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Byong Ho Jeon 3 Articles
Benign GI diease,Benign diesease & IBD,Surgical technique
Clinical outcomes of locking polymeric clip for laparoscopic appendectomy in patients with appendicitis: a retrospective comparison with loop ligature
Seokwon Kim, Byong Ho Jeon, Sang Sik Cho, Ui Sup Shin, Sun Mi Moon
Ann Coloproctol. 2022;38(2):160-165.   Published online January 18, 2022
DOI: https://doi.org/10.3393/ac.2021.00598.0085
  • 3,223 View
  • 181 Download
  • 3 Web of Science
  • 2 Citations
AbstractAbstract PDF
Purpose
This study aimed to compare the clinical outcomes of laparoscopic appendectomy (LA) according to the method of appendiceal stump closure.
Methods
Patients who underwent LA for appendicitis between 2010 and 2020 were retrospectively reviewed. Patients were classified into locking polymeric clip (LPC) and loop ligature (LL) groups. Clinical outcomes were compared between the groups.
Results
LPC and LL were used in 188 (56.6%) and 144 patients (43.4%), respectively for appendiceal stump closure. No significant differences were observed in sex, age, comorbidities, and the severity of appendicitis between the groups. The median operative time was shorter in the LPC group than in the LL group (64.5 minutes vs. 71.5 minutes, P=0.027). The median hospital stay was longer in the LL group than in the LPC group (4 days vs. 3 days, P=0.020). Postoperative incidences of intraabdominal abscess and ileus were higher in the LL group than in the LPC group (4.2% vs. 1.1%, P=0.082 and 2.8% vs. 0%, P=0.035; respectively). The readmission rate was higher in the LL group than that in the LPC group (6.3% vs. 1.1%, P=0.012).
Conclusion
Using LPC for appendiceal stump closure during LA for appendicitis was associated with lower postoperative complication rate, shorter operative time, and shorter hospital stay compared to the use of LL. Operative time above 60 minutes and the use of LL were identified as independent risk factors for postoperative complications in LA. Therefore, LPC could be considered a more favorable closure method than LL during LA for appendicitis.

Citations

Citations to this article as recorded by  
  • Comparison of polymeric clip and endoloop in laparoscopic appendectomy: A systematic review and meta-analysis
    Aashish Kumar, Muhammad Saqlain Mustafa, Muhammad Ashir Shafique, Abdul Haseeb, Hussain Sohail Rangwala, Haimath Kumar, Burhanuddin Sohail Rangwala, Adarsh Raja, Sandesh Raja, Syed Muhammad Sinaan Ali
    Surgery.2024; 176(5): 1329.     CrossRef
  • Advantages of using a polymeric clip versus an endoloop during laparoscopic appendectomy in uncomplicated appendicitis: a randomized controlled study
    Kil-yong Lee, Jaeim Lee, Youn Young Park, Seong Taek Oh
    World Journal of Emergency Surgery.2023;[Epub]     CrossRef
Malignant disease, Rectal cancer,Prognosis and adjuvant therapy,Colorectal cancer
The Impact of Primary Tumor Resection on Survival in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases
Ki Yoon Doah, Ui Sup Shin, Byong Ho Jeon, Sang Sik Cho, Sun Mi Moon
Ann Coloproctol. 2021;37(2):94-100.   Published online April 30, 2021
DOI: https://doi.org/10.3393/ac.2020.09.15.1
  • 4,182 View
  • 86 Download
  • 15 Citations
AbstractAbstract PDF
Purpose
This study was conducted to evaluate the effectiveness of primary tumor resection (PTR) in asymptomatic colorectal cancer (CRC) patients with unresectable metastases using the inverse probability of treatment weighting (IPTW) method to minimize selection bias.
Methods
We selected 146 patients diagnosed with stage IV CRC with unresectable metastasis between 2001 and 2018 from our institutional database. In a multivariate logistic regression model using the patients’ baseline covariates associated with PTR, we applied the IPTW method based on a propensity score and performed a weighted Cox proportional regression analysis to estimate survival according to PTR.
Results
Upfront PTR was performed in 98 patients, and no significant differences in baseline factors were detected. The upweighted median survival of the PTR group was 18 months and that of the non-PTR group was 15 months (P = 0.15). After applying the IPTW, the PTR was still insignificant in the univariate Cox regression (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.5–1.21). However, in the multivariate weighted Cox regression with adjustment for other covariates, the PTR showed a significantly decreased risk of cancer-related death (HR, 0.61; 95% CI, 0.40–0.94).
Conclusion
In this study, we showed that asymptomatic CRC patients with unresectable metastases could gain a survival benefit from upfront PTR by analysis with the IPTW method. However, randomized controlled trials are mandatory.

Citations

Citations to this article as recorded by  
  • Primary tumor resection for asymptomatic colorectal cancer patients with synchronous unresectable metastases: a meta-analysis of randomized controlled trials and case-matched studies
    Jun Huang, Jiahao Zhou, Ping Zhang, Qingbin Wu, Ziqiang Wang
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Effect of primary tumor resection on survival in patients with asymptomatic unresectable metastatic colorectal cancer: a systematic review and meta-analysis
    Chengren Zhang, Cong Cao, Lili Liu, Yaochun Lv, Jingjing Li, Jiyong Lu, Shuai Wang, Binbin Du, Xiongfei Yang
    Expert Review of Anticancer Therapy.2023; 23(1): 107.     CrossRef
  • The role of upfront primary tumor resection in asymptomatic patients with unresectable stage IV colorectal cancer: A systematic review and meta-analysis
    Zongyu Liang, Zhiyuan Liu, Chengzhi Huang, Xin Chen, Zhaojun Zhang, Meijuan Xiang, Weixian Hu, Junjiang Wang, Xingyu Feng, Xueqing Yao
    Frontiers in Surgery.2023;[Epub]     CrossRef
  • Primary tumor resection in colorectal cancer patients with unresectable distant metastases: a minireview
    Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Palliative primary tumor resection in minimally symptomatic (asymptomatic) patients with colorectal cancer and synchronous unresectable metastases versus chemotherapy alone: a metaanalysis
    Iu. V. Alimova, Yu. A. Shelygin, E. G. Rybakov, M. V. Alekseev
    Koloproktologia.2023; 22(2): 126.     CrossRef
  • The impact of primary tumor resection for asymptomatic colorectal cancer patients with unresectable metastases: a systematic review and meta-analysis
    Shuyuan Li, Liqiang Ji, Jie Huang, Ye Wang, Peng Liu, Wei Zhang, Zheng Lou
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • The impact of palliative primary tumor resection on overall survival in minimally symptomatic (asymptomatic) colorectal cancer and synchronous unresectable metastases vs chemotherapy only: a comparative study of outcomes
    Iu. V. Alimova, S. I. Achkasov, Yu. A. Shelygin, M. V. Alekseev, V. N. Kashnikov, M. Yu. Fedyanin, M. A. Danilov, E. G. Rybakov
    Koloproktologia.2023; 22(4): 10.     CrossRef
  • Recurrence Patterns and Risk Factors after Curative Resection for Colorectal Cancer: Insights for Postoperative Surveillance Strategies
    Hyo Seon Ryu, Jin Kim, Ye Ryung Park, Eun Hae Cho, Jeong Min Choo, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak
    Cancers.2023; 15(24): 5791.     CrossRef
  • Palliative primary tumor resection in minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases: when is it necessary? (systematic review)
    Iu. V. Alimova, Yu. A. Shelygin, E. G. Rybakov
    Koloproktologia.2022; 21(3): 99.     CrossRef
  • Surgical treatment for metastatic colorectal cancer
    Eun Jung Park, Seung Hyuk Baik
    Journal of the Korean Medical Association.2022; 65(9): 568.     CrossRef
  • Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version
    Eun Jung Park, Seung Hyuk Baik
    Journal of the Anus, Rectum and Colon.2022; 6(4): 213.     CrossRef
  • Molecular analyses of peritoneal metastasis from colorectal cancer
    Chang Hyun Kim
    Journal of the Korean Medical Association.2022; 65(9): 586.     CrossRef
  • Molecular Analyses in Peritoneal Metastasis from Colorectal Cancer: A Review-An English Version
    Chang Hyun Kim
    Journal of the Anus, Rectum and Colon.2022; 6(4): 197.     CrossRef
  • Primary Tumor Resection in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases: Can It Improve Survival?
    Myong Hoon Ihn
    Annals of Coloproctology.2021; 37(2): 71.     CrossRef
  • Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
    Young Jin Kim, Chang Hyun Kim
    Annals of Coloproctology.2021; 37(6): 425.     CrossRef
Neutrophil to Lymphocyte Ratio: A Predictive Marker for Treatment Outcomes in Patients With Rectal Cancer Who Underwent Neoadjuvant Chemoradiation Followed by Surgery
Byong Ho Jeon, Ui Sup Shin, Sun Mi Moon, Jung Il Choi, Mi-Sook Kim, Kie Hwan Kim, Se-Jin Sung
Ann Coloproctol. 2019;35(2):100-106.   Published online April 30, 2019
DOI: https://doi.org/10.3393/ac.2018.10.01
  • 4,807 View
  • 130 Download
  • 15 Web of Science
  • 16 Citations
AbstractAbstract PDF
Purpose
In this study, we investigated the role of neutrophil to lymphocyte ratio (NLR) as a predictor of tumor response and as a prognostic factor in patients with rectal cancer who had undergone curative surgery after neoadjuvant chemoradiation therapy (nCRT).
Methods
Between January 2009 and July 2016, we collected 140 consecutive patients who had undergone curative intent surgery after nCRT due to rectal adenocarcinoma. We obtained the pre- and post-nCRT NLR by dividing the neutrophil count by the lymphocyte count. The cutoff value was obtained using receiver operating characteristic analysis for tumor response and using maximally selected rank analysis for recurrence-free survival (RFS). The relationship among NLR, tumor response, and RFS was assessed by adjusting the possible clinico-pathological confounding factors.
Results
The possibility of pathologic complete response (pCR) was significantly decreased in high pre- (>2.77) and postnCRT NLR (>3.23) in univariate regression analysis. In multivariate analysis, high post-nCRT NLR was an independent negative predictive factor for pCR (adjusted odds ratio, 0.365; 95% confidence interval [CI], 0.145–0.918). The 5-year RFS of all patients was 74.6% during the median 37 months of follow-up. Patients with higher pre- (>2.66) and post-nCRT NLR (>5.21) showed lower 5-year RFS rates (53.1 vs. 83.3%, P = 0.006) (69.2 vs. 75.7%, P = 0.054). In multivariate Cox analysis, high pre-nCRT NLR was an independent poor prognostic factor for RFS (adjusted hazard ratio, 2.300; 95% CI, 1.061–4.985).
Conclusion
Elevated NLR was a negative predictive marker for pCR and was independently associated with decreased RFS. For confirmation, a large-scale study with appropriate controls is needed.

Citations

Citations to this article as recorded by  
  • Landscape of Biomarkers and Pathologic Response in Rectal Cancer: Where We Stand?
    Abrahams Ocanto, Macarena Teja, Francesco Amorelli, Felipe Couñago, Ariel Gomez Palacios, Diego Alcaraz, Ramón Cantero
    Cancers.2024; 16(23): 4047.     CrossRef
  • Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis
    Giuseppe Portale, Patrizia Bartolotta, Danila Azzolina, Dario Gregori, Valentino Fiscon
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • NEUTROPHIL-LYMPHOCYTE RATIO (NLR) AND LYMPHOPENIAAS PROGNOSTIC FACTORS OF OVERALL SURVIVAL IN LOCALADVANCED RECTAL CANCER
    Ocanto A, Morera R, Rodríguez I, Cantero R
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2023; : 11.     CrossRef
  • Neutrophil-to-lymphocyte ratio predicts survival of patients with rectal cancer receiving neo-adjuvant chemoradiation followed by radical resection: a meta-analysis
    Giuseppe Colloca, Antonella Venturino, Domenico Guarneri
    Expert Review of Anticancer Therapy.2023; 23(4): 421.     CrossRef
  • Efficacy of concurrent radiotherapy in patients with locally advanced rectal cancer and synchronous metastasis receiving systemic therapy
    Tzu-Chieh Yin, Po-Jung Chen, Yung-Sung Yeh, Ching-Chun Li, Yen-Cheng Chen, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Chun-Ming Huang, Hsiang-Lin Tsai, Jaw-Yuan Wang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The Crying Need for a Better Response Assessment in Rectal Cancer
    Samuel Amintas, Nicolas Giraud, Benjamin Fernandez, Charles Dupin, Quentin Denost, Aurelie Garant, Nora Frulio, Denis Smith, Anne Rullier, Eric Rullier, Te Vuong, Sandrine Dabernat, Véronique Vendrely
    Current Treatment Options in Oncology.2023; 24(11): 1507.     CrossRef
  • Prognostic Role of Peripheral Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy
    Şefika Arzu Ergen, Ceren Barlas, Cumhur Yıldırım, Didem Çolpan Öksüz
    Journal of Gastrointestinal Cancer.2022; 53(1): 151.     CrossRef
  • Deep regional hyperthermia combined with modern concurrent chemoradiotherapy increases T-downstaging rate in locally advanced rectal cancer
    Yuxia Wang, Siyi Lu, Yuxia Shao, Ran Peng, Xuemin Li, Junjie Wang, Hao Wang
    International Journal of Hyperthermia.2022; 39(1): 431.     CrossRef
  • High Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Low Lymphocyte Levels Are Correlated With Worse Pathological Complete Response Rates
    Serdar Karakaya, İbrahim Karadağ, Mehmet Emin Yılmaz, Ömür Berna Çakmak Öksüzoğlu
    Cureus.2022;[Epub]     CrossRef
  • Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
    Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui-Jae Bang, Hyejin Do, Hyang-Rae Lee, Youngwan Kim
    Annals of Coloproctology.2022; 38(2): 97.     CrossRef
  • Watch and wait strategies for rectal cancer: A systematic review
    In Ja Park
    Precision and Future Medicine.2022; 6(2): 91.     CrossRef
  • Histopathological and Haemogram Features Correlate with Prognosis in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiation without Pathological Complete Response
    Yu-Ming Huang, Hsi-Hsien Hsu, Chien-Kuo Liu, Ching-Kuo Yang, Po-Li Tsai, Tzu-Yin Tang, Shih-Ming Hsu, Yu-Jen Chen
    Journal of Clinical Medicine.2022; 11(17): 4947.     CrossRef
  • Prognostic and predictive value of neutrophil-to-lymphocyte ratio after curative rectal cancer resection: A systematic review and meta-analysis
    Hytham K.S. Hamid, George N. Davis, Mario Trejo-Avila, Patrick O. Igwe, Andrés Garcia-Marín
    Surgical Oncology.2021; 37: 101556.     CrossRef
  • The prognostic utility of pre‐treatment neutrophil‐to‐lymphocyte‐ratio (NLR) in colorectal cancer: A systematic review and meta‐analysis
    Mate Naszai, Alina Kurjan, Timothy S. Maughan
    Cancer Medicine.2021; 10(17): 5983.     CrossRef
  • Predictive Ability of Neutrophil-Lymphocyte Ratio in Determining Tumor Staging in Colorectal Cancer
    Chirag Pereira, Jiju Mohan, Shankar Gururaj, Prajwal Chandrashekhara
    Cureus.2021;[Epub]     CrossRef
  • An inflammation index-based prediction of treatment response to neoadjuvant chemoradiotherapy for rectal mucinous adenocarcinoma
    Yanwu Sun, Zhekun Huang, Pan Chi
    International Journal of Clinical Oncology.2020; 25(7): 1299.     CrossRef

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