Caused by Aloe vera Bezoars: A Case Report
In Taik Hong, Jae Myung Cha, Hye Jin Ki, Min Seob Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeoun, Sung Il Choi
The Korean Journal of Gastroenterology.2017; 69(5): 312. CrossRef
Small bowel obstruction attributable to phytobezoar
Nasrin Razavianzadeh, Behzad Foroutan, Farhad Honarvar, Mohammad Forozeshfard
Oxford Medical Case Reports.2016; 2016(12): omw092. CrossRef
Intestinal obstruction due to phytobezoars: An update
Enis Dikicier
World Journal of Clinical Cases.2015; 3(8): 721. CrossRef
Bezoar-induced small bowel obstruction: Clinical characteristics and diagnostic value of multi-slice spiral computed tomography
Pei-Yuan Wang
World Journal of Gastroenterology.2015; 21(33): 9774. CrossRef
Imaging differentiation of phytobezoar and small-bowel faeces: CT characteristics with quantitative analysis in patients with small- bowel obstruction
Ya-Cheng Chen, Chang-Hsien Liu, Hsian-He Hsu, Chih-Yung Yu, Hong-Hau Wang, Hsiu-Lung Fan, Ran-Chou Chen, Wei-Chou Chang
European Radiology.2015; 25(4): 922. CrossRef
Ultrasonographic differentiation of bezoar from feces in small bowel obstruction
Kyung Hoon Lee, Hyun Young Han, Hee Jin Kim, Hee Kyung Kim, Moon Soo Lee
Ultrasonography.2015; 34(3): 211. CrossRef
Bulbus psododivertikülde mide çıkış obstrüksiyonuna neden olan ve gastroskopi ile mideye alınması sonrası ileus gelişen bezoar: olgu sunumu ve literatürün gözden geçirilmesi (duodenal bezoar)
Ahmet UYANIKOĞLU, Haşim NAR, Ahmet ŞEKER, Ferzan AYDIN, Yusuf YÜCEL, Necati YENİCE
Endoskopi Gastrointestinal.2015; 23(2): 58. CrossRef
Two cases of small bowel obstruction secondary to a swallowed potato
E Castren, A Hakeem, N S Mahmood, K Aryal
BMJ Case Reports.2015; : bcr2015213744. CrossRef
Phytobezoar: an unexpected cause of bowel obstruction in a pregnant woman with a history of Roux-en-Y gastric bypass
Faustine Deront Bourdin, Antonio Iannelli, Jerôme Delotte
Surgery for Obesity and Related Diseases.2014; 10(6): e49. CrossRef
Bezoar: An unusual cause of intestinal obstruction
K. Stratakis, A. Tsepelaki, E. Karallas, K. Koutsopoulos
Hellenic Journal of Surgery.2014; 86(1): 29. CrossRef
Intussusception caused by dried apricot: A case report
Yana Puckett, Jon Nathan, Sharmila Dissanaike
International Journal of Surgery Case Reports.2014; 5(12): 1254. CrossRef
Acute small bowel obstruction in a girl, caused by a jejunal bezoar composed of textile fibers
S. Zwaveling, D.C. van der Zee
Journal of Pediatric Surgery Case Reports.2013; 1(8): 192. CrossRef
Complications of Bezoar in Children: What Is New?
Kam Lun Ellis Hon, Jean Cheng, Chung Mo Chow, Hon Ming Cheung, Kam Lau Cheung, Yuk Him Tam, Alexander K. C. Leung
Case Reports in Pediatrics.2013; 2013: 1. CrossRef

Are Mutations of the EGFR Gene Promising Predictive Markers for Anti-EGFR mAbs in Colorectal Carcinomas?: Dong-Guk Park; J Korean Soc Coloproctol. 2011;27(3):103-104. Published online June 30, 2011; DOI: https://doi.org/10.3393/jksc.2011.27.3.103

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Effects of DCA on Cell Cycle Proteins in Colonocytes: Yun-Hyung Ha, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):254-259. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.254

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Abstract PDF

Purpose

Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous studies have been based on studies on colon cancer cell lines, the effect of DCA on normal colonocytes is unknown.

Methods

Normal colonocytes and Caco-2 and HCT116 cells were treated with 20 µM and 250 µM of DCA, and the effect of different concentrations of DCA was measured based on the expression of cell-cycle-related proteins by using Western blots.

Results

The expressions of CDK2 and cyclin D1 for different concentrations of DCA in normal colonocytes and colon cancer cells were similar, but the expressions of cyclin E and A were significantly different. In HCT116 colon cancer cells, the expression of cyclin E increased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin E was not changed or decreased. In HCT116 colon cancer cells, the expression of cyclin A was not changed or decreased regardless of the DCA concentration, but in normal colonocytes and Caco-2 cells, the expression of cyclin A was increased at a DCA concentration of 20 µM.

Conclusion

The effect of DCA on stimulating cell proliferation suggests that DNA synthesis is stimulated by an increased expression of cyclin E in colon cancer cells. Our results suggest that a low dose of DCA induces cellular proliferation through increased expression of cyclin A and that a high dose of DCA induces decreased expression of cyclin E and CDK2 in normal colonocytes.

Citations

Citations to this article as recorded by

Implication of gut microbes and its metabolites in colorectal cancer
Arun Kumar, Asgar Ali, Raj Kishore Kapardar, Ghulam Mehdi Dar, Nimisha, Apurva, Abhay Kumar Sharma, Renu Verma, Real Sumayya Abdul Sattar, Ejaj Ahmad, Bhawna Mahajan, Sundeep Singh Saluja
Journal of Cancer Research and Clinical Oncology.2023; 149(1): 441. CrossRef
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer
Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar, Rob Van Houdt
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner
Wei Zhu, Yan Si, Jun Xu, Yu Lin, Jing‐Zi Wang, Mengda Cao, Shanwen Sun, Qiang Ding, Lingjun Zhu, Ji‐Fu Wei
Journal of Cellular and Molecular Medicine.2020; 24(6): 3521. CrossRef
Microbiota in cancer development and treatment
Muhammad Hassan Raza, Kamni Gul, Abida Arshad, Naveeda Riaz, Usman Waheed, Abdul Rauf, Fahad Aldakheel, Shatha Alduraywish, Maqbool Ur Rehman, Muhammad Abdullah, Muhammad Arshad
Journal of Cancer Research and Clinical Oncology.2019; 145(1): 49. CrossRef
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer
Huawei Zeng, Shahid Umar, Bret Rust, Darina Lazarova, Michael Bordonaro
International Journal of Molecular Sciences.2019; 20(5): 1214. CrossRef
Dysbiosis of gut microbiota in promoting the development of colorectal cancer
Shaomin Zou, Lekun Fang, Mong-Hong Lee
Gastroenterology Report.2018; 6(1): 1. CrossRef
Oxidative stress: a key regulator of leiomyoma cell survival
Nicole M. Fletcher, Mohammed S. Abusamaan, Ira Memaj, Mohammed G. Saed, Ayman Al-Hendy, Michael P. Diamond, Ghassan M. Saed
Fertility and Sterility.2017; 107(6): 1387. CrossRef
Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53-mediated pathway
HAI-BO YANG, WEI SONG, MEI-DIE CHENG, HAI-FANG FAN, XU GU, YING QIAO, XIN LU, RUI-HE YU, LAN-YING CHEN
Molecular Medicine Reports.2015; 11(4): 2749. CrossRef
Differential Regulation of EGFR–MAPK Signaling by Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in Colon Cancer
Sara M. Centuori, Jesse D. Martinez
Digestive Diseases and Sciences.2014; 59(10): 2367. CrossRef
Bile acids in the colon, from healthy to cytotoxic molecules
Juan I. Barrasa, Nieves Olmo, Ma Antonia Lizarbe, Javier Turnay
Toxicology in Vitro.2013; 27(2): 964. CrossRef
Sodium deoxycholate inhibits chick duodenal calcium absorption through oxidative stress and apoptosis
María A. Rivoira, Ana M. Marchionatti, Viviana A. Centeno, Gabriela E. Díaz de Barboza, María E. Peralta López, Nori G. Tolosa de Talamoni
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2012; 162(4): 397. CrossRef

Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells: Won Jun Sohn, Jung Won Lee, Dong-Guk Park; J Korean Soc Coloproctol. 2010;26(4):246-253. Published online August 31, 2010; DOI: https://doi.org/10.3393/jksc.2010.26.4.246

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Abstract PDF

Purpose

Oxaliplatin is a third-generation platinum compound, and it has no nephrotoxicity and has reduced bone marrow toxicity. Cancer cells that are resistant to cisplatin are sensitive to oxaliplatin. Oxaliplatin is used widely for the treatment of colon cancers. Recently, oxaliplatin was reported to inhibit the expression of survivin, which protects cell apoptosis. However, there are no reports on the expressions of survivin variants and the changes in intracellular localization of survivin in cancer cells. We studied the expression of survivin caused by oxaliplatin in HCT116 colon cancer cells, and we observed the localization of survivin in the mitotic phase.

Methods

We treated the HCT116 colon cancer cells with 2.0 µM of oxaliplatin, and we studied the expressions of survivin protein, and survivin mRNA variants, as well as the changes in intracellular localization, by using the Western blot method, RT-PCR, immunocytochemistry, and flowcytometry.

Results

Oxaliplatin inhibits the expression of the survivin protein and survivin mRNA in HCT116 colon cancer cells. The expression of the survivin-2B variants, which have no antiapoptotic activity but control cell mitosis by localization on a microtubule, is reduced continuously 2 days after treatment with oxaliplatin. In immunocytochemistry, expression of survivin in the cytoplasm is reduced and especially is not expressed in microtubules and contractile rings.

Conclusion

One of the mechanisms of oxaliplatin is to inhibit the expression of and to change the localization of survivin. Based on these results, we suggest that changes in the expression of survivin variants and in their localization are two effects of oxaliplatin.

Citations

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Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial
M Verstraete, A Debucquoy, J Dekervel, J van Pelt, C Verslype, E Devos, G Chiritescu, K Dumon, A D'Hoore, O Gevaert, X Sagaert, E Van Cutsem, K Haustermans
British Journal of Cancer.2015; 112(8): 1314. CrossRef
Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
Dong-Guk Park
Annals of Surgical Treatment and Research.2014; 86(2): 68. CrossRef

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